238 Matching Annotations
  1. Apr 2024
  2. aacrjournals.org aacrjournals.org
    The chromatin remodeler CHD4 sustains Ewing Sarcoma cell survival by controlling global chromatin architecture
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    1. scibot 19 Apr 2024
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      DOI: 10.1158/0008-5472.CAN-22-3950

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    aacrjournals.org/cancerres/article/84/2/241/733111/The-Chromatin-Remodeler-CHD4-Sustains-Ewing
  3. www.sciencedirect.com www.sciencedirect.com
    H2AK119ub1 differentially fine-tunes gene expression by modulating canonical PRC1- and H1-dependent chromatin compaction
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    sciencedirect.com/science/article/pii/S1097276524001369
  4. Mar 2024
  5. www.sciencedirect.com www.sciencedirect.com
    The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA
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      DOI: 10.1016/j.devcel.2024.02.008

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    sciencedirect.com/science/article/pii/S1534580724001072
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    Deficiency of lncRNA MERRICAL abrogates macrophage chemotaxis and diabetes-associated atherosclerosis
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      DOI: 10.1016/j.celrep.2024.113815

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    sciencedirect.com/science/article/pii/S2211124724001438
  7. Feb 2024
  8. 52.53.155.43 52.53.155.43
    241-html.html
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    1. scibot 23 Feb 2024
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    52.53.155.43/ef1c2343cba3a29438101d6931686796493196a8/241-html.html
  9. www.cell.com www.cell.com
    Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma
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      DOI: 10.1016/j.cmet.2024.01.018

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    cell.com/cell-metabolism/abstract/S1550-4131(24)00018-4
  10. 52.53.155.43 52.53.155.43
    bvae029-html.html
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      DOI: 10.1210/jendso/bvae029

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    52.53.155.43/91f4741c570f637c33beb2463bb95c19a65c82ea/bvae029-html.html
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    Locus-level L1 DNA methylation profiling reveals the epigenetic and transcriptional interplay between L1s and their integration sites
    1
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      DOI: 10.1016/j.xgen.2024.100498

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    sciencedirect.com/science/article/pii/S2666979X24000259
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    Histone methylation readers MRG1/2 interact with PIF4 to promote thermomorphogenesis in Arabidopsis
    1
    1. scibot 06 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113726

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    sciencedirect.com/science/article/pii/S2211124724000548
  13. Jan 2024
  14. www.sciencedirect.com www.sciencedirect.com
    Spatiotemporal role of SETD2-H3K36me3 in murine pancreatic organogenesis
    1
    1. scibot 25 Jan 2024
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    sciencedirect.com/science/article/pii/S2211124724000317
  15. www.cell.com www.cell.com
    Epigenetic regulator RNF20 underlies temporal hierarchy of gene expression to regulate postnatal cardiomyocyte polarization
    1
    1. scibot 25 Jan 2024
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      DOI: 10.1016/j.celrep.2023.113416

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    cell.com/cell-reports/abstract/S2211-1247(23)01428-6
  16. www.sciencedirect.com www.sciencedirect.com
    Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice
    1
    1. scibot 19 Jan 2024
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      DOI: 10.1016/j.neuron.2023.12.004

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    sciencedirect.com/science/article/pii/S0896627323009340
  17. www.sciencedirect.com www.sciencedirect.com
    XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells
    1
    1. scibot 05 Jan 2024
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      DOI: 10.1016/j.cell.2023.11.033

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    sciencedirect.com/science/article/pii/S0092867423013193
  18. Dec 2023
  19. www.sciencedirect.com www.sciencedirect.com
    Crosstalk between chromatin and Shavenbaby defines transcriptional output along the Drosophila intestinal stem cell lineage
    1
    1. scibot 20 Dec 2023
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      DOI: 10.1016/j.isci.2023.108624

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    sciencedirect.com/science/article/pii/S2589004223027013
  20. www.sciencedirect.com www.sciencedirect.com
    KDM5B predicts temozolomide-resistant subclones in glioblastoma
    1
    1. scibot 20 Dec 2023
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      DOI: 10.1016/j.isci.2023.108596

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    sciencedirect.com/science/article/pii/S2589004223026731
  21. www.sciencedirect.com www.sciencedirect.com
    Super-enhancers include classical enhancers and facilitators to fully activate gene expression
    1
    1. scibot 16 Dec 2023
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      DOI: 10.1016/j.cell.2023.11.030

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    sciencedirect.com/science/article/pii/S0092867423013168
  22. Nov 2023
  23. www.biorxiv.org www.biorxiv.org
    ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers
    1
    1. scibot 03 Nov 2023
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      DOI: 10.1101/2023.10.24.563645

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    biorxiv.org/content/10.1101/2023.10.24.563645v1
  24. Oct 2023
  25. www.sciencedirect.com www.sciencedirect.com
    Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation
    1
    1. scibot 28 Oct 2023
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      DOI: 10.1016/j.stem.2023.09.007

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    sciencedirect.com/science/article/pii/S1934590923003284
  26. Sep 2023
  27. www.sciencedirect.com www.sciencedirect.com
    Perturbations in 3D genome organization can promote acquired drug resistance
    1
    1. scibot 30 Sep 2023
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      DOI: 10.1016/j.celrep.2023.113124

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    sciencedirect.com/science/article/pii/S2211124723011361
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nuclear miR-150 enhances hepatic lipid accumulation by targeting RNA transcripts overlapping the PLIN2 promoter
    1
    1. scibot 23 Sep 2023
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      DOI: 10.1016/j.isci.2023.107837

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    ncbi.nlm.nih.gov/pmc/articles/PMC10509351/
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stromal cells-specific retinoic acid determines parturition timing at single-cell and spatial-temporal resolution
    1
    1. scibot 20 Sep 2023
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      DOI: 10.1016/j.isci.2023.107796

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    ncbi.nlm.nih.gov/pmc/articles/PMC10502414/
  30. link.springer.com link.springer.com
    SMYD2 regulates vascular smooth muscle cell phenotypic switching and intimal hyperplasia via interaction with myocardin
    1
    1. scibot 07 Sep 2023
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      DOI: 10.1007/s00018-023-04883-9

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    link.springer.com/article/10.1007/s00018-023-04883-9
  31. Aug 2023
  32. 52.53.155.43 52.53.155.43
    Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function
    2
    1. scibot 18 Aug 2023
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      DOI: 10.1016/j.celrep.2023.112914

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      DOI: 10.1016/j.celrep.2023.112914

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    52.53.155.43/464fcb14db36fa0ad68672734eea21dbff7f105c/PIIS2211124723009257-html.html
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone variants shape chromatin states in Arabidopsis
    1
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      DOI: 10.7554/eLife.87714

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    ncbi.nlm.nih.gov/pmc/articles/PMC10393023/
  34. Jul 2023
  35. www.sciencedirect.com www.sciencedirect.com
    The default and directed pathways of hepatoblast differentiation involve distinct epigenomic mechanisms
    1
    1. scibot 27 Jul 2023
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      DOI: 10.1016/j.devcel.2023.07.002

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    sciencedirect.com/science/article/abs/pii/S1534580723003325
  36. www.sciencedirect.com www.sciencedirect.com
    TONSOKU is required for the maintenance of repressive chromatin modifications in Arabidopsis
    1
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      DOI: 10.1016/j.celrep.2023.112738

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    sciencedirect.com/science/article/pii/S2211124723007490
  37. Jun 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation
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      DOI: 10.1016/j.celrep.2023.112578

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    sciencedirect.com/science/article/pii/S2211124723005892
  39. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Mesenchymal stem cells overexpressing heme oxygenase-1 ameliorate lipopolysaccharide-induced acute lung injury in rats
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    1. scibot 01 Jun 2023
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      DOI: 10.1002/jcp.27488

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    onlinelibrary.wiley.com/doi/10.1002/jcp.27488
  40. May 2023
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYCOBACTERIUM MANRESENSIS INDUCES TRAINED IMMUNITY IN VITRO
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      DOI: 10.1016/j.isci.2023.106873

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    ncbi.nlm.nih.gov/pmc/articles/PMC10182650/
  42. www.sciencedirect.com www.sciencedirect.com
    Chemical-induced epigenome resetting for regeneration program activation in human cells
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      DOI: 10.1016/j.celrep.2023.112547

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    sciencedirect.com/science/article/pii/S2211124723005582
  43. www.sciencedirect.com www.sciencedirect.com
    Mechanical pressure-induced dedifferentiation of myofibroblasts inhibits scarring via SMYD3/ITGBL1 signaling
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      DOI: 10.1016/j.devcel.2023.04.014

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    sciencedirect.com/science/article/pii/S1534580723001909
  44. www.sciencedirect.com www.sciencedirect.com
    Co-transcriptional genome surveillance by HUSH is coupled to termination machinery
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      DOI: 10.1016/j.molcel.2023.04.014

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    sciencedirect.com/science/article/pii/S109727652300285X
  45. www.nature.com www.nature.com
    Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells
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      DOI: 10.1038/s41467-023-38316-9

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    nature.com/articles/s41467-023-38316-9
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SMYD2 Regulates Vascular Smooth Muscle Cell Phenotypic Switching and Intimal Hyperplasia via Interaction with Myocardin
    1
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      DOI: 10.21203/rs.3.rs-2721176/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10120764/
  47. Apr 2023
  48. www.sciencedirect.com www.sciencedirect.com
    ERCC6L2 mitigates replication stress and promotes centromere stability
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      DOI: 10.1016/j.celrep.2023.112329

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    sciencedirect.com/science/article/pii/S2211124723003406
  49. 52.53.155.43 52.53.155.43
    Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B cell fate decisions and yields T cell-depleted lymphomas
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      DOI: 10.1101/2023.02.13.528351

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    52.53.155.43/f4b0048cc7a871a681c39b83d20e963f1e4d0c2b/2023.02.13.528351v1.full-html.html
  50. Mar 2023
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 Stabilization and Chromatin Condensation
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      DOI: 10.1158/2767-9764.CRC-22-0255

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    ncbi.nlm.nih.gov/pmc/articles/PMC9949381/
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    TRIM28 represses renal cell carcinoma cell proliferation by inhibiting TFE3/KDM6A-regulated autophagy
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      DOI: 10.1016/j.jbc.2023.104621

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    sciencedirect.com/science/article/pii/S0021925823002636
  53. Feb 2023
  54. www.sciencedirect.com www.sciencedirect.com
    Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice
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      DOI: 10.1016/j.cell.2022.12.047

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    sciencedirect.com/science/article/pii/S0092867422016300
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  56. Jan 2023
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    Principles of 3D chromosome folding and evolutionary genome reshuffling in mammals
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    BRPF1 bridges H3K4me3 and H3K23ac in human ESCs and is essential to pluripotency
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    Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes
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    MOZ and Menin-MLL Complexes are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor
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  61. Dec 2022
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    Hypoxia induces transgenerational epigenetic inheritance of small RNAs
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    KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition
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  64. Nov 2022
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    Mcm2 promotes stem cell differentiation via its ability to bind H3-H4
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    Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia
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    FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ
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    Loss of the Ash2l subunit of histone H3K4 methyltransferase complexes promotes chromatin compaction at promoters
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    FOXR2 is an epigenetically regulated pan-cancer oncogene that activates ETS transcriptional circuits
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  70. Oct 2022
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    FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ
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    Deficiency of peroxisomal NUDT7 stimulates de novo lipogenesis in hepatocytes
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    Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infection
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  74. Sep 2022
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    Histone H1 regulates non-coding RNA turnover on chromatin in a m6A-dependent manner
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    Coronatine Enhances Chilling Tolerance of Tomato Plants by Inducing Chilling-Related Epigenetic Adaptations and Transcriptional Reprogramming
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    Methionine metabolism controls the B cell EBV epigenome and viral latency
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  78. Aug 2022
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    Repeat-based holocentromeres influence genome architecture and karyotype evolution
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  80. Jul 2022
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    Induction of senescence upon loss of the Ash2l core subunit of H3K4 methyltransferase complexes
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    Inhibition of DYRK1A, via histone modification, promotes cardiomyocyte cell cycle activation and cardiac repair after myocardial infarction
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  83. Jun 2022
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    An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma
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    Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells
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    MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines
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    Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes
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  89. May 2022
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    Binary outcomes of enhancer activity underlie stable random monoallelic expression
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    Alcohol induced increases in sperm Histone H3 lysine 4 trimethylation correlate with increased placental CTCF occupancy and altered developmental programming
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    Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging
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  94. Apr 2022
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    H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ
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    Single-cell profiling of transcriptome and histone modifications with EpiDamID
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    MUC1-C Dictates JUN and BAF-mediated Chromatin Remodeling at Enhancer Signatures in Cancer Stem Cells
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  98. Mar 2022
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    PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade
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    MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape
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    Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages
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  102. Feb 2022
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    The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation
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    In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration
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  105. Jan 2022
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    ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder
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      DOI: 10.1016/j.neuron.2021.12.035

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    Parallel Reporter Assays Identify Altered Regulatory Role of rs684232 in Leading to Prostate Cancer Predisposition
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    Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency
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    Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules
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    KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance
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    Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance
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    A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis.
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    Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy
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    DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity
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    Methylation of histone H3 at lysine 37 by Set1 and Set2 prevents spurious DNA replication
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    Opposing Effects of Cohesin and Transcription on CTCF Organization Revealed by Super-resolution Imaging
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    PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells
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    The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation
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    MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23
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    Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation
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    Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use
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    Chromatin Organization in Early Land Plants Reveals an Ancestral Association between H3K27me3, Transposons, and Constitutive Heterochromatin
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    Bookmarking by Non-pioneer Transcription Factors during Liver Development Establishes Competence for Future Gene Activation
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    Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation
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    G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program
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    Prior Hypoxia Exposure Enhances Murine Microglial Inflammatory Gene Expression in vitro Without Concomitant H3K4me3 Enrichment
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    Epigenetic Mechanisms Contribute to Evolutionary Adaptation of Gene Network Activity under Environmental Selection
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    DUX-miR-344-ZMYM2-Mediated Activation of MERVL LTRs Induces a Totipotent 2C-like State
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    MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells
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    Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis
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    The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair
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    p53 Integrates Temporal WDR5 Inputs during Neuroectoderm and Mesoderm Differentiation of Mouse Embryonic Stem Cells
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    Regulated Proteolysis of MutSγ Controls Meiotic Crossing Over
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    Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer
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    Chromatin Organization in Early Land Plants Reveals an Ancestral Association between H3K27me3, Transposons, and Constitutive Heterochromatin
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    Bookmarking by Non-pioneer Transcription Factors during Liver Development Establishes Competence for Future Gene Activation
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    KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer
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    Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming
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    The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis
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    The TGFB2-AS1 lncRNA Regulates TGF-β Signaling by Modulating Corepressor Activity
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    An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer
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    A Role for FACT in RNA Polymerase II Promoter-Proximal Pausing
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    DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation
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    The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair
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    Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs
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    Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG
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    Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons
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    TrxG Complex Catalytic and Non-catalytic Activity Play Distinct Roles in Pancreas Progenitor Specification and Differentiation
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    DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns
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    Enhanced Anti-lymphoma Activity of CAR19-iNKT Cells Underpinned by Dual CD19 and CD1d Targeting
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    Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells
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    The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands
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    MEF2B Instructs Germinal Center Development and Acts as an Oncogene in B Cell Lymphomagenesis
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    The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially Organizes Megabase Distant Genes in the Developing Forebrain
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    Transcription Elongation Can Affect Genome 3D Structure
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    A Chromatin Basis for Cell Lineage and Disease Risk in the Human Pancreas
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    Architectural Proteins and Pluripotency Factors Cooperate to Orchestrate the Transcriptional Response of hESCs to Temperature Stress
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    Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module
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