292 Matching Annotations
  1. Nov 2024
  2. www.sciencedirect.com www.sciencedirect.com
    A PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells
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    1. scibot 14 Nov 2024
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      DOI: 10.1016/j.chembiol.2024.10.008

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    sciencedirect.com/science/article/pii/S2451945624004434
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Insulin Mediates Lipopolysaccharide-Induced Inflammatory Responses and Oxidative Stress in BV2 Microglia
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    1. scibot 10 Nov 2024
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      DOI: 10.2147/JIR.S481101

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    pmc.ncbi.nlm.nih.gov/articles/PMC11539848/
  4. Sep 2024
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    TRPV4 Blockage Inhibits the Neurogenesis in the Adult Hippocampal Dentate Gyrus Following Pilocarpine‑Induced Status Epilepticus
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    1. scibot 27 Sep 2024
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      DOI: 10.1007/s12035-024-04504-x

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    link.springer.com/article/10.1007/s12035-024-04504-x
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    FNIP1 suppresses colorectal cancer progression through inhibiting STAT3 phosphorylation and nuclear translocation
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    1. scibot 25 Sep 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11389550/
  7. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 25 Sep 2024
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      DOI: 10.1111/bph.15169

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      Curator comments: Phospho-p38 MAPK (Thr180/Tyr182) (D3F9) XP Rabbit mAb antibody Cell Signaling Technology Cat# 4511

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    Key roles of C2/GAP domains in SYNGAP1-related pathophysiology
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    1. scibot 13 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724010842
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    Aged fibroblast-derived extracellular vesicles promote angiogenesis in melanoma
    1
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    sciencedirect.com/science/article/pii/S2211124724010726
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    Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy
    1
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    sciencedirect.com/science/article/pii/S0092867424009048
  11. Aug 2024
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    Non-canonical autophosphorylation of RIPK1 drives timely pyroptosis to control Yersinia infection
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    sciencedirect.com/science/article/pii/S2211124724009914
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    The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response
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    sciencedirect.com/science/article/pii/S2211124724009586
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    Senescent endometrial stromal cells transmit reactive oxygen species to the trophoblast-like cells and impair spreading of blastocyst-like spheroids
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    academic.oup.com/molehr/article/28/12/gaac039/6825317
  15. Jul 2024
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    Arrestin-3-assisted activation of JNK3 mediates dopaminergic behavioral sensitization
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    sciencedirect.com/science/article/pii/S2666379124003276
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    Netrin signaling mediates survival of dormant epithelial ovarian cancer cells
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    1. scibot 20 Jul 2024
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      DOI: 10.7554/eLife.91766

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    ncbi.nlm.nih.gov/pmc/articles/PMC11257678/
  18. Jun 2024
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Minocycline Abrogates Individual Differences in Nerve Injury-Evoked Affective Disturbances in Male Rats and Prevents Associated Supraspinal Neuroinflammation
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    1. scibot 22 Jun 2024
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      DOI: 10.1007/s11481-024-10132-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC11180027/
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gossypetin targets the liver-brain axis to alleviate pre-existing liver fibrosis and hippocampal neuroinflammation in mice
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    1. scibot 13 Jun 2024
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      DOI: 10.3389/fphar.2024.1385330

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  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 envelope protein regulates innate immune tolerance
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11140213/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GLUT2 regulation of p38 MAPK isoform protein expression and p38 phosphorylation in male versus female rat hypothalamic primary astrocyte Cultures
    1
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      DOI: 10.1016/j.ibneur.2024.05.008

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    ncbi.nlm.nih.gov/pmc/articles/PMC11144729/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress
    1
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  24. May 2024
  25. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle
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    1. scibot 24 May 2024
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      DOI: 10.1113/JP285719

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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP285719
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    A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death
    1
    1. scibot 24 May 2024
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      DOI: 10.1016/j.immuni.2024.04.025

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    sciencedirect.com/science/article/pii/S1074761324002309
  27. 52.53.155.43 52.53.155.43
    TRIM2 Selectively Regulates Inflammation-Driven Pathological Angiogenesis without Affecting Physiological Hypoxia-Mediated Angiogenesis
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    1. scibot 17 May 2024
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      DOI: 10.20944/preprints202402.1027.v1

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      DOI: 10.20944/preprints202402.1027.v1

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  28. 52.53.155.43 52.53.155.43
    Host-pathogen Coadaptation by running with PAR protein
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    1. scibot 10 May 2024
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    52.53.155.43/ed26dad54fa8ad8f27865dcc79d9a69d83befd62/2024.01.31.578330v1.full-html.html
  29. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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      DOI: 10.1111/bph.16356

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16356
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    Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease
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    1. scibot 01 May 2024
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      DOI: 10.1016/j.stem.2024.04.002

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    sciencedirect.com/science/article/pii/S1934590924001292
  31. Apr 2024
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    Lysosomal dysfunction by inactivation of V-ATPase drives innate immune response in C. elegans
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      DOI: 10.1016/j.celrep.2024.114138

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  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tgif1-deficiency impairs cytoskeletal architecture in osteoblasts by activating PAK3 signaling
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      DOI: 10.7554/eLife.94265

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    6-O-angeloylplenolin inhibits osteoclastogenesis in vitro via suppressing c-Src/NF-κB/NFATc1 pathways and ameliorates bone resorption in collagen-induced arthritis mouse model
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    S1PR3 agonism and S1P lyase inhibition rescue mice in the severe state of experimental sepsis
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    sciencedirect.com/science/article/pii/S0753332224004591
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    Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress
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    SWI/SNF complex-mediated chromatin remodelling in Candida glabrata promotes immune evasion
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    CircTMEM165 facilitates endothelial repair by modulating mitochondrial fission via miR-192/SCP2 in vitro and in vivo
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    ncbi.nlm.nih.gov/pmc/articles/PMC11000015/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRIM2 Selectively Regulates Inflammation-Driven Pathological Angiogenesis without Affecting Physiological Hypoxia-Mediated Angiogenesis
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      DOI: 10.3390/ijms25063343

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    Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome
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    sciencedirect.com/science/article/pii/S209012322400119X
  41. Mar 2024
  42. www.sciencedirect.com www.sciencedirect.com
    Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L
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    sciencedirect.com/science/article/pii/S2211124724003267
  43. 52.53.155.43 52.53.155.43
    Human seminal extracellular vesicles enhance endometrial receptivity through leukemia inhibitory factor
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      DOI: 10.1210/endocr/bqae035

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      DOI: 10.1210/endocr/bqae035

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    First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure
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      DOI: 10.1016/j.cell.2024.02.023

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    Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin α2β1
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    Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma
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    Pacritinib Inhibition of IRAK1 Blocks Aberrant TLR8 Signalling by SARS-CoV-2 and HIV-1-Derived RNA
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    Proteomic-Based Approach Reveals the Involvement of Apolipoprotein A-I in Related Phenotypes of Autism Spectrum Disorder in the BTBR Mouse Model
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    TREM2 improves neurological dysfunction and attenuates neuroinflammation, TLR signaling and neuronal apoptosis in the acute phase of intracerebral hemorrhage
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    Platelet p110β mediates platelet-leukocyte interaction and curtails bacterial dissemination in pneumococcal pneumonia
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    P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection
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    Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infection
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    cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic activation of senescence-associated T cells
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    Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia
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    BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer
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    Ablating Lgr5-expressing prostatic stromal cells activates the ERK-mediated mechanosensory signaling and disrupts prostate tissue homeostasis
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    Tripartite Motif 38 Attenuates Cardiac Fibrosis after Myocardial Infarction by Suppressing TAK1 Activation via TAB2/3 Degradation
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    The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways
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    EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression
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    Transmissible ER stress between macrophages and tumor cells configures tumor microenvironment
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  154. Jun 2022
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  156. journals.lww.com journals.lww.com
    Muse cells decrease the neuroinflammatory response by... : Neural Regeneration Research
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    Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
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  158. May 2022
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    SM22α-lineage niche cells regulate intramembranous bone regeneration via PDGFRβ-triggered hydrogen sulfide production
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    Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
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    Dual HDAC/BRD4 Inhibitors Relieves Neuropathic Pain by Attenuating Inflammatory Response in Microglia After Spared Nerve Injury
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    In situ synthesis and unidirectional insertion of membrane proteins in liposome-immobilized silica stationary phase for rapid preparation of microaffinity chromatography
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    Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial/macrophage polarization
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    The GADD45G/p38 MAPK/CDC25B signaling pathway enhances neurite outgrowth by promoting microtubule polymerization
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  167. Mar 2022
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    Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte/macrophage polarization
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    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
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  173. Feb 2022
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    Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation
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    Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression
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  179. Jan 2022
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    Inhibition of transcription factor NFAT activity in activated platelets enhances their aggregation and exacerbates gram-negative bacterial septicemia
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  181. Dec 2021
  182. www.cell.com www.cell.com
    SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes
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    Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice
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    The spike protein of SARS-CoV-2 virus induces heme oxygenase-1: Pathophysiologic implications
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  186. Nov 2021
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    Differential ER Stress as a Driver of Cell Fate following Ricin Toxin Exposure
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    Carbon dioxide inhibits COVID-19-type proinflammatory responses through extracellular signal-regulated kinases 1 and 2, novel carbon dioxide sensors
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  190. Oct 2021
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    Bletinib ameliorates neutrophilic inflammation and lung injury by inhibiting Src family kinase phosphorylation and activity
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    Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
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    Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice
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    Nitric Oxide Induces a Janus Kinase-1-Dependent Inflammatory Response in Primary Murine Astrocytes - John D. Nowery, Rylee N. Cisney, Jacob W. Feldmann, Gordon P. Meares, 2021
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    KDM6B epigenetically regulated-interleukin-6 expression in the dorsal root ganglia and spinal dorsal horn contributes to the development and maintenance of neuropathic pain following peripheral nerve injury in male rats
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    Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis
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    Breast tumor kinase (Brk/PTK6) mediates advanced cancer phenotypes via SH2-domain dependent activation of RhoA and aryl hydrocarbon receptor (AhR) signaling
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    Differential Actions of Estrogen Receptor α and β via Non-Genomic Signaling in Human Prostate Stem and Progenitor Cells
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    Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer
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  213. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Activation of spinal PDGFRβ in microglia promotes neuronal autophagy via p38 MAPK pathway in morphine-tolerant rats
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    Peripheral Nerve Injury Triggers Neuroinflammation in the Medial Prefrontal Cortex and Ventral Hippocampus in a Subgroup of Rats with Coincident Affective Behavioural Changes
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    New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis
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    Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness
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    Differential Effects of Toll-Like Receptor Activation and Differential Mediation by MAP Kinases of Immune Responses in Microglial Cells
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    An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress
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    IL-17 Inhibits Oligodendrocyte Progenitor Cell Proliferation and Differentiation by Increasing K+ Channel Kv1.3
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