697 Matching Annotations
  1. Aug 2025
  2. www.sciencedirect.com www.sciencedirect.com
    Homocysitaconate controls inflammation through reshaping methionine metabolism and N-homocysteinylation
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    sciencedirect.com/science/article/pii/S1550413125003572
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    Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation
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    Immunotherapeutic targeting of NY-ESO-1 in malignant meningiomas with TCR-transduced T-cells
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    link.springer.com/article/10.1007/s11060-025-05200-z
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    DNASE1L3-expressing dendritic cells promote CD8+ T cell function and anti-PD-(L)1 therapy efficacy by degrading neutrophil extracellular traps
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    cell.com/cancer-cell/abstract/S1535-6108(25)00320-4
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Redistribution of fragmented mitochondria ensures symmetric organelle partitioning and faithful chromosome segregation in mitotic mouse zygotes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12339001/
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    A long-lasting prolactin stimulates galactopoiesis in mice.
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    Targeting the MYC oncogene with a selective bi-steric mTORC1 inhibitor elicits tumor regression in MYC-driven cancers
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    sciencedirect.com/science/article/pii/S2451945625002272
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    Caveolin-1/PPARα axis suppresses T follicular helper cell response in primary Sjögren disease
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    CHI3L3+ immature neutrophils inhibit anti-tumor immunity and impede immune checkpoint blockade therapy in bone metastases
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    The urokinase receptor/uPAR is a major effector of p53 gain-of-function mutations in gemcitabine-treated pancreatic ductal adenocarcinoma
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    Azenosertib Is a Potent and Selective WEE1 Kinase Inhibitor with Broad Antitumor Activity Across a Range of Solid Tumors
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    Ginsenoside 20(S)-Rg3 upregulates SQLE to reprogram cholesterol metabolism of ovarian cancer cells
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  15. Jul 2025
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    PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth
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    Targeting NAD+ Metabolism Vulnerability in FH-Deficient Hereditary Leiomyomatosis and Renal Cell Carcinoma with the Novel NAMPT Inhibitor OT-82
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    Distinct adipose progenitor cells emerging with age drive active adipogenesis
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    Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity
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    Artemisinin synergizes with CCCP in autophagic cell death induction via ER stress in uveal melanoma
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    Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens
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    RECLASSIFICATION OF ATM MISSENSE VARIANTS OF UNCERTAIN SIGNIFICANCE BY INTEGRATING RESULTS FROM SYSTEMATIC FUNCTIONAL ASSAYS INTO AN ACMG POINTS-BASED FRAMEWORK
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    Unlocking the therapeutic potential of rigosertib as a selective therapy for ovarian cancer
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    High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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  28. Jun 2025
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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    PRPS activity tunes redox homeostasis in Myc-driven lymphoma
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    TNFR2 contributes to synaptic potentiation failure in hippocampal synapses and memory loss in a familial Alzheimer’s disease mouse model
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    Combined inhibition of KAT6A/B and Menin reverses estrogen receptor-driven gene expression programs in breast cancer
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    Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells
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    MT-125 inhibits non-muscle myosin IIA and IIB and prolongs survival in glioblastoma
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    ROUX-en-Y gastric bypass surgery improves metabolic syndrome–related erectile dysfunction in mice via the IRS-1/PI3K/AKT/eNOS pathway
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  36. May 2025
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    Cross-species tropism of AAV.CPP.16 in the respiratory tract and its gene therapies against pulmonary fibrosis and viral infection
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    12-Lipoxygenase inhibition improves glycemia and obesity-associated inflammation in male human gene replacement mice
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    Highly specific Immunoproteasome inhibitor M3258 induces proteotoxic stress and apoptosis in KMT2A::AFF1 driven acute lymphoblastic leukemia
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    TOP1 Mutations and Cross-Resistance to Antibody–Drug Conjugates in Patients with Metastatic Breast Cancer
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  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells
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    Secreted spermidine synthase reveals a paracrine role for PGC1α-induced growth suppression in prostate cancer
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    Characterization and comparative analysis of multifunctional natural killer cell engagers during antitumor responses
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    De novo serine biosynthesis is protective in mitochondrial disease
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  46. Apr 2025
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    Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia
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    Cytosolic cytochrome c represses ferroptosis
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    Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance
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    Design, Synthesis, and SAR of Covalent KIT and PDGFRA InhibitorsExploring Their Potential in Targeting GIST
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    Lysyl Oxidases Are Necessary for Myometrial Contractility and On-time Parturition in Mice
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    Profiling the Activity of the Potent and Highly Selective CDK2 Inhibitor BLU-222 Reveals Determinants of Response in CCNE1-Aberrant Ovarian and Endometrial Tumors
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    PRDM1 Is a Key Regulator of the NKT-cell Central Memory Program and Effector Function
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    Oncogenic KRAS Addiction States Differentially Influence MTH1 Expression and 8-oxodGTPase Activity in Lung Adenocarcinoma
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  57. Mar 2025
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    Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma
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    Bromocriptine improves glucose tolerance in obese mice via central dopamine D2 receptor-independent mechanism
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    Protective ApoE variants support neuronal function by extracting peroxidated lipids
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    Dual role of HO-1 in mediating antiviral immune responses and mitigating excessive inflammatory damage during influenza virus infection
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    Compact transcription factor cassettes generate functional, engraftable motor neurons by direct conversion
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    PTPσ-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD
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    LTA4H improves the tumor microenvironment and prevents HCC progression via targeting the HNRNPA1/LTBP1/TGF-β axis
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    Inhibition of PRC2 enables self-renewal of blastoid-competent naive pluripotent stem cells from chimpanzee
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    Realigned transsulfuration drives BRAF-V600E-targeted therapy resistance in melanoma
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    Large-scale control over collective cell migration using light-activated epidermal growth factor receptors
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  69. Feb 2025
  70. www.cell.com www.cell.com
    EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models
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  71. dx.doi.org dx.doi.org
    Relaxin Modulates the Genomic Actions and Biological Effects of Estrogen in the Myometrium
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    PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1
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    Yeast TIA1 coordinates with Npl3 to promote ATG1 translation during starvation
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    A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
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  75. aacrjournals.org aacrjournals.org
    TGF-β antagonizes IFN-γ-mediated adaptive immune evasion via activation of the AKT-Smad3-SHP1 axis in lung adenocarcinoma
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    Biguanides antithetically regulate tumor properties by the dose-dependent mitochondrial reprogramming-driven c-Src pathway
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    Adipocyte-specific Steap4 deficiency reduced thermogenesis and energy expenditure in mice
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  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MYC and HSF1 Cooperate to Drive Sensitivity to Polo-like Kinase 1 Inhibitor Volasertib in High-grade Serous Ovarian Cancer
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  82. Jan 2025
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    A genetically encoded fluorescent biosensor for visualization of acetyl-CoA in live cells
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    CDKN2A/B homozygous deletion sensitizes IDH-mutant glioma to CDK4/6 inhibition
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    Menin orchestrates macrophage reprogramming to maintain the pulmonary immune homeostasis
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    The adaptor protein Miro1 modulates horizontal transfer of mitochondria in mouse melanoma models
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    Metabolic reprogramming of macrophages by PKM2 promotes IL-10 production via adenosine
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    Ribosome customization and functional diversification among P-stalk proteins regulate late poxvirus protein synthesis
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    Structures of ATP-binding cassette transporter ABCC1 reveal the molecular basis of cyclic dinucleotide cGAMP export
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    Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma
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  188. Apr 2024
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  190. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  202. Mar 2024
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  213. Feb 2024
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