177 Matching Annotations
  1. Sep 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription
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    1. scibot 25 Sep 2024
      RRID:AB10694233

      DOI: 10.1038/s44319-024-00217-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC11387499/
  3. www.sciencedirect.com www.sciencedirect.com
    Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling
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    1. scibot 25 Sep 2024
      RRID:AB_1069423

      DOI: 10.1016/j.chembiol.2019.11.014

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    sciencedirect.com/science/article/pii/S2451945619303964
  4. Aug 2024
  5. www.cell.com www.cell.com
    RIPK1 Promotes Energy Sensing by the mTORC1 Pathway
    1
    1. scibot 02 Aug 2024
      S6 phospho-Ser240/244

      DOI: 10.1016/j.molcel.2020.11.008

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    cell.com/molecular-cell/fulltext/S1097-2765(20)30786-3
  6. Jul 2024
  7. www.sciencedirect.com www.sciencedirect.com
    Kmt2c restricts G-CSF-driven HSC mobilization and granulocyte production in a methyltransferase-independent manner
    2
    1. scibot 25 Jul 2024
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      DOI: 10.1016/j.celrep.2024.114542

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      AB_10694233

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    sciencedirect.com/science/article/pii/S2211124724008714
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance
    1
    1. scibot 19 Jul 2024
      RRID:AB_10694233

      DOI: 10.1016/j.isci.2024.109912

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    ncbi.nlm.nih.gov/pmc/articles/PMC11225835/
  9. Jun 2024
  10. www.sciencedirect.com www.sciencedirect.com
    PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer
    1
    1. scibot 21 Jun 2024
      RRID:AB_10695727

      DOI: 10.1016/j.cmet.2024.05.015

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    sciencedirect.com/science/article/pii/S1550413124001918
  11. May 2024
  12. www.sciencedirect.com www.sciencedirect.com
    Analyzing efficiency of a lentiviral shRNA knockdown system in human enteroids using western blot and flow cytometry
    1
    1. scibot 30 May 2024
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      DOI: 10.1016/j.xpro.2024.103082

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    sciencedirect.com/science/article/pii/S2666166724002478
  13. 52.53.155.43 52.53.155.43
    Mechanisms Driving Fasting-Induced Protection from Genotoxic Injury in the Small Intestine
    3
    1. scibot 24 May 2024
      RRID:AB_10694233

      DOI: 10.1152/ajpgi.00126.2023

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      DOI: 10.1152/ajpgi.00126.2023

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      RRID:AB_10694233

      DOI: 10.1152/ajpgi.00126.2023

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    52.53.155.43/930a5a5a8b2489c0ec72d025108e06cc5c87d2d2/deans-fielder-et-al-2024-mechanisms-driving-fasting-induced-protection-from-genotoxic-injury-in-the-small-intestine-html.html
  14. www.sciencedirect.com www.sciencedirect.com
    Novel therapeutic strategies targeting bypass pathways and mitochondrial dysfunction to combat resistance to RET inhibitors in NSCLC
    1
    1. scibot 21 May 2024
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      DOI: 10.1016/j.bbadis.2024.167249

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    sciencedirect.com/science/article/pii/S0925443924002382
  15. www.sciencedirect.com www.sciencedirect.com
    Leucyl-tRNA synthetase contributes to muscle weakness through mTORC1 activation and autophagy suppression in a mouse model of Duchenne Muscular Dystrophy
    1
    1. scibot 17 May 2024
      RRID: AB_10694233

      DOI: 10.1016/j.ajpath.2024.04.006

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  16. 52.53.155.43 52.53.155.43
    Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids
    2
    1. scibot 09 May 2024
      RRID:AB_10694233

      DOI: 10.1016/j.celrep.2024.114173

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    2. scibot 03 May 2024
      RRID:AB_10694233

      DOI: 10.1016/j.celrep.2024.114173

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    52.53.155.43/7165d3b920717872e9ecee45ef5f3cb3a7917c57/mmc6-html.html
  17. www.sciencedirect.com www.sciencedirect.com
    A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1
    1
    1. scibot 08 May 2024
      RRID:AB_10694233

      DOI: 10.1016/j.cmet.2024.04.015

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    sciencedirect.com/science/article/pii/S1550413124001359
  18. Apr 2024
  19. www.cell.com www.cell.com
    The complete Kaposi sarcoma-associated herpesvirus genome induces early-onset, metastatic angiosarcoma in transgenic mice
    1
    1. scibot 23 Apr 2024
      Cell Signaling TechnologiesCat#5364

      DOI: 10.1016/j.chom.2024.03.012

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    cell.com/cell-host-microbe/fulltext/S1931-3128(24)00112-4
  20. 52.53.155.43 52.53.155.43
    12958_2024_1204_MOESM1_ESM-html.html
    1
    1. scibot 05 Apr 2024
      AB_10694233

      DOI: 10.1186/s12958-024-01204-y

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    52.53.155.43/d3bb518aa444c98d6cfb77a0666830bf57a4ed47/12958_2024_1204_MOESM1_ESM-html.html
  21. Mar 2024
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
    1
    1. scibot 27 Mar 2024
      RRID:AB_10694233

      DOI: 10.1080/15384047.2024.2332000

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    ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
  23. www.sciencedirect.com www.sciencedirect.com
    SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis
    2
    1. scibot 22 Mar 2024
      RRID:AB_10694233

      DOI: 10.1016/j.celrep.2024.113975

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      DOI: 10.1016/j.celrep.2024.113975

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    sciencedirect.com/science/article/pii/S2211124724003036
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates epilepsy downstream of somatic PTEN loss
    1
    1. scibot 17 Mar 2024
      RRID:AB_10694233

      DOI: 10.7554/eLife.91323

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    ncbi.nlm.nih.gov/pmc/articles/PMC10942640/
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function
    1
    1. scibot 17 Mar 2024
      RRID:AB_10694233

      DOI: 10.7554/eLife.91010

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    ncbi.nlm.nih.gov/pmc/articles/PMC10942629/
  26. www.sciencedirect.com www.sciencedirect.com
    Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability
    2
    1. scibot 06 Mar 2024
      RRID:AB_10694233

      DOI: 10.1016/j.cmet.2024.02.004

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      DOI: 10.1016/j.cmet.2024.02.004

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    sciencedirect.com/science/article/pii/S1550413124000500
  27. Feb 2024
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
    1
    1. scibot 01 Feb 2024
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      DOI: 10.1038/s41698-024-00496-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC10810864/
  29. Jan 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension
    1
    1. scibot 23 Jan 2024
      RRID:AB_10694233

      DOI: 10.1126/sciadv.adk6524

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    ncbi.nlm.nih.gov/pmc/articles/PMC10798563/
  31. Dec 2023
  32. www.sciencedirect.com www.sciencedirect.com
    Nutrient-regulated control of lysosome function by signaling lipid conversion
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    1. scibot 02 Dec 2023
      RRID:AB_10694233

      DOI: 10.1016/j.cell.2023.09.027

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    sciencedirect.com/science/article/pii/S0092867423010814
  33. Nov 2023
  34. www.sciencedirect.com www.sciencedirect.com
    Tsc2 coordinates neuroprogenitor differentiation
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    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.isci.2023.108442

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    sciencedirect.com/science/article/pii/S2589004223025191
  35. www.sciencedirect.com www.sciencedirect.com
    mTORC1 promotes cell growth via m6A-dependent mRNA degradation
    1
    1. scibot 17 Nov 2023
      RRID:AB_10694233

      DOI: 10.1016/j.molcel.2021.03.010

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    sciencedirect.com/science/article/pii/S1097276521001787
  36. Oct 2023
  37. www.embopress.org www.embopress.org
    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
    1
    1. scibot 20 Oct 2023
      RRID:AB_10694233

      DOI: 10.15252/embr.202356815

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    embopress.org/doi/10.15252/embr.202356815
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex
    1
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      DOI: 10.1016/j.celrep.2023.112838

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    ncbi.nlm.nih.gov/pmc/articles/PMC10529098/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer
    1
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      DOI: 10.7554/eLife.85898

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    ncbi.nlm.nih.gov/pmc/articles/PMC10541180/
  40. Sep 2023
  41. www.sciencedirect.com www.sciencedirect.com
    Underpinning the food matrix regulation of post-exercise myofibrillar protein synthesis by comparing salmon ingestion versus the sum of its isolated nutrients in healthy young adults
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      DOI: 10.1016/j.tjnut.2023.02.037

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    sciencedirect.com/science/article/pii/S0022316623352799
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway
    1
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      DOI: 10.7554/eLife.85036

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    ncbi.nlm.nih.gov/pmc/articles/PMC10476966/
  43. Aug 2023
  44. www.biorxiv.org www.biorxiv.org
    Hyperactivity of mTORC1 or mTORC2-dependent signaling causes epilepsy downstream of somatic PTEN loss
    1
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      DOI: 10.1101/2023.08.18.553856

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    biorxiv.org/content/10.1101/2023.08.18.553856v2
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    Lipocalin-2 induces mitochondrial dysfunction in renal tubular cells via mTOR pathway activation
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      DOI: 10.1016/j.celrep.2023.113032

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    sciencedirect.com/science/article/pii/S2211124723010434
  46. www.sciencedirect.com www.sciencedirect.com
    FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1
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      DOI: 10.1016/j.molcel.2023.07.017

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    sciencedirect.com/science/article/abs/pii/S1097276523005609
  47. Jul 2023
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylated S6K1 and 4E-BP1 play different roles in constitutively active Rheb-mediated retinal ganglion cell survival and axon regeneration after optic nerve injury
    1
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      DOI: 10.4103/1673-5374.371372

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    ncbi.nlm.nih.gov/pmc/articles/PMC10360084/
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Srgap2 suppression ameliorates retinal ganglion cell degeneration in mice
    1
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      AB_10694233

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    ncbi.nlm.nih.gov/pmc/articles/PMC10328280/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N-myc mediated translation control is a therapeutic vulnerability in medulloblastoma
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      DOI: 10.1158/0008-5472.CAN-22-0945

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    ncbi.nlm.nih.gov/pmc/articles/PMC9812901/
  51. link.springer.com link.springer.com
    mTORC1-mediated acquisition of reward-related representations by hippocampal somatostatin interneurons
    1
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      DOI: 10.1186/s13041-023-01042-w

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  52. Jun 2023
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    Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation
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    Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution
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    ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
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  56. May 2023
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    Maturation of nucleus accumbens synaptic transmission signals a critical period for the rescue of social deficits in a mouse model of autism spectrum disorder
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    Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment
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    Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo
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    Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex
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  62. Apr 2023
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    A Novel Method for Visualizing In-Vivo Rates of Protein Degradation Provides Insight into how TRIM28 Regulates Muscle Size
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    Maturation of Nucleus Accumbens Synaptic Transmission Signals a Critical Period for the Rescue of Social Deficits in a Mouse Model of Autism Spectrum Disorder
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    Large neutral amino acid levels tune perinatal neuronal excitability and survival
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    Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity
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    mTORC1-mediated acquisition of reward-related spatial representations by hippocampal somatostatin interneuronsa
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    Injury primes mutation-bearing astrocytes for dedifferentiation in later life
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    Stress Granules determine the Development of Obesity-associated Pancreatic Cancer
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    GOT1 regulates CD8+ effector and memory T cell generation
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  77. Dec 2022
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    The oncogenic PI3K-induced transcriptomic landscape reveals key functions in splicing and gene expression regulation
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    PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer
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    DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting
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    BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors
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    mTORC1 function in hippocampal parvalbumin interneurons: regulation of firing and long-term potentiation of intrinsic excitability but not long-term contextual fear memory and context discrimination
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    p57Kip2 imposes the reserve stem cell state of gastric chief cells
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    YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth
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    Weight loss and cystic disease progression in autosomal dominant polycystic kidney disease
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  103. Dec 2021
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    Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation
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    F5-peptide and mTORC1/rpS6 effectively enhance BTB transport function in the testis – lesson from the adjudin model
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    jneurosci.org/content/38/22/5096
  201. www.sciencedirect.com www.sciencedirect.com
    mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation
    1
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    sciencedirect.com/science/article/pii/S1097276518303460
  202. www.sciencedirect.com www.sciencedirect.com
    Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
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      RRID:AB_10694233

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    sciencedirect.com/science/article/pii/S0092867418305865
  203. www.jneurosci.org www.jneurosci.org
    Palladin Is a Neuron-Specific Translational Target of mTOR Signaling That Regulates Axon Morphogenesis
    1
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    jneurosci.org/content/38/21/4985
  204. www.sciencedirect.com www.sciencedirect.com
    mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance
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    sciencedirect.com/science/article/pii/S1934590917304605
  205. www.sciencedirect.com www.sciencedirect.com
    Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor
    1
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    sciencedirect.com/science/article/pii/S1535610818300692
  206. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Phagocytosis of antibody‐opsonized tumor cells leads to the formation of a discrete vacuolar compartment in macrophages
    1
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      Curator: @evieth

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    onlinelibrary.wiley.com/doi/full/10.1111/tra.12552
  207. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy
    1
    1. scibot 05 Nov 2018
      rabbit anti-p-S6 (S240/244) (1:2000, Cell Signaling #5364)

      Curator: @evieth

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    ncbi.nlm.nih.gov/pmc/articles/PMC5824782/
  208. www.sciencedirect.com www.sciencedirect.com
    Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations
    1
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    sciencedirect.com/science/article/pii/S1550413117306290
  209. www.sciencedirect.com www.sciencedirect.com
    Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling
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    sciencedirect.com/science/article/pii/S0092867417312631
  210. www.sciencedirect.com www.sciencedirect.com
    Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation
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    sciencedirect.com/science/article/pii/S0092867417311236
  211. Nov 2017
  212. www.sciencedirect.com www.sciencedirect.com
    mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein
    1
    1. scibot 08 Nov 2017
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      Curator: @Jmenke

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  213. www.jneurosci.org www.jneurosci.org
    PTEN Loss Increases the Connectivity of Fast Synaptic Motifs and Functional Connectivity in a Developing Hippocampal Network
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      Curator: @patriciaelyse_

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    jneurosci.org/content/37/36/8595
  214. www.sciencedirect.com www.sciencedirect.com
    A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice
    1
    1. scibot 08 Nov 2017
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      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1550413117304904
  215. www.sciencedirect.com www.sciencedirect.com
    Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye
    1
    1. scibot 08 Nov 2017
      RRID:AB_10694233

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1534580717305968
  216. elifesciences.org elifesciences.org
    LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
    1
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      AB_10694233

      Curator: @chewbeccax

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    elifesciences.org/articles/25237
  217. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors
    2
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      AB_10694233

      Curator: @gabimpine

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      AB_10694233

      Curator: @gabimpine

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    ncbi.nlm.nih.gov/pmc/articles/PMC5241115/