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  1. Aug 2018
    1. Adverse Event Monitoring

      How often are you monitoring? What values or s/s are you monitoring? What are the critical values? And what's the plan if these things happen?

    1. potassium is 2.7 mEq/L and the normal range is 3.5-5.1 mEq/L. If his levels are not within normal limits more electrolytes may need to be added

      Is LR sufficient to raise your potassium this much? Your patient is at risk for cardiac arrest... I suggest considering this fact.

    1. Adverse Event Monitoring

      how often are you monitoring? what values s/s are you monitoring for? what are the critical values? what is your plan if these things occur?

    2. monitored for signs of anaphylaxis during the first dose. During prolonged therapy of Menopenem MH should be monitored for renal function, liver function, and CBC. 3 While MH is taking Chlordiazepoxide, he needs to be monitored closely for sedation, respiratory depression, and delirium.

      This whole part is adverse events... not therapeutic.

    3. Within the benzodiazepine class there was not medication that showed better efficacy, although there was a trend for better efficacy with chloridazepoxide

      Don't do this. Find specific reasons to back up your choice of using Librium....

    4. 1 to 2 hours

      I don't think this is recommended.... Look at this again. And are you really trying to sedate him? There are faster ways if thats you're goal.....

    5. IV help the potassium, calcium, and magnesium

      How? What are you giving him in this magic IV? KCl? Kacetate? MgSulfate? CaGluconate? CaCl? Are all of these necessary to replace? (Hint: what is his ionized Ca?)

    1. New Drug Therapy

      Are there emergent electrolyte disturbances present that you need to correct? Are there nutritional/vitamin deficiencies you need to correct?

    2. consult physician about pain management

      Why? You're the pharmacist... the physician is likely to ask for your recommendation so go ahead and formulate one.

    3. If the results show that a change in therapy is necessary, and then the physician should be consulted

      Shorten this to "Abx therapy should be adjusted according to results of these"

    4. decreased liver functio

      Is his liver function actually decreased? What are ALT/AST actually measuring? I like Ativan as the choice, but I don't necessarily agree with this portion of the rationale...

    5. electrolyte improvement

      Which electrolytes? LR doesn't contain every electrolyte... also look at how much of each electrolyte LR has and consider if this is sufficient for your patient.

    1. New Drug Therapy

      Consider the whole patient. Are there emergent electrolyte disturbances that need to be fixed? Are there nutritional/vitamin deficiencies present?

    2. Adverse Event Monitoring

      How often are you monitoring? What exactly are you monitoring? What are the critical values? And what is your plan if these things happen?

    3. liver function

      What are you basing his liver function off of? Can AST/ALT be falsely elevated in pancreatitis and AWS? What do AST/ALT measure anyways? Is his liver function actually poor? Things to consider. I like the Ativan choice though...

    4. hospitals prefer it on their formularies

      But why do hospitals prefer it? This isn't a good reason to use in your treatment plan... you need to find a specific benefit to merrem whether its the side effect profile or cost...

    5. C-reactive protein

      This is just a free piece of information... but CRP is kind of a poor marker to use because its not specific at all. So really LR's advantage is decreased inflammation....

    1. Adverse Event Monitoring

      I know you ran out of room... but Adverse Events is a super important section... so I would revisit other sections and cut out parts that aren't absolutely necessary and abreviate where you can (it's fine to use LR for Lactated Ringers if you establish it first...)

    2. lorazepam has a relatively short half-life, which would be appropriate for MH who is in a critical state with decreased organ function

      Solid job mentioning all this. Your rationale section is fantastic. I would however revisit any emergent electrolyte issues or nutritional deficiencies that may be present and address them. LR doesn't necessarily cover all the electrolytes and it doesn't have a whole lot of some of the electrolytes, so look into this.

    3. New Drug Therapy

      Consider the whole patient. Are there emergent electrolyte disturbances present that need correction? What about nutritional deficiencies related to AWS?

    1. Supportive care is the main treatment for benzodiazepine overdose due to the adverse risks associated with the reversal agent flumazenil

      This is a great line. Good job knowing this.

    2. IV formulation

      Why is this necessary? Why won't oral work? -- I only mention this because at the beginning you said he could continue oral Tylenol and Pepcid...

    1. Didn't have time to put in citations yet! Please ignore, thanks!

      You're on the right track... Don't think too hard about this stuff. And focus on your major goals: 1) Patient stability (fluids/electrolytes) 2) Infection (ABx) 3) AWS (anxiety/agitation)

    2. New Drug Therapy

      Consider your whole patient. Are there electrolyte disturbances present that are cause for emergent concern? Are any of this nutrients/vitamins deficient due to AWS? Do you need to replace these things?

      Note: Look into what and how much of each electrolyte LR contains and think about whether or not this will be sufficient for your patient or if additional replacement will be needed....

    1. New Drug Therapy

      Consider your whole patient. Are there emergent electrolyte disturbances present? How is his nutrition? Do you need to do anything regarding nutrition or electrolytes?

    2. Y-site compatible with meropenem

      This doesn't matter if your Merrem is being infused over 5min (per New Drug Therapy section).... There are MANY reasons why Ativan is a good choice, so look into it a bit more and make a rationale argument for its use.

    3. compatible

      You need to look into this.... Are you suggesting putting the Merrem into the LR solution? Or are you suggesting that it's Y-site compatible as an IV piggyback? Totally different things.

    4. sodium, potassium, and calcium

      Look at how much of each of these it contains. Will this be sufficient for you patient? Are any of his electrolyte abnormalities life-threatening? Also, what's your plan for Mag?

    1. New Drug Therapy

      You just tried to hurry and submit something so you could get comments, and I get it.... You need to consider this dude as a whole. What do his electrolytes look like? What is your plan to correct them? Does he really need fentanyl? What's the risk of giving fentanyl and diazepam together? How are you going to monitor this? What is his nutritional status? Are there concerns from a nutrition standpoint with AWS that you need to address?

    2. MH is a 34-year-old white male that presented to clinic with severe epigastric pain and complaints of diarrhea and vomiting for the past few weeks.MH looks malnourished, dehydrated and very confused. After assessment MH was diagnosed with moderately severe acute onset chronic pancreatitis.

      Don't include this in your plan. Just jump into the goals you have for him.

    1. decreased liver function

      Can ALT/AST be elevated due to pancreatitis and AWS? Does it always mean that his liver isn't working? Look into this. What do ALT and AST actually measure....

    2. solution

      Look at what electolytes LR contains and how much of each it has... is this sufficient for your patient to be restored to normal? Are any of his electrolyte depletions acutely dangerous?

    1. if clinician uses opioid

      Technically respiratory depression can happen with just benzos too... so you need to be monitoring for this regardless of pain meds. What are you going to do if it happens? D/C ativan? Intubate? Bipap? Flumanezil?

    2. Sedation is also a common reaction that can be considered an adverse effect, but it also shows that therapy is successfu

      I don't know that I agree with you. Look into the sedation scales... If sedation is your goal then you wouldn't use mono-therapy with a benzo... But sedation really shouldn't be your primary goal here... I would leave sedation as an adverse event, not an assessment of therapeutic effect.

    3. balance of electrolytes

      Consider the electrolytes and the amounts of each electrolyte the patient is going to receive from LR and the banana bag... Are all his electrolytes covered? Are the amounts sufficient to his needs?

    4. electrolyte

      Banana bags only have 3 electrolytes... Na, Cl, and Mg... Further more, what rate should you infuse the banana bag at? What volume is the banana bag? These are all important.

    5. Beginning therapy to treat his infected pancreatitis and dehydration would allow for MH to increase his quality of life

      "Goal is to increase QoL...." Don't get bogged down in including all the extra words... you need the space.

    6. onsider beginning insulin therapy

      You recommend this in New Drug Therapy, not in goals. His goal would simply be to lower glucose (include the specific value).

    7. MH is currently experiencing pain in the epigastric region with continual nausea, diarrhea and vomiting as well as a mild fever, anxiety and confusion. Patient is no longer eating and has an increased heart rate and temperature. MH�??s electrolytes including sodium, potassium, calcium, and magnesium are below normal limits

      Graders have the case pages and don't need a summary of what's wrong... It's good to just jump right in with the goals.

    1. New Drug Therapy

      Did you consider your patients electrolytes deficiencies and nutritional imbalances? Look into this and see if there is anything you may have missed.

    2. caused by lorazepam

      It is important to know that acidosis is only caused by IV lorazepam... So if you're giving tablets this point is mute and can be deleted. IV lorazepam contains propylene glycol (thats the mechanism of its metabolic acidosis.... tablets don't have this). Free piece of knowledge.

    3. onitor for possible acidosis

      This a good point. Include the values you're looking at. Also why is this a concern? (Hint: What else causes metabolic acidosis?... Alcohol toxicity?)

    4. physician will need to be consulted about initiation of insulin for glucose contro

      Why? You are a pharmacist. Make a recommendation to the physician regarding when insulin will be needed.