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    Impaired phase separation and nucleolar functions in hiPSC models of SNORD118-related ribosomopathies
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    sciencedirect.com/science/article/pii/S2589004224016559
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    FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition
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    sciencedirect.com/science/article/pii/S2211124724007939
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    Immune Checkpoint Inhibition-related Neuroinflammation Disrupts Cognitive Function
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    biorxiv.org/content/10.1101/2024.07.01.601087v1
  5. Jul 2024
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SETDB1 regulates short interspersed nuclear elements and chromatin loop organization in mouse neural precursor cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11221086/
  7. Jun 2024
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    Memory loss and aberrant neurogenesis in mice exposed to patient anti-N-methyl-d-aspartate receptor antibodies
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    sciencedirect.com/science/article/pii/S001448862400164X
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    Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
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    sciencedirect.com/science/article/pii/S1534580724003277
  10. May 2024
  11. 52.53.155.43 52.53.155.43
    2024.02.25.581951v1.full-html.html
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    Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors
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    sciencedirect.com/science/article/pii/S2211124724005333
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    Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus
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    Metabolic regulator ERRγ governs gastric stem cell differentiation into acid-secreting parietal cells
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    EGF-mediated suppression of cell extrusion during mucosal damage attenuates opportunistic fungal invasion
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  16. 52.53.155.43 52.53.155.43
    Unprocessed Genomic Uracil as a Source of DNA Replication Stress in Cancer Cells
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    Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulation
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    AdipoRon promotes amyloid-β clearance through enhancing autophagy via nuclear GAPDH-induced sirtuin 1 activation in Alzheimer's disease
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  19. Apr 2024
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    Unprocessed genomic uracil as a source of DNA replication stress in cancer cells
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    Numb positively regulates Hedgehog signaling at the ciliary pocket
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    AXL/WRNIP1 mediates replication stress response and promotes therapy resistance and metachronous metastasis in HER2+ breast cancer
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      DOI: 10.1158/0008-5472.CAN-23-1459

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    aacrjournals.org/cancerres/article/84/5/675/734930/AXL-WRNIP1-Mediates-Replication-Stress-Response
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    RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells
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    PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair
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    Selective vulnerability of the ventral hippocampus-prelimbic cortex axis parvalbumin interneuron network underlies learning deficits of fragile X mice
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    A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation
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    Enhanced mitochondrial fusion during a critical period of synaptic plasticity in adult-born neurons
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    The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity
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    sciencedirect.com/science/article/pii/S0092867424002502
  29. Mar 2024
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    Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma
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    sciencedirect.com/science/article/pii/S2666379124001149
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    Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape
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    Metaplastic regeneration in the mouse stomach requires a reactive oxygen species pathway
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    PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA
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    RTF2 controls replication repriming and ribonucleotide excision at the replisome
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    Human cortical neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression
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  36. Feb 2024
  37. www.sciencedirect.com www.sciencedirect.com
    ESCRT-I protein UBAP1 controls ventricular expansion and cortical neurogenesis via modulating adherens junctions of radial glial cells
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    sciencedirect.com/science/article/pii/S2211124724001463
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    A Phase 1 Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-Dose Gemcitabine in Metastatic Pancreatic Adenocarcinoma Patients
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    aacrjournals.org/clincancerres/article/29/24/5047/731678/A-Phase-I-Expansion-Cohort-Study-Evaluating-the
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    Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection
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    Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety
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      DOI: 10.1016/j.immuni.2024.01.018

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    Neonatal brain injury unravels transcriptional and signaling changes underlying the reactivation of cortical progenitors
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    sciencedirect.com/science/article/pii/S2211124724000627
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Temozolomide sensitizes ARID1A-mutated cancers to PARP inhibitors
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      DOI: 10.1158/0008-5472.CAN-22-3646

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    ncbi.nlm.nih.gov/pmc/articles/PMC10527942/
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    SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway
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    Specialized replication mechanisms maintain genome stability at human centromeres
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    RNF4 prevents genomic instability caused by chronic DNA under-replication
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    DNA combing versus DNA spreading and the separation of sister chromatids
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    Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury
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    Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells
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    In silico protein interaction screening uncovers DONSON’s role in replication initiation
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    BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair
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    Silencing dentate newborn neurons alters excitatory/inhibitory balance and impairs behavioral inhibition and flexibility
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    Distinct modes of telomere synthesis and extension contribute to Alternative Lengthening of Telomeres
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    Silencing dentate newborn neurons alters excitatory/inhibitory balance and impairs behavioral inhibition and flexibility
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  55. Dec 2023
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    Ethanol induces replication fork stalling and membrane stress in immortalized laryngeal cells
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    A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling
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    PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition
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    FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination
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    Delayed maturation and migration of excitatory neurons in the juvenile mouse paralaminar amygdala
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    Spatiotemporal transcriptome atlas reveals the regional specification of the developing human brain
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    Lysosomal dynamics regulate mammalian cortical neurogenesis
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    Protocol for lentivirus-mediated delivery of genes to study neurogenesis and cognitive function in adult rodents
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    Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging
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    53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication
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    The role of desmoplakin for neuronal function in the dentate gyrus and anxiety-related behavior
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    Microbial-dependent recruitment of immature myeloid cells promotes intestinal regeneration.
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    Divergent Recruitment of Developmentally-Defined Neuronal Ensembles Supports Memory Dynamics
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    Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma
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  72. Oct 2023
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    Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer
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    Regional Differences in Progenitor Consumption Dynamics Shape Brain Growth during Development
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    Dual-targeting AAV9P1-mediated neuronal reprogramming in a mouse model of traumatic brain injury
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    Astrocytic endothelin-1 overexpression impairs learning and memory ability in ischemic stroke via altered hippocampal neurogenesis and lipid metabolism
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    The splicing factor DHX38 enables retinal development through safeguarding genome integrity
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    ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms
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    Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancer
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    Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis
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  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lmx1a is a master regulator of the cortical hem
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    Ethanol changes Nestin-promoter induced neural stem cells to disturb newborn dendritic spine remodeling in the hippocampus of mice
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    Wound-healing plasticity enables clonal expansion of founder progenitor cells in colitis
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    Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells
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    Social recognition memory differences between mouse strains: On the effects of social isolation, adult neurogenesis, and environmental enrichment
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    Pleiotrophin ameliorates age-induced adult hippocampal neurogenesis decline and cognitive dysfunction
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    Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis
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    Presenilin enhancer2 is critical for the transition of apical progenitors to neurons but not basal progenitors in the developing hippocampus
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    The P-body protein 4E-T represses translation to regulate the balance between cell genesis and establishment of the postnatal NSC pool
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  126. Feb 2023
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    D-2-hydroxyglutarate dehydrogenase governs adult neural stem cell activation and promotes histone acetylation via ATP-citrate lyase
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    Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks
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    SUMOylation of HNRNPA2B1 modulates RPA dynamics during unperturbed replication and genotoxic stress responses
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    The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model
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    Increased replication origin firing links replication stress to whole chromosomal instability in human cancer
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    POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps
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    Glucagon-receptor-antagonism-mediated β-cell regeneration as an effective anti-diabetic therapy
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    BMP4 Exerts Anti-Neurogenic Effect via Inducing Id3 during Aging
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      DOI: 10.3390/biomedicines10051147

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  184. May 2022
  185. www.sciencedirect.com www.sciencedirect.com
    Nde1 is required for heterochromatin compaction and stability in neocortical neurons
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  186. Apr 2022
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    In vivo partial cellular reprogramming enhances liver plasticity and regeneration
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    Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation
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    DNA replication profiling by molecular combing on single DNA fibers
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    Progenitor potential of lung epithelial organoid cells in a transplantation model
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  191. Mar 2022
  192. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Coactivator-associated arginine methyltransferase 1 controls oligodendrocyte differentiation in the corpus callosum during early brain development
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      DOI: 10.1002/dneu.22871

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  193. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Both excitatory and inhibitory neurons transiently form clusters at the outermost region of the developing mammalian cerebral neocortex
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    Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting
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    Glucagon-Like Peptide-2 Stimulates S-Phase Entry of Intestinal Lgr5+ Stem Cells
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    Human cytomegalovirus forms phase-separated compartments at viral genomes to facilitate viral replication
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    SRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewal
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    YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth
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  199. Feb 2022
  200. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    A novel Lgi1 mutation causes white matter abnormalities and impairs motor coordination in mice
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      DOI: 10.1096/fj.202101652R

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    In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration
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  202. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chemogenetic manipulation of microglia inhibits neuroinflammation and neuropathic pain in mice
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  203. Jan 2022
  204. www.sciencedirect.com www.sciencedirect.com
    WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity
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    Adaptive differentiation promotes intestinal villus recovery
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  206. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods
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      DOI: 10.7554/eLife.70685

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  207. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The developmental origins of heterodonty and acrodonty as revealed by reptile dentitions
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      DOI: 10.1126/sciadv.abj7912

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  208. Dec 2021
  209. www.science.org www.science.org
    The developmental origins of heterodonty and acrodonty as revealed by reptile dentitions
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    The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
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  211. Nov 2021
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    The TFAM-to-mtDNA ratio defines inner-cellular nucleoid populations with distinct activity levels
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    DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks
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    Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring
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  215. Oct 2021
  216. link.springer.com link.springer.com
    Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models
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      DOI: 10.1186/s13046-021-02124-0

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  217. link.springer.com link.springer.com
    Tissue-resident M2 macrophages directly contact primary sensory neurons in the sensory ganglia after nerve injury
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    Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells
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  219. Sep 2021
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    Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy
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    Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps
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    Sensitive timing of undifferentiation in oligodendrocyte progenitor cells and their enhanced maturation in primary visual cortex of binocularly enucleated mice
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      DOI: 10.1371/journal.pone.0257395

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    Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis
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    REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps
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    Utilizing mouse optic nerve crush to examine CNS remyelination
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    Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche
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