- Aug 2018
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pharmd.umc.edu pharmd.umc.edu
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calcium (15 mEq
Is this necessary? What is his ionized Ca?
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356
Never. Use an appropriate bag size (100, 150, 250, 500, 1L)...
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Tylenol ES to another pain relief medication such as naproxen
are you sure? Is he at risk for GI bleed?
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pharmd.umc.edu pharmd.umc.edu
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Adverse Event Monitoring
How often are you monitoring? What values or s/s are you monitoring? What are the critical values? And what's the plan if these things happen?
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signs of anaphylaxi
what are these?
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frequen
how frequent?
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signs of infection
such as? WBC? Fever? etc?
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Therapeutic Monitoring
Include values for your monitoring parameters.... and how often you are going to monitor them
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more effective
in what ways?
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continue taking Pepcid
Are you sure? Can he take oral meds with his n/v? If so, cool, but consider these things.
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Diazepam
Why not Ativan or Librium?
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No difference
So this isn't a good reason to choose imipenem... you need to include a good reason... SEs? Cost?
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250mL/hr via IV infusion
for how long
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IV potassium, calcium, and magnesium
In what forms? What doses? For how long? Are all of these necessary (Hint: Look at your patient's ionized Ca).
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1 to 2
avoid ranges
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48 to 72
avoid ranges
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20 to 30
avoid ranges
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pharmd.umc.edu pharmd.umc.edu
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over sedation, respiratory depression
What values do you look at to monitor these? How often?
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has not improved
Has not improved by when? What are you switching to?
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lipid levels
lipid? you mean liver enzyme?
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potassium is 2.7 mEq/L and the normal range is 3.5-5.1 mEq/L. If his levels are not within normal limits more electrolytes may need to be added
Is LR sufficient to raise your potassium this much? Your patient is at risk for cardiac arrest... I suggest considering this fact.
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monitored
How often?
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if
of
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lesser
is lesser a word?
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lesser
Is this really a word?
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less side effects
What specific side effects does it avoid?
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electrolyte balance
What electrolytes are in LR? How much of each is in LR? Are these sufficient amounts to replace your patients deficiencies?
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New Drug Therap
Consider any emergent electrolyte disturbances that you need to fix. Consider nutritional deficiencies you need to fix.
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7-10
avoid ranges
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Previous Meds
What about Bactrim, Pepcid, and his enzymes??
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pharmd.umc.edu pharmd.umc.edu
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Adverse Event Monitoring
how often are you monitoring? what values s/s are you monitoring for? what are the critical values? what is your plan if these things occur?
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Therapeutic Monitoring
how often are you monitoring, what values or s/s are you monitoring for?
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monitored for signs of anaphylaxis during the first dose. During prolonged therapy of Menopenem MH should be monitored for renal function, liver function, and CBC. 3 While MH is taking Chlordiazepoxide, he needs to be monitored closely for sedation, respiratory depression, and delirium.
This whole part is adverse events... not therapeutic.
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signs of anaphylaxis
what are these
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closely
how often are you monitoring?
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48 to 72
avoid ranges
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Within the benzodiazepine class there was not medication that showed better efficacy, although there was a trend for better efficacy with chloridazepoxide
Don't do this. Find specific reasons to back up your choice of using Librium....
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V potassium, calcium, and magnesium
What forms and what doses and for how long?
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CrCl of 37mL/minute
Good.
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tablet
Oral? It's fine but remember to justify this route in rationale
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1 to 2 hours
I don't think this is recommended.... Look at this again. And are you really trying to sedate him? There are faster ways if thats you're goal.....
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IV help the potassium, calcium, and magnesium
How? What are you giving him in this magic IV? KCl? Kacetate? MgSulfate? CaGluconate? CaCl? Are all of these necessary to replace? (Hint: what is his ionized Ca?)
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help with inflammation
What about fluid resuscitation and electrolyte status?
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48 to 72
don't use ranges
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debridement is unnecessary
Huh?
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continue taking Pepcid
Can he tolerate oral meds? N/v? Is this appropriate for pancreatitis patients?
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pharmd.umc.edu pharmd.umc.edu
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New Drug Therapy
Are there emergent electrolyte disturbances present that you need to correct? Are there nutritional/vitamin deficiencies you need to correct?
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metabolic alkalosis
What are the values you're looking at for this?
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consult the physician
You are the pharmacist... make a recommendation about what to do....
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glucose levels, to see if addressing his acute pancreatitis was able to normalize (77-106 mg/dL)
Is the goal for inpatient?
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consult physician about pain management
Why? You're the pharmacist... the physician is likely to ask for your recommendation so go ahead and formulate one.
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Clinical Institute Withdrawal Assessment
Excellent
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If the therapy is causing harm or failing to treat the suspected infection, a new antibiotic therapy may need to be addressed.
Adverse events....
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monitor the liver and renal function to ensure drug is working properly
This should be in adverse events....
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anaphylactic reaction
This should be in adverse events.... What are the s/s? What do you do if this happens?
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If the results show that a change in therapy is necessary, and then the physician should be consulted
Shorten this to "Abx therapy should be adjusted according to results of these"
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liver malfunction as shown by his ALT 168 (9-52 U/L) and AST 330 (8-39 U/L) levels.
Not entirely accurate.... Research what ALT/AST actually measure.
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decreased liver functio
Is his liver function actually decreased? What are ALT/AST actually measuring? I like Ativan as the choice, but I don't necessarily agree with this portion of the rationale...
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electrolytes (sodium, calcium, potassium, lactate
Look at how much of each of these it has... are they sufficient amounts for your patient??
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by mouth
can he tolerate oral meds?
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electrolyte improvement
Which electrolytes? LR doesn't contain every electrolyte... also look at how much of each electrolyte LR has and consider if this is sufficient for your patient.
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3 minutes
I have never seen this.... Double check.
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every 8 hours
Is merrem renally adjusted?
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continue the OTC Pepcid
Can he tolerate oral meds with N/V? Always consider this with every patient you encounter...
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pharmd.umc.edu pharmd.umc.edu
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New Drug Therapy
Consider the whole patient. Are there emergent electrolyte disturbances that need to be fixed? Are there nutritional/vitamin deficiencies present?
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Adverse Event Monitoring
How often are you monitoring? What exactly are you monitoring? What are the critical values? And what is your plan if these things happen?
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metabolic alkalosis
How is this defined? What are the values?
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assessed continuously for oversedation
How are these assessed? This isn't Therapeutic. Move this to adverse event!!
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monitored
How often and for what? What are the s/s of DT?
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CBC to monitor
How often?
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monitored
How often?
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24-48
avoid ranges
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symptom-triggered
Good. But you need to mention how this works.... what is the scale/tool used?
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liver function
What are you basing his liver function off of? Can AST/ALT be falsely elevated in pancreatitis and AWS? What do AST/ALT measure anyways? Is his liver function actually poor? Things to consider. I like the Ativan choice though...
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hospitals prefer it on their formularies
But why do hospitals prefer it? This isn't a good reason to use in your treatment plan... you need to find a specific benefit to merrem whether its the side effect profile or cost...
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potassium
How much potassium is in LR? Is this a sufficient amount? Is it bad if potassium is low? You need to consider these things.
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C-reactive protein
This is just a free piece of information... but CRP is kind of a poor marker to use because its not specific at all. So really LR's advantage is decreased inflammation....
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15-20
dont use ranges
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15-20
dont use ranges
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cultures come back
until sensitivities you mean?
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15-30
dont use ranges
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24-48hours
dont use ranges
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continue his pancreaze and Pepcid
He can tolerate oral meds with N/V?
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pharmd.umc.edu pharmd.umc.edu
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Adverse Event Monitoring
I know you ran out of room... but Adverse Events is a super important section... so I would revisit other sections and cut out parts that aren't absolutely necessary and abreviate where you can (it's fine to use LR for Lactated Ringers if you establish it first...)
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sedation
How is this assessed? What are your critical values for sedation/resp depression? And what is your course of action if these are met?
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monitored
How often?
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0,lor
Spacing issue.
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continued
and probably for susceptibility too?
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(>0.5mL/kg/hr)
Yes. Excellent. Thank you for including this.
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monitored
How often?
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lorazepam has a relatively short half-life, which would be appropriate for MH who is in a critical state with decreased organ function
Solid job mentioning all this. Your rationale section is fantastic. I would however revisit any emergent electrolyte issues or nutritional deficiencies that may be present and address them. LR doesn't necessarily cover all the electrolytes and it doesn't have a whole lot of some of the electrolytes, so look into this.
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pH stabilizing
Why does this matter to your patient? What is his anion gap? Does he have an acid/base disorder?
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decreased CrC
Excellent.
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Meropenem
Excellent job mentioning all the options and reasons you didn't choose them. Could shorten it if needed.
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New Drug Therapy
Consider the whole patient. Are there emergent electrolyte disturbances present that need correction? What about nutritional deficiencies related to AWS?
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plastic container
Bag? Lol
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continue Pepcid OTC
Can the patient tolerate oral meds? N/V?
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glucose levels (current 219mg/dL; goal 77-106
Is this the right goal for inpatient?
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pharmd.umc.edu pharmd.umc.edu
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Supportive care is the main treatment for benzodiazepine overdose due to the adverse risks associated with the reversal agent flumazenil
This is a great line. Good job knowing this.
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Monitor
How often are you monitoring for these things and what is your plan if these things happen?
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Therapeutic Monitoring
How often are you monitoring? What should you monitor in terms of electrolytes?
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IV formulation
Why is this necessary? Why won't oral work? -- I only mention this because at the beginning you said he could continue oral Tylenol and Pepcid...
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pharmd.umc.edu pharmd.umc.edu
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Didn't have time to put in citations yet! Please ignore, thanks!
You're on the right track... Don't think too hard about this stuff. And focus on your major goals: 1) Patient stability (fluids/electrolytes) 2) Infection (ABx) 3) AWS (anxiety/agitation)
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respiratory depression
How do you measure this? What's the critical value? What's the plan if this happens?
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D/C drug
What alternative drug would you recommend?
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Adverse Event Monitoring
How often will you monitor? What are you critical values? What is your plan if those critical values are met?
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hyperkalemia
You need to look at how much potassium LR contains... Is this a real concern?
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5-10mg
which one? 5mg vs 10mg is a big difference....
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hourly
good!
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Urine and blood culture
will these cultures be sufficient for pancreatitis?
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fever and WBC count
goals?
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24-48
Don't use a range.
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frequent
How often is frequent?
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BUN and serum creatinine
What are your specific goals
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New Drug Therapy
Consider your whole patient. Are there electrolyte disturbances present that are cause for emergent concern? Are any of this nutrients/vitamins deficient due to AWS? Do you need to replace these things?
Note: Look into what and how much of each electrolyte LR contains and think about whether or not this will be sufficient for your patient or if additional replacement will be needed....
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Meropenem
Need to mention why merrem over imipenem.... several reasons.
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q12 due to renal
Good!
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(CIWA-Ar)
Excellent!
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targeted
Excellent!!
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normal ranges
Consider goal ranges for these
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pharmd.umc.edu pharmd.umc.edu
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New Drug Therapy
Consider your whole patient. Are there emergent electrolyte disturbances present? How is his nutrition? Do you need to do anything regarding nutrition or electrolytes?
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Adverse Event Monitoring
How often are you monitoring, what values are you specifically monitoring, and what is your plan if things go south?
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Clinical Institute Withdrawal Assessment
Excellent... But how are you using it? What value are looking for to ensure therapeutic effect?
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Monitor menta
How often?
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monitor pain
How often?
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monitored
How often?
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consult with doctor
MH is in the hospital and the doctor has asked for your recommendations... so what is your judgement in regards to insulin?
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glucose within 77-106
Is this your goal for inpatients?
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magnesium
By what mechanism? LR doesn't have Mag...
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monitored
How often?
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Y-site compatible with meropenem
This doesn't matter if your Merrem is being infused over 5min (per New Drug Therapy section).... There are MANY reasons why Ativan is a good choice, so look into it a bit more and make a rationale argument for its use.
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3 times a day whereas imipenem is 4 time
Is this really that big of a benefit if your patient is in the hospital? What is another benefit of Merrem?
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compatible
You need to look into this.... Are you suggesting putting the Merrem into the LR solution? Or are you suggesting that it's Y-site compatible as an IV piggyback? Totally different things.
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sodium, potassium, and calcium
Look at how much of each of these it contains. Will this be sufficient for you patient? Are any of his electrolyte abnormalities life-threatening? Also, what's your plan for Mag?
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8 hours
Does he need renal adjustment? Merrem is one of the Abx that is renally adjusted...
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5
5? Are you sure? Double check.
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24 to 48
Which one?
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Previous Meds
What about pepcid....
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glucose (77-106 mg/dL
Double check that this is the right goal for someone in the hosptial
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pharmd.umc.edu pharmd.umc.edu
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New Drug Therapy
You just tried to hurry and submit something so you could get comments, and I get it.... You need to consider this dude as a whole. What do his electrolytes look like? What is your plan to correct them? Does he really need fentanyl? What's the risk of giving fentanyl and diazepam together? How are you going to monitor this? What is his nutritional status? Are there concerns from a nutrition standpoint with AWS that you need to address?
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(3ml/kg/hour)
Okay... but why did you proceed to give it over 30min? Don't do this.
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MH is a 34-year-old white male that presented to clinic with severe epigastric pain and complaints of diarrhea and vomiting for the past few weeks.MH looks malnourished, dehydrated and very confused. After assessment MH was diagnosed with moderately severe acute onset chronic pancreatitis.
Don't include this in your plan. Just jump into the goals you have for him.
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pharmd.umc.edu pharmd.umc.edu
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chosen
Why did you choose to dose Lorazepam the way you did? Is there another way?
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espiratory rate decreases
What critical value are you looking for?
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over sedated or delirious
How are you monitoring this? Is there a lab value, tool, or scale you can use?
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monitored throughout the day
How often?
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Reduced confusion and anxiety
How are you measuring this? Is there a lab value, tool, or scale you can use?
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3.54
Check this level... Typically normal range for WBC is 4-11
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magnesium to 1.5 mg/dL
Really?? Does LR have Mg in it? Check this out.
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frequently
How frequently?
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decreased liver function
Can ALT/AST be elevated due to pancreatitis and AWS? Does it always mean that his liver isn't working? Look into this. What do ALT and AST actually measure....
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Lorazepam
Why did you choose to give it IV if you were cool with giving oral Pepcid at the beginning? Need to think about and address these things.
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chlordiazepoxide can cause decreased liver function
Is there another reason to use Ativan over Librium?
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serious adverse effects
Specifically what effects are you avoiding?
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Lactated Ringer�??s and normal saline solutions
What are these called? Crystalloids.... Will save you space.
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solution
Look at what electolytes LR contains and how much of each it has... is this sufficient for your patient to be restored to normal? Are any of his electrolyte depletions acutely dangerous?
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375
I would stick to a normal bag size (100, 250, 500, 1L)...
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range
Give these ranges... It's just as dangerous for levels to above the range so you need to list these ranges.
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pharmd.umc.edu pharmd.umc.edu
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sedation
How are you monitoring sedation? Is there a scale?
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acidosis
What is the value you look at for this? Why would this occur? (Hint: what causes metabolic acidosis? how is that related to IV ativan?)
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if clinician uses opioid
Technically respiratory depression can happen with just benzos too... so you need to be monitoring for this regardless of pain meds. What are you going to do if it happens? D/C ativan? Intubate? Bipap? Flumanezil?
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espiratory depression
What are the critical values you're assessing here? RR? O2sat?
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clinician should begin therapy with C. diff susceptible antibiotic
Do you know what antibiotic you would recommend? I suggest knowing these things.
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Adverse Event Monitoring
You need to mention how often you are monitoring each thing and what your plan is if these things happen.
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Common adverse reaction
How often are you monitoring for these reactions?
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Sedation is also a common reaction that can be considered an adverse effect, but it also shows that therapy is successfu
I don't know that I agree with you. Look into the sedation scales... If sedation is your goal then you wouldn't use mono-therapy with a benzo... But sedation really shouldn't be your primary goal here... I would leave sedation as an adverse event, not an assessment of therapeutic effect.
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efficacy of lorazepam
Is there a specific way like a scale to measure effectiveness of benzos in AWS?
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[9][20]
Weird spacing again.
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complete blood count
How often are you assessing this?
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signs
How often are you assessing the vitals?
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25-50
Don't use a range. Also... May be better to put >0.5mL/kg/hr
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-48
Don't use a range.
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frequent
How frequent? and what exactly are you assessing? specific values?
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comparing within the benzodiazepine
Why ativan over diazepam?
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urs. [9] To
Weird spacing here.
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37.47 mg/min
Excellent mention of this!
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balance of electrolytes
Consider the electrolytes and the amounts of each electrolyte the patient is going to receive from LR and the banana bag... Are all his electrolytes covered? Are the amounts sufficient to his needs?
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no longer delirious
Is this really the purpose of using Ativan? Or is it to decrease anxiety/agitation?
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15 to 20
Choose one, don't give a range.
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electrolyte
Banana bags only have 3 electrolytes... Na, Cl, and Mg... Further more, what rate should you infuse the banana bag at? What volume is the banana bag? These are all important.
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rehydration
Not really the purpose of the banana bag... Look into this.
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banana bag
I love banana bags.... There is fascinating research out there about banana bags that you may want to look at for general life knowledge.
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increased risk for hepatotoxicity
Look at Tylenol use in pancreatitis too...
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Pepcid OTC
Can he take this with N/V? Are oral meds his best option right now?
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Beginning therapy to treat his infected pancreatitis and dehydration would allow for MH to increase his quality of life
"Goal is to increase QoL...." Don't get bogged down in including all the extra words... you need the space.
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onsider beginning insulin therapy
You recommend this in New Drug Therapy, not in goals. His goal would simply be to lower glucose (include the specific value).
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signs and symptoms
What are these? What are you looking to improve?
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MH is currently experiencing pain in the epigastric region with continual nausea, diarrhea and vomiting as well as a mild fever, anxiety and confusion. Patient is no longer eating and has an increased heart rate and temperature. MH�??s electrolytes including sodium, potassium, calcium, and magnesium are below normal limits
Graders have the case pages and don't need a summary of what's wrong... It's good to just jump right in with the goals.
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pharmd.umc.edu pharmd.umc.edu
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New Drug Therapy
Did you consider your patients electrolytes deficiencies and nutritional imbalances? Look into this and see if there is anything you may have missed.
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caused by lorazepam
It is important to know that acidosis is only caused by IV lorazepam... So if you're giving tablets this point is mute and can be deleted. IV lorazepam contains propylene glycol (thats the mechanism of its metabolic acidosis.... tablets don't have this). Free piece of knowledge.
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onitor for possible acidosis
This a good point. Include the values you're looking at. Also why is this a concern? (Hint: What else causes metabolic acidosis?... Alcohol toxicity?)
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Monitor
How frequent are you monitoring?? You need a frequency for every monitoring parameter.
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hypernatremia and metabolic alkalosis
What are the values for these?
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cardiotoxicity
Why else are you monitoring for this? (Hint: Electrolytes... )
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4 to 8
Don't use a range.
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CIWA-Ar scor
Good!
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consult physician
Why? You're a pharmacist. Make a recommendation.
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physician will need to be consulted about initiation of insulin for glucose contro
Why? You are a pharmacist. Make a recommendation to the physician regarding when insulin will be needed.
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(77-106
Is this the inpatient goal?
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Monitor blood glucose
How often?
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