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  1. Last 7 days
  2. www.cell.com www.cell.com
    YY1-mediated enhancer-promoter communication in the immunoglobulin μ locus is regulated by MSL/MOF recruitment
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    cell.com/cell-reports/abstract/S2211-1247(24)00785-X
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    The COMPASS complex maintains the metastatic capacity imparted by a subpopulation of cells in UPS
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    ncbi.nlm.nih.gov/pmc/articles/PMC11233968/
  4. Jun 2024
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    Hypoxia-induced CTCF promotes EMT in breast cancer
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    Capturing totipotency in human cells through spliceosomal repression
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    sciencedirect.com/science/article/pii/S0092867424005191
  7. May 2024
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    Reduced histone H3K4 trimethylation in oral mucosa of patients with DYT-KMT2B
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    sciencedirect.com/science/article/pii/S1353802024010307
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    A chromatin code for limb segment identity in axolotl limb regeneration
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    XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC11091074/
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    The histone lysine methyltransferase MLL1 regulates the activation and functional specialization of regulatory T cells
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    sciencedirect.com/science/article/pii/S2211124724005503
  12. Apr 2024
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    The chromatin remodeler CHD4 sustains Ewing Sarcoma cell survival by controlling global chromatin architecture
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    aacrjournals.org/cancerres/article/84/2/241/733111/The-Chromatin-Remodeler-CHD4-Sustains-Ewing
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    H2AK119ub1 differentially fine-tunes gene expression by modulating canonical PRC1- and H1-dependent chromatin compaction
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    sciencedirect.com/science/article/pii/S1097276524001369
  15. Mar 2024
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    The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA
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    Deficiency of lncRNA MERRICAL abrogates macrophage chemotaxis and diabetes-associated atherosclerosis
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  18. Feb 2024
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    Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma
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    cell.com/cell-metabolism/abstract/S1550-4131(24)00018-4
  21. 52.53.155.43 52.53.155.43
    bvae029-html.html
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    Locus-level L1 DNA methylation profiling reveals the epigenetic and transcriptional interplay between L1s and their integration sites
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    sciencedirect.com/science/article/pii/S2666979X24000259
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    Histone methylation readers MRG1/2 interact with PIF4 to promote thermomorphogenesis in Arabidopsis
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  24. Jan 2024
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    Spatiotemporal role of SETD2-H3K36me3 in murine pancreatic organogenesis
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    sciencedirect.com/science/article/pii/S2211124724000317
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    Epigenetic regulator RNF20 underlies temporal hierarchy of gene expression to regulate postnatal cardiomyocyte polarization
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    cell.com/cell-reports/abstract/S2211-1247(23)01428-6
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    Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice
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    sciencedirect.com/science/article/pii/S0896627323009340
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    XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells
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    sciencedirect.com/science/article/pii/S0092867423013193
  29. Dec 2023
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    Crosstalk between chromatin and Shavenbaby defines transcriptional output along the Drosophila intestinal stem cell lineage
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    sciencedirect.com/science/article/pii/S2589004223027013
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    KDM5B predicts temozolomide-resistant subclones in glioblastoma
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    Super-enhancers include classical enhancers and facilitators to fully activate gene expression
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  33. Nov 2023
  34. www.biorxiv.org www.biorxiv.org
    ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers
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    biorxiv.org/content/10.1101/2023.10.24.563645v1
  35. Oct 2023
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    Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation
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    sciencedirect.com/science/article/pii/S1934590923003284
  37. Sep 2023
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    Perturbations in 3D genome organization can promote acquired drug resistance
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    Nuclear miR-150 enhances hepatic lipid accumulation by targeting RNA transcripts overlapping the PLIN2 promoter
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    ncbi.nlm.nih.gov/pmc/articles/PMC10509351/
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    Stromal cells-specific retinoic acid determines parturition timing at single-cell and spatial-temporal resolution
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    ncbi.nlm.nih.gov/pmc/articles/PMC10502414/
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    SMYD2 regulates vascular smooth muscle cell phenotypic switching and intimal hyperplasia via interaction with myocardin
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      DOI: 10.1007/s00018-023-04883-9

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    link.springer.com/article/10.1007/s00018-023-04883-9
  42. Aug 2023
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    Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function
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    52.53.155.43/464fcb14db36fa0ad68672734eea21dbff7f105c/PIIS2211124723009257-html.html
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone variants shape chromatin states in Arabidopsis
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      DOI: 10.7554/eLife.87714

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    ncbi.nlm.nih.gov/pmc/articles/PMC10393023/
  45. Jul 2023
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    The default and directed pathways of hepatoblast differentiation involve distinct epigenomic mechanisms
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    sciencedirect.com/science/article/abs/pii/S1534580723003325
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    TONSOKU is required for the maintenance of repressive chromatin modifications in Arabidopsis
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    sciencedirect.com/science/article/pii/S2211124723007490
  48. Jun 2023
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    Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation
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    sciencedirect.com/science/article/pii/S2211124723005892
  50. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Mesenchymal stem cells overexpressing heme oxygenase-1 ameliorate lipopolysaccharide-induced acute lung injury in rats
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      DOI: 10.1002/jcp.27488

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    onlinelibrary.wiley.com/doi/10.1002/jcp.27488
  51. May 2023
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYCOBACTERIUM MANRESENSIS INDUCES TRAINED IMMUNITY IN VITRO
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    ncbi.nlm.nih.gov/pmc/articles/PMC10182650/
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    Chemical-induced epigenome resetting for regeneration program activation in human cells
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    sciencedirect.com/science/article/pii/S2211124723005582
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    Mechanical pressure-induced dedifferentiation of myofibroblasts inhibits scarring via SMYD3/ITGBL1 signaling
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    sciencedirect.com/science/article/pii/S1534580723001909
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    Co-transcriptional genome surveillance by HUSH is coupled to termination machinery
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    Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells
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    SMYD2 Regulates Vascular Smooth Muscle Cell Phenotypic Switching and Intimal Hyperplasia via Interaction with Myocardin
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  58. Apr 2023
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    ERCC6L2 mitigates replication stress and promotes centromere stability
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  60. 52.53.155.43 52.53.155.43
    Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B cell fate decisions and yields T cell-depleted lymphomas
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  61. Mar 2023
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 Stabilization and Chromatin Condensation
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    TRIM28 represses renal cell carcinoma cell proliferation by inhibiting TFE3/KDM6A-regulated autophagy
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  64. Feb 2023
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    Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice
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    Decorating chromatin for enhanced genome editing using CRISPR-Cas9
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  67. Jan 2023
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    Principles of 3D chromosome folding and evolutionary genome reshuffling in mammals
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    BRPF1 bridges H3K4me3 and H3K23ac in human ESCs and is essential to pluripotency
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    Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes
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  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MOZ and Menin-MLL Complexes are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor
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  72. Dec 2022
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    Hypoxia induces transgenerational epigenetic inheritance of small RNAs
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    KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition
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  75. Nov 2022
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mcm2 promotes stem cell differentiation via its ability to bind H3-H4
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    Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia
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  78. www.science.org www.science.org
    FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ
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      DOI: 10.1126/sciadv.abq4831

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  79. 52.53.155.43 52.53.155.43
    Loss of the Ash2l subunit of histone H3K4 methyltransferase complexes promotes chromatin compaction at promoters
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  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FOXR2 is an epigenetically regulated pan-cancer oncogene that activates ETS transcriptional circuits
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  81. Oct 2022
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    FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ
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    Deficiency of peroxisomal NUDT7 stimulates de novo lipogenesis in hepatocytes
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    Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infection
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  85. Sep 2022
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    Histone H1 regulates non-coding RNA turnover on chromatin in a m6A-dependent manner
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    Coronatine Enhances Chilling Tolerance of Tomato Plants by Inducing Chilling-Related Epigenetic Adaptations and Transcriptional Reprogramming
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    Methionine metabolism controls the B cell EBV epigenome and viral latency
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  89. Aug 2022
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    Repeat-based holocentromeres influence genome architecture and karyotype evolution
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  91. Jul 2022
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    Induction of senescence upon loss of the Ash2l core subunit of H3K4 methyltransferase complexes
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    Inhibition of DYRK1A, via histone modification, promotes cardiomyocyte cell cycle activation and cardiac repair after myocardial infarction
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  94. Jun 2022
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    An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma
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    Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells
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    MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines
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    Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes
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  100. May 2022
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    Binary outcomes of enhancer activity underlie stable random monoallelic expression
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    Feedback from nuclear RNA on transcription promotes robust RNA concentration homeostasis in human cells
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    Alcohol induced increases in sperm Histone H3 lysine 4 trimethylation correlate with increased placental CTCF occupancy and altered developmental programming
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    Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging
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  105. Apr 2022
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    H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ
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    Single-cell profiling of transcriptome and histone modifications with EpiDamID
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    MUC1-C Dictates JUN and BAF-mediated Chromatin Remodeling at Enhancer Signatures in Cancer Stem Cells
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    PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade
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    MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape
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    Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages
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    The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation
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    In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration
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    ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder
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    Opioid receptor signaling suppresses leukemia through both catalytic and non-catalytic functions of TET2
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    SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers
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    Single-cell-resolved dynamics of chromatin architecture delineate cell and regulatory states in zebrafish embryos
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    DOCK8-expressing T follicular helper cells newly generated beyond self-organized criticality cause systemic lupus erythematosus
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    SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity
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    Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts
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    Reprogramming of H3K9bhb at regulatory elements is a key feature of fasting in the small intestine
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    An epigenetic mechanism underlying chromosome 17p deletion-driven tumorigenesis
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    NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain
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  133. Sep 2021
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    Comparison of Histone H3K4me3 between IVF and ICSI Technologies and between Boy and Girl Offspring
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    Parallel Reporter Assays Identify Altered Regulatory Role of rs684232 in Leading to Prostate Cancer Predisposition
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    Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency
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    Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules
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    KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance
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    Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance
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    Examining the Roles of H3K4 Methylation States with Systematically Characterized Antibodies
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    A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers
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    Combinatorial Targeting by MicroRNAs Co-ordinates Post-transcriptional Control of EMT
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    Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency
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    A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis.
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    Retinoid X Receptor Activation Alters the Chromatin Landscape To Commit Mesenchymal Stem Cells to the Adipose Lineage
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    Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity
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    Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy
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    DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity
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    A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing
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    Methylation of histone H3 at lysine 37 by Set1 and Set2 prevents spurious DNA replication
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    Opposing Effects of Cohesin and Transcription on CTCF Organization Revealed by Super-resolution Imaging
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    PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells
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    Robust Hi-C Maps of Enhancer-Promoter Interactions Reveal the Function of Non-coding Genome in Neural Development and Diseases
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    The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation
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    Folding Keratin Gene Clusters during Skin Regional Specification
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    The chromatin-remodeling protein BAF60/SWP73A regulates the plant immune receptor NLRs
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    MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23
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    Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation
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    Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation
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    Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use
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    A unique histone 3 lysine 14 chromatin signature underlies tissue-specific gene regulation
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    Chromatin Organization in Early Land Plants Reveals an Ancestral Association between H3K27me3, Transposons, and Constitutive Heterochromatin
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    Bookmarking by Non-pioneer Transcription Factors during Liver Development Establishes Competence for Future Gene Activation
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    Generation of PRMT6 homozygous knockout human embryonic stem cell lines
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    Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation
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    G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program
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    Prior Hypoxia Exposure Enhances Murine Microglial Inflammatory Gene Expression in vitro Without Concomitant H3K4me3 Enrichment
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    PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment
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  186. Oct 2020
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    Epigenetic Mechanisms Contribute to Evolutionary Adaptation of Gene Network Activity under Environmental Selection
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    Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma
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    DUX-miR-344-ZMYM2-Mediated Activation of MERVL LTRs Induces a Totipotent 2C-like State
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    MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells
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    Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis
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    The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair
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    p53 Integrates Temporal WDR5 Inputs during Neuroectoderm and Mesoderm Differentiation of Mouse Embryonic Stem Cells
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    Regulated Proteolysis of MutSγ Controls Meiotic Crossing Over
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    MicroRNA-9 Fine-Tunes Dendritic Cell Function by Suppressing Negative Regulators in a Cell-Type-Specific Manner
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    Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer
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    Chromatin Organization in Early Land Plants Reveals an Ancestral Association between H3K27me3, Transposons, and Constitutive Heterochromatin
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    The Dm-Myb Oncoprotein Contributes to Insulator Function and Stabilizes Repressive H3K27me3 PcG Domains
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    Bookmarking by Non-pioneer Transcription Factors during Liver Development Establishes Competence for Future Gene Activation
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    Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming
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    The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair
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    The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability
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    The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes
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    Native Chromatin Proteomics Reveals a Role for Specific Nucleoporins in Heterochromatin Organization and Maintenance
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    Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs
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    Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG
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    Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons
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    TrxG Complex Catalytic and Non-catalytic Activity Play Distinct Roles in Pancreas Progenitor Specification and Differentiation
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    DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns
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    Enhanced Anti-lymphoma Activity of CAR19-iNKT Cells Underpinned by Dual CD19 and CD1d Targeting
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