298 Matching Annotations
  1. Nov 2024
  2. www.biorxiv.org www.biorxiv.org
    Structure of the TXNL1-bound proteasome
    1
    1. scibot 15 Nov 2024
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      DOI: 10.1101/2024.11.08.622741

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    biorxiv.org/content/10.1101/2024.11.08.622741v1
  3. www.embopress.org www.embopress.org
    Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways
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    1. scibot 14 Nov 2024
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      DOI: 10.1038/s44318-024-00290-3

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    embopress.org/doi/10.1038/s44318-024-00290-3
  4. 52.53.155.43 52.53.155.43
    wang-et-al-2024-nuclear-receptor-e75-nr1d2-promotes-tumor-malignant-transformation-by-integrating-hippo-and-notch-html.html
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    1. scibot 14 Nov 2024
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    52.53.155.43/052dd78e8f9f0d46ee449e71fc9d1d608c537305/wang-et-al-2024-nuclear-receptor-e75-nr1d2-promotes-tumor-malignant-transformation-by-integrating-hippo-and-notch-html.html
  5. www.sciencedirect.com www.sciencedirect.com
    USP7 deubiquitinates KRAS and promotes non-small cell lung cancer
    1
    1. scibot 14 Nov 2024
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      DOI: 10.1016/j.celrep.2024.114917

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    sciencedirect.com/science/article/pii/S2211124724012683
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    Residue Y362 is crucial for FLIPL to impart catalytic activity to pro-caspase-8 to suppress necroptosis
    1
    1. scibot 11 Nov 2024
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      DOI: 10.1016/j.celrep.2024.114966

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    sciencedirect.com/science/article/pii/S2211124724013172
  7. Sep 2024
  8. www.biorxiv.org www.biorxiv.org
    Cryo-EM Structure of Phospholipase Cε Defines N-terminal Domains and their Roles in Activity
    1
    1. scibot 29 Sep 2024
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      DOI: 10.1101/2024.09.11.612521

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    biorxiv.org/content/10.1101/2024.09.11.612521v1
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    CircPOLA2 sensitizes non-small cell lung cancer cells to ferroptosis and suppresses tumorigenesis via the Merlin-YAP signaling pathway
    1
    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S2589004224020571
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    Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity
    1
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    sciencedirect.com/science/article/pii/S2211124724011136
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    LHP1 and INO80 cooperate with ethylene signaling for warm ambient temperature response by activating specific bivalent genes
    1
    1. scibot 13 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724011094
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    CD14 is a decision-maker between Fas-mediated death and inflammation
    1
    1. scibot 04 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724010362
  13. Aug 2024
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Galectin-3 induces pathogenic immunosuppressive macrophages through interaction with TREM2 in lung cancer
    1
    1. scibot 22 Aug 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11321020/
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    Malic enzyme 2 maintains metabolic state and anti-tumor immunity of CD8+ T cells
    1
    1. scibot 22 Aug 2024
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    sciencedirect.com/science/article/pii/S1097276524006191
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability
    1
    1. scibot 21 Aug 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11366124/
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    The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response
    1
    1. scibot 20 Aug 2024
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    sciencedirect.com/science/article/pii/S2211124724009586
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    Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies
    1
    1. scibot 20 Aug 2024
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      DOI: 10.1016/j.chembiol.2024.07.005

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    sciencedirect.com/science/article/pii/S2451945624003076
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    The ribosomal protein L22 binds the MDM4 pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stress
    1
    1. scibot 20 Aug 2024
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    sciencedirect.com/science/article/pii/S2211124724009604
  20. academic.oup.com academic.oup.com
    First Compound Heterozygous Mutations of DMP1 Causing Rare Autosomal Recessive Hypophosphatemic Rickets Type 1
    1
    1. scibot 02 Aug 2024
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      DOI: 10.1210/clinem/dgac640

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    academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgac640/6806102
  21. 52.53.155.43 52.53.155.43
    Supplemental_Materials (1)-html.html
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    1. scibot 02 Aug 2024
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      DOI: 10.2337/figshare.21183496

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    52.53.155.43/d88ad76d933f2aaeca09b3b316a302f76c99bbf1/Supplemental_Materials (1)-html.html
  22. Jul 2024
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer
    2
    1. scibot 31 Jul 2024
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      DOI: 10.1158/2159-8290.CD-23-0539

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      DOI: 10.1158/2159-8290.CD-23-0539

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    ncbi.nlm.nih.gov/pmc/articles/PMC11285331/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration
    1
    1. scibot 24 Jul 2024
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      DOI: 10.1016/j.celrep.2021.109363

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    ncbi.nlm.nih.gov/pmc/articles/PMC8328392/
  25. www.cell.com www.cell.com
    TSPAN4 influences glioblastoma progression through regulating EGFR stability
    1
    1. scibot 16 Jul 2024
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      DOI: 10.1016/j.isci.2024.110417

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    cell.com/iscience/fulltext/S2589-0042(24)01642-0
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    Synthetic lethal CRISPR screen identifies a cancer cell-intrinsic role of PD-L1 in regulation of vulnerability to ferroptosis
    1
    1. scibot 12 Jul 2024
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    sciencedirect.com/science/article/pii/S2211124724008064
  27. www.sciencedirect.com www.sciencedirect.com
    SWI/SNF chromatin remodeling factor BAF60b restrains inflammatory diseases by affecting regulatory T cell migration
    2
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    sciencedirect.com/science/article/pii/S2211124724007873
  28. www.cell.com www.cell.com
    Extracellular vesicles from alveolar macrophages harboring phagocytosed methicillin-resistant Staphylococcus aureus induce necroptosis
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    cell.com/cell-reports/fulltext/S2211-1247(24)00782-4
  29. Jun 2024
  30. elifesciences.org elifesciences.org
    RAPSYN-mediated neddylation of BCR-ABL alternatively determines the fate of Philadelphia chromosome-positive leukemia
    1
    1. scibot 14 Jun 2024
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      DOI: 10.7554/eLife.88375

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    elifesciences.org/articles/88375
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol to test for the formation of ternary protein complexes in vivo or in vitro using a two-step immunoprecipitation approach
    1
    1. scibot 05 Jun 2024
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      DOI: 10.1016/j.xpro.2024.103080

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    ncbi.nlm.nih.gov/pmc/articles/PMC11141244/
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein
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      DOI: 10.1038/s41467-024-49016-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC11143359/
  33. May 2024
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11108982/
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    Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor
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    sciencedirect.com/science/article/pii/S0092867424004483
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    Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer
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    sciencedirect.com/science/article/pii/S2211124724005023
  37. Apr 2024
  38. www.sciencedirect.com www.sciencedirect.com
    25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages
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    sciencedirect.com/science/article/pii/S1074761324001420
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tissue-specific O-GlcNAcylation profiling identifies substrates in translational machinery in Drosophila mushroom body contributing to olfactory learning
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      DOI: 10.7554/eLife.91269

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    ncbi.nlm.nih.gov/pmc/articles/PMC11018347/
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    Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling
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    ncbi.nlm.nih.gov/pmc/articles/PMC11148513/
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    ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion
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    sciencedirect.com/science/article/pii/S0092867424003106
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    Heterogeneity of tethered agonist signaling in adhesion G protein-coupled receptors
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    sciencedirect.com/science/article/pii/S245194562400120X
  43. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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      DOI: 10.1002/1873-3468.14866

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    febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14866
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    Bifunctional transcription factors SlERF.H5 and H7 activate cell wall and repress gibberellin biosynthesis genes in tomato via a conserved motif
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    sciencedirect.com/science/article/pii/S1534580724001746
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome editing of FTR42 improves zebrafish survival against virus infection by enhancing IFN immunity
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      DOI: 10.1016/j.isci.2024.109497

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    ncbi.nlm.nih.gov/pmc/articles/PMC10973201/
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    Cortactin interacts with αDystrobrevin-1 and regulates murine neuromuscular junction morphology
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    Mouse models of human CNTNAP1-associated congenital hypomyelinating neuropathy and genetic restoration of murine neurological deficits
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    Angiotensin II type-2 receptor attenuates liver fibrosis progression by suppressing IRE1α-XBP1 pathway
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    Targeting VCP potentiates immune checkpoint therapy for colorectal cancer
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    Modification of Lysine-260 2-hydroxyisobutyrylation destabilizes ALDH1A1 expression to regulate bladder cancer progression
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  96. www.science.org www.science.org
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    Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy
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    Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping
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    Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A
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    USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase separation potential
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    ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
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    The miR-17∼92 miRNAs promote plasma cell differentiation by suppressing SOCS3-mediated NIK degradation
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    NFYC-37 promotes tumor growth by activating the mevalonate pathway in bladder cancer
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    Clinically Defined Mutations in MEN1 Alter Its Tumor-suppressive Function Through Increased Menin Turnover
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    Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1
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    Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation
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    UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders
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    IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance
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    Heat shock factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat shock response
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    The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy
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    Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway
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    CHD1 promotes sensitivity to Aurora kinase inhibitors by suppressing interaction of AURKA with its coactivator TPX2
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    Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis
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    Tripartite Motif 38 Attenuates Cardiac Fibrosis after Myocardial Infarction by Suppressing TAK1 Activation via TAB2/3 Degradation
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