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  1. Apr 2022
  2. www.sciencedirect.com www.sciencedirect.com
    Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice
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    1. scibot 21 Apr 2022
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    sciencedirect.com/science/article/pii/S2666379122001148
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    Functional coupling of TRPM2 and extrasynaptic NMDARs exacerbates excitotoxicity in ischemic brain injury
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    sciencedirect.com/science/article/pii/S0896627322002574
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    Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation
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    sciencedirect.com/science/article/pii/S1097276522002647
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    Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer
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    sciencedirect.com/science/article/pii/S221112472200393X
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    Melanomas with concurrent BRAF non-p.V600 and NF1 loss-of-function mutations are targetable by BRAF/MEK inhibitor combination therapy
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    sciencedirect.com/science/article/pii/S2211124722003862
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    Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins
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    sciencedirect.com/science/article/pii/S2211124722003722
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    ADAM17 regulates p75NTR–mediated fibrinolysis and nerve remyelination
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    jneurosci.org/content/42/12/2433
  9. aacrjournals.org aacrjournals.org
    δ-Tocotrienol is the most potent vitamin E form in inhibiting prostate cancer cell growth and inhibits prostate carcinogenesis in Ptenp-/- mice
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    aacrjournals.org/cancerpreventionresearch/article/15/4/233/682296/Tocotrienol-is-the-Most-Potent-Vitamin-E-Form-in
  10. Mar 2022
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    Pathogen size alters C-type lectin receptor signaling in dendritic cells to influence CD4 Th9 cell differentiation
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    sciencedirect.com/science/article/pii/S2211124722003114
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    A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
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    sciencedirect.com/science/article/pii/S2211124722002583
  13. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Crosstalk between ERK and MRTF-A signaling regulates TGFβ1-induced epithelial-mesenchymal transition
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    1. scibot 05 Mar 2022
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    onlinelibrary.wiley.com/doi/10.1002/jcp.30705
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Peripheral nerve fibroblasts secrete neurotrophic factors to promote axon growth of motoneurons
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    1. scibot 04 Mar 2022
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    ncbi.nlm.nih.gov/pmc/articles/PMC8820717/
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    Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages
    1
    1. scibot 03 Mar 2022
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      DOI: 10.7554/eLife.69982

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  16. elifesciences.org elifesciences.org
    A non-bactericidal cathelicidin provides prophylactic efficacy against bacterial infection by driving phagocyte influx
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    1. scibot 03 Mar 2022
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      DOI: 10.7554/eLife.72849

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    elifesciences.org/articles/72849
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    Creatine transport and creatine kinase activity is required for CD8+ T cell immunity
    1
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    sciencedirect.com/science/article/pii/S2211124722001735
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    Diacylglycerol kinase η regulates cell proliferation and its levels are elevated by glucocorticoids in undifferentiated neuroblastoma cells
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    1. scibot 02 Mar 2022
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    sciencedirect.com/science/article/pii/S0006291X22003059
  19. Feb 2022
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells
    1
    1. scibot 19 Feb 2022
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      DOI: 10.26508/lsa.202101187

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    ncbi.nlm.nih.gov/pmc/articles/PMC8807877/
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pigment Epithelium Derived Factor Is Involved in the Late Phase of Osteosarcoma Metastasis by Increasing Extravasation and Cell-Cell Adhesion
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    ncbi.nlm.nih.gov/pmc/articles/PMC8842676/
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    Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
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    1. scibot 11 Feb 2022
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    sciencedirect.com/science/article/pii/S221112472200033X
  23. www.nature.com www.nature.com
    Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo
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    1. scibot 01 Feb 2022
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      DOI: 10.1038/s41375-020-01077-1

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    nature.com/articles/s41375-020-01077-1
  24. Jan 2022
  25. www.sciencedirect.com www.sciencedirect.com
    Acetylation-dependent regulation of BRAF oncogenic function
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    sciencedirect.com/science/article/pii/S2211124721017629
  26. elifesciences.org elifesciences.org
    Addition of a carboxy-terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice
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    1. scibot 13 Jan 2022
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      DOI: 10.7554/eLife.72937

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    elifesciences.org/articles/72937
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transgenic overexpression of CTRP3 does not prevent alcohol induced hepatic steatosis in female mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC8740976/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua
    1
    1. scibot 07 Jan 2022
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      DOI: 10.7554/eLife.71769

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    ncbi.nlm.nih.gov/pmc/articles/PMC8700290/
  29. Dec 2021
  30. www.sciencedirect.com www.sciencedirect.com
    RhoA within myofibers controls satellite cell microenvironment to allow hypertrophic growth
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      DOI: 10.1016/j.isci.2021.103616

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    sciencedirect.com/science/article/pii/S2589004221015868
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    The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth
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    1. scibot 28 Dec 2021
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    sciencedirect.com/science/article/pii/S1534580721009941
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    APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain
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    sciencedirect.com/science/article/pii/S1097276521010339
  33. elifesciences.org elifesciences.org
    Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology
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    elifesciences.org/articles/73430
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    GFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway
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  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo efficacy of tesevatinib in patient-derived xenograft glioblastoma models may be limited by tissue binding and compensatory signaling
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      DOI: 10.1158/1535-7163.MCT-20-0640

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    ncbi.nlm.nih.gov/pmc/articles/PMC8172524/
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genomic and experimental evidence that ALKATI does not predict single agent sensitivity to ALK inhibitors
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    ncbi.nlm.nih.gov/pmc/articles/PMC8603052/
  37. reader.elsevier.com reader.elsevier.com
    Lysophosphatidic acid shifts metabolic and transcriptional landscapes to induce a distinct cellular state in human pluripotent stem cells
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    CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
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  39. Nov 2021
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p190RhoGAP Filters Competing Signals to Resolve Axon Guidance Conflicts
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      DOI: 10.1016/j.neuron.2019.02.034

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    ncbi.nlm.nih.gov/pmc/articles/PMC8608148/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly
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      DOI: 10.7554/eLife.71575

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    ncbi.nlm.nih.gov/pmc/articles/PMC8598234/
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    Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities
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  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AXL cooperates with EGFR to mediate neutrophil elastase-induced migration of prostate cancer cells
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      DOI: 10.1016/j.isci.2021.103270

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    ncbi.nlm.nih.gov/pmc/articles/PMC8567381/
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    Role of adipocyte Na,K-ATPase oxidant amplification loop in cognitive decline and neurodegeneration
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      DOI: 10.1016/j.isci.2021.103262

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    sciencedirect.com/science/article/pii/S2589004221012311
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    TGF-β orchestrates the phenotype and function of monocytic myeloid-derived suppressor cells in colorectal cancer
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      DOI: 10.1007/s00262-021-03081-5

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    link.springer.com/article/10.1007/s00262-021-03081-5
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    LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency
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      DOI: 10.1016/j.medj.2021.10.002

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    Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis
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    Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway
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    Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice
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    Inhibition of astrocyte FAK–JNK signaling promotes subventricular zone neurogenesis through CNTF
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    Regulator of G protein signaling 12 enhances osteoclastogenesis by suppressing Nrf2-dependent antioxidant proteins to promote the generation of reactive oxygen species
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      ERK1/2, rabbit polyclonal

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  104. jbiomedsci.biomedcentral.com jbiomedsci.biomedcentral.com
    Cilostazol inhibits hyperglucose-induced vascular smooth muscle cell dysfunction by modulating the RAGE/ERK/NF-κB signaling pathways
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    CDK12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS1‐ErbB‐PI3K signaling
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    Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer
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    The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase
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    Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors
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    BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association
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  114. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Exposure to far‐infrared ray attenuates methamphetamine‐induced impairment in recognition memory through inhibition of protein kinase C δ in male mice: Comparison with the antipsychotic clozapine
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      AB_330744u00a0

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    Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway
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      AB_330744

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  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  124. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Intra‐prelimbic cortical inhibition of striatal‐enriched tyrosine phosphatase suppresses cocaine seeking in rats
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      RRID:AB_10695746

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  126. www.jneurosci.org www.jneurosci.org
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      RRID:AB_10695746

      DOI: 10.1523/JNEUROSCI.0864-14.2014

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      DOI: 10.1523/JNEUROSCI.2238-14.2014

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  129. onlinelibrary.wiley.com onlinelibrary.wiley.com
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  130. www.sciencedirect.com www.sciencedirect.com
    Maternal separation stress reduced prenatal-ethanol-induced increase in exploratory behaviour and extracellular signal-regulated kinase activity
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      DOI: 10.1016/j.bbr.2018.06.004

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  131. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX
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      DOI: 10.7554/eLife.66596

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    An iPSC model of hereditary sensory neuropathy-1 reveals L-serine-responsive deficits in neuronal ganglioside composition and axoglial interactions
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  135. Jun 2021
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    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
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    Cadmium-induced hypertension is associated with renal myosin light chain phosphatase inhibition via increased T697 phosphorylation and p44 mitogen-activated protein kinase levels
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    Endothelial insulin receptors promote VEGF-A signaling via ERK1/2 and sprouting angiogenesis
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    Table 2 | Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition
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    The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation
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    The E3 ligase TRAF4 Promotes IGF Signaling by Mediating Atypical Ubiquitination of IRS-1
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    The selective lipoprotein-associated phospholipase A2 inhibitor darapladib triggers irreversible actions on glioma cell apoptosis and mitochondrial dysfunction
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    Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex
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    Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer
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    Positive Reinforcing Mechanisms between GPR120 and PPARγ Modulate Insulin Sensitivity
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    Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells
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    Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia
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    N‐glycosylation of the human neuropeptide QRFP receptor QRFPR is essential for ligand binding and receptor activation
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    Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer
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    Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth
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  176. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling
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  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function
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  178. www.sciencedirect.com www.sciencedirect.com
    PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK
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  179. Mar 2021
  180. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hericium erinaceus mycelium and its small bioactive compounds promote oligodendrocyte maturation with an increase in myelin basic protein
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  181. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Extracellular signal‐regulated kinases 2 (Erk2) and Erk5 in the central nervous system differentially contribute to central sensitization in male mice
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    Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis
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    Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy
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  184. Feb 2021
  185. academic.oup.com academic.oup.com
    Activation of ovarian taste receptors inhibits progesterone production potentially via NO/cGMP and apoptotic signaling
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    N6-methyladenosine (m6A) is an endogenous A3 adenosine receptor ligand
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  187. www.sciencedirect.com www.sciencedirect.com
    Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination
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    Myeloid-derived Growth Factor Promotes Intestinal Glucagon-like Peptide-1 Production in Male Mice with Type 2 Diabetes
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      DOI: 10.1210/endocr/bqaa003

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  189. onlinelibrary.wiley.com onlinelibrary.wiley.com
    LncRNA RP6‐65G23.1 accelerates proliferation and inhibits apoptosis via p‐ERK1/2/p‐AKT signaling pathway on keratinocytes
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  190. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Suppression of adipocyte differentiation by low‐intensity pulsed ultrasound via inhibition of insulin signaling and promotion of CCN family protein 2
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  191. atm.amegroups.com atm.amegroups.com
    MiR-3121-3p promotes tumor invasion and metastasis by suppressing Rap1GAP in papillary thyroid cancer in vitro
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  192. insight.jci.org insight.jci.org
    Asymmetric cell division promotes therapeutic resistance in glioblastoma stem cells
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  193. Jan 2021
  194. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Monomeric/dimeric forms of Fgf15/FGF19 show differential activity in hepatocyte proliferation and metabolic function
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      DOI: 10.1096/fj.202002203R

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  195. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders
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      DOI: 10.7554/eLife.56630

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  196. link.springer.com link.springer.com
    Lactate regulates autophagy through ROS-mediated activation of ERK1/2/m-TOR/p-70S6K pathway in skeletal muscle
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      DOI: 10.1007/s12079-020-00599-8

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  197. Dec 2020
  198. www.sciencedirect.com www.sciencedirect.com
    Exosomal miR-193a and let-7g accelerate cancer progression on primary colorectal cancer and paired peritoneal metastatic cancer
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      DOI: 10.1016/j.tranon.2020.101000

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  199. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Gpr37l1/prosaposin receptor regulates Ptch1 trafficking, Shh production, and cell proliferation in cerebellar primary astrocytes
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      DOI: 10.1002/jnr.24775

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  200. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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      DOI: 10.1111/bph.15060

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  201. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Ascorbate deficiency decreases dopamine release in gulo–/– and APP/PSEN1 mice
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  202. Nov 2020
  203. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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      DOI: 10.1111/bph.15269

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  204. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Lysophosphatidic acid induces thrombospondin‐1 production in primary cultured rat cortical astrocytes
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      DOI: 10.1111/jnc.15227

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  205. Oct 2020
  206. elifesciences.org elifesciences.org
    Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila
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      DOI: 10.7554/eLife.57395

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  207. www.jneurosci.org www.jneurosci.org
    Phosphorylation of eIF2α promotes Schwann cell differentiation and myelination in CMT1B mice with activated UPR
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      DOI: 10.1523/JNEUROSCI.0957-20.2020

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  208. link.springer.com link.springer.com
    Repurposing mesalazine against cardiac fibrosis in vitro
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      ERK 1/2 (p42/44)

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  209. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis
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      DOI: 10.7554/eLife.59442

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  210. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism
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      DOI: 10.7554/eLife.58941

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  211. www.sciencedirect.com www.sciencedirect.com
    Activation of EphrinB2 Signaling Promotes Adaptive Venous Remodeling in Murine Arteriovenous Fistulae
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      DOI: 10.1016/j.jss.2020.08.071

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  212. www.sciencedirect.com www.sciencedirect.com
    Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation
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      DOI: 10.1016/j.cell.2020.09.002

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  213. Sep 2020
  214. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of astrocyte FAK–JNK signaling promotes subventricular zone neurogenesis through CNTF
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      DOI: 10.1002/glia.23498

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  215. www.sciencedirect.com www.sciencedirect.com
    Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense
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      DOI: 10.1016/j.cell.2020.03.040

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  216. www.sciencedirect.com www.sciencedirect.com
    Oncogenic Signaling Alters Cell Shape and Mechanics to Facilitate Cell Division under Confinement
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      DOI: 10.1016/j.devcel.2020.01.004

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    Angiotensin II-upregulated MAP kinase phosphatase-3 modulates FOXO1 and p21 in adrenocortical H295R cells
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      DOI: 10.1016/j.heliyon.2020.e03519

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