272 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Maternally inherited siRNAs initiate piRNA cluster formation
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    pmc.ncbi.nlm.nih.gov/articles/PMC10846595/
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    Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging
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    sciencedirect.com/science/article/pii/S0092867424012017
  4. Nov 2024
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    Acute multi-level response to defective de novo chromatin assembly in S-phase
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    sciencedirect.com/science/article/pii/S1097276524008633
  6. Oct 2024
  7. aacrjournals.org aacrjournals.org
    H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
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      DOI: 10.1158/2159-8290.CD-20-0461

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    aacrjournals.org/cancerdiscovery/article/10/12/1968/2414/H3-3-G34W-Promotes-Growth-and-Impedes
  8. Sep 2024
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    Metformin decelerates aging clock in male monkeys
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    sciencedirect.com/science/article/pii/S0092867424009140
  10. Aug 2024
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    Genome access is transcription factor-specific and defined by nucleosome position
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    sciencedirect.com/science/article/pii/S1097276524006634
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    Artificially inserted strong promoter containing multiple G-quadruplexes induces long-range chromatin modification
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      DOI: 10.7554/eLife.96216

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    ncbi.nlm.nih.gov/pmc/articles/PMC11333042/
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    Reorganization of H3K9me heterochromatin leads to neuronal impairment via the cascading destruction of the KDM3B-centered epigenomic network
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    sciencedirect.com/science/article/pii/S2589004224016055
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    Nucleosome remodeler exclusion by histone deacetylation enforces heterochromatic silencing and epigenetic inheritance
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    sciencedirect.com/science/article/pii/S1097276524005823
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    Sphingomyelin Synthase 2 Inhibition Ameliorates Cerebral Ischemic Reperfusion Injury Through Reducing the Recruitment of Toll‐Like Receptor 4 to Lipid Rafts
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    ahajournals.org/doi/abs/10.1161/JAHA.119.012885
  16. Jul 2024
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    TERT activation targets DNA methylation and multiple aging hallmarks
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    Systematic dissection of sequence features affecting binding specificity of a pioneer factor reveals binding synergy between FOXA1 and AP-1
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  19. www.cell.com www.cell.com
    TULIPs decorate the three-dimensional genome of PFA ependymoma
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    cell.com/cell/abstract/S0092-8674(24)00697-4
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SETDB1 regulates short interspersed nuclear elements and chromatin loop organization in mouse neural precursor cells
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  21. Jun 2024
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    An enhancer RNA recruits KMT2A to regulate transcription of Myb
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    The role of JMJD2A in immune evasion and malignant behavior of esophageal squamous cell carcinoma
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    sciencedirect.com/science/article/pii/S1567576924009214
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    Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease
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    link.springer.com/article/10.1038/s41594-024-01320-8
  25. May 2024
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    Heterochromatic 3D genome organization is directed by HP1a- and H3K9-dependent and independent mechanisms
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  27. 52.53.155.43 52.53.155.43
    2024.02.25.581951v1.full-html.html
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  28. Apr 2024
  29. rupress.org rupress.org
    Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization
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    SAFB restricts contact domain boundaries associated with L1 chimeric transcription
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    Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer
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    sciencedirect.com/science/article/pii/S1535610824000904
  32. Mar 2024
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    Mitotic chromosomes are self-entangled and disentangle through a topoisomerase-II-dependent two-stage exit from mitosis
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  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Engineered FSHD mutations results in D4Z4 heterochromatin disruption and feedforward DUX4 network activation
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    The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA
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    sciencedirect.com/science/article/pii/S1534580724001072
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    ApoE maintains neuronal integrity via miRNA and H3K27me3-mediated repression.
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    sciencedirect.com/science/article/pii/S2589004224004528
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    Cellular senescence is associated with the spatial evolution toward a higher metastatic phenotype in colorectal cancer
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    sciencedirect.com/science/article/pii/S2211124724002407
  38. Feb 2024
  39. www.cell.com www.cell.com
    Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma
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    cell.com/cell-metabolism/abstract/S1550-4131(24)00018-4
  40. 52.53.155.43 52.53.155.43
    The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells
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    52.53.155.43/d532629e4f1cf755a6f5c302a21018f2c97350c4/reisbeck-et-al-2023-the-iron-chelator-and-oxphos-inhibitor-vlx600-induces-mitophagy-and-an-autophagy-dependent-type-of (1)-html.html
  41. journals.physiology.org journals.physiology.org
    The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells
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    journals.physiology.org/doi/10.1152/ajpcell.00293.2023
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    FOXA1 forms biomolecular condensates that unpack condensed chromatin to function as a pioneer factor
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    sciencedirect.com/science/article/abs/pii/S1097276523009656
  43. Jan 2024
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    PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression
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      DOI: 10.1016/j.devcel.2023.12.015

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    sciencedirect.com/science/article/pii/S1534580723006962
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    XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells
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      DOI: 10.1016/j.cell.2023.11.033

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    sciencedirect.com/science/article/pii/S0092867423013193
  46. Dec 2023
  47. www.sciencedirect.com www.sciencedirect.com
    A histone deacetylase network regulates epigenetic reprogramming and viral silencing in HIV-infected cells
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      DOI: 10.1016/j.chembiol.2023.11.009

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    sciencedirect.com/science/article/pii/S2451945623004245
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    Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome
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    Cell stretching activates an ATM mechano-transduction pathway that remodels cytoskeleton and chromatin
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    Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation
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    Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease
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    Exposure to high-sugar diet induces transgenerational changes in sweet sensitivity and feeding behavior via H3K27me3 reprogramming
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    The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr
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  67. Aug 2023
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    Globally elevated levels of histone H3 lysine 9 trimethylation in early infancy are associated with poor growth trajectory in Bangladeshi children
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  69. Jul 2023
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  71. Jun 2023
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    DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs
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    Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging
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  75. May 2023
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    Site-specific R-loops induce CGG repeat contraction and fragile X gene reactivation
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    Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures
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  82. Mar 2023
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    Antagonism of TRPV4 channels partially reduces mechanotransduction in rat skeletal muscle afferents
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    Massively parallel characterization of CRISPR activator efficacy in human induced pluripotent stem cells and neurons
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    Exposure to high-sugar diet induces transgenerational changes in sweet sensitivity and feeding behavior via H3K27me3 reprogramming
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    TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state
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    Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice
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    Principles of 3D chromosome folding and evolutionary genome reshuffling in mammals
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    TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis
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    Safeguarding Drosophila female germ cell identity depends on an H3K9me3 mini domain guided by a ZAD zinc finger protein
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  96. Dec 2022
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    Structure and functional mapping of the KRAB-KAP1 repressor complex
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    Hypoxia induces transgenerational epigenetic inheritance of small RNAs
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    Loss of the Ash2l subunit of histone H3K4 methyltransferase complexes promotes chromatin compaction at promoters
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  101. Oct 2022
  102. www.nature.com www.nature.com
    Off-the-shelf proximity biotinylation using ProtA-TurboID
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  103. Sep 2022
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    Confined migration induces heterochromatin formation and alters chromatin accessibility
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  105. Aug 2022
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    Aberrant Epigenetic Alteration of PAX1 Expression Contributes to Parathyroid Tumorigenesis
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  107. Jul 2022
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    Distinct p53 isoforms code for opposing transcriptional outcomes
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    Induction of senescence upon loss of the Ash2l core subunit of H3K4 methyltransferase complexes
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    Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development
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    Inhibition of DYRK1A, via histone modification, promotes cardiomyocyte cell cycle activation and cardiac repair after myocardial infarction
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  112. Jun 2022
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    Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia
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    Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells
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    Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration
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    Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1
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  117. May 2022
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    Binary outcomes of enhancer activity underlie stable random monoallelic expression
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    Feedback from nuclear RNA on transcription promotes robust RNA concentration homeostasis in human cells
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    Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging
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    Nde1 is required for heterochromatin compaction and stability in neocortical neurons
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  122. Apr 2022
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    Heterochromatic repeat clustering imposes a physical barrier on homologous recombination to prevent chromosomal translocations
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    Genome-wide functional perturbation of human microsatellite repeats using engineered zinc finger transcription factors
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    Single-cell profiling of transcriptome and histone modifications with EpiDamID
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  126. Mar 2022
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    Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression
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    A cell-sorting-based protocol for cell cycle small-scale ChIP sequencing
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    An Inducible CRISPR/Cas9 Screen Identifies DTX2 as a Transcriptional Regulator of Human Telomerase
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    Recruitment of DNA to tumor-derived microvesicles
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  131. Jan 2022
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    Dynamic chromatin state profiling reveals regulatory roles of auxin and cytokinin in shoot regeneration
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    SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers
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    Defects in Emerin-nucleoskeleton binding disrupt nuclear structure and promote breast cancer cell motility and metastasis
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  135. Dec 2021
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    Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology
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    SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity
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  138. Nov 2021
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    Reprogramming of H3K9bhb at regulatory elements is a key feature of fasting in the small intestine
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    Loss of sister kinetochore co-orientation and peri-centromeric cohesin protection after meiosis I depends on cleavage of centromeric REC8
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    Coronavirus induces diabetic macrophage-mediated inflammation via SETDB2
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    Cell division- and DNA replication-free reprogramming of somatic nuclei for embryonic transcription
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  143. Oct 2021
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    A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development
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    Collective regulation of chromatin modifications predicts replication timing during cell cycle
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    PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation
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    Global chromatin relabeling accompanies spatial inversion of chromatin in rod photoreceptors
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    Defining Proximity Proteomics of Histone Modifications by Antibody-mediated Protein A-APEX2 Labeling
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    A protocol to quantify chromatin compaction with confocal and super-resolution microscopy in cultured cells
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  150. Sep 2021
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    Global chromatin relabeling accompanies spatial inversion of chromatin in rod photoreceptors
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    Aging-Dependent Downregulation of SUV39H1 Histone Methyltransferase Increases Susceptibility to Stress-Induced Depressive Behavior
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    piRNA-independent transposon silencing by the Drosophila THO complex
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  154. Aug 2021
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    Parallel pathways for recruiting effector proteins determine centromere drive and suppression
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    Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules
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    C. elegans Heterochromatin Factor SET-32 Plays an Essential Role in Transgenerational Establishment of Nuclear RNAi-Mediated Epigenetic Silencing
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    Aging increases vulnerability to stress-induced depression via upregulation of NADPH oxidase in mice
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    Deleting Mecp2 from the cerebellum rather than its neuronal subtypes causes a delay in motor learning in mice
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    The Essential Function of SETDB1 in Homologous Chromosome Pairing and Synapsis during Meiosis
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  215. Dec 2020
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  217. Nov 2020
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    H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation
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    Formation of the CenH3-Deficient Holocentromere in Lepidoptera Avoids Active Chromatin
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  220. Oct 2020
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    TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
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    Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres
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    4D Genome Rewiring during Oncogene-Induced and Replicative Senescence
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    Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence
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    Systematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation
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    Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria
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    Adaptive Evolution Targets a piRNA Precursor Transcription Network
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    Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation
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    Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
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    CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma
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    Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage
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    Aging increases vulnerability to stress-induced depression via upregulation of NADPH oxidase in mice
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    Co-dependent Assembly of Drosophila piRNA Precursor Complexes and piRNA Cluster Heterochromatin
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      Rabbit anti H3K9me3

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    Loss of Dystroglycan Drives Cellular Senescence via Defective Mitosis-Mediated Genomic Instability
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    LINE-1 specific nuclear organization in mice olfactory sensory neurons
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  240. Jan 2020
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    The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis
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    H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis
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