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  2. aacrjournals.org aacrjournals.org
    Overproduction of Gastrointestinal 5-HT Promotes Colitis-Associated Colorectal Cancer Progression via Enhancing NLRP3 Inflammasome Activation
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    1. scibot 02 Oct 2024
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      DOI: 10.1158/2326-6066.CIR-20-1043

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    aacrjournals.org/cancerimmunolres/article/9/9/1008/666146/Overproduction-of-Gastrointestinal-5-HT-Promotes
  3. aacrjournals.org aacrjournals.org
    Conophylline Inhibits Hepatocellular Carcinoma by Inhibiting Activated Cancer-associated Fibroblasts Through Suppression of G Protein–coupled Receptor 68
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    1. scibot 02 Oct 2024
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      DOI: 10.1158/1535-7163.MCT-20-0150

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    aacrjournals.org/mct/article/20/6/1019/673256/Conophylline-Inhibits-Hepatocellular-Carcinoma-by
  4. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 27 Sep 2024
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      DOI: 10.1111/bph.17320

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17320
  5. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A novel inhibitor of class IIa histone deacetylases attenuates collagen-induced arthritis
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    1. scibot 27 Sep 2024
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      DOI: 10.1111/bph.17306

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17306
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    Myeloid beta-arrestin 2 depletion attenuates metabolic dysfunction-associated steatohepatitis via the metabolic reprogramming of macrophages
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    1. scibot 26 Sep 2024
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      DOI: 10.1016/j.cmet.2024.08.010

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    sciencedirect.com/science/article/pii/S1550413124003620
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    Sodium Butyrate Exacerbates Parkinson’s Disease by Aggravating Neuroinflammation and Colonic Inflammation in MPTP-Induced Mice Model
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    1. scibot 25 Sep 2024
      RRID:AB_2797709

      DOI: 10.1007/s11064-020-03074-3

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      Curator comments: NF-kappaB p65 (D14E12) XP Rabbit mAb antibody Cell Signaling Technology Cat# 8242

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    link.springer.com/article/10.1007/s11064-020-03074-3
  8. www.eneuro.org www.eneuro.org
    MANF ablation causes prolonged activation of the UPR without neurodegeneration in the mouse midbrain dopamine system
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    1. scibot 25 Sep 2024
      RRID:AB_331284

      DOI: 10.1523/ENEURO.0477-19.2019

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    2. scibot 25 Sep 2024
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      DOI: 10.1523/ENEURO.0477-19.2019

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      Curator comments: Rabbit Anti-NF-KappaB p65, phospho (Ser536) Monoclonal Antibody, Unconjugated, Clone 93H1 Cell Signaling Technology Cat# 3033

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  9. Sep 2024
  10. www.sciencedirect.com www.sciencedirect.com
    Silencing of TXNIP attenuates oxidative stress injury in HEI-OC1 by inhibiting the activation of NLRP3 and NF-κB
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    1. scibot 13 Sep 2024
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    sciencedirect.com/science/article/pii/S240584402413784X
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    Aged fibroblast-derived extracellular vesicles promote angiogenesis in melanoma
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    1. scibot 12 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724010726
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    E3 ubiquitin ligase ANKIB1 attenuates antiviral immune responses by promoting K48-linked polyubiquitination of MAVS
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    1. scibot 04 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724010386
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    CD14 is a decision-maker between Fas-mediated death and inflammation
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    1. scibot 04 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724010362
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    Beyond mitochondrial transfer, cell fusion rescues metabolic dysfunction and boosts malignancy in adenoid cystic carcinoma
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    1. scibot 04 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724010039
  15. Aug 2024
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    Gemcitabine therapeutically disrupts essential SIRT1-mediated p53 repression in atypical teratoid/rhabdoid tumors
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    1. scibot 29 Aug 2024
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    sciencedirect.com/science/article/pii/S266637912400421X
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    Cordycepin exhibits both antiviral and anti-inflammatory effects against dengue virus infection
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    1. scibot 28 Aug 2024
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  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Macrophage ILF3 promotes abdominal aortic aneurysm by inducing inflammatory imbalance in male mice
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    1. scibot 27 Aug 2024
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      DOI: 10.1038/s41467-024-51030-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC11344041/
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    Non-canonical autophosphorylation of RIPK1 drives timely pyroptosis to control Yersinia infection
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    1. scibot 22 Aug 2024
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  20. pubs.rsc.org pubs.rsc.org
    Hexane Insoluble Fraction from Purple Rice Extract Improves Steatohepatitis and Fibrosis via Inhibition of NF-κB and JNK Signaling
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    1. scibot 19 Aug 2024
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      DOI: 10.1039/D4FO00292J

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    pubs.rsc.org/en/content/articlelanding/2024/fo/d4fo00292j
  21. www.mdpi.com www.mdpi.com
    TCF19 Impacts a Network of Inflammatory and DNA Damage Response Genes in the Pancreatic β-Cell
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    1. scibot 02 Aug 2024
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  22. Jul 2024
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    A human commensal-pathogenic fungus suppresses host immunity via targeting TBK1
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    1. scibot 31 Jul 2024
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    sciencedirect.com/science/article/pii/S1931312824002622
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Parkin-regulated metabolomic change in cartilage in the treatment of osteoarthritis
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    1. scibot 30 Jul 2024
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      DOI: 10.1016/j.isci.2024.110597

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    ncbi.nlm.nih.gov/pmc/articles/PMC11363567/
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Monoacylglycerol acyltransferase-2 inhibits colorectal carcinogenesis in APCmin+/− mice
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    1. scibot 27 Jul 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11269928/
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    Targeting type I DED interactions at the DED filament serves as a sensitive switch for cell fate decisions
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    sciencedirect.com/science/article/pii/S2451945624002745
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    Both enantiomers of β-aminoisobutyric acid BAIBA regulate Fgf23 via MRGPRD receptor by activating distinct signaling pathways in osteocytes
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    sciencedirect.com/science/article/pii/S2211124724007253
  28. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The SASP factor IL-6 sustains cell-autonomous senescent cells via a cGAS-STING-NFκB intracrine senescent noncanonical pathway
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      DOI: 10.1111/acel.14258

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    onlinelibrary.wiley.com/doi/10.1111/acel.14258
  29. www.sciencedirect.com www.sciencedirect.com
    A new neuroprotective candidate TJ1 targeting amyloidogenesis in 5xFAD Alzheimer’s disease mice
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    1. scibot 19 Jul 2024
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      DOI: 10.1016/j.intimp.2024.112653

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    sciencedirect.com/science/article/pii/S1567576924011743
  30. www.cell.com www.cell.com
    DOT1L/H3K79me2 represses HIV-1 reactivation via recruiting DCAF1
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    1. scibot 18 Jul 2024
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    cell.com/cell-reports/fulltext/S2211-1247(24)00696-X
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication
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  32. Jun 2024
  33. www.sciencedirect.com www.sciencedirect.com
    Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer
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    sciencedirect.com/science/article/pii/S155041312400189X
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    Monomethyl fumarate attenuates lung Ischemia/Reperfusion injury by disrupting the GAPDH/Siah1 signaling cascade
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    Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells
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    sciencedirect.com/science/article/pii/S1934590924001851
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    TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons
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      DOI: 10.1016/j.cell.2024.05.030

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  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptional Synergy in Human Aortic Endothelial Cells is Vulnerable to Combination p300/CBP and BET Bromodomain Inhibition
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    ncbi.nlm.nih.gov/pmc/articles/PMC11167439/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 envelope protein regulates innate immune tolerance
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    A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML
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    sciencedirect.com/science/article/pii/S2666379124002842
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    Endonucleolytic RNA cleavage drives changes in gene expression during the innate immune response
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  41. www.sciencedirect.com www.sciencedirect.com
    Blockage of L2HGDH-mediated S-2HG catabolism orchestrates macrophage polarization to elicit antitumor immunity
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    sciencedirect.com/science/article/pii/S2211124724006284
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress
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    ncbi.nlm.nih.gov/pmc/articles/PMC11140209/
  43. May 2024
  44. www.sciencedirect.com www.sciencedirect.com
    Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng
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    Allosteric inhibitor of SHP2 enhances macrophage endocytosis and bacteria elimination by increasing caveolae activation and protects against bacterial sepsis
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    The relevance between abnormally elevated serum ceramide and cognitive impairment in Alzheimer’s disease model mice and its mechanism
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  89. Jan 2024
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    Histone lactylation inhibits RARγ expression in macrophages to promote colorectal tumorigenesis through activation of TRAF6-IL-6-STAT3 signaling
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    Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors
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    miRNA-194-3p represses NF-κB in gliomas to attenuate iPSC genes and proneural to mesenchymal transition.
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    hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50
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  98. Dec 2023
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    Nanocurcumin attenuates pyroptosis and inflammation through inhibiting NF-κB/GSDMD signal in high altitude-associated acute liver injury
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    Blockade of CCR5 suppresses paclitaxel-induced peripheral neuropathic pain caused by increased deoxycholic acid
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    Transcriptomic analysis of sorted lung cells revealed a proviral activity of the NF-κB pathway toward SARS-CoV-2
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    Micheliolide exerts effects in myeloproliferative neoplasms through inhibiting STAT3/5 phosphorylation via covalent binding to STAT3/5 proteins
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    Culin5 aggravates hypoxic pulmonary hypertension by activating TRAF6/NF-κB/HIF-1α/VEGF
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    Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
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    Deubiquitylating Enzyme OTUB1 Facilitates Neuronal Survival After Intracerebral Hemorrhage Via Inhibiting NF-κB-triggered Apoptotic Cascades
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    The miR-17∼92 miRNAs promote plasma cell differentiation by suppressing SOCS3-mediated NIK degradation
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    Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis
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    TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice
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    Hedgehog receptors exert immune-surveillance roles in the epidermis across species
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    IRP1 Mediated Ferroptosis Reverses Temozolomide Resistance in Glioblastoma via Affecting LCN2/FPN1 Signaling Axis Depended on NFKB2
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  128. Jul 2023
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    Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice
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    Caffeoylquinic acids isolated from Lonicera japonica Thunb. as TAK1 inhibitors protects against LPS plus IFN-γ-stimulated inflammation by interacting with KEAP1-regulated NRF2 activation
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    Innate immune pathway modulator screen identifies STING pathway activation as a strategy to inhibit multiple families of arbo and respiratory viruses
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    Statins enhances antitumor effect of oxaliplatin in KRAS-mutated colorectal cancer cells and inhibits oxaliplatin-induced neuropathy
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    N,N-Dimethyl-3β-hydroxycholenamide attenuates neuronal death and retinal inflammation in retinal ischemia/reperfusion injury by inhibiting Ninjurin 1
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  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1
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  175. Mar 2023
  176. 52.53.155.43 52.53.155.43
    A high-sucrose diet exacerbates the left ventricular phenotype in a high fat-fed streptozotocin rat model of diabetic cardiomyopathy
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    Combination therapy with ultrasound and 2D nanomaterials promotes recovery after spinal cord injury via Piezo1 downregulation
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    Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity
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    Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease
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    Periostin deficiency reduces PD-1+ tumor-associated macrophage infiltration and enhances anti-PD-1 efficacy in colorectal cancer
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    CDK1 bridges NF-κB and β-catenin signaling in response to H. pylori infection in gastric tumorigenesis
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    Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma
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    Streptolysin S targets the sodium-bicarbonate cotransporter NBCn1 to induce inflammation and cytotoxicity in human keratinocytes during Group A Streptococcal infection
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    STAT3 is activated by CTGF-mediated tumor-stroma cross talk to promote HCC progression.
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    Dual anti-angiogenic and anti-metastatic activity of myriocin synergistically enhances the anti-tumor activity of cisplatin
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    The epigenetic state of IL-4-polarized macrophages enables inflammatory cistromic expansion and extended synergistic response to TLR ligands
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    COMPREHENSIVE DRUG RESPONSE PROFILING AND PAN-OMIC ANALYSIS IDENTIFIED THERAPEUTIC CANDIDATES AND PROGNOSTIC BIOMARKERS FOR ASIAN CHOLANGIOCARCINOMA
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    journals.lww.com/nrronline/Fulltext/2023/04000/Spliceosomal_GTPase_Eftud2_regulates_microglial.31.aspx