263 Matching Annotations
  1. Apr 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication
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    1. scibot 20 Apr 2024
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  3. 52.53.155.43 52.53.155.43
    elife-92755-v2-html.html
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    1. scibot 13 Apr 2024
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      DOI: 10.7554/elife.92755

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    An RNA-dependent and phase-separated active subnuclear compartment safeguards repressive chromatin domains
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    1. scibot 10 Apr 2024
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      DOI: 10.1016/j.molcel.2024.03.015

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  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
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    1. scibot 10 Apr 2024
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      DOI: 10.1016/j.isci.2024.109524

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    ncbi.nlm.nih.gov/pmc/articles/PMC10993188/
  6. Mar 2024
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    Molecular determinants and signaling effects of PKA RIα phase separation
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    1. scibot 28 Mar 2024
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    sciencedirect.com/science/article/pii/S1097276524001849
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    Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin
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    1. scibot 22 Mar 2024
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      DOI: 10.7554/eLife.92755

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    ncbi.nlm.nih.gov/pmc/articles/PMC10950329/
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    Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood–brain barrier
    1
    1. scibot 19 Mar 2024
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      DOI: 10.1186/s12987-024-00529-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC10941402/
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    Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity
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    1. scibot 19 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113965

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    sciencedirect.com/science/article/pii/S2211124724002936
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    Control of meiotic entry by dual inhibition of a key mitotic transcription factor
    1
    1. scibot 16 Mar 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10939502/
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    HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus
    1
    1. scibot 12 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113788

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  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGF1R deficiency in vascular smooth muscle cells impairs myogenic autoregulation and cognition in mice
    2
    1. scibot 03 Mar 2024
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      DOI: 10.3389/fnagi.2024.1320808

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      DOI: 10.3389/fnagi.2024.1320808

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  14. Feb 2024
  15. 52.53.155.43 52.53.155.43
    AURKA enhances the glycolysis and development of ovarian endometriosis through ERβ
    1
    1. scibot 28 Feb 2024
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      DOI: 10.1210/endocr/bqae018

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    52.53.155.43/763b9f4f88af8a11d49032bb21ea7f98fd438708/bqae018-html.html
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    Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription
    1
    1. scibot 27 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113816

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  17. 52.53.155.43 52.53.155.43
    RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation
    1
    1. scibot 22 Feb 2024
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      DOI: 10.1101/2023.10.05.561021

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    52.53.155.43/19126de606c776a10e00c0c9a385ef3636eaaf16/2023.10.05.561021v2.full (1)-html.html
  18. 52.53.155.43 52.53.155.43
    The β6 Integrin Negatively Regulates TLR7-Mediated Epithelial Immunity via Autophagy During Influenza A Virus Infection
    2
    1. scibot 22 Feb 2024
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      DOI: 10.1101/2023.08.28.555098

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      DOI: 10.1101/2023.08.28.555098

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  19. 52.53.155.43 52.53.155.43
    Identification of an H-Ras nanocluster disrupting peptide
    2
    1. scibot 22 Feb 2024
      RRID:AB_1095616

      DOI: 10.1101/2023.09.07.556635

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    52.53.155.43/50febc729cb1f3f2f29f241e3592121bf7d8fba9/2023.09.07.556635v1.full-html.html
  20. 52.53.155.43 52.53.155.43
    An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth
    1
    1. scibot 22 Feb 2024
      RRID:AB_1095616

      DOI: 10.1101/2023.08.23.554263

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    Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis
    1
    1. scibot 16 Feb 2024
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      DOI: 10.1016/j.cell.2024.01.030

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    sciencedirect.com/science/article/pii/S0092867424000679
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity
    1
    1. scibot 08 Feb 2024
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      DOI: 10.1038/s41467-024-45303-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10838306/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Precision formulation, a new concept to improve dietary amino acid absorption based on the study of cationic amino acid transporters
    1
    1. scibot 08 Feb 2024
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      DOI: 10.1016/j.isci.2024.108894

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  24. Jan 2024
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    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
    1
    1. scibot 25 Jan 2024
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      DOI: 10.1016/j.molcel.2023.12.039

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    sciencedirect.com/science/article/pii/S1097276523010857
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    DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells
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      DOI: 10.1016/j.isci.2023.108760

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    sciencedirect.com/science/article/pii/S2589004223028377
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    Live-cell imaging defines a threshold in CDK activity at the G2/M transition
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    1. scibot 19 Jan 2024
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      DOI: 10.1016/j.devcel.2023.12.014

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    sciencedirect.com/science/article/pii/S1534580723006950
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    METTL17 is an Fe-S cluster checkpoint for mitochondrial translation
    1
    1. scibot 11 Jan 2024
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      DOI: 10.1016/j.molcel.2023.12.016

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  29. Dec 2023
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures
    1
    1. scibot 28 Dec 2023
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      DOI: 10.3389/fnmol.2023.1323431

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    ncbi.nlm.nih.gov/pmc/articles/PMC10749327/
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    Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity
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      DOI: 10.1016/j.xcrm.2023.101341

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    sciencedirect.com/science/article/pii/S266637912300558X
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    Dynamic landscape of the intracellular termini of acid-sensing ion channel 1a
    1
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      DOI: 10.7554/eLife.90755

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    ncbi.nlm.nih.gov/pmc/articles/PMC10699805/
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    Calmodulin regulates protease versus co-chaperone activity of a metacaspase
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      DOI: 10.1016/j.celrep.2023.113372

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    Single-cell analysis reveals a weak macrophage subpopulation response to Mycobacterium tuberculosis infection
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  35. Nov 2023
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    Solid-to-liquid phase transition in the dissolution of cytosolic misfolded-protein aggregates
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      DOI: 10.1016/j.isci.2023.108334

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    sciencedirect.com/science/article/pii/S2589004223024112
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    Manipulating the 3D organization of the largest synthetic yeast chromosome
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    Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions
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    sciencedirect.com/science/article/pii/S0092867423010796
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    Interplay between stochastic enzyme activity and microtubule stability drives detyrosination enrichment on microtubule subsets
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      DOI: 10.1016/j.cub.2023.10.068

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    sciencedirect.com/science/article/abs/pii/S0960982223015063
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    Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains
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      DOI: 10.1016/j.xgen.2023.100419

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  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Temporally specific gene expression and chromatin remodeling programs regulate a conserved Pdyn enhancer
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      DOI: 10.7554/eLife.89993

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    ncbi.nlm.nih.gov/pmc/articles/PMC10631760/
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    In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target
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      DOI: 10.1158/2643-3230.BCD-22-0086

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  43. aacrjournals.org aacrjournals.org
    MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
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  44. Oct 2023
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    Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2
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    Contribution of radixin and ezrin to the maintenance of hepatocytes' excretory function in health and disease
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    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
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    Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse
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    α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity
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    PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model
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    The transcriptional regulator Ume6 is a major driver of early gene expression during gametogenesis
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  52. Sep 2023
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    Essential role of the amino-terminal region of Drosha for the Microprocessor function
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  54. Aug 2023
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    Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties
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    A dynamic actin cytoskeleton is required to prevent constitutive VDAC-dependent MAPK signalling and aberrant lipid homeostasis
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    Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects
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    A peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms
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  59. Jul 2023
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    The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling
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    The C-terminus of Sudan ebolavirus VP40 contains a functionally important CXnC motif, a target for redox modifications
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  62. Jun 2023
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    Clonal evolution in tyrosine kinase inhibitor-resistance: lessons from in vitro-models
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    Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis
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    SRSF10 regulates proliferation of neural progenitor cells and affects neurogenesis in developing mouse neocortex
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    Comparative landscape of genetic dependencies in human and chimpanzee stem cells
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    Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification
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    Inducible Knockout of 14-3-3β Attenuates Proliferation and Spheroid Formation in a Human Glioblastoma Cell Line U87MG
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    Tumor cell-intrinsic and tumor microenvironmental conditions co-determine signaling by the glycoimmune checkpoint receptor Siglec-7
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  70. May 2023
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    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
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    EWSR1 maintains centromere identity
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    Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions
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    Methylated histones on mitotic chromosomes promote Topoisomerase IIα function for high fidelity chromosome segregation.
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    Calcineurin associates with centrosomes and regulates cilia length maintenance
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  76. Apr 2023
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    RAGE and its ligand amyloid beta promote retinal ganglion cell loss following ischemia-reperfusion injury
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    The Transcriptional Regulator Ume6 is a Major Driver of Early Gene Expression during Gametogenesis
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    N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+ T cell responsiveness.
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    Proteomic discovery of chemical probes that perturb protein complexes in human cells
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    UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS
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  82. Mar 2023
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    Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD
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    Lipidomic analysis of adipose-derived extracellular vesicles reveals specific EV lipid sorting informative of the obesity metabolic state
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    Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture
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    Regulation of DNA damage response by trimeric G-proteins
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    IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment
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  89. Jan 2023
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    Microglial reprogramming by Hv1 antagonism protects neurons from inflammatory and glutamate toxicity
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    Intron retention of an adhesion GPCR generates single transmembrane-helix isoforms to enable 7TM-adhesion GPCR function
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    An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes
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    Carbonic anhydrases in development: morphological observations and gene expression profiling in sea urchin embryos exposed to acetazolamide
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    Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits
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    A minimal construct of nuclear-import receptor Karyopherin-β2 defines the regions critical for chaperone and disaggregation activity
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    Cocaine sensitizes the CD4+ T cells for HIV infection by co-stimulating NFAT and AP-1
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    Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease at 16q11.2 and MAPT H1 loci
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    Nanobodies identify an activated state of the TRIB2 pseudokinase
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    Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer
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    Identification of growth hormone receptor as a relevant target for precision medicine in low-EGFR expressing glioblastoma
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    Genome-wide expression and methylation analyses reveal aberrant cell adhesion signaling in tyrosine kinase inhibitor-resistant CML cells
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    MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines
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    Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes
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    Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function
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    Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes
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    Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense
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    Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
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    Renal Klotho and inorganic phosphate are extrinsic factors that antagonistically regulate hematopoietic stem cell maintenance
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    LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
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    NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems
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    Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses
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    Super-Resolution Imaging of the Filtration Barrier Suggests a Role for Podocin R229Q in Genetic Predisposition to Glomerular Disease
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    Calpain-2 regulates hypoxia/HIF-induced plasticity toward amoeboid cancer cell migration and metastasis
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    Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation
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    The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation
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    Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites
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    An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens
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    Gut microbiome ADP-ribosyltransferases are widespread phage-encoded fitness factors
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    The Presynaptic Scaffold Protein Bassoon in Forebrain Excitatory Neurons Mediates Hippocampal Circuit Maturation: Potential Involvement of TrkB Signalling
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    Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons
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    Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca2+ Leakage from the Endoplasmic Reticulum
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    The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages
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    Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D2 Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor
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      goat anti-rabbit IRDye680RD

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    Glutamatergic receptor expression changes in the Alzheimer's disease hippocampus and entorhinal cortex
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    Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis
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  177. Jun 2021
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    Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice
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    Passive Immunity to Vibrio cholerae O1 Afforded by a Human Monoclonal IgA1 Antibody Expressed in Milk
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    A role for the ribosome-associated complex in activation of the IRE1 branch of UPR
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    High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol
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    HIV-induced neuroinflammation inhibits oligodendrocyte maturation via glutamate-dependent activation of the PERK arm of the integrated stress response
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    Endogenous p53 expression in human and mouse is not regulated by its 3′UTR
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    The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
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    Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities
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    Tumor Reliance on Cytosolic versus Mitochondrial One-Carbon Flux Depends on Folate Availability
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    Argonaute-CLIP delineates versatile, functional RNAi networks in Aedes aegypti, a major vector of human viruses
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    Changes in mitochondrial morphology modulate LPS-induced loss of calcium homeostasis in BV-2 microglial cells
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    TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51K133A
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    Opposite Surfaces of the Cdc15 F-BAR Domain Create a Membrane Platform That Coordinates Cytoskeletal and Signaling Components for Cytokinesis
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  217. Nov 2020
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    Loss of Muscle Carnitine Palmitoyltransferase 2 Prevents Diet-Induced Obesity and Insulin Resistance despite Long-Chain Acylcarnitine Accumulation
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    Structure-Based Identification and Functional Characterization of a Lipocalin in the Malaria Parasite Plasmodium falciparum
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      DOI: 10.1523/JNEUROSCI.1076-19.2019

      Resource: (LI-COR Biosciences Cat# 926-68071, RRID:AB_10956166)

      Curator: @ethanbadger

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      RRIDCUR:Validated RRID:AB_10956166
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    jneurosci.org/content/40/2/459
  235. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions
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    1. scibot 16 Sep 2020
      RRID:AB_10956166

      DOI: 10.7554/eLife.49894

      Resource: (LI-COR Biosciences Cat# 926-68071, RRID:AB_10956166)

      Curator: @evieth

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    ncbi.nlm.nih.gov/pmc/articles/PMC6959991/
  236. www.sciencedirect.com www.sciencedirect.com
    Translation Initiation Site Profiling Reveals Widespread Synthesis of Non-AUG-Initiated Protein Isoforms in Yeast
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    1. scibot 16 Sep 2020
      RRID:AB_10956166

      DOI: 10.1016/j.cels.2020.06.011

      Resource: (LI-COR Biosciences Cat# 926-68071, RRID:AB_10956166)

      Curator: @Naa003

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    sciencedirect.com/science/article/pii/S2405471220302404
  237. www.sciencedirect.com www.sciencedirect.com
    Fyn Kinase Controls Tau Aggregation In Vivo
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    1. scibot 14 Sep 2020
      RRID:AB_10956166

      DOI: 10.1016/j.celrep.2020.108045

      Resource: (LI-COR Biosciences Cat# 926-68071, RRID:AB_10956166)

      Curator: @Naa003

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      RRIDCUR:Validated RRID:AB_10956166
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    sciencedirect.com/science/article/pii/S2211124720310305