1,241 Matching Annotations
  1. Sep 2020
  2. www.sciencedirect.com www.sciencedirect.com
    Mn2+ Directly Activates cGAS and Structural Analysis Suggests Mn2+ Induces a Noncanonical Catalytic Synthesis of 2′3′-cGAMP
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    sciencedirect.com/science/article/pii/S221112472031038X
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    The Septate Junction Protein Tsp2A Restricts Intestinal Stem Cell Activity via Endocytic Regulation of aPKC and Hippo Signaling
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    cell.com/cell-reports/abstract/S2211-1247(18)32024-2
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    Pathogenic Variants in CEP85L Cause Sporadic and Familial Posterior Predominant Lissencephaly
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    sciencedirect.com/science/article/pii/S0896627320300532
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    LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice
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    sciencedirect.com/science/article/pii/S1097276520300022
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    Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver
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    sciencedirect.com/science/article/pii/S0092867420304761
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    Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons
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    RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia
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    sciencedirect.com/science/article/pii/S193459092030148X
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    ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair
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    A terminal selector prevents a Hox transcriptional switch to safeguard motor neuron identity throughout life
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    Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration In Vivo
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    Differential song deficits after lentivirus-mediated knockdown of FoxP1, FoxP2 or FoxP4 in Area X of juvenile zebra finches
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      DOI: 10.1523/JNEUROSCI.1250-19.2019

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    The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs
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    Structures of Gα Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms
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    The G3BP1-Family-USP10 Deubiquitinase Complex Rescues Ubiquitinated 40S Subunits of Ribosomes Stalled in Translation from Lysosomal Degradation
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    AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
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      DOI: 10.1038/s41467-020-14812-0

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    p53 Integrates Temporal WDR5 Inputs during Neuroectoderm and Mesoderm Differentiation of Mouse Embryonic Stem Cells
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    RBM45 associates with nuclear stress bodies and forms nuclear inclusions during chronic cellular stress and in neurodegenerative diseases
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      DOI: 10.1186/s40478-020-00965-y

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    Ubiquitylation of the ER-Shaping Protein Lunapark via the CRL3KLHL12 Ubiquitin Ligase Complex
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    The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency
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      DOI: 10.1016/j.celrep.2020.107985

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    sciencedirect.com/science/article/pii/S2211124720309700
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    ELAC1 Repairs tRNAs Cleaved during Ribosome-Associated Quality Control
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    Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody
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      DOI: 10.1016/j.cell.2020.01.029

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    sciencedirect.com/science/article/pii/S0092867420301100
  23. www.embopress.org www.embopress.org
    Organismal benefits of transcription speed control at gene boundaries
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      DOI: 10.15252/embr.201949315

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    Regulated Proteolysis of MutSγ Controls Meiotic Crossing Over
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    SENP3 Suppresses Osteoclastogenesis by De-conjugating SUMO2/3 from IRF8 in Bone Marrow-Derived Monocytes
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    Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition
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    The Cdc48 Complex Alleviates the Cytotoxicity of Misfolded Proteins by Regulating Ubiquitin Homeostasis
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      DOI: 10.1016/j.celrep.2020.107898

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    An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication
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    Regulation of Nucleotide Metabolism and Germline Proliferation in Response to Nucleotide Imbalance and Genotoxic Stresses by EndoU Nuclease
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  30. www.nature.com www.nature.com
    Tead transcription factors differentially regulate cortical development
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      DOI: 10.1038/s41598-020-61490-5

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    Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins
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      DOI: 10.7554/eLife.52896

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    Sen1 Is Recruited to Replication Forks via Ctf4 and Mrc1 and Promotes Genome Stability
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    MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation
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    Deamidation Shunts RelA from Mediating Inflammation to Aerobic Glycolysis
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    Maintenance of Cardiolipin and Crista Structure Requires Cooperative Functions of Mitochondrial Dynamics and Phospholipid Transport
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      DOI: 10.1016/j.celrep.2018.12.070

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    cell.com/cell-reports/abstract/S2211-1247(18)32015-1
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ORANGE: A CRISPR/Cas9-based genome editing toolbox for epitope tagging of endogenous proteins in neurons
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      DOI: 10.1371/journal.pbio.3000665

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    Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and Malignant Progression of Breast Cancer through the RNH1/TRIM21/mTOR Cascade
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    MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development
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    Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer
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    Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription
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      DOI: 10.1016/j.molcel.2020.01.008

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    Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice
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    Targeting the Oncogenic Long Non-coding RNA SLNCR1 by Blocking Its Sequence-Specific Binding to the Androgen Receptor
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    Homeostatic Control of Meiotic Prophase Checkpoint Function by Pch2 and Hop1
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    Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains
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    KAP1 Is a Chromatin Reader that Couples Steps of RNA Polymerase II Transcription to Sustain Oncogenic Programs
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    The role of Rif1 in telomere length regulation is separable from its role in origin firing
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    Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission
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    Protein O-GlcNAc Modification Links Dietary and Gut Microbial Cues to the Differentiation of Enteroendocrine L Cells
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    MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome
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    PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis
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    Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase
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    Cohesin Removal Reprograms Gene Expression upon Mitotic Entry
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    Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death
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  55. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    The cell adhesion molecule L1 interacts with nuclear proteins via its intracellular domain
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      DOI: 10.1096/fj.201902242R

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    Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase
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      DOI: 10.1016/j.cell.2019.12.012

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    The Mammalian Cap-Specific m6Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues
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  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding
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      DOI: 10.7554/eLife.54387

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    JNK signalling regulates antioxidant responses in neurons
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  60. www.cell.com www.cell.com
    WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop
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      DOI: 10.1016/j.celrep.2018.12.023

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    Distinct Roles of Mitochondrial HIGD1A and HIGD2A in Respiratory Complex and Supercomplex Biogenesis
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    Histone H4K20 Demethylation by Two hHR23 Proteins
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  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling
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      DOI: 10.7554/eLife.50670

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    Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly
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  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Requirement for US28 During Cytomegalovirus Latency Is Independent of US27 and US29 Gene Expression
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      DOI: 10.3389/fcimb.2020.00186

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  66. www.cell.com www.cell.com
    An Allosteric Interaction Network Promotes Conformation State-Dependent Eviction of the Nas6 Assembly Chaperone from Nascent 26S Proteasomes
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  67. www.embopress.org www.embopress.org
    Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
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      FLAG antibody

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    Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription
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    The Human Cytomegalovirus pUL145 Isoforms Act as Viral DDB1-Cullin-Associated Factors to Instruct Host Protein Degradation to Impede Innate Immunity
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    High expression of miR-135b predicts malignant transformation and poor prognosis of gastric cancer
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      anti-Flag

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    Oxidation of HDAC4 by Nox4-derived H2O2 maintains tube formation by endothelial cells
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      Flag tag

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    A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release
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      Mouse monoclonal anti-Flag M2

      DOI: 10.1016/j.celrep.2020.107960

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  73. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Biallelic loss‐of‐function variants in TBC1D2B cause a neurodevelopmental disorder with seizures and gingival overgrowth
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      monoclonal mouse anti‐Flag

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  74. www.nature.com www.nature.com
    Conditional control of fluorescent protein degradation by an auxin-dependent nanobody
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      anti-Flag M2

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  75. elifesciences.org elifesciences.org
    HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137
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      anti-FLAG

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  76. rupress.org rupress.org
    Glioma stem-like cells evade interferon suppression through MBD3/NuRD complex–mediated STAT1 downregulation
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      DOI: 10.1084/jem.20191340

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    Ankyrin Is An Intracellular Tether for TMC Mechanotransduction Channels
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      DOI: 10.1016/j.neuron.2020.03.026

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    Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer’s Disease-Related Models
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      DOI: 10.1016/j.celrep.2020.01.060

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    Dopamine Uses the DRD5-ARRB2-PP2A Signaling Axis to Block the TRAF6-Mediated NF-κB Pathway and Suppress Systemic Inflammation
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    Acetylation of UHRF1 Regulates Hemi-methylated DNA Binding and Maintenance of Genome-wide DNA Methylation
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    The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules
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    A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex
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    53BP1 Supports Immunoglobulin Class Switch Recombination Independently of Its DNA Double-Strand Break End Protection Function
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    Hedgehog Acyltransferase Promotes Uptake of Palmitoyl-CoA across the Endoplasmic Reticulum Membrane
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    The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3
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    The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function
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    SAMHD1 Modulates Early Steps during Human Cytomegalovirus Infection by Limiting NF-κB Activation
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    LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease
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    Single-Molecule Nanoscopy Elucidates RNA Polymerase II Transcription at Single Genes in Live Cells
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    The Phosphatase PP1 Promotes Mitotic Slippage through Mad3 Dephosphorylation
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    Dynamic Growth and Shrinkage of the Salmonella-Containing Vacuole Determines the Intracellular Pathogen Niche
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    Msp1 Clears Mistargeted Proteins by Facilitating Their Transfer from Mitochondria to the ER
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    Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel
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    EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex
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    MAVS O-GlcNAcylation Is Essential for Host Antiviral Immunity against Lethal RNA Viruses
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    C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex
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    The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair
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    RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether
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    Altering the Temporal Regulation of One Transcription Factor Drives Evolutionary Trade-Offs between Head Sensory Organs
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    The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages
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    PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1
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    SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα
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    Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15
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    A Translation-Activating Function of MIWI/piRNA during Mouse Spermiogenesis
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    NHR-14 loss of function couples intestinal iron uptake with innate immunity in C. elegans through PQM-1 signaling
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    Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex
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    DNA-Packing Portal and Capsid-Associated Tegument Complexes in the Tumor Herpesvirus KSHV
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    Tubulin detyrosination promotes human trophoblast syncytium formation
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    Histone deacetylase 6 promotes growth of glioblastoma through the MKK7/JNK/c‐Jun signaling pathway
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    Functional Analysis of the Replication Fork Proteome Identifies BET Proteins as PCNA Regulators
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    KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis
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    Histone Recycling by FACT and Spt6 during Transcription Prevents the Scrambling of Histone Modifications
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    Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance
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    Poly(ADP-Ribose) Polymerase 2 Recruits Replication Protein A to Sites of LINE-1 Integration to Facilitate Retrotransposition
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    CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways
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    GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis
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    Condensin locates at transcriptional termination sites in mitosis, possibly releasing mitotic transcripts
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    Sugar Alcohols of Polyol Pathway Serve as Alarmins to Mediate Local-Systemic Innate Immune Communication in Drosophila
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    Salmonella Coiled-Coil- and TIR-Containing TcpS Evades the Innate Immune System and Subdues Inflammation
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    Roles of Collagen XXV and Its Putative Receptors PTPσ/δ in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder
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    Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments
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    PCNA Unloading Is Negatively Regulated by BET Proteins
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    CPG15/Neuritin Mimics Experience in Selecting Excitatory Synapses for Stabilization by Facilitating PSD95 Recruitment
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    Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication
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    Directed RNase H Cleavage of Nascent Transcripts Causes Transcription Termination
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    KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels
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    Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis
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    CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing
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    Attenuation of the Innate Immune Response against Viral Infection Due to ZNF598-Promoted Binding of FAT10 to RIG-I
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    Determining cellular CTCF and cohesin abundances to constrain 3D genome models
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    The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes
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    NPGPx-Mediated Adaptation to Oxidative Stress Protects Motor Neurons from Degeneration in Aging by Directly Modulating O-GlcNAcase
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    HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis
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    Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1
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    LHY2 Integrates Night-Length Information to Determine Timing of Poplar Photoperiodic Growth
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    STRIPAK Members Orchestrate Hippo and Insulin Receptor Signaling to Promote Neural Stem Cell Reactivation
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    Semaphorin 2b Regulates Sleep-Circuit Formation in the Drosophila Central Brain
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    CCDC74A/B are K-fiber crosslinkers required for chromosomal alignment
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      DOI: 10.1186/s12915-019-0694-9

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    Sumoylation of Smc5 Promotes Error-free Bypass at Damaged Replication Forks
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    The GTPase Domain of MX2 Interacts with the HIV-1 Capsid, Enabling Its Short Isoform to Moderate Antiviral Restriction
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    Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21
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    α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development
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    Cell Width Dictates Type VI Secretion Tail Length
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    A Consensus Binding Motif for the PP4 Protein Phosphatase
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    mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux
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  156. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A mechanism for differential sorting of the planar cell polarity proteins Frizzled6 and Vangl2 at the trans-Golgi network
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      DOI: 10.1074/jbc.RA118.001906

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    An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling
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    Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination
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      DOI: 10.1016/j.neuron.2019.02.018

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    A rare autism-associated MINT2/APBA2 mutation disrupts neurexin trafficking and synaptic function
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      DOI: 10.1038/s41598-019-42635-7

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    RNA Targets Ribogenesis Factor WDR43 to Chromatin for Transcription and Pluripotency Control
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      DOI: 10.1016/j.molcel.2019.05.007

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    Inhibition of Hsp70 Suppresses Neuronal Hyperexcitability and Attenuates Epilepsy by Enhancing A-Type Potassium Current
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      DOI: 10.1016/j.celrep.2018.12.032

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      DOI: 10.1016/j.celrep.2019.02.006

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