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206 Matching Annotations

Aug 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225017158-main-html.html

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1. scibot 29 Aug 2025
  
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  RRID:AB_10694233
  
  DOI: 10.1016/j.isci.2025.113454
  
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52.53.155.43/d86d60ff30b3ad94317a5f54629a255673424141/1-s2.0-S2589004225017158-main-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Novel roles for the GPI-anchor cleaving enzyme, GDE2, in hippocampal synaptic morphology and function

1
1. scibot 06 Aug 2025
  
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  DOI: 10.1523/ENEURO.0102-25.2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12320762/
www.biorxiv.org www.biorxiv.org

Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size

1
1. scibot 01 Aug 2025
  
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  RRID:AB_10694233
  
  DOI: 10.1101/2025.07.23.666188
  
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biorxiv.org/content/10.1101/2025.07.23.666188v1
Jul 2025
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Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice

1
1. scibot 30 Jul 2025
  
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  RRID:AB_10694233
  
  DOI: 10.1101/2025.07.23.666448
  
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biorxiv.org/content/10.1101/2025.07.23.666448v1
www.science.org www.science.org

Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling

1
1. scibot 25 Jul 2025
  
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  RRID:AB_10694233
  
  DOI: 10.1126/science.adm9805
  
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science.org/doi/10.1126/science.adm9805
52.53.155.43 52.53.155.43

2025.07.14.664742v1.full-html.html

1
1. scibot 25 Jul 2025
  
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  AB_10694233
  
  DOI: 10.1101/2025.07.14.664742
  
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52.53.155.43/0ddeb0d5c1e9d78409db30015477d90afb34bbce/2025.07.14.664742v1.full-html.html
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Unlocking the therapeutic potential of rigosertib as a selective therapy for ovarian cancer

1
1. scibot 08 Jul 2025
  
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  RRID:AB_10694233
  
  DOI: 10.1016/j.xcrm.2025.102218
  
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sciencedirect.com/science/article/pii/S2666379125002915
dx.doi.org dx.doi.org

The planar cell polarity (PCP) protein Fat 1 in Sertoli cell function

1
1. scibot 02 Jul 2025
  
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  DOI: 10.1210/endocr/bqae041
  
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dx.doi.org/10.1210/endocr/bqae041
Jun 2025
dx.doi.org dx.doi.org

Alterations in dopaminergic innervation and receptors in focal cortical dysplasia

1
1. scibot 18 Jun 2025
  
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  RRID:AB_10694233
  
  DOI: 10.1093/brain/awaf080
  
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dx.doi.org/10.1093/brain/awaf080
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance

1
1. scibot 22 May 2025
  
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  RRID:AB_10694233
  
  DOI: 10.7554/eLife.104979
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12092004/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development

1
1. scibot 21 May 2025
  
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  RRID:AB_10694233
  
  DOI: 10.7554/eLife.103615
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12055001/
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 20 May 2025
  
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  RRID:AB_10694233
  
  DOI: 10.1101/2025.04.30.651453
  
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52.53.155.43/dd3c8f74e9cdc1e420d33be7f8443dfa69ebea7a/PDF-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Lipolysis-derived fatty acids are needed for homeostatic control of sterol element-binding protein-1c driven hepatic lipogenesis

1
1. scibot 19 May 2025
  
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  AB_10694233
  
  DOI: 10.1038/s42003-025-08002-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11982389/
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Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8+ T lymphocytes and aggravates spinal cord injury

1
1. scibot 18 May 2025
  
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  RRID:AB_10694233
  
  DOI: 10.1016/j.neuron.2025.04.003
  
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sciencedirect.com/science/article/pii/S0896627325002594
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Lymphatic endothelial mTORC1 instructs metabolic and developmental signaling during lymphangiogenesis

1
1. scibot 17 May 2025
  
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  RRID:AB_10694233
  
  DOI: 10.1016/j.devcel.2025.04.012
  
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sciencedirect.com/science/article/pii/S1534580725002503
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Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling

1
1. scibot 16 May 2025
  
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  RRID:AB_10694233
  
  DOI: 10.1016/j.celrep.2025.115647
  
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sciencedirect.com/science/article/pii/S2211124725004188
Apr 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

β-Cell Dedifferentiation in HOMA-βlow and HOMA-βhigh Subjects

1
1. scibot 24 Apr 2025
  
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  RRID:AB_10694233
  
  DOI: 10.1210/clinem/dgae538
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12012814/
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Remote limb ischemic conditioning alleviates steatohepatitis via extracellular vesicle-mediated muscle-liver crosstalk

1
1. scibot 01 Apr 2025
  
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  RRID:AB_10694233
  
  DOI: 10.1016/j.cmet.2025.02.009
  
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sciencedirect.com/science/article/pii/S1550413125000671
Mar 2025
onlinelibrary.wiley.com onlinelibrary.wiley.com

Hippocampal Inhibitory Interneuron-Specific DREADDs Treatment Alters mTORC1-4E-BP Signaling and Impairs Memory Formation

1
1. scibot 25 Mar 2025
  
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  AB_10694233
  
  DOI: 10.1111/jnc.70048
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.70048
www.cell.com www.cell.com

Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression

1
1. scibot 23 Mar 2025
  
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  RRID:AB_10694233
  
  DOI: 10.1016/j.immuni.2025.02.023
  
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cell.com/immunity/fulltext/S1074-7613(25)00090-1
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Effective targeting of PDGFRA-altered high-grade glioma with avapritinib

1
1. scibot 14 Mar 2025
  
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  RRID:AB_10694233
  
  DOI: 10.1016/j.ccell.2025.02.018
  
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sciencedirect.com/science/article/pii/S1535610825000704
Feb 2025
52.53.155.43 52.53.155.43

SSRN-id4201001-html.html

1
1. scibot 27 Feb 2025
  
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  RRID:AB_10694233
  
  DOI: 10.1038/s41563-021-01125-w
  
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52.53.155.43/9f725bf3f599e42d5dbb6f9ce5bf62e7266e766b/bd26a435-800e-42f7-b486-b37feef9c55a-meca-html.html
52.53.155.43 52.53.155.43

Lysosomal LRRC8 complex regulates lysosomal pH, morphology and systemic glucose metabolism

1
1. scibot 06 Feb 2025
  
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  RRID:AB_10694233
  
  DOI: 10.1101/2024.09.22.614256
  
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52.53.155.43/17ba4619add80e0a0ad5b6123d474628a07b56f8/2024.09.22.614256.full-html.html
Jan 2025
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Glioma-induced alterations in excitatory neurons are reversed by mTOR inhibition

1
1. scibot 23 Jan 2025
  
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  RRID:AB_10694233
  
  DOI: 10.1016/j.neuron.2024.12.026
  
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sciencedirect.com/science/article/pii/S0896627324009267
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Repeated sevoflurane exposure causes hypomyelination in the prefrontal cortex of adult male mice

1
1. scibot 15 Jan 2025
  
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  RRID: AB_10694233
  
  DOI: 10.1038/s41598-025-85834-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11718107/
Dec 2024
www.cell.com www.cell.com

TFEB triggers a matrix degradation and invasion program in triple-negative breast cancer cells upon mTORC1 repression

1
1. scibot 29 Dec 2024
  
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  RRID:AB_10694233
  
  DOI: 10.1016/j.devcel.2024.12.005
  
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cell.com/developmental-cell/fulltext/S1534-5807(24)00727-5
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Maternal gut microbiota influence stem cell function in offspring

1
1. scibot 12 Dec 2024
  
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  RRID:AB_10694233
  
  DOI: 10.1016/j.stem.2024.10.003
  
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sciencedirect.com/science/article/pii/S1934590924003655
52.53.155.43 52.53.155.43

1-s2.0-S2589004224027913-main-html.html

1
1. scibot 12 Dec 2024
  
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  AB_10694233
  
  DOI: 10.1016/j.isci.2024.111564
  
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52.53.155.43/bb9e8a3f1ed0d9e1121d67e11af5663597f8cb3d/1-s2.0-S2589004224027913-main-html.html
52.53.155.43 52.53.155.43

1-s2.0-S2352345X24001905-main-html.html

1
1. scibot 06 Dec 2024
  
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  RRID:AB_10694233
  
  DOI: 10.1016/j.jcmgh.2024.101435
  
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52.53.155.43/146d0010e10afd14f9f59c7c1c16c7dc3feeaeeb/1-s2.0-S2352345X24001905-main-html.html
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription

1
1. scibot 25 Sep 2024
  
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  RRID:AB10694233
  
  DOI: 10.1038/s44319-024-00217-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11387499/
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Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling

1
1. scibot 25 Sep 2024
  
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  RRID:AB_1069423
  
  DOI: 10.1016/j.chembiol.2019.11.014
  
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  Curator: @ethanbadger
  
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sciencedirect.com/science/article/pii/S2451945619303964
Aug 2024
www.cell.com www.cell.com

RIPK1 Promotes Energy Sensing by the mTORC1 Pathway

1
1. scibot 02 Aug 2024
  
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  S6 phospho-Ser240/244
  
  DOI: 10.1016/j.molcel.2020.11.008
  
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cell.com/molecular-cell/fulltext/S1097-2765(20)30786-3
Jul 2024
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Kmt2c restricts G-CSF-driven HSC mobilization and granulocyte production in a methyltransferase-independent manner

2
1. scibot 25 Jul 2024
  
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  AB_10694233
  
  DOI: 10.1016/j.celrep.2024.114542
  
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2. scibot 25 Jul 2024
  
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  AB_10694233
  
  DOI: 10.1016/j.celrep.2024.114542
  
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sciencedirect.com/science/article/pii/S2211124724008714
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance

1
1. scibot 19 Jul 2024
  
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  RRID:AB_10694233
  
  DOI: 10.1016/j.isci.2024.109912
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11225835/
Jun 2024
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PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer

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Analyzing efficiency of a lentiviral shRNA knockdown system in human enteroids using western blot and flow cytometry

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Mechanisms Driving Fasting-Induced Protection from Genotoxic Injury in the Small Intestine

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Novel therapeutic strategies targeting bypass pathways and mitochondrial dysfunction to combat resistance to RET inhibitors in NSCLC

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Leucyl-tRNA synthetase contributes to muscle weakness through mTORC1 activation and autophagy suppression in a mouse model of Duchenne Muscular Dystrophy

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Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids

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A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1

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The complete Kaposi sarcoma-associated herpesvirus genome induces early-onset, metastatic angiosarcoma in transgenic mice

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12958_2024_1204_MOESM1_ESM-html.html

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The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies

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SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis

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Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates epilepsy downstream of somatic PTEN loss

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The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function

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Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability

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Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer

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MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension

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Nutrient-regulated control of lysosome function by signaling lipid conversion

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Tsc2 coordinates neuroprogenitor differentiation

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mTORC1 promotes cell growth via m6A-dependent mRNA degradation

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The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes

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Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex

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ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer

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Underpinning the food matrix regulation of post-exercise myofibrillar protein synthesis by comparing salmon ingestion versus the sum of its isolated nutrients in healthy young adults

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A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway

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Hyperactivity of mTORC1 or mTORC2-dependent signaling causes epilepsy downstream of somatic PTEN loss

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Lipocalin-2 induces mitochondrial dysfunction in renal tubular cells via mTOR pathway activation

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FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1

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Phosphorylated S6K1 and 4E-BP1 play different roles in constitutively active Rheb-mediated retinal ganglion cell survival and axon regeneration after optic nerve injury

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Srgap2 suppression ameliorates retinal ganglion cell degeneration in mice

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N-myc mediated translation control is a therapeutic vulnerability in medulloblastoma

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mTORC1-mediated acquisition of reward-related representations by hippocampal somatostatin interneurons

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Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation

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Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution

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ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma

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Maturation of nucleus accumbens synaptic transmission signals a critical period for the rescue of social deficits in a mouse model of autism spectrum disorder

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C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection

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Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment

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Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo

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Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex

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A Novel Method for Visualizing In-Vivo Rates of Protein Degradation Provides Insight into how TRIM28 Regulates Muscle Size

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Sensory detection of female olfactory cues as a central regulator of energy metabolism and body weight in male mice

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Translational and post-translational dynamics in a model peptidergic system

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Maturation of Nucleus Accumbens Synaptic Transmission Signals a Critical Period for the Rescue of Social Deficits in a Mouse Model of Autism Spectrum Disorder

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Large neutral amino acid levels tune perinatal neuronal excitability and survival

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Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity

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mTORC1-mediated acquisition of reward-related spatial representations by hippocampal somatostatin interneuronsa

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Injury primes mutation-bearing astrocytes for dedifferentiation in later life

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Stress Granules determine the Development of Obesity-associated Pancreatic Cancer

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GOT1 regulates CD8+ effector and memory T cell generation

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SSRN-id4201001-html.html

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The oncogenic PI3K-induced transcriptomic landscape reveals key functions in splicing and gene expression regulation

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can-22-0945-html.html

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PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer

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DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting

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mTORC1 is required for epigenetic silencing during β-cell functional maturation

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Segmentation, tracking and cell cycle analysis of live-cell imaging data with Cell-ACDC

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Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging

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High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition

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PTEN and LKB1 are differentially required in Gli1-expressing mesenchymal cells to suppress gastrointestinal polyposis

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Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis

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The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis

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BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors

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NR2F1 is a barrier to dissemination of early stage breast cancer cells.

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mTORC1 function in hippocampal parvalbumin interneurons: regulation of firing and long-term potentiation of intrinsic excitability but not long-term contextual fear memory and context discrimination

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p57Kip2 imposes the reserve stem cell state of gastric chief cells

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YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth

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Biphasic regulation of glutamine consumption by WNT during osteoblast differentiation

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Weight loss and cystic disease progression in autosomal dominant polycystic kidney disease

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Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation

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Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

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Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation

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Targeted therapy to β3 integrin reduces chemoresistance in breast cancer bone metastases

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Cell size is a determinant of stem cell potential during aging

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japplphysiol.00295.2021-html.html

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Combined whole-organ imaging at single-cell resolution and immunohistochemical analysis of prostate cancer and its liver and brain metastases

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Early resistance training-mediated stimulation of daily muscle protein synthetic responses to higher habitual protein intake in middle-aged adults

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A Role for Translational Regulation by S6 Kinase and a Downstream Target in Inflammatory Pain

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Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase

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Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia

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Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism

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Loss of Tsc1 from striatal direct pathway neurons impairs endocannabinoid-LTD and enhances motor routine learning

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The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life

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Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors

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Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function

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Regulation of blood-testis barrier dynamics by the mTORC1/rpS6 signaling complex: an in vitro study

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F5-peptide and mTORC1/rpS6 effectively enhance BTB transport function in the testis – lesson from the adjudin model

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SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis

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OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin

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The non-hormonal male contraceptive adjudin exerts its effects via MAPs and signaling proteins mTORC1/rpS6 and FAK-Y407

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NC1-peptide from collagen α3 (IV) chains in the basement membrane of testes regulates spermatogenesis via p-FAK-Y407

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Proper mTORC1 activity is required for glucose sensing and early adaptation in human pancreatic beta cell

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Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility

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Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression

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Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology

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Transient phases of OXPHOS inhibitor resistance reveal underlying metabolic heterogeneity in single cells

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Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle

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Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice

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Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum

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Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer

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Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors

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The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function

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mTORC1 promotes cell growth via m6A-dependent mRNA degradation

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Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis

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Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis

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Mapping of the contraction-induced phosphoproteome identifies TRIM28 as a significant regulator of skeletal muscle size and function

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Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

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Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation

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In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition

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Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice

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Microglial mTOR is neuronal protective and anti-epileptogenic in the pilocarpine model of temporal lobe epilepsy

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Electronic Cigarette Liquid Constituents Induce Nasal and Tracheal Sensory Irritation in Mice in Regionally Dependent Fashion

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Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis

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SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism

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Δ9‐Tetrahydrocannabinol promotes oligodendrocyte development and CNS myelination in vivo

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Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors

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mTORC1/rpS6 signaling complex modifies BTB transport function: an in vivo study using the adjudin model

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Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons

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A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve

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Tau Reduction Prevents Key Features of Autism in Mouse Models

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PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypes

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Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission

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Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR

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Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner | American Journal of Physiology-Endocrinology and Metabolism

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  monoclonal rabbit phospho-S6 Ribosomal Protein
  
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Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia

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mTORC1/rpS6 and spermatogenic function in the testis – insights from the adjudin model

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Nociceptor deletion of Tsc2 enhances axon regeneration by inducing a conditioning injury response in dorsal root ganglia

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Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters

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Synergistic Highly Potent Targeted Drug Combinations in different Pheochromocytoma Models including Human Tumor Cultures

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A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas

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Regulation of BTB dynamics in spermatogenesis – insights from the adjudin toxicant model

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  DOI: 10.1093/toxsci/kfz180
  
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Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer

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Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer

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Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination

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RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis

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R-Ras1 and R-Ras2 Are Essential for Oligodendrocyte Differentiation and Survival for Correct Myelination in the Central Nervous System

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mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation

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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

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Palladin Is a Neuron-Specific Translational Target of mTOR Signaling That Regulates Axon Morphogenesis

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mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance

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Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor

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Phagocytosis of antibody‐opsonized tumor cells leads to the formation of a discrete vacuolar compartment in macrophages

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mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy

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Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations

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Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling

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Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation

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mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein

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