858 Matching Annotations
  1. Nov 2021
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tpl2 contributes to IL-1β-induced IL-8 expression via ERK1/2 activation in canine dermal fibroblasts
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    1. scibot 09 Nov 2021
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      DOI: 10.1371/journal.pone.0259489

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    ncbi.nlm.nih.gov/pmc/articles/PMC8568182/
  3. www.sciencedirect.com www.sciencedirect.com
    Role of adipocyte Na,K-ATPase oxidant amplification loop in cognitive decline and neurodegeneration
    1
    1. scibot 09 Nov 2021
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      DOI: 10.1016/j.isci.2021.103262

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    sciencedirect.com/science/article/pii/S2589004221012311
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    GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12
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    1. scibot 09 Nov 2021
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    sciencedirect.com/science/article/pii/S2589004221012803
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload
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    1. scibot 05 Nov 2021
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      DOI: 10.7554/eLife.58313

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    ncbi.nlm.nih.gov/pmc/articles/PMC8547954/
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glut1 expression in tumor-associated neutrophils promotes lung cancer growth and resistance to radiotherapy
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    1. scibot 05 Nov 2021
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      DOI: 10.1158/0008-5472.CAN-20-2870

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    ncbi.nlm.nih.gov/pmc/articles/PMC8137580/
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    LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency
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    1. scibot 04 Nov 2021
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    sciencedirect.com/science/article/pii/S2666634021003421
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    Convergence of distinct signaling pathways on synaptic scaling to trigger rapid antidepressant action
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    sciencedirect.com/science/article/pii/S2211124721013917
  9. Oct 2021
  10. www.sciencedirect.com www.sciencedirect.com
    MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer
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    1. scibot 29 Oct 2021
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    sciencedirect.com/science/article/pii/S2589004221011925
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    Retinoic acid signaling is directly activated in cardiomyocytes and protects mouse hearts from apoptosis after myocardial infarction
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8530512/
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    Anti-Inflammatory and Antimicrobial Volatile Oils: Fennel and Cumin Inhibit Neutrophilic Inflammation via Regulating Calcium and MAPKs
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    1. scibot 28 Oct 2021
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    ncbi.nlm.nih.gov/pmc/articles/PMC8545060/
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    Cell geometry, signal dampening, and a bimodal transcriptional response underlie the spatial precision of an ERK-mediated embryonic induction
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    1. scibot 21 Oct 2021
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    sciencedirect.com/science/article/pii/S1534580721007693
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    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
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    1. scibot 21 Oct 2021
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    sciencedirect.com/science/article/pii/S2211124721013371
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    Proteomic and phosphoproteomic analyses identify liver-related signaling in retinal pigment epithelial cells during EMT
    1
    1. scibot 21 Oct 2021
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    sciencedirect.com/science/article/pii/S2211124721013334
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    Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas
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    1. scibot 21 Oct 2021
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      DOI: 10.1016/j.celrep.2021.109873

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    sciencedirect.com/science/article/pii/S2211124721013401
  17. mct.aacrjournals.org mct.aacrjournals.org
    Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor–Resistant Melanoma
    1
    1. scibot 20 Oct 2021
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      DOI: 10.1158/1535-7163.MCT-20-1126

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  18. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 20 Oct 2021
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      DOI: 10.1111/bph.15616

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15616
  19. www.sciencedirect.com www.sciencedirect.com
    PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory
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    sciencedirect.com/science/article/pii/S221112472101264X
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    Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
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    1. scibot 06 Oct 2021
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    sciencedirect.com/science/article/pii/S2211124721012316
  21. www.sciencedirect.com www.sciencedirect.com
    Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice
    1
    1. scibot 05 Oct 2021
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      DOI: 10.1016/j.devcel.2021.09.008

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    sciencedirect.com/science/article/pii/S1534580721007267
  22. Sep 2021
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mesenchymal stem cells attenuate liver fibrosis by targeting Ly6Chi/lo macrophages through activating the cytokine-paracrine and apoptotic pathways
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    1. scibot 28 Sep 2021
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      DOI: 10.1038/s41420-021-00584-z

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    ncbi.nlm.nih.gov/pmc/articles/PMC8437974/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling
    1
    1. scibot 22 Sep 2021
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      DOI: 10.7554/eLife.68843

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    ncbi.nlm.nih.gov/pmc/articles/PMC8445623/
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    Aging-Dependent Downregulation of SUV39H1 Histone Methyltransferase Increases Susceptibility to Stress-Induced Depressive Behavior
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    1. scibot 22 Sep 2021
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      DOI: 10.1007/s12035-021-02529-0

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    link.springer.com/article/10.1007/s12035-021-02529-0
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    Diurnal regulation of oxidative phosphorylation restricts hepatocyte proliferation and inflammation
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    1. scibot 08 Sep 2021
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    sciencedirect.com/science/article/pii/S2211124721011037
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    SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages
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      DOI: 10.1016/j.celrep.2021.109662

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    sciencedirect.com/science/article/pii/S2211124721011062
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    KDM6B epigenetically regulated-interleukin-6 expression in the dorsal root ganglia and spinal dorsal horn contributes to the development and maintenance of neuropathic pain following peripheral nerve injury in male rats
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    sciencedirect.com/science/article/pii/S0889159121005213
  29. Aug 2021
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Role of hypothalamic MAPK/ERK signaling and central action of FGF1 in diabetes remission
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    ncbi.nlm.nih.gov/pmc/articles/PMC8368994/
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    Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis
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    sciencedirect.com/science/article/pii/S2211124721010342
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    Dynamic bi-directional phosphorylation events associated with the reciprocal regulation of synapses during homeostatic up- and down-scaling
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    sciencedirect.com/science/article/pii/S2211124721010172
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    Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy
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      DOI: 10.1016/j.ccell.2021.07.023

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    sciencedirect.com/science/article/pii/S1535610821004025
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    The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis
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      DOI: 10.1016/j.immuni.2021.06.008

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    sciencedirect.com/science/article/pii/S1074761321002521
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    NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms
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    sciencedirect.com/science/article/pii/S2211124721009451
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    Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments
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    Cytohesin-2 mediates group I metabotropic glutamate receptor-dependent mechanical allodynia through the activation of ADP ribosylation factor 6 in the spinal cord
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    sciencedirect.com/science/article/pii/S0969996121002151
  38. www.nature.com www.nature.com
    Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system
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    nature.com/articles/s41467-021-24821-2
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    A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies
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    A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength
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    sciencedirect.com/science/article/pii/S2211124721008901
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1016/j.cell.2017.07.031

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    ncbi.nlm.nih.gov/pmc/articles/PMC6381294/
  42. elifesciences.org elifesciences.org
    GIPC proteins negatively modulate Plexind1 signaling during vascular development
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      DOI: 10.7554/eLife.30454

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    elifesciences.org/articles/30454
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC5522529/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6410498/
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      DOI: 10.1016/j.ebiom.2018.04.005

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  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TrkB‐mediated activation of the phosphatidylinositol‐3‐kinase/Akt cascade reduces the damage inflicted by oxygen‐glucose deprivation in area CA3 of the rat hippocampus
    1
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      DOI: 10.1111/ejn.13880

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  92. academic.oup.com academic.oup.com
    Selective androgen receptor modulator S42 suppresses prostate cancer cell proliferation
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      AB_2315112

      DOI: 10.1210/en.2018-00099

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      AB_2315112u00a0

      DOI: 10.1210/en.2018-00099

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  93. www.sciencedirect.com www.sciencedirect.com
    Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression
    2
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    Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness
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      Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XPu00a0Rabbit mAb

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  95. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Sprouty1 regulates neuritogenesis and survival of cortical neurons
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    Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling
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  97. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Sustained activation of ERK1/2 MAPK in Schwann cells causes corneal neurofibroma
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      DOI: 10.1002/jnr.24067

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  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  99. www.cell.com www.cell.com
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  101. pubs.acs.org pubs.acs.org
    Pierced Lasso Topology Controls Function in Leptin
    1
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      AB_2281741

      DOI: 10.1021/acs.jpcb.6b11506

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    Behavioral and cellular dopamine D1 and D3 receptor-mediated synergy: Implications for L-DOPA-induced dyskinesia
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    Maternal separation stress reduced prenatal-ethanol-induced increase in exploratory behaviour and extracellular signal-regulated kinase activity
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  104. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Early ethanol exposure and vinpocetine treatment alter learning‐ and memory‐related proteins in the rat hippocampus and prefrontal cortex
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      DOI: 10.1002/jnr.23894

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  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis
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      DOI: 10.15252/msb.20145877

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  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Contextual Fear Memory Maintenance Changes Expression of pMAPK, BDNF and IBA-1 in the Pre-limbic Cortex in a Layer-Specific Manner
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      DOI: 10.3389/fncir.2021.660199

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    Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX
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    Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling
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    The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression
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    Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer
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    Doxorubicin induces dysregulation of AMPA receptor and impairs hippocampal synaptic plasticity leading to learning and memory deficits
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    Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target
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  116. Jun 2021
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    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
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    Planarian stem cells sense the identity of the missing pharynx to launch its targeted regeneration
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    Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation
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    Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch
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    DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity
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    OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin
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    Protective effects of Da-cheng-qi decoction in rats with intracerebral hemorrhage
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    Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1
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    Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis
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  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-PanIN-seq unveils that ARID1A deficiency promotes pancreatic tumorigenesis by attenuating KRAS-induced senescence
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    Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma
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    Extensive remodeling of the extracellular matrix during aging contributes to age-dependent impairments of muscle stem cell functionality
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    The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia
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    A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2α-induced corpus luteum regression
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    Stk24 protects against obesity-associated metabolic disorders by disrupting the NLRP3 inflammasome
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    The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation
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    Cyclooxygenase inhibition attenuates brain angiogenesis and independently decreases mouse survival under hypoxia
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    Dynamic subcellular localization and transcription activity of the SRF cofactor MKL2 in the striatum are regulated by MAPK
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    VEGF receptor 2 (KDR) protects airways from mucus metaplasia through a Sox9-dependent pathway
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    UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling
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    SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells
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    LDLR inhibition promotes hepatocellular carcinoma proliferation and metastasis by elevating intracellular cholesterol synthesis through MEK/ERK signaling pathway
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    PDZ domain protein SYNJ2BP regulates GRK-dependent Sst2A phosphorylation and downstream MAPK signaling
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    Cell of Origin Influences Pancreatic Cancer Subtype
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    Synergistic interaction of nerve growth factor and glial cell‐line derived neurotrophic factor in muscular mechanical hyperalgesia in rats
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    Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains
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    Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis
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    The protective role of Ephrin-B2/EphB4 signaling in osteogenic differentiation under inflammatory environment
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    Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium
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    Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1-42 infused rat model
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    Diazepam and SL-327 synergistically attenuate anxiety-like behaviours in mice – Possible hippocampal MAPKs specificity
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    Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation
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    Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy
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    eEF2/eEF2K Pathway in the Mature Dentate Gyrus Determines Neurogenesis Level and Cognition
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      Anti-Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP® Rabbit mAb

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    Hydroxychloroquine Inhibits Macrophage Activation and Attenuates Renal Fibrosis After Ischemia-Reperfusion Injury
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    Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids
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    Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways
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      Rabbit anti-Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) Monoclonal antibody

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    Pharmacoproteomics Identifies Kinase Pathways that Drive the Epithelial-Mesenchymal Transition and Drug Resistance in Hepatocellular Carcinoma
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    TNFα-Erk1/2 signaling pathway-regulated SerpinE1 and SerpinB2 are involved in lipopolysaccharide-induced porcine granulosa cell proliferation
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    An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping
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    Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor Design
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    β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors
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    Cell Lineage-Based Stratification for Glioblastoma
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    Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer
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    Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer
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    Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules
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  170. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CDKN2A Deletion in Melanoma Excludes T Cell Infiltration by Repressing Chemokine Expression in a Cell Cycle-Dependent Manner
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  172. www.sciencedirect.com www.sciencedirect.com
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    An inhibitory circuit from brainstem to GnRH neurons in male mice: a new role for the RFRP receptor
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  174. www.nature.com www.nature.com
    Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling
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  175. Mar 2021
  176. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenetic modulation reveals differentiation state specificity of oncogene addiction
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  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock
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    Rab5 and Rab11 maintain hematopoietic homeostasis by restricting multiple signaling pathways in Drosophila
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    Recombinant human growth hormone activates neuroprotective growth factors in hypoxic brain injury in neonatal mice
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    Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy
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  182. Feb 2021
  183. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS
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  184. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models
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  185. www.cell.com www.cell.com
    Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex
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  186. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Gut microbiota regulate cognitive deficits and amyloid deposition in a model of Alzheimer’s disease
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    Glucocorticoids attenuate interleukin‐6‐induced c‐Fos and Egr1 expression and impair neuritogenesis in PC12 cells
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    Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo
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    Inhibition of FGF10-ERK signal activation suppresses intraductal papillary neoplasm of the bile duct and its associated carcinomas
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    Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination
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    Gangliosides in the differentiation process of primary neurons: the specific role of GM1-oligosaccharide
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    Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells
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    Gnrh3 regulates PGC proliferation and sex differentiation in developing zebrafish
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    Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization
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    Tyrosine kinase inhibitors protect the salivary gland from radiation damage by increasing DNA double strand break repair
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    Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes
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  197. Jan 2021
  198. www.frontiersin.org www.frontiersin.org
    DL-3n-Butylphthalide Improves Blood–Brain Barrier Integrity in Rat After Middle Cerebral Artery Occlusion
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  199. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Monomeric/dimeric forms of Fgf15/FGF19 show differential activity in hepatocyte proliferation and metabolic function
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    Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer
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  201. link.springer.com link.springer.com
    Lactate regulates autophagy through ROS-mediated activation of ERK1/2/m-TOR/p-70S6K pathway in skeletal muscle
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  202. Dec 2020
  203. www.cell.com www.cell.com
    Neuropeptides Modulate Local Astrocytes to Regulate Adult Hippocampal Neural Stem Cells
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  204. www.sciencedirect.com www.sciencedirect.com
    Gain-of-function hot spot mutant p53R248Q regulation of integrin/FAK/ERK signaling in esophageal squamous cell carcinoma
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    Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death
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      Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204)

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  206. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Ascorbate deficiency decreases dopamine release in gulo–/– and APP/PSEN1 mice
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      P‐p44/42 MAPK

      DOI: 10.1111/jnc.15151

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  207. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  208. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Hetero-oligomerization of Rho and Ras GTPases Connects GPCR Activation to mTORC2-AKT Signaling
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  209. Nov 2020
  210. www.cell.com www.cell.com
    Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait
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