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  1. Nov 2022
  2. www.sciencedirect.com www.sciencedirect.com
    Activation of Wnt/β-catenin signaling by Zeb1 in endothelial progenitors induces vascular quiescence entry
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    1. scibot 24 Nov 2022
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    sciencedirect.com/science/article/pii/S2211124722015686
  3. academic.oup.com academic.oup.com
    Effect of inactivation of Mst1 and Mst2 in the mouse adrenal cortex
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    1. scibot 19 Nov 2022
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      DOI: 10.1210/jendso/bvac143

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    academic.oup.com/jes/article/7/1/bvac143/6702160
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    Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer
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      DOI: 10.1016/j.xcrm.2022.100815

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    sciencedirect.com/science/article/pii/S2666379122003743
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    Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling
    1
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    sciencedirect.com/science/article/pii/S2211124722014462
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    Integration of single-cell transcriptome and chromatin accessibility of early gonads development among goats, pigs, macaques, and humans
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      DOI: 10.1016/j.celrep.2022.111587

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    sciencedirect.com/science/article/pii/S2211124722014528
  7. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Deletion of Nox4 enhances remyelination following cuprizone-induced demyelination by increasing phagocytic capacity of microglia and macrophages in mice
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      DOI: 10.1002/glia.24292

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    onlinelibrary.wiley.com/doi/10.1002/glia.24292
  8. Oct 2022
  9. www.sciencedirect.com www.sciencedirect.com
    TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways
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    1. scibot 28 Oct 2022
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    sciencedirect.com/science/article/pii/S0092867422012521
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preservation effect of imeglimin on pancreatic β-cell mass: Noninvasive evaluation using 111In-exendin-4 SPECT/CT imaging and the perspective of mitochondrial involvements
    1
    1. scibot 26 Oct 2022
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      DOI: 10.3389/fendo.2022.1010825

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    ncbi.nlm.nih.gov/pmc/articles/PMC9559817/
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    BCAT1 redox function maintains mitotic fidelity
    1
    1. scibot 20 Oct 2022
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    sciencedirect.com/science/article/pii/S2211124722013791
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    A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1
    1
    1. scibot 12 Oct 2022
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    sciencedirect.com/science/article/pii/S2211124722013250
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    Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas
    1
    1. scibot 07 Oct 2022
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    sciencedirect.com/science/article/pii/S1097276522008966
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    Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization
    1
    1. scibot 07 Oct 2022
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      DOI: 10.1016/j.chembiol.2022.09.002

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    sciencedirect.com/science/article/pii/S2451945622003506
  15. Sep 2022
  16. www.sciencedirect.com www.sciencedirect.com
    Microglial control of neuronal development via somatic purinergic junctions
    1
    1. scibot 21 Sep 2022
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    sciencedirect.com/science/article/pii/S2211124722012013
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tenascin-C fibronectin D domain is involved in the fine-tuning of glial response to CNS injury in vitro
    1
    1. scibot 21 Sep 2022
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      DOI: 10.3389/fcell.2022.952208

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    ncbi.nlm.nih.gov/pmc/articles/PMC9462431/
  18. www.sciencedirect.com www.sciencedirect.com
    BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer
    1
    1. scibot 15 Sep 2022
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      DOI: 10.1016/j.celrep.2022.111304

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    sciencedirect.com/science/article/pii/S2211124722011287
  19. www.sciencedirect.com www.sciencedirect.com
    Endothelial cells regulated by RNF20 orchestrate the proliferation and differentiation of neural precursor cells during embryonic development
    1
    1. scibot 15 Sep 2022
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      DOI: 10.1016/j.celrep.2022.111350

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    sciencedirect.com/science/article/pii/S2211124722011780
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins
    1
    1. scibot 10 Sep 2022
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      DOI: 10.1158/2159-8290.CD-22-0043

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    ncbi.nlm.nih.gov/pmc/articles/PMC9437572/
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p75NTR prevents the onset of cerebellar granule cell migration via RhoA activation
    1
    1. scibot 02 Sep 2022
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      DOI: 10.7554/eLife.79934

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    ncbi.nlm.nih.gov/pmc/articles/PMC9427104/
  22. Aug 2022
  23. www.sciencedirect.com www.sciencedirect.com
    Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers
    1
    1. scibot 31 Aug 2022
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    sciencedirect.com/science/article/pii/S2211124722011160
  24. www.sciencedirect.com www.sciencedirect.com
    The RNA helicase DDX5 cooperates with EHMT2 to sustain alveolar rhabdomyosarcoma growth
    1
    1. scibot 31 Aug 2022
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    sciencedirect.com/science/article/pii/S2211124722010853
  25. 52.53.155.43 52.53.155.43
    can-21-2908-html.html
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      DOI: 10.1158/0008-5472.CAN-21-2908

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    The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells
    1
    1. scibot 23 Aug 2022
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      DOI: 10.1016/j.stem.2022.07.010

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    sciencedirect.com/science/article/pii/S1934590922003332
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    Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy
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      DOI: 10.1016/j.stem.2022.07.009

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    sciencedirect.com/science/article/pii/S1934590922003046
  28. 52.53.155.43 52.53.155.43
    Resolving the lineage relationship between malignant cells and vascular cells in glioblastomas
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      DOI: 10.1093/procel/pwac006

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  29. www.sciencedirect.com www.sciencedirect.com
    Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock
    1
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    sciencedirect.com/science/article/pii/S2211124722010257
  30. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Molecular and histological correlates of cognitive decline across age in male C57BL/6J mice
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      DOI: 10.1002/brb3.2736

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    onlinelibrary.wiley.com/doi/10.1002/brb3.2736
  31. www.nature.com www.nature.com
    1-Indanone retards cyst development in ADPKD mouse model by stabilizing tubulin and down-regulating anterograde transport of cilia
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      DOI: 10.1038/s41401-022-00937-z

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    nature.com/articles/s41401-022-00937-z
  32. Jul 2022
  33. www.nature.com www.nature.com
    Multifocal organoids reveal clonal associations between synchronous intestinal tumors with pervasive heterogeneous drug responses
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    1. scibot 27 Jul 2022
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      DOI: 10.1038/s41525-022-00313-0

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    nature.com/articles/s41525-022-00313-0
  34. www.sciencedirect.com www.sciencedirect.com
    PTEN and LKB1 are differentially required in Gli1-expressing mesenchymal cells to suppress gastrointestinal polyposis
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    sciencedirect.com/science/article/pii/S2211124722009317
  35. www.sciencedirect.com www.sciencedirect.com
    Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells
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    sciencedirect.com/science/article/pii/S1534580722004464
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    Ubiquitination and deubiquitination of 4E-T regulate neural progenitor cell maintenance and neurogenesis by controlling P-body formation
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    sciencedirect.com/science/article/pii/S2211124722008683
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    Small RNAs derived from tRNA fragmentation regulate the functional maturation of neonatal β cells
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    sciencedirect.com/science/article/pii/S2211124722008671
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    Beta-blockers disrupt mitochondrial bioenergetics and increase radiotherapy efficacy independently of beta-adrenergic receptors in medulloblastoma
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    sciencedirect.com/science/article/pii/S2352396422003309
  39. journals.sagepub.com journals.sagepub.com
    Lanthionine Ketimine Ethyl Ester Accelerates Remyelination in a Mouse Model of Multiple Sclerosis - Jeffrey L. Dupree, Pablo M. Paez, Seema K. Tiwari-Woodruff, Travis T. Denton, Kenneth Hensley, Christina G. Angeliu, Anne I. Boullerne, Sergey Kalinin, Sophia Egge, Veronica T. Cheli, Giancarlo Denaroso, Kelley C. Atkinson, Micah Feri, Douglas L. Feinstein, 2022
    1
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    journals.sagepub.com/doi/full/10.1177/17590914221112352
  40. Jun 2022
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Patient-Derived Tumor Organoids for Guidance of Personalized Drug Therapies in Recurrent Glioblastoma
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      DOI: 10.3390/ijms23126572

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    ncbi.nlm.nih.gov/pmc/articles/PMC9223608/
  42. www.jneurosci.org www.jneurosci.org
    Disruption of endosomal sorting in Schwann cells leads to defective myelination and endosomal abnormalities observed in Charcot-Marie-Tooth disease
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      DOI: 10.1523/JNEUROSCI.2481-21.2022

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    jneurosci.org/content/42/25/5085
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Grafted human ESC-derived astroglia repair spinal cord injury via activation of host anti-inflammatory microglia in the lesion area
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      DOI: 10.7150/thno.70929

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    ncbi.nlm.nih.gov/pmc/articles/PMC9169351/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Progression Patterns in Non-Contrast-Enhancing Gliomas Support Brain Tumor Responsiveness to Surgical Lesions
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      DOI: 10.3389/pore.2022.1610268

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    ncbi.nlm.nih.gov/pmc/articles/PMC9189286/
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Iloprost requires the Frizzled 9 receptor to prevent lung cancer
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      DOI: 10.1016/j.isci.2022.104442

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    ncbi.nlm.nih.gov/pmc/articles/PMC9189122/
  46. aacrjournals.org aacrjournals.org
    Liver Endothelium Promotes HER3-mediated Cell Survival in Colorectal Cancer with Wild-type and Mutant KRAS
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      DOI: 10.1158/1541-7786.MCR-21-0633

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    Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues
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    Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging
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    An injury-responsive Rac-to-Rho GTPase switch drives activation of muscle stem cells through rapid cytoskeletal remodeling
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    Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization
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    WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy
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    Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model
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    Coactivator-associated arginine methyltransferase 1 controls oligodendrocyte differentiation in the corpus callosum during early brain development
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    A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer
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    MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding
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    Acquired hydrocephalus is associated with neuroinflammation, progenitor loss, and cellular changes in the subventricular zone and periventricular white matter
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    miR-137 and miR-122, two outer subventricular zone non-coding RNAs, regulate basal progenitor expansion and neuronal differentiation
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    Histone Acetylation Defects in Brain Precursor Cells: A Potential Pathogenic Mechanism Causing Proliferation and Differentiation Dysfunctions in Mitochondrial Aspartate-Glutamate Carrier Isoform 1 Deficiency
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    Lipid droplet dynamics regulate adult muscle stem cell fate
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    Molecular dynamics and functional characterization of I37R-CFTR lasso mutation provide insights into channel gating activity
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    Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors
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    Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness
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  94. Dec 2021
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    Preventive effect of sanguinarine on intestinal injury in mice exposed to whole abdominal irradiation
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    Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity
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    Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug Responses
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    Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer
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    Nasal obstruction during the growth period modulates the Wnt/β-Catenin pathway and brain-derived neurotrophic factor production in association with tyrosine kinase receptor B mRNA reduction in mouse hippocampus
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    The role of epithelial progesterone receptor isoforms in embryo implantation
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    Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes
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    Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids
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    Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis
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  106. Nov 2021
  107. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Oligodendrocyte progenitor proliferation is disinhibited following traumatic brain injury in leukemia inhibitory factor heterozygous mice
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  108. 52.53.155.43 52.53.155.43
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    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
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    MiR-674-5p Suppresses the Proliferation and Migration of Glioma Cells by Targeting Cul4b
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    Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction
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    Dietary nitrate supplementation prevents radiotherapy-induced xerostomia
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    Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring
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  114. Oct 2021
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    Zyxin Mediates Vascular Repair via Endothelial Migration Promoted by Forskolin in Mice
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    Stretching of the retinal pigment epithelium contributes to zebrafish optic cup morphogenesis
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    RNF8-mediated regulation of Akt promotes lung cancer cell survival and resistance to DNA damage
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  118. Sep 2021
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    H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity
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    SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling
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    Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development
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    Long noncoding RNA lnc-POP1-1 upregulated by VN1R5 promotes cisplatin resistance in head and neck squamous cell carcinoma through interaction with MCM5
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    ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction
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    The fate of notch-1 transcript is linked to cell cycle dynamics by activity of a natural antisense transcript
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    Pro-inflammatory and proliferative microglia drive progression of glioblastoma
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    Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models
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    Rewiring of human neurodevelopmental gene regulatory programs by human accelerated regions
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    UV-induced reduction in Polycomb repression promotes epidermal pigmentation
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  130. Aug 2021
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    Connexin 43 and Sonic Hedgehog Pathway Interplay in Glioblastoma Cell Proliferation and Migration
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    Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy
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  134. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transgenic modeling of Ndr2 gene amplification reveals disturbance of hippocampus circuitry and function
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    The Presynaptic Scaffold Protein Bassoon in Forebrain Excitatory Neurons Mediates Hippocampal Circuit Maturation: Potential Involvement of TrkB Signalling
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  136. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression
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    Adrenomedullin ameliorates pulmonary fibrosis by regulating TGF-β-Smads signaling and myofibroblast differentiation
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    Male and Female Mice Exhibit Divergent Responses of the Cortical Vasculature to Traumatic Brain Injury
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    Conditional Deletion of the L-Type Calcium Channel Cav1.2 in Oligodendrocyte Progenitor Cells Affects Postnatal Myelination in Mice
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    Ultra-High-Frequency Reprogramming of Individual Long-Term Hematopoietic Stem Cells Yields Low Somatic Variant Induced Pluripotent Stem Cells
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    BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation
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    Bortezomib Alone and in Combination With Salinosporamid A Induces Apoptosis and Promotes Pheochromocytoma Cell Death In Vitro and in Female Nude Mice
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    Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer
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    Tracing colonic embryonic transcriptional profiles and their reactivation upon intestinal damage
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    Effects of Toll-like receptor 4 inhibition on spatial memory and cell proliferation in male and female adult and aged mice
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    Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ
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    AMPK Activation Regulates LTBP4-Dependent TGF-β1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy
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    Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
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    The Divalent Metal Transporter 1 (DMT1) Is Required for Iron Uptake and Normal Development of Oligodendrocyte Progenitor Cells
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    PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling
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    Ultra-High-Frequency Reprogramming of Individual Long-Term Hematopoietic Stem Cells Yields Low Somatic Variant Induced Pluripotent Stem Cells
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    Diosmetin induces apoptosis and enhances the chemotherapeutic efficacy of paclitaxel in non‐small cell lung cancer cells via Nrf2 inhibition
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    Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy
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    Ablation of proliferating neural stem cells during early life is sufficient to reduce adult hippocampal neurogenesis
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  176. elifesciences.org elifesciences.org
    Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ
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    The Polyploid State Plays a Tumor-Suppressive Role in the Liver
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    Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer
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  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Myocardin-related transcription factor and serum response factor regulate cilium turnover by both transcriptional and local mechanisms
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      DOI: 10.1016/j.isci.2021.102739

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  180. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KY19382, a novel activator of Wnt/β‐catenin signalling, promotes hair regrowth and hair follicle neogenesis
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      DOI: 10.1111/bph.15438

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  181. www.sciencedirect.com www.sciencedirect.com
    Regional specialization and fate specification of bone stromal cells in skeletal development
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  182. www.cell.com www.cell.com
    Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer
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    cell.com/molecular-cell/fulltext/S1097-2765(21)00493-7
  183. Jun 2021
  184. academic.oup.com academic.oup.com
    CX3CL1–CX3CR1 signalling deficiency exacerbates obesity-induced inflammation and insulin resistance in male mice
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      DOI: 10.1210/endocr/bqab064

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    academic.oup.com/endo/article/162/6/bqab064/6188411
  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Plexin-B2 controls the timing of differentiation and the motility of cerebellar granule neurons
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    High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity
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  187. www.sciencedirect.com www.sciencedirect.com
    miR-24 controls the regenerative competence of hair follicle progenitors by targeting Plk3
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    Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis
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  189. www.nature.com www.nature.com
    MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancer
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      DOI: 10.1038/s41523-021-00273-1

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  190. May 2021
  191. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction
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  192. www.sciencedirect.com www.sciencedirect.com
    Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening
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  193. www.sciencedirect.com www.sciencedirect.com
    Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs
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  194. www.sciencedirect.com www.sciencedirect.com
    LEFTY1 Is a Dual-SMAD Inhibitor that Promotes Mammary Progenitor Growth and Tumorigenesis
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    Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium
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  196. www.sciencedirect.com www.sciencedirect.com
    The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis
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    Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome
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    Mechanical instability of adherens junctions overrides intrinsic quiescence of hair follicle stem cells
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    Negative elongation factor regulates muscle progenitor expansion for efficient myofiber repair and stem cell pool repopulation
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    A Single-Cell Transcriptomic Atlas of Human Skin Aging
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    sciencedirect.com/science/article/pii/S1534580720308777
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    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
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    DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma
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  203. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology
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      DOI: 10.7554/eLife.66904

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  204. www.sciencedirect.com www.sciencedirect.com
    Optogenetic activation of local colonic sympathetic innervations attenuates colitis by limiting immune cell extravasation
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    sciencedirect.com/science/article/pii/S1074761321001692
  205. Apr 2021
  206. www.sciencedirect.com www.sciencedirect.com
    Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis
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      DOI: 10.1016/j.cmet.2020.10.005

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    sciencedirect.com/science/article/pii/S1550413120305386
  207. www.sciencedirect.com www.sciencedirect.com
    The Major Pre- and Postmenopausal Estrogens Play Opposing Roles in Obesity-Driven Mammary Inflammation and Breast Cancer Development
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      Anti-Ki67 Rabbit polyclonal

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    sciencedirect.com/science/article/pii/S1550413120302473
  208. link.springer.com link.springer.com
    Glutamine deficiency promotes stemness and chemoresistance in tumor cells through DRP1-induced mitochondrial fragmentation
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    link.springer.com/article/10.1007/s00018-021-03818-6
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    An in vitro assay to quantify satellite cell activation using isolated mouse myofibers
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    sciencedirect.com/science/article/pii/S2666166721001891
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    Mutant p53 suppresses innate immune signaling to promote tumorigenesis
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  211. www.sciencedirect.com www.sciencedirect.com
    Single-Cell Characterization of Malignant Phenotypes and Developmental Trajectories of Adrenal Neuroblastoma
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    Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer
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  213. www.sciencedirect.com www.sciencedirect.com
    In vivo reprogramming of NG2 glia enables adult neurogenesis and functional recovery following spinal cord injury
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