5,106 Matching Annotations
- Dec 2020
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tissues
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hierarchy
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heterogeneity
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human cell landscape (HCL)
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human organs
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cell-type
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humans
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single-cell mRNA sequencing
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single-cell atlas
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Single-cell analysis
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europepmc.org europepmc.org
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therapeutic potential
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immune disorders
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blood
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paediatric
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differentiation potential
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erythroid
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gestation
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yolk sac
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fetal liver
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map
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innate lymphoid cell precursors
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natural killer
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mast cells
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fetal skin
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fetal liver
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haematopoiesis
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erythropoiesis
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immune cell
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blood
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tissue
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microenvironment
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infer differentiation trajectories
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development
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immune cells
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human blood
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cells
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yolk sac
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kidney
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skin
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liver
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single-cell transcriptome profiling
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humans
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HSC
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HSC
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MPPs
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MPPs
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MPPs
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MPPs
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multipotent progenitors
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HSC
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HSC
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haematopoietic stem cells
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differentiation
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self-renewal
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fetal liver
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haematopoiesis
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europepmc.org europepmc.org
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discovery
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conceptual framework
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cellular
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molecular basis
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human organ
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NOTCH signalling
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TNFRSF12A
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TNFRSF12A
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PDGFR
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pathways
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pro-fibrogenic
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PDGFRα+ collagen-producing mesenchymal cells
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endothelial cells
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scar-associated macrophages,
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ligand and receptor interactions
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therapeutic targets
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liver cirrhosis
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fibrosis
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fibrotic
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transmigration of leucocytes
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cirrhosis
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PLVAP+ endothelial cells
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ACKR1+
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pro-fibrogenic
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circulating monocytes
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liver fibrosis
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TREM2+CD9+ subpopulation of macrophages
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human liver
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cirrhotic
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healthy
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non-parenchymal cell types
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molecular definitions
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human cells
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transcriptomes
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therapeutic targets
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disease pathogenesis
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cellular
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molecular mechanisms
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antifibrotic therapies
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fibrosis
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worldwide
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Liver cirrhosis
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cause of death
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europepmc.org europepmc.org
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patients
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personalized therapies
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signaling pathways
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next-generation sequencing
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pulmonary fibrosis
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subjects
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subjects
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epithelial cells
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alveolar macrophages
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atlas
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single-cell atlas
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data
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web-based tool
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senescent cells
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airway stem cells
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Wnt secretion and response
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expression of genes
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epithelial cells
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fibrosis
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patients
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control subjects
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subjects
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profibrotic alveolar macrophages
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Main Results
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Measurements
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Methods
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Rationale
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flow-sorted cells
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bulk RNA-sequencing
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immunohistochemistry
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data
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in situ RNA hybridization
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bronchoscopic cryobiospy
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pulmonary fibrosis
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recipients
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transplant donors
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lung tissue
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pulmonary fibrosis
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pulmonary fibrosis
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pulmonary fibrosis
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pulmonary fibrosis
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pulmonary fibrosis
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pulmonary fibrosis
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lung tissue
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cell types
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epithelial cells
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alveolar macrophages
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single-cell RNA sequencing
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single-cell RNA sequencing
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Single-cell RNA sequencing
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pathogenesis
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pulmonary fibrosis
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human lung
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cell populations
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europepmc.org europepmc.org
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asymptomatic patients.
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symptomatic
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blood malignancie
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disease
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bone marrow
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malignant plasma cells
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liquid biopsy
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personalized therapies
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myeloma
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active
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tumor plasma cells
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minimal residual disease
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early disease
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progression spectrum
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single cell RNA sequencing
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Single cell analysis
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expression
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asymptomatic individuals
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multiple myeloma
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multiple myeloma
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multiple myeloma
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individuals
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heterogeneity
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single cell RNA sequencing
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treatments
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early diagnosis
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heterogeneity
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disease
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blood cancer
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plasma cell
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plasma cell malignancy,
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europepmc.org europepmc.org
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infection
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pathogenesis
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COVID-19
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data
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vulnerability
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viral processes
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RHO GTPase
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pathways
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differentiating cells
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transient secretory cell type
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subsegmental bronchial branches
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tissues
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single cell RNA sequencing
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single nuclei
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subsegmental bronchial branches
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donors
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