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    TSPAN4 influences glioblastoma progression through regulating EGFR stability
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    cell.com/iscience/abstract/S2589-0042(24)01642-0
  3. Jul 2024
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    Synthetic lethal CRISPR screen identifies a cancer cell-intrinsic role of PD-L1 in regulation of vulnerability to ferroptosis
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    SWI/SNF chromatin remodeling factor BAF60b restrains inflammatory diseases by affecting regulatory T cell migration
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    Extracellular vesicles from alveolar macrophages harboring phagocytosed methicillin-resistant Staphylococcus aureus induce necroptosis
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  7. Jun 2024
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    RAPSYN-mediated neddylation of BCR-ABL alternatively determines the fate of Philadelphia chromosome-positive leukemia
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    Protocol to test for the formation of ternary protein complexes in vivo or in vitro using a two-step immunoprecipitation approach
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    Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein
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  11. May 2024
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    Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors
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    Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor
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    Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer
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  15. Apr 2024
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    25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages
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    Tissue-specific O-GlcNAcylation profiling identifies substrates in translational machinery in Drosophila mushroom body contributing to olfactory learning
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    Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling
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    ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion
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    Heterogeneity of tethered agonist signaling in adhesion G protein-coupled receptors
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    Bifunctional transcription factors SlERF.H5 and H7 activate cell wall and repress gibberellin biosynthesis genes in tomato via a conserved motif
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    Genome editing of FTR42 improves zebrafish survival against virus infection by enhancing IFN immunity
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    Cortactin interacts with αDystrobrevin-1 and regulates murine neuromuscular junction morphology
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  25. Mar 2024
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    MARCH2, a novel oncogene-regulated SNAIL E3 ligase, suppresses triple negative breast cancer metastases
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    Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape
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    Matrilin-3 supports neuroprotection in ischemic stroke by suppressing astrocyte-mediated neuroinflammation
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    Angiotensin II type-2 receptor signaling facilitates liver injury repair and regeneration via inactivation of Hippo pathway
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    Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance
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    Housekeeping U1 snRNA facilitates antiviral innate immunity by promoting TRIM25-mediated RIG-I activation
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    Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome
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    Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders
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  34. Feb 2024
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    PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity
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    Ethylene-MPK8-ERF.C1-PR module confers resistance against Botrytis cinerea in tomato fruit without compromising ripening
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    ATG5 attenuates inflammatory signaling in mouse embryonic stem cells to control differentiation
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    Sphingolipid metabolism controls mammalian heart regeneration
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    Cell-type-specific expression of tRNAs in the brain regulates cellular homeostasis
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    Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma
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    A small-molecule degrader selectively inhibits the growth of ALK-rearranged lung cancer with ceritinib resistance
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    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
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    The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs
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    Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men
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    Osimertinib covalently binds to CD34 and eliminates myeloid leukemia stem/progenitor cells
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    Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors
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    NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance
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    MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction
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    ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
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    The miR-17∼92 miRNAs promote plasma cell differentiation by suppressing SOCS3-mediated NIK degradation
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    NFYC-37 promotes tumor growth by activating the mevalonate pathway in bladder cancer
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    Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner
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    Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis
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    Dual Acting Peptides Target EZH2 and AR: a New Paradigm for Effective Treatment of Castration-Resistant Prostate Cancer
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    Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteins
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    Fat body-derived Spz5 remotely facilitates tumor-suppressive cell competition through Toll-6-α-Spectrin axis-mediated Hippo activation
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    Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses
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    Intracellular complement C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesis
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    A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of its bound metabolic mRNAs
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  188. May 2022
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    HIV-1 exploits the Fanconi anemia pathway for viral DNA integration
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    Evidence for reduced BRCA2 functional activity in Homo sapiens after divergence from the chimpanzee-human last common ancestor
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    Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs
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    ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer
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    WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy
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    Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation
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    MiR-205-5p/GGCT attenuates growth and metastasis of papillary thyroid cancer by regulating CD44
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    Targeting HNRNPM inhibits cancer stemness and enhances antitumor immunity in Wnt-activated hepatocellular carcinoma
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    YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth
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    A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells
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    ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression
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    Anti-recombination function of MutSα restricts telomere extension by ALT-associated homology-directed repair
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    Redox-sensitive cyclophilin A elicits chemoresistance through realigning cellular oxidative status in colorectal cancer
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    Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site
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    Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues
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    Mechanistic Insights into COVID-19 by Global Analysis of the SARS-CoV-2 3CLpro Substrate Degradome
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    ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes
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    Effect of Three NR3C1 mutations in Pathogenesis of Pituitary ACTH Adenoma
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    H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity
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  225. Aug 2021
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    YAP regulates alveolar epithelial cell differentiation and AGER via NFIB/KLF5/NKX2-1
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    Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes
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    Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2
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    Compartmentalization-Aided Interaction Screening Reveals Extensive High-Order Complexes within the SARS-CoV-2 Proteome
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