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    Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis
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    Extracellular and intracellular sphingosine‐1‐phosphate distinctly regulates exocytosis in chromaffin cells
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    Vaccinia‐related kinase 2 modulates role of dysbindin by regulating protein stability
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    CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4
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    Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling
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    Genome-Scale Transcriptional Regulatory Network Models of Psychiatric and Neurodegenerative Disorders
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    Structural and Functional Insights into Host Death Domains Inactivation by the Bacterial Arginine GlcNAcyltransferase Effector
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    Role of Nampt-Sirt6 Axis in Renal Proximal Tubules in Extracellular Matrix Deposition in Diabetic Nephropathy
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    Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site
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    FOXM1 Deubiquitination by USP21 Regulates Cell Cycle Progression and Paclitaxel Sensitivity in Basal-like Breast Cancer
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    TOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus Latency
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    Fusion of Reprogramming Factors Alters the Trajectory of Somatic Lineage Conversion
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    FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling
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    ZEB1 Represses Neural Differentiation and Cooperates with CTBP2 to Dynamically Regulate Cell Migration during Neocortex Development
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    Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production
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    CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1
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    The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria
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    Iruka Eliminates Dysfunctional Argonaute by Selective Ubiquitination of Its Empty State
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    Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease
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    Exon Junction Complex Shapes the Transcriptome by Repressing Recursive Splicing
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    Molecular Interface of Neuronal Innate Immunity, Synaptic Vesicle Stabilization, and Presynaptic Homeostatic Plasticity
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    Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks
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    Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response
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    MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis
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    A Novel Alternative Splicing Mechanism That Enhances Human 5-HT1A Receptor RNA Stability Is Altered in Major Depression
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    ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer
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    The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands
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    Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma
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    Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate
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    LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling
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    A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to Stimulate Type II Topoisomerases and Enable DNA Replication
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    A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission
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    A Kinesin-5, Cin8, Recruits Protein Phosphatase 1 to Kinetochores and Regulates Chromosome Segregation
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    Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase
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    Differential Splicing of ANP32A in Birds Alters Its Ability to Stimulate RNA Synthesis by Restricted Influenza Polymerase
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    Repression of Somatic Genes by Selective Recruitment of HDAC3 by BLIMP1 Is Essential for Mouse Primordial Germ Cell Fate Determination
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    Differential Requirement for Translation Initiation Factor Pathways during Ecdysone-Dependent Neuronal Remodeling in Drosophila
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    Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency
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    SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function
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    Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase
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    Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate
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    An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses
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    Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations
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    Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death
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    Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109
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    NonA and CPX Link the Circadian Clockwork to Locomotor Activity in Drosophila
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    BLM Potentiates c-Jun Degradation and Alters Its Function as an Oncogenic Transcription Factor
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    Yorkie Functions at the Cell Cortex to Promote Myosin Activation in a Non-transcriptional Manner
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    MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation
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    Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex
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    Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis
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    SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis
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    HDAC3-selective inhibition activates brown and beige fat through PRDM16
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    Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2
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    Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins
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    Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to α-Synuclein Gain
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    Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance
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    Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency
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    The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation
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    USP8 Deubiquitinates SHANK3 to Control Synapse Density and SHANK3 Activity-dependent Protein Levels
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    Epigenetic Promoter DNA Methylation of miR-124 Promotes HIV-1 Tat-Mediated Microglial Activation via MECP2-STAT3 Axis
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    Arabidopsis ARGONAUTE 1 Binds Chromatin to Promote Gene Transcription in Response to Hormones and Stresses
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    Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication
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    Palladin Is a Neuron-Specific Translational Target of mTOR Signaling That Regulates Axon Morphogenesis
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    A Sialylated Voltage-Dependent Ca2+ Channel Binds Hemagglutinin and Mediates Influenza A Virus Entry into Mammalian Cells
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    EP300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis
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    ZNFX-1 Functions within Perinuclear Nuage to Balance Epigenetic Signals
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    Complement C3 Drives Autophagy-Dependent Restriction of Cyto-invasive Bacteria
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    A Metabolic Basis for Endothelial-to-Mesenchymal Transition
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    Atypical Cadherin Dachsous1b Interacts with Ttc28 and Aurora B to Control Microtubule Dynamics in Embryonic Cleavages
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    Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase
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    The InR/Akt/TORC1 Growth-Promoting Signaling Negatively Regulates JAK/STAT Activity and Migratory Cell Fate during Morphogenesis
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    A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline
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    Novel RNA-Affinity Proteogenomics Dissects Tumor Heterogeneity for Revealing Personalized Markers in Precision Prognosis of Cancer
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    Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression
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    Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis
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    Tumor-Repopulating Cells Induce PD-1 Expression in CD8+ T Cells by Transferring Kynurenine and AhR Activation
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    A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C. elegans
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    Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes
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    Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch
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    GRASP55 Senses Glucose Deprivation through O-GlcNAcylation to Promote Autophagosome-Lysosome Fusion
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    Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms
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    The Receptor-like Cytoplasmic Kinase BIK1 Localizes to the Nucleus and Regulates Defense Hormone Expression during Plant Innate Immunity
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    KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity
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    Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia
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    A compartmentalized signaling network mediates crossover control in meiosis
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    Genetic Intersection of Tsix and Hedgehog Signaling during the Initiation of X-Chromosome Inactivation
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    ICE1 promotes the link between splicing and nonsense-mediated mRNA decay
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    Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation
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    Dissection of affinity captured LINE-1 macromolecular complexes
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    Bis-Indole–Derived NR4A1 Ligands and Metformin Exhibit NR4A1-Dependent Glucose Metabolism and Uptake in C2C12 Cells
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    SPIN1 promotes tumorigenesis by blocking the uL18 (universal large ribosomal subunit protein 18)-MDM2-p53 pathway in human cancer
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    Drosophila Fezf coordinates laminar-specific connectivity through cell-intrinsic and cell-extrinsic mechanisms
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    NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins
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    FOXL2C134W-Induced CYP19 Expression via Cooperation With SMAD3 in HGrC1 Cells
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    Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons
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    DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis
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    Identification of PNG kinase substrates uncovers interactions with the translational repressor TRAL in the oocyte-to-embryo transition
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    A Distinct Class of Genome Rearrangements Driven by Heterologous Recombination
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    ROS-Mediated 15-Hydroxyprostaglandin Dehydrogenase Degradation via Cysteine Oxidation Promotes NAD+-Mediated Epithelial-Mesenchymal Transition
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    Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells
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    R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling
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    Life-Long Neurogenic Activity of Individual Neural Stem Cells and Continuous Growth Establish an Outside-In Architecture in the Teleost Pallium
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    Slp1-Emp65: A Guardian Factor that Protects Folding Polypeptides from Promiscuous Degradation
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