595 Matching Annotations
  1. Sep 2020
  2. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    HSP90 Inhibitor, 17-DMAG, Alone and in Combination with Lapatinib Attenuates Acquired Lapatinib-Resistance in ER-positive, HER2-Overexpressing Breast Cancer Cell Line
    1
    1. scibot 23 Sep 2020
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      DOI: 10.3390/cancers12092630

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    pubmed.ncbi.nlm.nih.gov/32942617/
  3. www.sciencedirect.com www.sciencedirect.com
    Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas
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      DOI: 10.1016/j.ccell.2020.02.002

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    sciencedirect.com/science/article/pii/S153561082030091X
  4. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System
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      DOI: 10.1016/j.chembiol.2020.06.013

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    pubmed.ncbi.nlm.nih.gov/32668203/
  5. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Sleep deprivation regulates availability of PrPC and Aβ peptides which can impair interaction between PrPC and laminin and neuronal plasticity
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    1. scibot 23 Sep 2020
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      DOI: 10.1111/jnc.14960

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14960
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    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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      DOI: 10.1016/j.cell.2020.05.053

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    sciencedirect.com/science/article/pii/S0092867420306863
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    JNK signalling regulates antioxidant responses in neurons
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    sciencedirect.com/science/article/pii/S2213231720309174
  8. elifesciences.org elifesciences.org
    Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species
    1
    1. scibot 17 Sep 2020
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      DOI: 10.7554/eLife.53370

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    elifesciences.org/articles/53370
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    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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    1. scibot 17 Sep 2020
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      DOI: 10.1016/j.cell.2020.02.019

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    sciencedirect.com/science/article/pii/S009286742030163X
  10. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System
    1
    1. scibot 16 Sep 2020
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      DOI: 10.1016/j.chembiol.2020.06.012

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  11. academic.oup.com academic.oup.com
    Inhibitory Interplay of SULT2B1b Sulfotransferase with AKR1C3 Aldo-keto Reductase in Prostate Cancer
    1
    1. scibot 16 Sep 2020
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      DOI: 10.1210/endocr/bqz042

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    academic.oup.com/endo/article/161/2/bqz042/5693375
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    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
    1
    1. scibot 16 Sep 2020
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      DOI: 10.1016/j.celrep.2020.107764

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    sciencedirect.com/science/article/pii/S2211124720307440
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip
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    1. scibot 16 Sep 2020
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      DOI: 10.7554/eLife.53627

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    ncbi.nlm.nih.gov/pmc/articles/PMC7062472/
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    Interleukin-33 Signaling Controls the Development of Iron-Recycling Macrophages
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    1. scibot 15 Sep 2020
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      DOI: 10.1016/j.immuni.2020.03.006

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    sciencedirect.com/science/article/pii/S1074761320301199
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    Defining and Targeting Adaptations to Oncogenic KRASG12C Inhibition Using Quantitative Temporal Proteomics
    1
    1. scibot 14 Sep 2020
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      DOI: 10.1016/j.celrep.2020.03.021

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    sciencedirect.com/science/article/pii/S2211124720303284
  16. link.springer.com link.springer.com
    Injectable Hydrogel Containing Tauroursodeoxycholic Acid for Anti-neuroinflammatory Therapy After Spinal Cord Injury in Rats
    1
    1. scibot 14 Sep 2020
      AB_330744

      DOI: 10.1007/s12035-020-02010-4

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    link.springer.com/article/10.1007/s12035-020-02010-4
  17. dev.biologists.org dev.biologists.org
    Vessel-derived angiocrine IGF-1 promotes Meckel's cartilage proliferation to drive jaw growth during embryogenesis
    1
    1. scibot 13 Sep 2020
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      DOI: 10.1242/dev.190488

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    dev.biologists.org/content/147/11/dev190488
  18. www.sciencedirect.com www.sciencedirect.com
    mTORC1 Signaling Controls TLR2-Mediated T-Cell Activation by Inducing TIRAP Expression
    1
    1. scibot 09 Sep 2020
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      DOI: 10.1016/j.celrep.2020.107911

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    sciencedirect.com/science/article/pii/S2211124720308925
  19. academic.oup.com academic.oup.com
    DPP-4 inhibition with anagliptin reduces lipotoxicity-induced insulin resistance and steatohepatitis in male mice
    1
    1. scibot 09 Sep 2020
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      DOI: 10.1210/endocr/bqaa139

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    academic.oup.com/endo/article/161/10/bqaa139/5892311
  20. www.sciencedirect.com www.sciencedirect.com
    Protein synthesis inhibition promotes nitric oxide generation and activation of CGKII-dependent downstream signaling pathways in the retina
    1
    1. scibot 08 Sep 2020
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      DOI: 10.1016/j.bbamcr.2020.118732

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    sciencedirect.com/science/article/pii/S0167488920300902
  21. www.sciencedirect.com www.sciencedirect.com
    Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
    1
    1. scibot 08 Sep 2020
      RRID:AB_330744

      DOI: 10.1016/j.ccell.2019.12.006

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    sciencedirect.com/science/article/pii/S1535610819305768
  22. www.sciencedirect.com www.sciencedirect.com
    Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate Decisions at the G2 Checkpoint for DNA Damage
    1
    1. scibot 07 Sep 2020
      RRID:AB_330744

      DOI: 10.1016/j.celrep.2020.01.074

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    sciencedirect.com/science/article/pii/S2211124720300991
  23. www.cell.com www.cell.com
    Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer
    2
    1. scibot 07 Sep 2020
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      DOI: 10.1016/j.ccell.2019.12.012

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    2. scibot 03 Sep 2020
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      DOI: 10.1016/j.ccell.2019.12.012

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    cell.com/cancer-cell/abstract/S1535-6108(19)30582-3
  24. www.sciencedirect.com www.sciencedirect.com
    Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing
    1
    1. scibot 07 Sep 2020
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      DOI: 10.1016/j.celrep.2019.12.043

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    sciencedirect.com/science/article/pii/S2211124719317000
  25. www.sciencedirect.com www.sciencedirect.com
    Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer
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    1. scibot 06 Sep 2020
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      DOI: 10.1016/j.ccell.2020.02.003

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    sciencedirect.com/science/article/pii/S1535610820300921
  26. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling
    1
    1. scibot 05 Sep 2020
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      DOI: 10.1111/jnc.15032

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15032
  27. www.cell.com www.cell.com
    Long-Term Memory Engram Cells Are Established by c-Fos/CREB Transcriptional Cycling
    1
    1. scibot 04 Sep 2020
      RRID: AB_330744

      DOI: 10.1016/j.celrep.2018.11.022

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    cell.com/cell-reports/fulltext/S2211-1247(18)31768-6
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    PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells
    1
    1. scibot 04 Sep 2020
      ERK1/2

      DOI: 10.1016/j.immuni.2018.05.006

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  29. www.sciencedirect.com www.sciencedirect.com
    The Leucine-Rich Repeat Region of CARMIL1 Regulates IL-1-Mediated ERK Activation, MMP Expression, and Collagen Degradation
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      Rabbit polyclonal anti-p44/42 MAPK

      DOI: 10.1016/j.celrep.2020.107781

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  30. elifesciences.org elifesciences.org
    Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling
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    1. scibot 04 Sep 2020
      rabbit anti-ERK1/2

      DOI: 10.7554/eLife.23968

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  31. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Activation of astrocytic sigma‐1 receptor exerts antidepressant‐like effect via facilitating CD38‐driven mitochondria transfer
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      DOI: 10.1002/glia.23850

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    onlinelibrary.wiley.com/doi/10.1002/glia.23850
  32. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A non‐covalent inhibitor XMU‐MP‐3 overrides ibrutinib‐resistant BtkC481S mutation in B‐cell malignancies
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      DOI: 10.1111/bph.14809

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  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics
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      DOI: 10.7554/eLife.57410

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      DOI: 10.7554/eLife.57410

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    ncbi.nlm.nih.gov/pmc/articles/PMC7289600/
  34. onlinelibrary.wiley.com onlinelibrary.wiley.com
    FGF21 impedes peripheral myelin development by stimulating p38 MAPK/c‐Jun axis
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      DOI: 10.1002/jcp.29942

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    onlinelibrary.wiley.com/doi/10.1002/jcp.29942
  35. www.sciencedirect.com www.sciencedirect.com
    Adipocyte Fatty Acid Transfer Supports Megakaryocyte Maturation
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      DOI: 10.1016/j.celrep.2020.107875

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    sciencedirect.com/science/article/pii/S2211124720308561
  36. www.sciencedirect.com www.sciencedirect.com
    Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways
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      DOI: 10.1016/j.celrep.2020.03.019

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    sciencedirect.com/science/article/pii/S2211124720303260
  37. Aug 2020
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lovastatin, not Simvastatin, Corrects Core Phenotypes in the Fragile X Mouse Model
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      RRID:AB_330744

      DOI: 10.1523/ENEURO.0097-19.2019

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    ncbi.nlm.nih.gov/pmc/articles/PMC6565377/
  39. Jan 2020
  40. academic.oup.com academic.oup.com
    1,25-dihydroxyvitamin D maintains brush border membrane NaPi2a and attenuates phosphaturia in Hyp mice
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      RRID:AB_330744

      DOI: 10.1210/en.2019-00186

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    academic.oup.com/endo/article/160/10/2204/5522002
  41. www.sciencedirect.com www.sciencedirect.com
    Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation
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    Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer
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    Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation
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    Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between β-Arrestin Isoforms
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    An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma
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    Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis
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    A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas
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    EGFR Signaling Termination via Numb Trafficking in Ependymal Progenitors Controls Postnatal Neurogenic Niche Differentiation
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    The activity of the STriatal‐Enriched protein tyrosine Phosphatase (STEP) in neuronal cells is modulated by adenosine A2A receptor
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    Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization
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    Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs
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    N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration
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    Photocrosslinking Activity-Based Probes for Ubiquitin RING E3 Ligases
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    A Cellular-Resolution Atlas of the Larval Zebrafish Brain
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    Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers
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    Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth
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    Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer
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    New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis
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    Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan
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    KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
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    Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma
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    17β-Estradiol and ICI182,780 Differentially Regulate STAT5 Isoforms in Female Mammary Epithelium, With Distinct Outcomes
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    Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs
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    Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides
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    SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer
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    Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception
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    Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS
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    Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies
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    Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis
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    BMP6 down-regulates GDNF expression through SMAD1/5 and ERK1/2 signaling pathways in human granulosa-lutein cells
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    Loss of PRMT5 Promotes PDGFRα Degradation during Oligodendrocyte Differentiation and Myelination
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    Loss of STI1‐mediated neuronal survival and differentiation in disease‐associated mutations of prion protein
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    Adenosine A2A receptors are required for Glutamate mGluR5‐ and Dopamine D1 receptor‐evoked ERK1/2 phosphorylation in rat Hippocampus: Involvement of NMDA receptor
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    Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy
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    The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells
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    Inhibition of A-Type K+ Channels by Urotensin-II Induces Sensory Neuronal Hyperexcitability Through the PKCα-ERK Pathway
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    CD69 partially inhibits apoptosis and erythroid differentiation via CD24, and their knockdown increase imatinib sensitivity in BCR‐ABL‐positive cells
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    Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf)
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    Tuning of in vivo cognate B-T cell interactions by Intersectin 2 is required for effective anti-viral B cell immunity.
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    FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia
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    MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma
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    Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas
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    Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer
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  162. Nov 2017
  163. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development
    1
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  164. www.sciencedirect.com www.sciencedirect.com
    High-fat diet enhances hepatic ischemia-reperfusion injury-induced apoptosis: Role of glucocorticoid receptors
    1
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  165. academic.oup.com academic.oup.com
    Carbon Black Nanoparticles Inhibit Aromatase Expression and Estradiol Secretion in Human Granulosa Cells Through the ERK1/2 Pathway
    1
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      AB_330744

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  166. www.sciencedirect.com www.sciencedirect.com
    Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria
    1
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  167. elifesciences.org elifesciences.org
    Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system
    1
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    elifesciences.org/articles/29241
  168. academic.oup.com academic.oup.com
    Untitled document
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    academic.oup.com/endo/article/158/9/3015/3869337/Membrane-Androgen-Receptor-ZIP9-Induces-Croaker
  169. www.sciencedirect.com www.sciencedirect.com
    YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis
    1
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  170. www.jneurosci.org www.jneurosci.org
    Pharmacological Rescue of Long-Term Potentiation in Alzheimer Diseased Synapses
    2
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  171. www.eneuro.org www.eneuro.org
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    eneuro.org/content/4/2/ENEURO.0149-16.2017
  172. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Heparan sulfate alterations in extracellular matrix structures and fibroblast growth factor‐2 signaling impairment in the aged neurogenic niche
    1
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  173. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Purinergic receptor P2Y6 contributes to 1‐methyl‐4‐phenylpyridinium‐induced oxidative stress and cell death in neuronal SH‐SY5Y cells
    1
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  174. www.sciencedirect.com www.sciencedirect.com
    Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
    1
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  175. www.jneurosci.org www.jneurosci.org
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  176. academic.oup.com academic.oup.com
    Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice
    1
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    Complement C5aR1 Signaling Promotes Polarization and Proliferation of Embryonic Neural Progenitor Cells through PKCζ.
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  178. www.jneurosci.org www.jneurosci.org
    TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway
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  179. academic.oup.com academic.oup.com
    Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues
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  180. academic.oup.com academic.oup.com
    Reg2 Expression Is Required for Pancreatic Islet Compensation in Response to Aging and High-Fat Diet–Induced Obesity
    1
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  181. academic.oup.com academic.oup.com
    A Potential Role for Endoplasmic Reticulum Stress in Progesterone Deficiency in Obese Women
    1
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  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer’s Disease
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  183. elifesciences.org elifesciences.org
    The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration
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    elifesciences.org/content/6/e22871
  184. www.sciencedirect.com www.sciencedirect.com
    FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms
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    sciencedirect.com/science/article/pii/S1550413117301560
  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions
    2
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    ncbi.nlm.nih.gov/pmc/articles/PMC5092050/
  186. www.sciencedirect.com www.sciencedirect.com
    Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation
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  187. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation of β-arrestin2 at Thr383 by MEK underlies β-arrestin-dependent activation of Erk1/2 by GPCRs
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      AB_330744

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  188. www.sciencedirect.com www.sciencedirect.com
    Multivalent Small-Molecule Pan-RAS Inhibitors
    1
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      AB_330744

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    sciencedirect.com/science/article/pii/S0092867417301848
  189. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors
    2
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      p44/42 MAPK (Erk1/2) (#9102, AM: 330744)

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      330744

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  190. www.sciencedirect.com www.sciencedirect.com
    Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory “FADDosome” Complex upon TRAIL Stimulation
    1
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      Anti-ERK

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  191. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing
    2
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      AB_330744

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      AB_330744

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  192. elifesciences.org elifesciences.org
    Registered report: Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
    1
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      Rabbit α-ERK1/2

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  193. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function
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    onlinelibrary.wiley.com/doi/10.1111/jnc.13038/full