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pH-induced conformational changes and inhibition of the Lassa virus spike complex

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1. scibot 03 Sep 2025
  
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  DOI: 10.1016/j.chom.2025.07.020
  
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sciencedirect.com/science/article/pii/S1931312825002926
Aug 2025
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Alternatively spliced isoforms of IRF7 differentially regulate interferon expression to tune response to viral infection

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1. scibot 20 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116166
  
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sciencedirect.com/science/article/pii/S2211124725009374
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RNA Pol II inhibition activates cell death independently from the loss of transcription

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1. scibot 19 Aug 2025
  
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  DOI: 10.1016/j.cell.2025.07.034
  
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cell.com/cell/fulltext/S0092-8674(25)00856-6
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Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance

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1. scibot 15 Aug 2025
  
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  DOI: 10.1016/j.immuni.2025.07.013
  
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AND-1 is a critical regulator of R-loop dynamics and a target to overcome endocrine resistance

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1. scibot 13 Aug 2025
  
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  DOI: 10.1126/sciadv.adv2453
  
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Single-stranded DNA-binding proteins are essential components of the architectural LDB1 protein complex

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1. scibot 13 Aug 2025
  
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  DOI: 10.1016/j.molcel.2025.07.012
  
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AND-1 is a critical regulator of R-loop dynamics and a target to overcome endocrine resistance

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1. scibot 12 Aug 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12327453/
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Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia

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1. scibot 10 Aug 2025
  
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  DOI: 10.1016/j.nbd.2025.107024
  
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Zbtb16 determines the fate plasticity of cardiovascular progenitors through IGF2BP3-mediated mRNA stabilization

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1. scibot 08 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116127
  
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Novel roles for the GPI-anchor cleaving enzyme, GDE2, in hippocampal synaptic morphology and function

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1. scibot 06 Aug 2025
  
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  DOI: 10.1523/ENEURO.0102-25.2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12320762/
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Tumor cell-intrinsic Decr2 regulates ferroptosis and immunotherapy efficacy

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1. scibot 05 Aug 2025
  
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  DOI: 10.1158/2326-6066.CIR-24-0519
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12314507/
Jul 2025
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DNA mutagenesis driven by transcription factor competition with mismatch repair

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1. scibot 30 Jul 2025
  
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  DOI: 10.1016/j.cell.2025.07.003
  
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The Hippo pathway kinase MST1 mediates a feedback loop to maintain NLRP3 inflammasome homeostasis

1
1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116076
  
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Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens

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1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116002
  
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sciencedirect.com/science/article/pii/S2211124725007739
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A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients

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1. scibot 15 Jul 2025
  
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  DOI: 10.1038/s41594-025-01610-9
  
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nature.com/articles/s41594-025-01610-9
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Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia

1
1. scibot 08 Jul 2025
  
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  RRID:AB_2572291
  
  DOI: 10.1016/j.nbd.2025.107024
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12320091/
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FTO SUMOylation regulates the differentiation of bone marrow mesenchymal stromal cells in inflammatory bowel disease-induced bone loss

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1. scibot 08 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.115953
  
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CLDN4 palmitoylation promotes hepatic-to-biliary lineage transition and lenvatinib resistance in hepatocellular carcinoma

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1. scibot 01 Jul 2025
  
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  RRID:AB_2572291
  
  DOI: 10.1016/j.xcrm.2025.102208
  
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sciencedirect.com/science/article/pii/S2666379125002812
Jun 2025
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SSB cooperates with METTL16-mediated m6A RNA methylation to promote chemoresistance in colorectal cancer cells

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1. scibot 28 Jun 2025
  
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  RRID:AB_2572291
  
  DOI: 10.1016/j.celrep.2025.115926
  
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sciencedirect.com/science/article/pii/S2211124725006977
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Cingulin is an RNA-binding protein promoting pancreatic cancer through enhancing importin 7-mediated phospho-ERK nuclear translocation

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1. scibot 28 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115925
  
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sciencedirect.com/science/article/pii/S2211124725006965
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SUV39H1-dependent methyl-degron is a critical regulator of skeletal homeostasis

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1. scibot 28 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115910
  
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sciencedirect.com/science/article/pii/S2211124725006813
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Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma

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1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.molcel.2025.05.030
  
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sciencedirect.com/science/article/pii/S1097276525004691
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1. scibot 17 Jun 2025
  
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  DOI: 10.1158/2326-6066.cir-24-0519
  
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52.53.155.43/b476b28c82bb83bd9fe4ec113cb042cd5e05e58b/PDF-html.html
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Piezo1 senses hyphae and initiates host defense against pathogenic fungi

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1. scibot 17 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115839
  
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GPR45 modulates Gαs at primary cilia of the paraventricular hypothalamus to control food intake

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1. scibot 11 Jun 2025
  
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  DOI: 10.1126/science.adp3989
  
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Human genetic variation reveals FCRL3 is a lymphocyte receptor for Yersinia pestis

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.xgen.2025.100917
  
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GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRASG12D-mutant cancer

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115774
  
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Calcium-responsive phosphorylation of SlLHP1b epigenetically suppresses auxin synthesis to control drought-induced flower drop in tomato

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1. scibot 03 Jun 2025
  
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  DOI: 10.1016/j.devcel.2025.05.006
  
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sciencedirect.com/science/article/pii/S1534580725002965
May 2025
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A novel nonsense mutation of the glucocorticoid receptor gene causing glucocorticoid resistance with infertility

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1. scibot 28 May 2025
  
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  DOI: 10.1007/s12020-025-04280-1
  
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link.springer.com/article/10.1007/s12020-025-04280-1
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Astrocytic spermidine insufficiency contributes to enhanced pain sensitivity associated with ApoE4

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1. scibot 21 May 2025
  
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  DOI: 10.1186/s10194-025-02054-8
  
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Integrative characterization of MYC RNA-binding function

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1. scibot 19 May 2025
  
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  DOI: 10.1016/j.xgen.2025.100878
  
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PAF1C-mediated activation of CDK12/13 kinase activity is critical for CTD phosphorylation and transcript elongation

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.molcel.2025.04.012
  
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Mitochondrial CCN1 drives ferroptosis via fatty acid β-oxidation

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.devcel.2025.04.004
  
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KMT2C deficiency drives transdifferentiation of double-negative prostate cancer and confer resistance to AR-targeted therapy

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.ccell.2025.04.002
  
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sciencedirect.com/science/article/pii/S1535610825001394
Apr 2025
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ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition

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1. scibot 24 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.04.004
  
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Combined inhibition of de novo glutathione and nucleotide biosynthesis is synthetically lethal in glioblastoma

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1. scibot 24 Apr 2025
  
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  AB_2572291
  
  DOI: 10.1016/j.celrep.2025.115596
  
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KIF26B promotes bladder cancer progression via activating Wnt/β-catenin signaling in a TRAF2-dependent pathway

1
1. scibot 24 Apr 2025
  
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  RRID:AB_2572291
  
  DOI: 10.1016/j.celrep.2025.115595
  
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Transcriptional regulation by PHGDH drives amyloid pathology in Alzheimer’s disease

1
1. scibot 24 Apr 2025
  
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  DOI: 10.1016/j.cell.2025.03.045
  
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Histone acetyltransferase HAF2 associates with pyruvate dehydrogenase complex to control H3K14ac and H3K23ac in ethylene response

1
1. scibot 19 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115580
  
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Cytosolic cytochrome c represses ferroptosis

1
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  RRID:AB_2572291
  
  DOI: 10.1016/j.cmet.2025.03.014
  
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CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells

1
1. scibot 08 Apr 2025
  
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  DOI: 10.7554/eLife.103417
  
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A nuclear RNA degradation code is recognized by PAXT for eukaryotic transcriptome surveillance

1
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  DOI: 10.1016/j.molcel.2025.03.010
  
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Hypoxia-induced phase separation of ZHX2 alters chromatin looping to drive cancer metastasis

1
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  DOI: 10.1016/j.molcel.2025.03.009
  
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O-GlcNAcylation-mediated endothelial metabolic memory contributes to cardiac damage via small extracellular vesicles

1
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  RRID:AB_2572291
  
  DOI: 10.1016/j.cmet.2025.03.006
  
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FMNL2/SRC-mediated androgen receptor translocation into the nucleus promotes enzalutamide resistance of prostate cancer

1
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  RRID:AB_2572291
  
  DOI: 10.1016/j.isci.2025.112205
  
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Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions

1
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  RRID:AB_2572291
  
  DOI: 10.1016/j.cell.2025.02.021
  
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Mar 2025
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AGO2 mediates immunotherapy failure via suppressing tumor IFN-gamma response-dependent CD8+ T cell immunity

1
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  RRID:AB_2572291
  
  DOI: 10.1016/j.celrep.2025.115445
  
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Phosphatase PHLPP1 is an alveolar-macrophage-intrinsic transcriptional checkpoint controlling pulmonary fibrosis

1
1. scibot 13 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115399
  
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Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy

1
1. scibot 11 Mar 2025
  
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  RRID:AB_2572291
  
  DOI: 10.1016/j.ccell.2025.02.014
  
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Feb 2025
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TFEB/3 govern repair Schwann cell generation and function following peripheral nerve injury

1
1. scibot 27 Feb 2025
  
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  RRID:AB_2572291
  
  DOI: 10.1523/JNEUROSCI.0198-24.2024
  
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Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism

1
1. scibot 27 Feb 2025
  
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  RRID:AB_2572291
  
  DOI: 10.1016/j.cmet.2025.01.016
  
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Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

1
1. scibot 12 Feb 2025
  
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  RRID:AB_2572291
  
  DOI: 10.7554/eLife.92180
  
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USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation

1
1. scibot 08 Feb 2025
  
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  RRID:AB_2572291
  
  DOI: 10.1038/s41467-025-56564-9
  
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Mechano-electrical transduction components TMC1-CIB2 undergo a Ca2+-induced conformational change linked to hearing loss

7
1. scibot 07 Feb 2025
  
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  RRID:AB_2572291
  
  DOI: 10.1016/j.devcel.2025.01.004
  
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2. scibot 06 Feb 2025
  
  in Public
  
  RRID:AB_2572291
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2572291
3. scibot 05 Feb 2025
  
  in Public
  
  RRID:AB_2572291
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2572291
4. scibot 04 Feb 2025
  
  in Public
  
  RRID:AB_2572291
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2572291
5. scibot 03 Feb 2025
  
  in Public
  
  RRID:AB_2572291
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2572291
6. scibot 02 Feb 2025
  
  in Public
  
  RRID:AB_2572291
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2572291
7. scibot 01 Feb 2025
  
  in Public
  
  RRID:AB_2572291
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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sciencedirect.com/science/article/pii/S1534580725000048
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Rhodoquinone carries electrons in the mammalian electron transport chain

1
1. scibot 06 Feb 2025
  
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  RRID:AB_2572291
  
  DOI: 10.1016/j.cell.2024.12.007
  
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52.53.155.43 52.53.155.43

Toxicity of extracellular cGAMP and its analogs to T cells is due to SLC7A1-mediated import

1
1. scibot 06 Feb 2025
  
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  RRID:AB_25722
  
  DOI: 10.1101/2024.09.21.614248
  
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52.53.155.43/5ae47209b7006eb85d3adbe5cd2f83306ecd19fd/2024.09.21.614248.full-html.html
www.science.org www.science.org

Cryo-EM structure and regulation of human NAD kinase

1
1. scibot 04 Feb 2025
  
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  RRID:AB_2572291
  
  DOI: 10.1126/sciadv.ads2664
  
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Jan 2025
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Mechano-electrical transduction components TMC1-CIB2 undergo a Ca2+-induced conformational change linked to hearing loss

1
1. scibot 31 Jan 2025
  
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  RRID:AB_2572291
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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sciencedirect.com/science/article/pii/S1534580725000048
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Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis

1
1. scibot 30 Jan 2025
  
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  Cell Signaling TechnologyCat# 14793
  
  DOI: 10.1016/j.str.2020.03.007
  
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Cryo-EM structure and regulation of human NAD kinase

1
1. scibot 29 Jan 2025
  
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  RRID:AB_2572291
  
  DOI: 10.1126/sciadv.ads2664
  
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1-s2.0-S2589004225001324-main-html.html

1
1. scibot 23 Jan 2025
  
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  AB_2572291
  
  DOI: 10.1016/j.isci.2025.111872
  
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1-s2.0-S2589004225001142-main-html.html

1
1. scibot 23 Jan 2025
  
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  RRID:AB_257229
  
  DOI: 10.1016/j.isci.2025.111854
  
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52.53.155.43/4ba4d4aa1791368b1b3c245d42e19adb8410307c/1-s2.0-S2589004225001142-main-html.html
physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com

Skin disease-associated GJB4 variants differentially influence connexin stability, cell viability and channel function

1
1. scibot 17 Jan 2025
  
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  RRID:AB_2572291
  
  DOI: 10.1113/JP286367
  
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Menin orchestrates macrophage reprogramming to maintain the pulmonary immune homeostasis

1
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  RRID:AB_2572291
  
  DOI: 10.1016/j.celrep.2024.115219
  
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Gut microbiota protect against colorectal tumorigenesis through lncRNA Snhg9

1
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  RRID:AB_2572291
  
  DOI: 10.1016/j.devcel.2024.12.013
  
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Structural insights into the biochemical mechanism of the E2/E3 hybrid enzyme UBE2O

1
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  RRID:AB_2572291
  
  DOI: 10.1016/j.str.2024.12.002
  
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The de novo synthesis of GABA and its gene regulatory function control hepatocellular carcinoma metastasis

1
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  RRID:AB_2572291
  
  DOI: 10.1016/j.devcel.2024.12.007
  
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Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator

1
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  RRID:AB_2572291
  
  DOI: 10.1016/j.chembiol.2024.12.002
  
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Article PDF-html.html

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CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription

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1-s2.0-S2589004224027652-main-html.html

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Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening

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Genetic and microenvironmental evolution of colorectal liver metastases under chemotherapy

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Identification of a non-canonical planar cell polarity pathway triggered by light in the developing mouse retina

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Structure of the TXNL1-bound proteasome

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Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways

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wang-et-al-2024-nuclear-receptor-e75-nr1d2-promotes-tumor-malignant-transformation-by-integrating-hippo-and-notch-html.html

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USP7 deubiquitinates KRAS and promotes non-small cell lung cancer

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Residue Y362 is crucial for FLIPL to impart catalytic activity to pro-caspase-8 to suppress necroptosis

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Cryo-EM Structure of Phospholipase Cε Defines N-terminal Domains and their Roles in Activity

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CircPOLA2 sensitizes non-small cell lung cancer cells to ferroptosis and suppresses tumorigenesis via the Merlin-YAP signaling pathway

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Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity

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LHP1 and INO80 cooperate with ethylene signaling for warm ambient temperature response by activating specific bivalent genes

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CD14 is a decision-maker between Fas-mediated death and inflammation

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Galectin-3 induces pathogenic immunosuppressive macrophages through interaction with TREM2 in lung cancer

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Malic enzyme 2 maintains metabolic state and anti-tumor immunity of CD8+ T cells

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HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability

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The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response

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Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies

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The ribosomal protein L22 binds the MDM4 pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stress

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First Compound Heterozygous Mutations of DMP1 Causing Rare Autosomal Recessive Hypophosphatemic Rickets Type 1

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Supplemental_Materials (1)-html.html

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ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer

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Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration

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TSPAN4 influences glioblastoma progression through regulating EGFR stability

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Synthetic lethal CRISPR screen identifies a cancer cell-intrinsic role of PD-L1 in regulation of vulnerability to ferroptosis

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SWI/SNF chromatin remodeling factor BAF60b restrains inflammatory diseases by affecting regulatory T cell migration

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Extracellular vesicles from alveolar macrophages harboring phagocytosed methicillin-resistant Staphylococcus aureus induce necroptosis

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RAPSYN-mediated neddylation of BCR-ABL alternatively determines the fate of Philadelphia chromosome-positive leukemia

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Protocol to test for the formation of ternary protein complexes in vivo or in vitro using a two-step immunoprecipitation approach

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Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein

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Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors

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Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor

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Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer

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25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages

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Tissue-specific O-GlcNAcylation profiling identifies substrates in translational machinery in Drosophila mushroom body contributing to olfactory learning

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Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling

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ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion

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Heterogeneity of tethered agonist signaling in adhesion G protein-coupled receptors

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Bifunctional transcription factors SlERF.H5 and H7 activate cell wall and repress gibberellin biosynthesis genes in tomato via a conserved motif

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Genome editing of FTR42 improves zebrafish survival against virus infection by enhancing IFN immunity

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Cortactin interacts with αDystrobrevin-1 and regulates murine neuromuscular junction morphology

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MARCH2, a novel oncogene-regulated SNAIL E3 ligase, suppresses triple negative breast cancer metastases

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Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape

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Matrilin-3 supports neuroprotection in ischemic stroke by suppressing astrocyte-mediated neuroinflammation

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Angiotensin II type-2 receptor signaling facilitates liver injury repair and regeneration via inactivation of Hippo pathway

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Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance

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Housekeeping U1 snRNA facilitates antiviral innate immunity by promoting TRIM25-mediated RIG-I activation

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Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome

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Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders

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PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity

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Ethylene-MPK8-ERF.C1-PR module confers resistance against Botrytis cinerea in tomato fruit without compromising ripening

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ATG5 attenuates inflammatory signaling in mouse embryonic stem cells to control differentiation

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Sphingolipid metabolism controls mammalian heart regeneration

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Cell-type-specific expression of tRNAs in the brain regulates cellular homeostasis

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Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma

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A small-molecule degrader selectively inhibits the growth of ALK-rearranged lung cancer with ceritinib resistance

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EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis

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The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs

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Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men

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Osimertinib covalently binds to CD34 and eliminates myeloid leukemia stem/progenitor cells

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Targeting EMSY-mediated methionine metabolism is a potential therapeutic strategy for triple-negative breast cancer

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Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors

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Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity

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CRIP1 involves the pathogenesis of multiple myeloma via dual-regulation of proteasome and autophagy

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Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma

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Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors

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NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance

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Profiling nuclear cysteine ligandability and effects on nuclear localization using proximity labeling-coupled chemoproteomics

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Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase

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Protocol for the production and purification of an i-Motif-specific nanobody

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Rapid cloning-free mutagenesis of new SARS-CoV-2 variants using a novel reverse genetics platform

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SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction

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Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53

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Triggering endogenous Z-RNA sensing for anti-tumor therapy through ZBP1-dependent necroptosis

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Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish

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The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

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ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers

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MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction

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MiniBAR/GARRE1 is a dual Rac and Rab effector required for ciliogenesis

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Mouse models of human CNTNAP1-associated congenital hypomyelinating neuropathy and genetic restoration of murine neurological deficits

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Angiotensin II type-2 receptor attenuates liver fibrosis progression by suppressing IRE1α-XBP1 pathway

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Targeting VCP potentiates immune checkpoint therapy for colorectal cancer

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Modification of Lysine-260 2-hydroxyisobutyrylation destabilizes ALDH1A1 expression to regulate bladder cancer progression

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Blocking oligomerization is the most viable strategy to inhibit STING

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The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

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Vertebrate-class-specific binding modes of the alphavirus receptor MXRA8

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TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2

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Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy

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MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis

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Unannotated microprotein EMBOW regulates the interactome and chromatin and mitotic functions of WDR5

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Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping

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Myeloid BAF60a deficiency alters metabolic homeostasis and exacerbates atherosclerosis

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Enzymolysis-based RNA pull-down identifies YTHDC2 as an inhibitor of antiviral innate response

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Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells

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SARS-CoV-2 Nsp15 suppresses type I interferon production by inhibiting IRF3 phosphorylation and nuclear translocation

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Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A

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PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development

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USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase separation potential

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ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer

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  DOI: 10.1016/j.celrep.2023.112937
  
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2. scibot 10 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112937
  
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The miR-17∼92 miRNAs promote plasma cell differentiation by suppressing SOCS3-mediated NIK degradation

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1. scibot 18 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112968
  
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2. scibot 16 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112968
  
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NFYC-37 promotes tumor growth by activating the mevalonate pathway in bladder cancer

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1. scibot 17 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112963
  
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2. scibot 10 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112963
  
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5-HT1A and 5-HT2B receptor interaction and co-clustering regulate serotonergic neuron excitability. 5-HT receptor cross-talks shape 5-HT neuron activity

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1. scibot 16 Aug 2023
  
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Jul 2023
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Structural basis for membrane-proximal proteolysis of substrates by ADAM10

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1. scibot 29 Jul 2023
  
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Clinically Defined Mutations in MEN1 Alter Its Tumor-suppressive Function Through Increased Menin Turnover

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1. scibot 27 Jul 2023
  
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Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer

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1. scibot 21 Jul 2023
  
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Orphan quality control shapes network dynamics and gene expression

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1. scibot 21 Jul 2023
  
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Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling

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Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1

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1. scibot 06 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112726
  
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Modulation of cellular metabolism by protein crotonylation regulates pancreatic cancer progression

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1. scibot 24 Jun 2023
  
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Quantitative trait and transcriptome analysis of genetic complexity underpinning cardiac interatrial septation in mice using an advanced intercross line

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1. scibot 24 Jun 2023
  
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Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer

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1. scibot 23 Jun 2023
  
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Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation

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1. scibot 21 Jun 2023
  
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UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders

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1. scibot 21 Jun 2023
  
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