1,669 Matching Annotations
  1. Sep 2023
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    Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
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      DOI: 10.1016/j.chom.2023.08.003

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    sciencedirect.com/science/article/pii/S1931312823003281
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    Principles of assembly and regulation of condensates of Polycomb repressive complex 1 through phase separation
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      DOI: 10.1016/j.celrep.2023.113136

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    sciencedirect.com/science/article/pii/S2211124723011488
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    RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression
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    sciencedirect.com/science/article/pii/S1097276523006937
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    Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells
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    sciencedirect.com/science/article/pii/S1097276523006950
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    Identifying G protein-coupled receptors involved in adipose tissue function using the innovative RNA-seq database FATTLAS
    2
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    ncbi.nlm.nih.gov/pmc/articles/PMC10520334/
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    Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths
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    sciencedirect.com/science/article/pii/S1934590923002576
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    Acetylation reprograms MITF target selectivity and residence time
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      DOI: 10.1038/s41467-023-41793-7

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    nature.com/articles/s41467-023-41793-7
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    LAT1 (SLC7A5) catalyzes Copper(histidinate) transport switching from antiport to uniport mechanism.
    1
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    sciencedirect.com/science/article/pii/S2589004223018151
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    Chemoproteomic strategy identified p120-catenin glutathionylation regulates E-cadherin degradation and cell migration
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    sciencedirect.com/science/article/abs/pii/S2451945623002763
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    Direct recruitment of Mis18 to interphase spindle pole bodies promotes CENP-A chromatin assembly
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    sciencedirect.com/science/article/pii/S0960982223011430
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    MATR3 is an endogenous inhibitor of DUX4 in FSHD muscular dystrophy
    1
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    sciencedirect.com/science/article/pii/S2211124723011324
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    A NRF2 inhibitor selectively sensitizes KEAP1 mutant tumor cells to cisplatin and gefitinib by restoring NRF2-inhibitory function of KEAP1 mutants
    1
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    sciencedirect.com/science/article/pii/S2211124723011154
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHIP protects against septic acute kidney injury by inhibiting NLRP3-mediated pyroptosis
    1
    1. scibot 12 Sep 2023
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    ncbi.nlm.nih.gov/pmc/articles/PMC10492219/
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    Mechanism and evolutionary origins of alanine-tail C-degron recognition by E3 ligases Pirh2 and CRL2-KLHDC10
    1
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    sciencedirect.com/science/article/pii/S2211124723011117
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    A co-opted endogenous retroviral envelope promotes cell survival by controlling CTR1-mediated copper transport and homeostasis
    1
    1. scibot 08 Sep 2023
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      DOI: 10.1016/j.celrep.2023.113065

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    sciencedirect.com/science/article/pii/S2211124723010768
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHCHD2 Thr61Ile mutation impairs F1F0-ATPase assembly in in vitro and in vivo models of Parkinson’s disease
    1
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      DOI: 10.4103/1673-5374.378010

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    ncbi.nlm.nih.gov/pmc/articles/PMC10479855/
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    Anillin forms linear structures and facilitates furrow ingression after septin and formin depletion
    1
    1. scibot 07 Sep 2023
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      DOI: 10.1016/j.celrep.2023.113076

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    sciencedirect.com/science/article/pii/S2211124723010872
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    Structural basis of CD97 activation and G-protein coupling
    1
    1. scibot 07 Sep 2023
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      DOI: 10.1016/j.chembiol.2023.08.003

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    sciencedirect.com/science/article/abs/pii/S2451945623002751
  20. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Plk2 promotes synaptic destabilization through disruption of N-cadherin adhesion complexes during homeostatic adaptation to hyperexcitation
    1
    1. scibot 06 Sep 2023
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      DOI: 10.1111/jnc.15948

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15948
  21. Aug 2023
  22. www.sciencedirect.com www.sciencedirect.com
    Mechanical stimulation from the surrounding tissue activates mitochondrial energy metabolism in Drosophila differentiating germ cells
    1
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      DOI: 10.1016/j.devcel.2023.08.007

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    sciencedirect.com/science/article/abs/pii/S1534580723004033
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    Efficient genome editing in erythroid cells unveils novel MYB target genes and regulatory functions
    1
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      DOI: 10.1016/j.isci.2023.107641

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    sciencedirect.com/science/article/pii/S2589004223017182
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    MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy
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    sciencedirect.com/science/article/pii/S2211124723010562
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hypermethylation of RNF125 promotes autophagy-induced oxidative stress in asthma by increasing HMGB1 stability
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10432822/
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    A split-luciferase lysate-based approach to identify small-molecule modulators of phosphatase subunit interactions
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      DOI: 10.1016/j.chembiol.2023.07.018

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    sciencedirect.com/science/article/pii/S2451945623002428
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    Different mechanisms of synapsin-induced vesicle clustering at inhibitory and excitatory synapses
    1
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    TRAF7 is an essential regulator of blood vessel integrity during mouse embryonic and neonatal development
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    ncbi.nlm.nih.gov/pmc/articles/PMC10424150/
  29. 52.53.155.43 52.53.155.43
    Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function
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    52.53.155.43/464fcb14db36fa0ad68672734eea21dbff7f105c/PIIS2211124723009257-html.html
  30. 52.53.155.43 52.53.155.43
    PIIS221112472300952X-html.html
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    PIIS2589004223017029-html.html
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    E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response
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    A conserved family of immune effectors cleaves cellular ATP upon viral infection
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    sciencedirect.com/science/article/abs/pii/S0092867423007973
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    LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis
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    sciencedirect.com/science/article/pii/S2211124723009865
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol to assess receptor-ligand binding in C. elegans using adapted thermal shift assays
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    ncbi.nlm.nih.gov/pmc/articles/PMC10415787/
  36. www.science.org www.science.org
    Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
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      DOI: 10.1126/sciadv.adf6895

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    science.org/doi/10.1126/sciadv.adf6895
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased SIRT3 combined with PARP inhibition rescues motor function of SBMA mice
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      DOI: 10.1016/j.isci.2023.107375

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    ncbi.nlm.nih.gov/pmc/articles/PMC10433013/
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    Cooperative assembly confers regulatory specificity and long-term genetic circuit stability
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      DOI: 10.1016/j.cell.2023.07.012

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  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10403219/
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    Art2 mediates selective endocytosis of methionine transporters during adaptation to sphingolipid depletion
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    Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure
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    DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype
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    Clinically Defined Mutations in MEN1 Alter Its Tumor-suppressive Function Through Increased Menin Turnover
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    Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein
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    Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness
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    Phosphoribosyl-linked serine ubiquitination of USP14 by the SidE family effectors of Legionella excludes p62 from the bacterial phagosome
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    Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice
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    The oxidative folding of nascent polypeptides provides electrons for reductive reactions in the ER
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    Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition
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    Enterohemorrhagic Escherichia coli senses microbiota-derived nicotinamide to increase its virulence and colonization in the large intestine
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    Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification
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    A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer
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    IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance
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    RBM33 is a unique m6A RNA-binding protein that regulates ALKBH5 demethylase activity and substrate selectivity
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    A Wnt-induced lncRNA-DGCR5 splicing switch drives tumor-promoting inflammation in esophageal squamous cell carcinoma
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    PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway
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    Glutamate-releasing BEST1 channel is a new target for neuroprotection against ischemic stroke with wide time window
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    The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy
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    Methylated histones on mitotic chromosomes promote Topoisomerase IIα function for high fidelity chromosome segregation.
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    Protein quality control machinery supports primary ciliogenesis by eliminating GDP-bound Rab8-family GTPases
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    DUSP4 promotes esophageal squamous cell carcinoma progression by dephosphorylating HSP90β
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    The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells
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    Organism-wide, cell-type-specific secretome mapping of exercise training in mice
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    Stress granule formation inhibits stress-induced apoptosis by selectively sequestering executioner caspases
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    UTP18-mediated p21 mRNA instability drives adenoma-carcinoma progression in colorectal cancer
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    Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals
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    Ctnnb1/β-catenin inactivation in UCP1-positive adipocytes augments the browning of white adipose tissue
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    Germline and somatic inactivating FLCN variants in parathyroid cancer and atypical parathyroid tumors
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    The mechanism of STING autoinhibition and activation
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    Gαs slow conformational transition upon GTP binding and a novel Gαs regulator
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    Proteomic discovery of chemical probes that perturb protein complexes in human cells
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    Engineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut
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    Coronavirus Subverts ER-phagy by Hijacking FAM134B and ATL3 into p62 Condensates to Facilitate Viral Replication
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    A proinsulin-dependent interaction between ENPL-1 and ASNA-1 in neurons is required to maintain insulin secretion in C. elegans
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    ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer
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    Ecdysone signaling determines lateral polarity and remodels neurites to form Drosophila’s left-right brain asymmetry
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    X-chromosome target specificity diverged between dosage compensation mechanisms of two closely related Caenorhabditis species
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    Structural and functional properties of mSWI/SNF chromatin remodeling complexes revealed through single-cell perturbation screens
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    PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection
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    SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology
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    Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis
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    The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes for retrieval from cilia
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    TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX deficient cells
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    TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX deficient cells
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    Neofunctionalisation of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes
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    Proteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 Stabilization and Chromatin Condensation
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    Characterisation of the OTU domain deubiquitinase complement of Toxoplasma gondii
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    Capture RIC-seq reveals positional rules of PTBP1-associated RNA loops in splicing regulation
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    PQBP1 regulates striatum development through balancing striatal progenitor proliferation and differentiation
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    An optimized protocol to detect protein ubiquitination and activation by ubiquitination assay in vivo and CCK-8 assay
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    Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS
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    Topological regulation of a transmembrane protein by luminal-to-cytosolic retrotranslocation of glycosylated sequence
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    The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus
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    A single-copy knockin translating ribosome immunoprecipitation toolkit for tissue-specific profiling of actively translated mRNAs in C. elegans
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    Structural basis for the Rad6 activation by the Bre1 N-terminal domain
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    Characterization of the Tau Interactome in Human Brain Reveals Isoform-Dependent Interaction with 14-3-3 Family Proteins
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    A central chaperone-like role for 14-3-3 proteins in human cells
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    Deficiency of WTAP in islet beta cells results in beta cell failure and diabetes in mice
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    The tetraspan LHFPL5 is critical to establish maximal force sensitivity of the mechanotransduction channel of cochlear hair cells
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    A combinatorial approach to uncover an additional Integrator subunit
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    Recruitment of Polo-like kinase couples synapsis to meiotic progression via inactivation of CHK-2
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    Acetylated HOXB13 Regulated Super Enhancer Genes Define Therapeutic Vulnerabilities of Castration-Resistant Prostate Cancer
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    Cell context-dependent CFI-1/ARID3 functions control neuronal terminal differentiation
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    FAM193A is a positive regulator of p53 activity
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    An AlphaFold2 map of the 53BP1 pathway identifies a direct SHLD3-RIF1 interaction critical for DNA repair activity
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    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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    Global translational induction during NLR-mediated immunity in plants is dynamically regulated by CDC123, an ATP-sensitive protein
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    Non-canonical pattern recognition of a pathogen-derived metabolite by a nuclear hormone receptor identifies virulent bacteria in C. elegans
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