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Hepatic FoxO1 loss leads to pancreatic β cell deficiency via liver-derived C18/22/24 ceramides

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  DOI: 10.1016/j.chembiol.2026.09.002
  
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sciencedirect.com/science/article/pii/S2451945626003302
Oct 2026
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Molecular underpinnings of metastatic small renal masses

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1. scibot 02 Oct 2026
  
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  DOI: 10.1172/jci.insight.209036
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13596717/
Sep 2026
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HOPX regulates the development and lineage progression of human stem cell-derived outer radial glia-like cells

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1. scibot 29 Sep 2026
  
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  DOI: 10.1016/j.stemcr.2026.103087
  
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Engineering lymphatic collecting vessel phenotypes through combined hyaluronic acid cues and oscillatory shear stress

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1. scibot 09 Sep 2026
  
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  DOI: 10.1016/j.crmeth.2026.101574
  
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sciencedirect.com/science/article/pii/S2667237526002754
Aug 2026
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Hypoglycemic conditions enhance neonatal β-cell glucose responsiveness via AMPK/mTOR-increased KATP channel density

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1. scibot 27 Aug 2026
  
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  DOI: 10.1210/endocr/bqag085
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13504267/
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Excess intracellular lactate represses mRNA translation and tumor progression through lactate-tRNA charging

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1. scibot 18 Aug 2026
  
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  DOI: 10.1016/j.molcel.2026.07.026
  
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sciencedirect.com/science/article/pii/S1097276526005125
Jul 2026
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Single-cell gene programs define subtype identity and metastatic trajectories in renal cell carcinoma

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1. scibot 21 Jul 2026
  
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  DOI: 10.64898/2026.07.14.26357682
  
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medrxiv.org/content/10.64898/2026.07.14.26357682v1
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Persistent Human Quadriceps Muscle Volume Deficits Following <fc>ACL</fc> Reconstruction Are Associated With No Detectable Between‐Leg Differences in Vastus Lateralis Muscle Signaling at Rest or Immediately Following Resistance Exercise

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1. scibot 14 Jul 2026
  
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  DOI: 10.1111/sms.70343
  
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onlinelibrary.wiley.com/doi/10.1111/sms.70343
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MEK-dependent bioenergetic demand drives terminal CD8+ T cell exhaustion

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1. scibot 14 Jul 2026
  
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  DOI: 10.1016/j.immuni.2026.06.012
  
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sciencedirect.com/science/article/pii/S1074761326002633
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Psychological stress drives aging-like hematopoietic stem cell dysfunction through a brain-gut-bone marrow axis

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  DOI: 10.1016/j.stem.2026.05.012
  
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sciencedirect.com/science/article/pii/S1934590926002043
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Norepinephrine Couples Astrocytic Metabolism to mTOR-Driven Protein Synthesis

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1. scibot 03 Jul 2026
  
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  DOI: 10.1111/jnc.70507
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.70507
Jun 2026
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eIF4G2-Dependent Translation Restrains Pancreatic Cancer Progression

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1. scibot 23 Jun 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-4299
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13276777/
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Overcoming adaptive resistance to KRASG12D blockade in pancreatic cancer through vertical pathway inhibition

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1. scibot 19 Jun 2026
  
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  DOI: 10.1158/1078-0432.CCR-25-1788
  
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aacrjournals.org/clincancerres/article/32/11/2279/785357/Overcoming-Adaptive-Resistance-to-KRASG12D
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Lumbar intrathecal catheterization in rats targeting the cerebral cortex: a drug delivery method and validation

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1. scibot 11 Jun 2026
  
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  DOI: 10.64898/2026.06.01.727192
  
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biorxiv.org/content/10.64898/2026.06.01.727192v1
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Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice

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  DOI: 10.1038/s42255-026-01520-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13218935/
May 2026
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Cannabinoid CB1 receptors drive oligodendrocyte maturation during myelin regeneration

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1. scibot 30 May 2026
  
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  DOI: 10.1186/s12964-026-02852-w
  
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Loss of tumor suppressor NF2 mediates resistance to CAR T cell and anti-PD-1 therapy: Strategies to restore immunotherapy sensitivity

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1. scibot 29 May 2026
  
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  DOI: 10.1016/j.medj.2026.101149
  
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sciencedirect.com/science/article/pii/S2666634026001522
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Single-cell transcriptomics profiling elucidates RBP-driven metastatic signaling pathways in ER+ breast cancer

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1. scibot 29 May 2026
  
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  DOI: 10.1016/j.isci.2026.116155
  
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Fungal metabolite-based immunotherapy overcomes tumor-associated macrophage immunosuppression

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1. scibot 27 May 2026
  
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  DOI: 10.1016/j.xcrm.2026.102833
  
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Mechanism by which a linoleic acid metabolite suppresses cancer cell growth by inhibiting mTOR

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  DOI: 10.1016/j.chembiol.2026.04.004
  
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sciencedirect.com/science/article/pii/S2451945626001376
Apr 2026
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eIF4G2-dependent translation restrains pancreatic cancer progression

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  DOI: 10.64898/2026.03.14.711799
  
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biorxiv.org/content/10.64898/2026.03.14.711799v1
Mar 2026
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MYCT1–IFITM2/3 interaction links endothelial endolysosomal trafficking to white adipose tissue expansion

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  DOI: 10.1084/jem.20251497
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13016079/
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Transient proliferation by reversible YAP and mitogen control of the cyclin D1/p27 ratio

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1. scibot 11 Mar 2026
  
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  DOI: 10.1038/s42003-026-09590-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12957376/
Feb 2026
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Placing purines in precision medicine: Targeting a metabolic reliance in KRAS-mutant tumors

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Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

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  DOI: 10.1002/advs.202513711
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12915202/
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Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux

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  DOI: 10.1016/j.cell.2025.12.053
  
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LRRC8A-containing anion channels promote glioblastoma proliferation via a WNK1/mTORC2-dependent mechanism

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Mechanistic Language Modeling and Oxygenated 3D Screening Reveal Berberine and Enzalutamide Synergy in Resistant Prostate Cancer

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  DOI: 10.64898/2026.01.24.701539
  
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biorxiv.org/content/10.64898/2026.01.24.701539v1
Jan 2026
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Metabolic reprogramming during human neuron differentiation indicates glutaminase as a key determinant in Fragile X syndrome

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  DOI: 10.1016/j.celrep.2025.116857
  
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Dec 2025
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Sustained reductions in valine and isoleucine mediate anti-cancer pharmacological effects of inhibiting amino acid transporter LAT1 in cancer cells

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  DOI: 10.1186/s40170-025-00415-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12673697/
Nov 2025
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Vitamin B6 preserves the stemness-like phenotypes and antitumor ability of CD8+ T cells

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  DOI: 10.1016/j.devcel.2025.10.017
  
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sciencedirect.com:5037/science/article/pii/S1534580725006914
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Potentiation of noncanonical NF-κB signaling and marginal zone B cell expansion by CARD11-mediated regulation of p100 processing

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1. scibot 29 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116616
  
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sciencedirect.com:5037/science/article/pii/S2211124725013889
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Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan

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1. scibot 20 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116422
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12626231/
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Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size

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1. scibot 01 Nov 2025
  
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  DOI: 10.1152/ajpcell.00602.2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12551769/
Oct 2025
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Phosphoproteomics of osimertinib-tolerant persister cells reveals targetable kinase-substrate signatures

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1. scibot 07 Oct 2025
  
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  DOI: 10.1038/s44320-025-00141-1
  
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hsu-et-al-2025-phosphoproteomics-of-osimertinib-tolerant-persister-cells-reveals-targetable-kinase-substrate-signatures-html.html

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Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8+ T lymphocytes and aggravates spinal cord injury

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Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling

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Hippocampal Inhibitory Interneuron-Specific DREADDs Treatment Alters mTORC1-4E-BP Signaling and Impairs Memory Formation

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Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression

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Lysosomal LRRC8 complex regulates lysosomal pH, morphology and systemic glucose metabolism

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Glioma-induced alterations in excitatory neurons are reversed by mTOR inhibition

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TFEB triggers a matrix degradation and invasion program in triple-negative breast cancer cells upon mTORC1 repression

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Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription

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Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling

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RIPK1 Promotes Energy Sensing by the mTORC1 Pathway

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Kmt2c restricts G-CSF-driven HSC mobilization and granulocyte production in a methyltransferase-independent manner

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Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance

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PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer

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Analyzing efficiency of a lentiviral shRNA knockdown system in human enteroids using western blot and flow cytometry

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Mechanisms Driving Fasting-Induced Protection from Genotoxic Injury in the Small Intestine

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Novel therapeutic strategies targeting bypass pathways and mitochondrial dysfunction to combat resistance to RET inhibitors in NSCLC

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Leucyl-tRNA synthetase contributes to muscle weakness through mTORC1 activation and autophagy suppression in a mouse model of Duchenne Muscular Dystrophy

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Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids

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A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1

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The complete Kaposi sarcoma-associated herpesvirus genome induces early-onset, metastatic angiosarcoma in transgenic mice

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12958_2024_1204_MOESM1_ESM-html.html

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The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies

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SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis

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Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates epilepsy downstream of somatic PTEN loss

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The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function

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Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability

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Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer

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MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension

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Nutrient-regulated control of lysosome function by signaling lipid conversion

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Tsc2 coordinates neuroprogenitor differentiation

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mTORC1 promotes cell growth via m6A-dependent mRNA degradation

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The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes

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Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex

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ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer

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Underpinning the food matrix regulation of post-exercise myofibrillar protein synthesis by comparing salmon ingestion versus the sum of its isolated nutrients in healthy young adults

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A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway

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Hyperactivity of mTORC1 or mTORC2-dependent signaling causes epilepsy downstream of somatic PTEN loss

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Lipocalin-2 induces mitochondrial dysfunction in renal tubular cells via mTOR pathway activation

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FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1

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Phosphorylated S6K1 and 4E-BP1 play different roles in constitutively active Rheb-mediated retinal ganglion cell survival and axon regeneration after optic nerve injury

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Srgap2 suppression ameliorates retinal ganglion cell degeneration in mice

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N-myc mediated translation control is a therapeutic vulnerability in medulloblastoma

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mTORC1-mediated acquisition of reward-related representations by hippocampal somatostatin interneurons

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Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation

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Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution

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ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma

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Maturation of nucleus accumbens synaptic transmission signals a critical period for the rescue of social deficits in a mouse model of autism spectrum disorder

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C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection

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Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment

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Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo

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Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex

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A Novel Method for Visualizing In-Vivo Rates of Protein Degradation Provides Insight into how TRIM28 Regulates Muscle Size

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Sensory detection of female olfactory cues as a central regulator of energy metabolism and body weight in male mice

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Translational and post-translational dynamics in a model peptidergic system

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Maturation of Nucleus Accumbens Synaptic Transmission Signals a Critical Period for the Rescue of Social Deficits in a Mouse Model of Autism Spectrum Disorder

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Large neutral amino acid levels tune perinatal neuronal excitability and survival

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Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity

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mTORC1-mediated acquisition of reward-related spatial representations by hippocampal somatostatin interneuronsa

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Injury primes mutation-bearing astrocytes for dedifferentiation in later life

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Stress Granules determine the Development of Obesity-associated Pancreatic Cancer

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GOT1 regulates CD8+ effector and memory T cell generation

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SSRN-id4201001-html.html

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Dec 2022
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The oncogenic PI3K-induced transcriptomic landscape reveals key functions in splicing and gene expression regulation

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can-22-0945-html.html

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PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer

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DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting

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mTORC1 is required for epigenetic silencing during β-cell functional maturation

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Segmentation, tracking and cell cycle analysis of live-cell imaging data with Cell-ACDC

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Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging

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High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition

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PTEN and LKB1 are differentially required in Gli1-expressing mesenchymal cells to suppress gastrointestinal polyposis

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Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis

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The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis

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BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors

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NR2F1 is a barrier to dissemination of early stage breast cancer cells.

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mTORC1 function in hippocampal parvalbumin interneurons: regulation of firing and long-term potentiation of intrinsic excitability but not long-term contextual fear memory and context discrimination

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p57Kip2 imposes the reserve stem cell state of gastric chief cells

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YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth

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Biphasic regulation of glutamine consumption by WNT during osteoblast differentiation

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Weight loss and cystic disease progression in autosomal dominant polycystic kidney disease

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Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation

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Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

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Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation

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Targeted therapy to β3 integrin reduces chemoresistance in breast cancer bone metastases

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Cell size is a determinant of stem cell potential during aging

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japplphysiol.00295.2021-html.html

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Combined whole-organ imaging at single-cell resolution and immunohistochemical analysis of prostate cancer and its liver and brain metastases

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Early resistance training-mediated stimulation of daily muscle protein synthetic responses to higher habitual protein intake in middle-aged adults

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A Role for Translational Regulation by S6 Kinase and a Downstream Target in Inflammatory Pain

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Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase

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Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia

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Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism

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Loss of Tsc1 from striatal direct pathway neurons impairs endocannabinoid-LTD and enhances motor routine learning

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The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life

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Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors

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Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function

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Regulation of blood-testis barrier dynamics by the mTORC1/rpS6 signaling complex: an in vitro study

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F5-peptide and mTORC1/rpS6 effectively enhance BTB transport function in the testis – lesson from the adjudin model

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SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis

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OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin

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The non-hormonal male contraceptive adjudin exerts its effects via MAPs and signaling proteins mTORC1/rpS6 and FAK-Y407

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NC1-peptide from collagen α3 (IV) chains in the basement membrane of testes regulates spermatogenesis via p-FAK-Y407

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Proper mTORC1 activity is required for glucose sensing and early adaptation in human pancreatic beta cell

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Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility

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Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression

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Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology

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Transient phases of OXPHOS inhibitor resistance reveal underlying metabolic heterogeneity in single cells

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Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle

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Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice

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Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum

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Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer

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Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors

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The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function

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mTORC1 promotes cell growth via m6A-dependent mRNA degradation

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Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis

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Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis

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Mapping of the contraction-induced phosphoproteome identifies TRIM28 as a significant regulator of skeletal muscle size and function

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Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

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Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation

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In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition

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Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice

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Microglial mTOR is neuronal protective and anti-epileptogenic in the pilocarpine model of temporal lobe epilepsy

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Electronic Cigarette Liquid Constituents Induce Nasal and Tracheal Sensory Irritation in Mice in Regionally Dependent Fashion

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Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis

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SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism

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Sep 2020
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Δ9‐Tetrahydrocannabinol promotes oligodendrocyte development and CNS myelination in vivo

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  DOI: 10.1002/glia.23911
  
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Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors

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mTORC1/rpS6 signaling complex modifies BTB transport function: an in vivo study using the adjudin model

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Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons

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