453 Matching Annotations
  1. Jun 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Memory loss and aberrant neurogenesis in mice exposed to patient anti-N-methyl-d-aspartate receptor antibodies
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    1. scibot 07 Jun 2024
      Abcam, Ab6326

      DOI: 10.1016/j.expneurol.2024.114838

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    sciencedirect.com/science/article/pii/S001448862400164X
  3. www.sciencedirect.com www.sciencedirect.com
    Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
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    1. scibot 04 Jun 2024
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      DOI: 10.1016/j.devcel.2024.05.010

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    sciencedirect.com/science/article/pii/S1534580724003277
  4. May 2024
  5. 52.53.155.43 52.53.155.43
    2024.02.25.581951v1.full-html.html
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    1. scibot 16 May 2024
      RRID:AB_305426

      DOI: 10.1038/nature12362

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    Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors
    1
    1. scibot 16 May 2024
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      DOI: 10.1016/j.celrep.2024.114205

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    sciencedirect.com/science/article/pii/S2211124724005333
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    Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus
    1
    1. scibot 14 May 2024
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      DOI: 10.1016/j.celrep.2024.114226

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    sciencedirect.com/science/article/pii/S2211124724005540
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    Metabolic regulator ERRγ governs gastric stem cell differentiation into acid-secreting parietal cells
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      DOI: 10.1016/j.stem.2024.04.016

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    sciencedirect.com/science/article/pii/S1934590924001437
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    EGF-mediated suppression of cell extrusion during mucosal damage attenuates opportunistic fungal invasion
    1
    1. scibot 13 May 2024
      RRID:AB_305426

      DOI: 10.1016/j.celrep.2021.108896

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    sciencedirect.com/science/article/pii/S2211124721002102
  10. 52.53.155.43 52.53.155.43
    Unprocessed Genomic Uracil as a Source of DNA Replication Stress in Cancer Cells
    1
    1. scibot 10 May 2024
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      DOI: 10.1101/2024.02.05.578390

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  11. www.sciencedirect.com www.sciencedirect.com
    Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulation
    1
    1. scibot 07 May 2024
      AbcamAb6326; RRID: AB_305426

      DOI: 10.1016/j.celrep.2024.114193

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    sciencedirect.com/science/article/pii/S2211124724005217
  12. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    AdipoRon promotes amyloid-β clearance through enhancing autophagy via nuclear GAPDH-induced sirtuin 1 activation in Alzheimer's disease
    1
    1. scibot 03 May 2024
      RRID:AB_305426

      DOI: 10.1111/bph.16400

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16400
  13. Apr 2024
  14. www.sciencedirect.com www.sciencedirect.com
    Unprocessed genomic uracil as a source of DNA replication stress in cancer cells
    1
    1. scibot 30 Apr 2024
      RRID:AB_305426

      DOI: 10.1016/j.molcel.2024.04.004

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    sciencedirect.com/science/article/pii/S109727652400282X
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Numb positively regulates Hedgehog signaling at the ciliary pocket
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    1. scibot 29 Apr 2024
      RRID:AB_305426

      DOI: 10.1038/s41467-024-47244-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11045789/
  16. aacrjournals.org aacrjournals.org
    AXL/WRNIP1 mediates replication stress response and promotes therapy resistance and metachronous metastasis in HER2+ breast cancer
    1
    1. scibot 19 Apr 2024
      RRID:AB_305426

      DOI: 10.1158/0008-5472.CAN-23-1459

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    aacrjournals.org/cancerres/article/84/5/675/734930/AXL-WRNIP1-Mediates-Replication-Stress-Response
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    RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells
    2
    1. scibot 19 Apr 2024
      RRID:AB_305426

      DOI: 10.1016/j.celrep.2024.114116

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      RRID:AB_305426

      DOI: 10.1016/j.celrep.2024.114116

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    sciencedirect.com/science/article/pii/S2211124724004443
  18. www.embopress.org www.embopress.org
    PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair
    1
    1. scibot 18 Apr 2024
      AbcamCat# ab6326

      DOI: 10.1038/s44318-024-00043-2

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    embopress.org/doi/full/10.1038/s44318-024-00043-2
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    Selective vulnerability of the ventral hippocampus-prelimbic cortex axis parvalbumin interneuron network underlies learning deficits of fragile X mice
    1
    1. scibot 18 Apr 2024
      RRID:AB_305426

      DOI: 10.1016/j.celrep.2024.114124

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    sciencedirect.com/science/article/pii/S2211124724004522
  20. www.sciencedirect.com www.sciencedirect.com
    A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation
    1
    1. scibot 09 Apr 2024
      RRID:AB_305426

      DOI: 10.1016/j.celrep.2024.114024

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    sciencedirect.com/science/article/pii/S2211124724003528
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    Enhanced mitochondrial fusion during a critical period of synaptic plasticity in adult-born neurons
    1
    1. scibot 09 Apr 2024
      RRID:AB_305426

      DOI: 10.1016/j.neuron.2024.03.013

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    sciencedirect.com/science/article/pii/S0896627324001673
  22. www.sciencedirect.com www.sciencedirect.com
    The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity
    2
    1. scibot 02 Apr 2024
      RRID:AB_305426

      DOI: 10.1016/j.cell.2024.03.002

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      RRID:AB_305426

      DOI: 10.1016/j.cell.2024.03.002

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    sciencedirect.com/science/article/pii/S0092867424002502
  23. Mar 2024
  24. www.sciencedirect.com www.sciencedirect.com
    Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma
    2
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      RRID:AB_305426

      DOI: 10.1016/j.xcrm.2024.101468

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      DOI: 10.1016/j.xcrm.2024.101468

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    sciencedirect.com/science/article/pii/S2666379124001149
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    Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape
    1
    1. scibot 29 Mar 2024
      AB_305426

      DOI: 10.1016/j.molcel.2024.02.032

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    sciencedirect.com/science/article/pii/S1097276524001758
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    Metaplastic regeneration in the mouse stomach requires a reactive oxygen species pathway
    1
    1. scibot 27 Mar 2024
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    sciencedirect.com/science/article/pii/S1534580724001424
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    PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA
    2
    1. scibot 21 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113930

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      DOI: 10.1016/j.celrep.2024.113930

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    sciencedirect.com/science/article/pii/S2211124724002584
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
    1
    1. scibot 06 Mar 2024
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      DOI: 10.1038/s41467-024-45947-z

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    ncbi.nlm.nih.gov/pmc/articles/PMC10908796/
  29. www.sciencedirect.com www.sciencedirect.com
    Human cortical neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression
    2
    1. scibot 05 Mar 2024
      AB_305426

      DOI: 10.1016/j.neuron.2024.02.005

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    sciencedirect.com/science/article/pii/S0896627324000898
  30. Feb 2024
  31. www.sciencedirect.com www.sciencedirect.com
    ESCRT-I protein UBAP1 controls ventricular expansion and cortical neurogenesis via modulating adherens junctions of radial glial cells
    1
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      DOI: 10.1016/j.celrep.2024.113818

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    sciencedirect.com/science/article/pii/S2211124724001463
  32. aacrjournals.org aacrjournals.org
    A Phase 1 Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-Dose Gemcitabine in Metastatic Pancreatic Adenocarcinoma Patients
    1
    1. scibot 24 Feb 2024
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      DOI: 10.1158/1078-0432.CCR-23-2005

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    aacrjournals.org/clincancerres/article/29/24/5047/731678/A-Phase-I-Expansion-Cohort-Study-Evaluating-the
  33. www.sciencedirect.com www.sciencedirect.com
    Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection
    1
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      DOI: 10.1016/j.celrep.2024.113845

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    sciencedirect.com/science/article/pii/S2211124724001736
  34. www.sciencedirect.com www.sciencedirect.com
    Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety
    1
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      DOI: 10.1016/j.immuni.2024.01.018

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    sciencedirect.com/science/article/pii/S107476132400044X
  35. www.sciencedirect.com www.sciencedirect.com
    Neonatal brain injury unravels transcriptional and signaling changes underlying the reactivation of cortical progenitors
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      DOI: 10.1016/j.celrep.2024.113734

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    sciencedirect.com/science/article/pii/S2211124724000627
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Temozolomide sensitizes ARID1A-mutated cancers to PARP inhibitors
    1
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      DOI: 10.1158/0008-5472.CAN-22-3646

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    ncbi.nlm.nih.gov/pmc/articles/PMC10527942/
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    SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway
    1
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    sciencedirect.com/science/article/pii/S1534580724000443
  38. www.sciencedirect.com www.sciencedirect.com
    Specialized replication mechanisms maintain genome stability at human centromeres
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      DOI: 10.1016/j.molcel.2024.01.018

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    sciencedirect.com/science/article/pii/S1097276524000546
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    RNF4 prevents genomic instability caused by chronic DNA under-replication
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      DOI: 10.1016/j.dnarep.2024.103646

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    sciencedirect.com/science/article/pii/S1568786424000223
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DNA combing versus DNA spreading and the separation of sister chromatids
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      DOI: 10.1083/jcb.202305082

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    ncbi.nlm.nih.gov/pmc/articles/PMC10840220/
  41. www.sciencedirect.com www.sciencedirect.com
    Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury
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      DOI: 10.1016/j.immuni.2024.01.008

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  42. Jan 2024
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    Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells
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    In silico protein interaction screening uncovers DONSON’s role in replication initiation
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    BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair
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    Silencing dentate newborn neurons alters excitatory/inhibitory balance and impairs behavioral inhibition and flexibility
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    Distinct modes of telomere synthesis and extension contribute to Alternative Lengthening of Telomeres
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    Silencing dentate newborn neurons alters excitatory/inhibitory balance and impairs behavioral inhibition and flexibility
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    Ethanol induces replication fork stalling and membrane stress in immortalized laryngeal cells
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    A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling
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    PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition
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    FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination
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    Delayed maturation and migration of excitatory neurons in the juvenile mouse paralaminar amygdala
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    Spatiotemporal transcriptome atlas reveals the regional specification of the developing human brain
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    Lysosomal dynamics regulate mammalian cortical neurogenesis
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    Protocol for lentivirus-mediated delivery of genes to study neurogenesis and cognitive function in adult rodents
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    Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging
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    53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication
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    The role of desmoplakin for neuronal function in the dentate gyrus and anxiety-related behavior
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  62. Nov 2023
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    Microbial-dependent recruitment of immature myeloid cells promotes intestinal regeneration.
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    Divergent Recruitment of Developmentally-Defined Neuronal Ensembles Supports Memory Dynamics
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    Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma
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  66. Oct 2023
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    Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer
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    Regional Differences in Progenitor Consumption Dynamics Shape Brain Growth during Development
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    Dual-targeting AAV9P1-mediated neuronal reprogramming in a mouse model of traumatic brain injury
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    Astrocytic endothelin-1 overexpression impairs learning and memory ability in ischemic stroke via altered hippocampal neurogenesis and lipid metabolism
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    The splicing factor DHX38 enables retinal development through safeguarding genome integrity
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    ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms
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    Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancer
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    Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis
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    Ethanol changes Nestin-promoter induced neural stem cells to disturb newborn dendritic spine remodeling in the hippocampus of mice
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    Wound-healing plasticity enables clonal expansion of founder progenitor cells in colitis
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    Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells
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    Social recognition memory differences between mouse strains: On the effects of social isolation, adult neurogenesis, and environmental enrichment
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    In silico protein interaction screening uncovers DONSON’s role in replication initiation
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    Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging
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    Pleiotrophin ameliorates age-induced adult hippocampal neurogenesis decline and cognitive dysfunction
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    FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress
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    Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis
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    Calcium dynamics at the neural cell primary cilium regulate Hedgehog signaling–dependent neurogenesis in the embryonic neural tube
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    Presenilin enhancer2 is critical for the transition of apical progenitors to neurons but not basal progenitors in the developing hippocampus
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    D-2-hydroxyglutarate dehydrogenase governs adult neural stem cell activation and promotes histone acetylation via ATP-citrate lyase
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    Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks
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    SUMOylation of HNRNPA2B1 modulates RPA dynamics during unperturbed replication and genotoxic stress responses
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    Increased replication origin firing links replication stress to whole chromosomal instability in human cancer
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    POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps
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  182. www.sciencedirect.com www.sciencedirect.com
    Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation
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    DNA replication profiling by molecular combing on single DNA fibers
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    Progenitor potential of lung epithelial organoid cells in a transplantation model
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  185. Mar 2022
  186. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Coactivator-associated arginine methyltransferase 1 controls oligodendrocyte differentiation in the corpus callosum during early brain development
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      DOI: 10.1002/dneu.22871

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  187. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Both excitatory and inhibitory neurons transiently form clusters at the outermost region of the developing mammalian cerebral neocortex
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      DOI: 10.1002/cne.24634

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    Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting
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    Glucagon-Like Peptide-2 Stimulates S-Phase Entry of Intestinal Lgr5+ Stem Cells
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    Human cytomegalovirus forms phase-separated compartments at viral genomes to facilitate viral replication
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    SRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewal
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    YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth
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  193. Feb 2022
  194. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    A novel Lgi1 mutation causes white matter abnormalities and impairs motor coordination in mice
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      DOI: 10.1096/fj.202101652R

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    In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration
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  196. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chemogenetic manipulation of microglia inhibits neuroinflammation and neuropathic pain in mice
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  197. Jan 2022
  198. www.sciencedirect.com www.sciencedirect.com
    WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity
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    Adaptive differentiation promotes intestinal villus recovery
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  200. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods
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  201. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The developmental origins of heterodonty and acrodonty as revealed by reptile dentitions
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      DOI: 10.1126/sciadv.abj7912

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  202. Dec 2021
  203. www.science.org www.science.org
    The developmental origins of heterodonty and acrodonty as revealed by reptile dentitions
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  204. www.sciencedirect.com www.sciencedirect.com
    The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
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  205. Nov 2021
  206. www.sciencedirect.com www.sciencedirect.com
    The TFAM-to-mtDNA ratio defines inner-cellular nucleoid populations with distinct activity levels
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  207. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks
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    Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring
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  209. Oct 2021
  210. link.springer.com link.springer.com
    Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models
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      DOI: 10.1186/s13046-021-02124-0

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  211. link.springer.com link.springer.com
    Tissue-resident M2 macrophages directly contact primary sensory neurons in the sensory ganglia after nerve injury
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    Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells
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    sciencedirect.com/science/article/pii/S1097276521007474
  213. Sep 2021
  214. www.sciencedirect.com www.sciencedirect.com
    Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy
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    sciencedirect.com/science/article/pii/S1934590921003787
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    Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps
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  216. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sensitive timing of undifferentiation in oligodendrocyte progenitor cells and their enhanced maturation in primary visual cortex of binocularly enucleated mice
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      DOI: 10.1371/journal.pone.0257395

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    Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis
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    REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps
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    Utilizing mouse optic nerve crush to examine CNS remyelination
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    Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche
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    Rack1 is essential for corticogenesis by preventing p21-dependent senescence in neural stem cells
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  222. Aug 2021
  223. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Aging impairs the essential contributions of non-glial progenitors to neurorepair in the dorsal telencephalon of the Killifish Nothobranchius furzeri
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      DOI: 10.1111/acel.13464

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    onlinelibrary.wiley.com/doi/full/10.1111/acel.13464
  224. www.sciencedirect.com www.sciencedirect.com
    Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA
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  225. www.nature.com www.nature.com
    Prostaglandin signals from adult germline stem cells delay somatic ageing of Caenorhabditis elegans
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      DOI: 10.1038/s42255-019-0097-9

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    nature.com/articles/s42255-019-0097-9