297 Matching Annotations
  1. Last 7 days
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    Profound synthetic lethality between SMARCAL1 and FANCM
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    sciencedirect.com/science/article/pii/S1097276524008566
  3. Nov 2024
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    Two cooperative lipid binding sites within the pleckstrin homology domain are necessary for AKT binding and stabilization to the plasma membrane
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    sciencedirect.com/science/article/pii/S0969212624004556
  5. www.biorxiv.org www.biorxiv.org
    Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism
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    biorxiv.org/content/10.1101/2024.11.06.622291v1
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses
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    pmc.ncbi.nlm.nih.gov/articles/PMC11535224/
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    Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development
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  8. Sep 2024
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    Type-II kinase inhibitors that target Parkinson’s Disease-associated LRRK2
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    biorxiv.org/content/10.1101/2024.09.17.613365v1
  10. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Intracerebroventricular insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 diabetes mellitus
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    Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability
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    MED12 and CDK8/19 modulate androgen receptor activity and enzalutamide response in prostate cancer
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      DOI: 10.1210/endocr/bqae114

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    TGF-β and RAS jointly unmask primed enhancers to drive metastasis
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    Proteome-scale characterisation of motif-based interactome rewiring by disease mutations
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  15. Aug 2024
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    The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network
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    SV2A controls the surface nanoclustering and endocytic recruitment of Syt1 during synaptic vesicle recycling
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      DOI: 10.1111/jnc.16186

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    Dual effect of N-terminal deletion of cardiac myosin essential light chain in mitigating cardiomyopathy
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    The lateral habenula integrates age and experience to promote social transitions in developing rats
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    Redox heterogeneity in mouse embryonic stem cells individualizes cell fate decisions
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    DHTKD1 and OGDH display substrate overlap in cultured cells and form a hybrid 2-oxo acid dehydrogenase complex in vivo
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    academic.oup.com/hmg/hmg/advance-article-abstract/doi/10.1093/hmg/ddaa037/5803135
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    The V-ATPase/ATG16L1 axis is controlled by the V1H subunit
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  23. Jul 2024
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    An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II
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    Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics
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  26. Jun 2024
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    Capturing acyl–enzyme intermediates with genetically encoded 2,3-diaminopropionic acid for hydrolase substrate identification
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    Inhibition of NLRP3 inflammasome alleviates cognitive deficits in a mouse model of anti-NMDAR encephalitis induced by active immunization
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  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    De novo TLK1 and MDM1 mutations in a patient with a neurodevelopmental disorder and immunodeficiency
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    Truncated protein isoforms generate diversity of protein localization and function in yeast
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  31. 52.53.155.43 52.53.155.43
    elife-92755-v2-html.html
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      DOI: 10.7554/elife.92755

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  32. May 2024
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    Everolimus exerts anticancer effects through inhibiting the interaction of matrix metalloproteinase-7 with syndecan-2 in colon cancer cells
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      DOI: 10.1152/ajpcell.00669.2023

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    52.53.155.43/76598b44d554c4165a9f84a25bc34c671709ff41/lee-et-al-2024-everolimus-exerts-anticancer-effects-through-inhibiting-the-interaction-of-matrix-metalloproteinase-7-html.html
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    ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum
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    Beyond Glycolysis: Aldolase A is a Novel Effector in Reelin Mediated Dendritic Development
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  36. Apr 2024
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    Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia
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    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
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    GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies
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    In vivo bioluminescence imaging of the intracerebral fibroin-controlled AAV-α-synuclein diffusion for monitoring the central nervous system and peripheral expression
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    Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication
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  42. 52.53.155.43 52.53.155.43
    elife-92755-v2-html.html
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      DOI: 10.7554/elife.92755

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    An RNA-dependent and phase-separated active subnuclear compartment safeguards repressive chromatin domains
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    RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
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  45. Mar 2024
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    Molecular determinants and signaling effects of PKA RIα phase separation
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  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin
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  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood–brain barrier
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    Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity
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  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Control of meiotic entry by dual inhibition of a key mitotic transcription factor
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    HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus
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  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGF1R deficiency in vascular smooth muscle cells impairs myogenic autoregulation and cognition in mice
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  53. Feb 2024
  54. 52.53.155.43 52.53.155.43
    AURKA enhances the glycolysis and development of ovarian endometriosis through ERβ
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      DOI: 10.1210/endocr/bqae018

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  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription
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  56. 52.53.155.43 52.53.155.43
    RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation
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  57. 52.53.155.43 52.53.155.43
    The β6 Integrin Negatively Regulates TLR7-Mediated Epithelial Immunity via Autophagy During Influenza A Virus Infection
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  58. 52.53.155.43 52.53.155.43
    Identification of an H-Ras nanocluster disrupting peptide
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  59. 52.53.155.43 52.53.155.43
    An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth
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  60. www.sciencedirect.com www.sciencedirect.com
    Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis
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  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity
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  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Precision formulation, a new concept to improve dietary amino acid absorption based on the study of cationic amino acid transporters
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  63. Jan 2024
  64. www.sciencedirect.com www.sciencedirect.com
    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
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    DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells
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    Live-cell imaging defines a threshold in CDK activity at the G2/M transition
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  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    METTL17 is an Fe-S cluster checkpoint for mitochondrial translation
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  68. Dec 2023
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures
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    Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity
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    Dynamic landscape of the intracellular termini of acid-sensing ion channel 1a
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    Calmodulin regulates protease versus co-chaperone activity of a metacaspase
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    Single-cell analysis reveals a weak macrophage subpopulation response to Mycobacterium tuberculosis infection
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  74. Nov 2023
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    Solid-to-liquid phase transition in the dissolution of cytosolic misfolded-protein aggregates
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    Manipulating the 3D organization of the largest synthetic yeast chromosome
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    Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions
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    Interplay between stochastic enzyme activity and microtubule stability drives detyrosination enrichment on microtubule subsets
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    Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains
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    Temporally specific gene expression and chromatin remodeling programs regulate a conserved Pdyn enhancer
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    In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target
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  82. aacrjournals.org aacrjournals.org
    MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
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  83. Oct 2023
  84. www.sciencedirect.com www.sciencedirect.com
    Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2
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    Contribution of radixin and ezrin to the maintenance of hepatocytes' excretory function in health and disease
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    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
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  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse
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      DOI: 10.3389/fnagi.2023.1265151

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    α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity
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    PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model
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    The transcriptional regulator Ume6 is a major driver of early gene expression during gametogenesis
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    Essential role of the amino-terminal region of Drosha for the Microprocessor function
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    Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties
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    A dynamic actin cytoskeleton is required to prevent constitutive VDAC-dependent MAPK signalling and aberrant lipid homeostasis
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    Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects
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    The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling
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    The C-terminus of Sudan ebolavirus VP40 contains a functionally important CXnC motif, a target for redox modifications
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  101. Jun 2023
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    Clonal evolution in tyrosine kinase inhibitor-resistance: lessons from in vitro-models
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    Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis
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    Comparative landscape of genetic dependencies in human and chimpanzee stem cells
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    Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification
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    Inducible Knockout of 14-3-3β Attenuates Proliferation and Spheroid Formation in a Human Glioblastoma Cell Line U87MG
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    Tumor cell-intrinsic and tumor microenvironmental conditions co-determine signaling by the glycoimmune checkpoint receptor Siglec-7
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  109. May 2023
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    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
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    EWSR1 maintains centromere identity
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    Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions
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    Methylated histones on mitotic chromosomes promote Topoisomerase IIα function for high fidelity chromosome segregation.
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    Calcineurin associates with centrosomes and regulates cilia length maintenance
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    RAGE and its ligand amyloid beta promote retinal ganglion cell loss following ischemia-reperfusion injury
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    The Transcriptional Regulator Ume6 is a Major Driver of Early Gene Expression during Gametogenesis
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    N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+ T cell responsiveness.
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    Proteomic discovery of chemical probes that perturb protein complexes in human cells
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    UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS
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    Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD
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    Lipidomic analysis of adipose-derived extracellular vesicles reveals specific EV lipid sorting informative of the obesity metabolic state
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    Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture
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    IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment
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    Microglial reprogramming by Hv1 antagonism protects neurons from inflammatory and glutamate toxicity
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    Intron retention of an adhesion GPCR generates single transmembrane-helix isoforms to enable 7TM-adhesion GPCR function
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    An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes
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    Carbonic anhydrases in development: morphological observations and gene expression profiling in sea urchin embryos exposed to acetazolamide
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    Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits
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  134. Dec 2022
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    Meiotic nuclear pore complex remodeling provides key insights into nuclear basket organization
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    A minimal construct of nuclear-import receptor Karyopherin-β2 defines the regions critical for chaperone and disaggregation activity
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    Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules
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    Epidermal stratification requires retromer-mediated desmoglein-1 recycling
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    Cocaine sensitizes the CD4+ T cells for HIV infection by co-stimulating NFAT and AP-1
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  140. Nov 2022
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    TES-1/Tes and ZYX-1/Zyxin protect junctional actin networks under tension during epidermal morphogenesis in the C. elegans embryo
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    Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease at 16q11.2 and MAPT H1 loci
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  143. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic proteomic and phosphoproteomic atlas of corticostriatal axons in neurodevelopment
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  144. Oct 2022
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    BK Polyomavirus Requires the Mismatch Repair Pathway for DNA Damage Response Activation
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  146. Sep 2022
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    Nanobodies identify an activated state of the TRIB2 pseudokinase
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  148. Aug 2022
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    Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer
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  150. Jul 2022
  151. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Identification of growth hormone receptor as a relevant target for precision medicine in low-EGFR expressing glioblastoma
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    Genome-wide expression and methylation analyses reveal aberrant cell adhesion signaling in tyrosine kinase inhibitor-resistant CML cells
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  153. Jun 2022
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    MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines
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    Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease
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  156. Apr 2022
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    Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes
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    Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function
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    FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer
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  160. Mar 2022
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    Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes
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    Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense
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    Visualization of trigeminal ganglion sensory neuronal signaling regulated by Cdk5
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    Local hyperthermia therapy induces browning of white fat and treats obesity
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    RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1
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    Poly(ADP-ribose) drives condensation of FUS via a transient interaction
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    Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
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    An AMPKα2-specific phospho-switch controls lysosomal targeting for activation
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    Renal Klotho and inorganic phosphate are extrinsic factors that antagonistically regulate hematopoietic stem cell maintenance
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    LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
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    Maternal hypothyroidism in rats reduces placental lactogen, lowers insulin levels and causes glucose intolerance
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  173. Jan 2022
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    NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems
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    Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses
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  177. Dec 2021
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    Super-Resolution Imaging of the Filtration Barrier Suggests a Role for Podocin R229Q in Genetic Predisposition to Glomerular Disease
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    Wnt signaling mediates acquisition of blood–brain barrier properties in naïve endothelium derived from human pluripotent stem cells
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    Calpain-2 regulates hypoxia/HIF-induced plasticity toward amoeboid cancer cell migration and metastasis
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    Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts
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  182. Nov 2021
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    Characterization and prognostic value of LXR splice variants in triple-negative breast cancer
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    Programmed cortical ER collapse drives selective ER degradation and inheritance in yeast meiosis
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    The effect of age and sex on the expression of GABA signaling components in the human hippocampus and entorhinal cortex
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    Merkel cell polyomavirus T-antigens regulate DICER1 mRNA stability and translation through HSC70
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  187. Oct 2021
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    Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation
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    The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation
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    Luciferase reporter assays to monitor interferon signaling modulation by SARS-CoV-2 proteins
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    Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites
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    An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens
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    Gut microbiome ADP-ribosyltransferases are widespread phage-encoded fitness factors
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    The Presynaptic Scaffold Protein Bassoon in Forebrain Excitatory Neurons Mediates Hippocampal Circuit Maturation: Potential Involvement of TrkB Signalling
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    Severe deficiency of the voltage-gated sodium channel NaV1.2 elevates neuronal excitability in adult mice
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    Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix
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    PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K
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    Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca2+ Leakage from the Endoplasmic Reticulum
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    Elimination of vision-guided target attraction in Aedes aegypti using CRISPR
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    The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages
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    Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D2 Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor
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      goat anti-rabbit IRDye680RD

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    A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins
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    Glutamatergic receptor expression changes in the Alzheimer's disease hippocampus and entorhinal cortex
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    FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates
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    Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis
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  216. Jun 2021
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    Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice
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    Passive Immunity to Vibrio cholerae O1 Afforded by a Human Monoclonal IgA1 Antibody Expressed in Milk
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    A role for the ribosome-associated complex in activation of the IRE1 branch of UPR
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    High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol
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    HIV-induced neuroinflammation inhibits oligodendrocyte maturation via glutamate-dependent activation of the PERK arm of the integrated stress response
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    Endogenous p53 expression in human and mouse is not regulated by its 3′UTR
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    NPC1 regulates the distribution of phosphatidylinositol 4-kinases at Golgi and lysosomal membranes
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    Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms
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    Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities
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    TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation
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    Proteasome-Bound UCH37/UCHL5 Debranches Ubiquitin Chains to Promote Degradation
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    PIWI proteomics identifies Atari and Pasilla as piRNA biogenesis factors in Aedes mosquitoes
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      RRID:AB_10956166

      DOI: 10.1016/j.celrep.2021.109073

      Resource: (LI-COR Biosciences Cat# 926-68071, RRID:AB_10956166)

      Curator: @scibot

      SciCrunch record: RRID:AB_10956166

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      RRID:AB_10956166
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    sciencedirect.com/science/article/pii/S2211124721004046
  233. Apr 2021
  234. www.sciencedirect.com www.sciencedirect.com
    Tumor Reliance on Cytosolic versus Mitochondrial One-Carbon Flux Depends on Folate Availability
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    1. scibot 30 Apr 2021
      RRID:AB_10956166

      DOI: 10.1016/j.cmet.2020.12.002

      Resource: (LI-COR Biosciences Cat# 926-68071, RRID:AB_10956166)

      Curator: @scibot

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      RRID:AB_10956166
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    sciencedirect.com/science/article/pii/S1550413120306574
  235. www.cell.com www.cell.com
    IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis
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    1. scibot 20 Apr 2021
      RRID:AB_10956166

      DOI: 10.1016/j.ccell.2020.06.007

      Resource: (LI-COR Biosciences Cat# 926-68071, RRID:AB_10956166)

      Curator: @Naa003

      SciCrunch record: RRID:AB_10956166

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      RRID:AB_10956166 RRIDCUR:Validated
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    cell.com/cancer-cell/fulltext/S1535-6108(20)30311-1