1,669 Matching Annotations
  1. Mar 2022
  2. www.sciencedirect.com www.sciencedirect.com
    Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation
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      DOI: 10.1016/j.molcel.2022.01.020

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    sciencedirect.com/science/article/pii/S1097276522000855
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    Liquid-liquid phase separation of RBGD2/4 is required for heat stress resistance in Arabidopsis
    1
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      DOI: 10.1016/j.devcel.2022.02.005

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    sciencedirect.com/science/article/pii/S1534580722000715
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    Cryo-EM structure of the human TACAN in a closed state
    1
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      DOI: 10.1016/j.celrep.2022.110445

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    sciencedirect.com/science/article/pii/S2211124722001723
  5. Feb 2022
  6. www.sciencedirect.com www.sciencedirect.com
    Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns
    1
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      DOI: 10.1016/j.molcel.2021.12.010

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    sciencedirect.com/science/article/pii/S1097276521010728
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    Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress
    1
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    sciencedirect.com/science/article/pii/S1097276522000843
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    LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
    1
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      DOI: 10.15252/embj.2021108119

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    embopress.org/doi/abs/10.15252/embj.2021108119
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    Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4
    2
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      DOI: 10.1016/j.chembiol.2022.01.007

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    sciencedirect.com/science/article/pii/S2451945622000496
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The MuvB complex binds and stabilizes nucleosomes downstream of the transcription start site of cell-cycle dependent genes
    2
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      DOI: 10.1038/s41467-022-28094-1

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      DOI: 10.1038/s41467-022-28094-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC8792015/
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    Mechanistic impact of oligomer poisoning by dominant-negative CARD11 variants
    2
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      DOI: 10.1016/j.isci.2022.103810

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      DOI: 10.1016/j.isci.2022.103810

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    sciencedirect.com/science/article/pii/S2589004222000803
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    Epigenetic basis of oncogenic-Kras-mediated epithelial-cellular proliferation and plasticity
    2
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    sciencedirect.com/science/article/pii/S1534580722000065
  13. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II
    2
    1. scibot 11 Feb 2022
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      DOI: 10.1016/j.celrep.2022.110349

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      DOI: 10.1016/j.celrep.2022.110349

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    pubmed.ncbi.nlm.nih.gov/35139382/
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    CRAF dimerization with ARAF regulates KRAS-driven tumor growth
    2
    1. scibot 11 Feb 2022
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      DOI: 10.1016/j.celrep.2022.110351

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      DOI: 10.1016/j.celrep.2022.110351

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    sciencedirect.com/science/article/pii/S2211124722000675
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    Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
    2
    1. scibot 11 Feb 2022
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      DOI: 10.1016/j.celrep.2022.110322

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      DOI: 10.1016/j.celrep.2022.110322

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    sciencedirect.com/science/article/pii/S221112472200033X
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    Tethering Piezo channels to the actin cytoskeleton for mechanogating via the cadherin-β-catenin mechanotransduction complex
    2
    1. scibot 11 Feb 2022
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      DOI: 10.1016/j.celrep.2022.110342

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      DOI: 10.1016/j.celrep.2022.110342

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    sciencedirect.com/science/article/pii/S2211124722000584
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    Co-adaptor driven assembly of a CUL3 E3 ligase complex
    1
    1. scibot 04 Feb 2022
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      DOI: 10.1016/j.molcel.2022.01.004

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    sciencedirect.com/science/article/pii/S1097276522000041
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    In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration
    1
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      DOI: 10.1016/j.stem.2022.01.001

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    sciencedirect.com/science/article/pii/S1934590922000017
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency
    1
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      DOI: 10.1016/j.isci.2021.103525

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    ncbi.nlm.nih.gov/pmc/articles/PMC8786646/
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    Liquidambaric acid inhibits Wnt/β-catenin signaling and colon cancer via targeting TNF receptor-associated factor 2
    1
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      DOI: 10.1016/j.celrep.2022.110319

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    sciencedirect.com/science/article/pii/S2211124722000304
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Steroid hormone receptor and infiltrating immune cell status reveals therapeutic vulnerabilities of ESR1 mutant breast cancer.
    1
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      DOI: 10.1158/0008-5472.CAN-20-1200

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    ncbi.nlm.nih.gov/pmc/articles/PMC7854521/
  22. www.sciencedirect.com www.sciencedirect.com
    An oncogenic enhancer encodes selective selenium dependency in AML
    1
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      DOI: 10.1016/j.stem.2022.01.003

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    sciencedirect.com/science/article/pii/S1934590922000030
  23. www.nature.com www.nature.com
    Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo
    1
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      DOI: 10.1038/s41375-020-01077-1

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    nature.com/articles/s41375-020-01077-1
  24. Jan 2022
  25. www.molbiolcell.org www.molbiolcell.org
    Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport
    1
    1. scibot 28 Jan 2022
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      DOI: 10.1091/mbc.E21-06-0286

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    molbiolcell.org/doi/abs/10.1091/mbc.E21-06-0286
  26. www.sciencedirect.com www.sciencedirect.com
    Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells
    1
    1. scibot 27 Jan 2022
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      DOI: 10.1016/j.devcel.2021.12.020

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    sciencedirect.com/science/article/pii/S1534580721010406
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    Cas11 enables genome engineering in human cells with compact CRISPR-Cas3 systems
    1
    1. scibot 26 Jan 2022
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      DOI: 10.1016/j.molcel.2021.12.032

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    sciencedirect.com/science/article/pii/S1097276521011370
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    Compartmentalization of telomeres through DNA-scaffolded phase separation
    1
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      DOI: 10.1016/j.devcel.2021.12.017

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    sciencedirect.com/science/article/pii/S1534580721010376
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    Selective autophagy controls innate immune response through a TAK1/TAB2/SH3PX1 axis
    1
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      DOI: 10.1016/j.celrep.2021.110286

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    sciencedirect.com/science/article/pii/S2211124721018015
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    Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216
    1
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    sciencedirect.com/science/article/pii/S1097276521010674
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation
    1
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      DOI: 10.7554/eLife.72867

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    ncbi.nlm.nih.gov/pmc/articles/PMC8765754/
  32. www.sciencedirect.com www.sciencedirect.com
    A fluorescence recovery after photobleaching protocol to measure surface diffusion of DAGLα in primary cultured cortical mouse neurons
    1
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      DOI: 10.1016/j.xpro.2021.101118

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    sciencedirect.com/science/article/pii/S2666166721008248
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    Global RNA interactome of Salmonella discovers a 5′ UTR sponge for the MicF small RNA that connects membrane permeability to transport capacity
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    sciencedirect.com/science/article/pii/S1097276521011357
  34. elifesciences.org elifesciences.org
    insomniac links the development and function of a sleep-regulatory circuit
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      DOI: 10.7554/eLife.65437

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    elifesciences.org/articles/65437
  35. www.sciencedirect.com www.sciencedirect.com
    Metastasis enhancer PGRMC1 boosts store-operated Ca2+ entry by uncoiling Ca2+ sensor STIM1 for focal adhesion turnover and actomyosin formation
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    sciencedirect.com/science/article/pii/S2211124721017964
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nuclear NAD+-biosynthetic enzyme NMNAT1 facilitates development and early survival of retinal neurons
    1
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      DOI: 10.7554/eLife.71185

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    ncbi.nlm.nih.gov/pmc/articles/PMC8754432/
  37. www.sciencedirect.com www.sciencedirect.com
    Innate immune sensing of influenza A viral RNA through IFI16 promotes pyroptotic cell death
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      DOI: 10.1016/j.isci.2021.103714

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    sciencedirect.com/science/article/pii/S2589004221016849
  38. www.sciencedirect.com www.sciencedirect.com
    Endoplasmic reticulum-translocation is essential for APOL1 cellular toxicity
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      DOI: 10.1016/j.isci.2021.103717

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    sciencedirect.com/science/article/pii/S2589004221016874
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GS-CA1 and lenacapavir stabilize the HIV-1 core and modulate the core interaction with cellular factors
    1
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    The sex determination gene doublesex regulates expression and secretion of the basement membrane protein Collagen IV
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    Recruitment of MLL1 complex is essential for SETBP1 to induce myeloid transformation
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    Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality
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    An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance
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    Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2
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    CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism
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    The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
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    SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity
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    The Lon protease temporally restricts polar cell differentiation events during the Caulobacter cell cycle
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  82. Oct 2021
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    Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity
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    Reprogramming CBX8-PRC1 function with a positive allosteric modulator
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    P5A ATPase controls ER translocation of Wnt in neuronal migration
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    Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues
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    Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation
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    TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis
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    Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy
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    Deiodinase-3 is a thyrostat to regulate podocyte homeostasis
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    Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma
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    Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome
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    An in vitro system to silence mitochondrial gene expression
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    The Hsp90 cochaperone TTT promotes cotranslational maturation of PIKKs prior to complex assembly
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    Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress
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    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
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    Genome-wide RNA structure changes during human neurogenesis modulate gene regulatory networks
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    Gene bookmarking by the heat shock transcription factor programs the insulin-like signaling pathway
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    SARS-CoV-2 integral membrane proteins shape the serological responses of patients with COVID-19
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    TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson’s disease
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    A phosphate starvation response-centered network regulates mycorrhizal symbiosis
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  102. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Melatonin pretreatment alleviates the long-term synaptic toxicity and dysmyelination induced by neonatal Sevoflurane exposure via MT1 receptor-mediated Wnt signaling modulation
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  103. www.embopress.org www.embopress.org
    Promyelocytic leukemia protein targets MK2 to promote cytotoxicity
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      DOI: 10.15252/embr.202052254

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    Cancer cell immune mimicry delineates onco-immunologic modulation
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    The N-terminal domain of SARS-CoV-2 nsp1 plays key roles in suppression of cellular gene expression and preservation of viral gene expression
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    Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice
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    RetroCHMP3 blocks budding of enveloped viruses without blocking cytokinesis
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  108. Sep 2021
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification and Functional Characterization of a Novel Androgen Receptor Coregulator, EAP1
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    Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins
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    A prion accelerates proliferation at the expense of lifespan
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    Analysis of meiosis in Pristionchus pacificus reveals plasticity in homolog pairing and synapsis in the nematode lineage
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    Structural basis and regulation of the reductive stress response
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    ERα determines the chemoresistant function of mutant p53 involving the switch between lincRNA-p21 and DDB2 expressions
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    ERα is an RNA-binding protein sustaining tumor cell survival and drug resistance
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    NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis
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    A hydride transfer complex reprograms NAD metabolism and bypasses senescence
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    Mitochondrial-derived compartments facilitate cellular adaptation to amino acid stress
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    The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation
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  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease
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    DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation
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    The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation
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    Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism
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    Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns
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