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    Microbiota-derived lysophosphatidylcholine alleviates Alzheimer’s disease pathology via suppressing ferroptosis
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  3. Nov 2024
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    Two cooperative lipid binding sites within the pleckstrin homology domain are necessary for AKT binding and stabilization to the plasma membrane
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    Distinct effects of sacituzumab govitecan and berzosertib on DNA damage response in ovarian cancer
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    Intra-tumoral YAP and TAZ heterogeneity drives collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981
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    GM1 Oligosaccharide Ameliorates Rett Syndrome Phenotypes In Vitro and In Vivo via Trk Receptor Activation
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    Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells
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    The role of heparan sulfate in enhancing the chemotherapeutic response in triple-negative breast cancer
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    Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development
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    Glutamate Transport Proteins and Metabolic Enzymes are Poor Prognostic Factors in Invasive Lobular Carcinoma
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    Everolimus alleviates CD4+ T cell inflammation by regulating autophagy and cellular redox homeostasis
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  13. Oct 2024
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    ProDiVis: a method to normalize fluorescence signal localization in 3D specimens
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    Verapamil Prevents Decline of IGF-I in Subjects With Type 1 Diabetes and Promotes β-Cell IGF-I Signaling
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  16. Sep 2024
  17. www.biorxiv.org www.biorxiv.org
    Cryo-EM Structure of Phospholipase Cε Defines N-terminal Domains and their Roles in Activity
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    EDC-3 and EDC-4 regulate embryonic mRNA clearance and biomolecular condensate specialization
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    Click-chemistry-based protocol for detecting 4-octyl-itaconate-alkylated proteins in primary mouse macrophages
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    Myeloid beta-arrestin 2 depletion attenuates metabolic dysfunction-associated steatohepatitis via the metabolic reprogramming of macrophages
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    m6A-modified cenRNA stabilizes CENPA to ensure centromere integrity in cancer cells
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    Geranylgeranylated SCFFBXO10 regulates selective outer mitochondrial membrane proteostasis and function
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    Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription
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    Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium
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    Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity
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    NO-Dependent Akt Inactivation by S-Nitrosylation as a Possible Mechanism of STZ-Induced Neuronal Insulin Resistance
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    RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages
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    Crosstalk between butyrate oxidation in colonocyte and butyrate-producing bacteria
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    Treatment with a combination of myricitrin and exercise alleviates myocardial infarction in rats via suppressing Nrf2/HO-1 antioxidant pathway
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    Paraspeckle-independent co-transcriptional regulation of nuclear microRNA biogenesis by SFPQ
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    Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming
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    GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant
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  33. Aug 2024
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    PD-1 signaling limits expression of phospholipid phosphatase 1 and promotes intratumoral CD8+ T cell ferroptosis
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    Disruption of nuclear speckle integrity dysregulates RNA splicing in C9ORF72-FTD/ALS
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    Serine and glycine physiology reversibly modulate retinal and peripheral nerve function
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    TFE3 fusions direct an oncogenic transcriptional program that drives OXPHOS and unveils vulnerabilities in translocation renal cell carcinoma
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    Parkinson’s disease gene, Synaptojanin1, dysregulates the surface maintenance of the dopamine transporter
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    SIRT1 improves lactate homeostasis in the brain to alleviate parkinsonism via deacetylation and inhibition of PKM2
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    Bradykinin induces acute kidney injury after hypothermic circulatory arrest through repression of the Nrf2-xCT pathway
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    Traumatic Optic Neuropathy Is Associated with Visual Impairment, Neurodegeneration, and Endoplasmic Reticulum Stress in Adolescent Mice
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      β-Actin

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    Registered report: the microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
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      Mouse monoclonal IgG2b u03b1 beta-actin

      DOI: 10.7554/eLife.06434

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    Linking Hypothermia and Altered Metabolism with TrkB Activation
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      DOI: 10.1021/acschemneuro.3c00350

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  44. Jul 2024
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    Isogenic patient-derived organoids reveal early neurodevelopmental defects in spinal muscular atrophy initiation
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    2′-O-methylation at internal sites on mRNA promotes mRNA stability
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