266 Matching Annotations
  1. Last 7 days
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Artificially inserted strong promoter containing multiple G-quadruplexes induces long-range chromatin modification
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    1. scibot 23 Aug 2024
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      DOI: 10.7554/eLife.96216

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    ncbi.nlm.nih.gov/pmc/articles/PMC11333042/
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    Reorganization of H3K9me heterochromatin leads to neuronal impairment via the cascading destruction of the KDM3B-centered epigenomic network
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    sciencedirect.com/science/article/pii/S2589004224016055
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    Nucleosome remodeler exclusion by histone deacetylation enforces heterochromatic silencing and epigenetic inheritance
    1
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    sciencedirect.com/science/article/pii/S1097276524005823
  5. Aug 2024
  6. www.ahajournals.org www.ahajournals.org
    Sphingomyelin Synthase 2 Inhibition Ameliorates Cerebral Ischemic Reperfusion Injury Through Reducing the Recruitment of Toll‐Like Receptor 4 to Lipid Rafts
    1
    1. scibot 02 Aug 2024
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      DOI: 10.1161/JAHA.119.012885

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    ahajournals.org/doi/abs/10.1161/JAHA.119.012885
  7. Jul 2024
  8. www.sciencedirect.com www.sciencedirect.com
    TERT activation targets DNA methylation and multiple aging hallmarks
    1
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      DOI: 10.1016/j.cell.2024.05.048

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    sciencedirect.com/science/article/pii/S0092867424005920
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    Systematic dissection of sequence features affecting binding specificity of a pioneer factor reveals binding synergy between FOXA1 and AP-1
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      DOI: 10.1016/j.molcel.2024.06.022

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    sciencedirect.com/science/article/pii/S109727652400529X
  10. www.cell.com www.cell.com
    TULIPs decorate the three-dimensional genome of PFA ependymoma
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      DOI: 10.1016/j.cell.2024.06.023

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      DOI: 10.1016/j.cell.2024.06.023

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    cell.com/cell/abstract/S0092-8674(24)00697-4
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SETDB1 regulates short interspersed nuclear elements and chromatin loop organization in mouse neural precursor cells
    1
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      DOI: 10.1186/s13059-024-03327-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC11221086/
  12. Jun 2024
  13. www.sciencedirect.com www.sciencedirect.com
    An enhancer RNA recruits KMT2A to regulate transcription of Myb
    1
    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.celrep.2024.114378

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    sciencedirect.com/science/article/pii/S221112472400706X
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    The role of JMJD2A in immune evasion and malignant behavior of esophageal squamous cell carcinoma
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      DOI: 10.1016/j.intimp.2024.112401

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    sciencedirect.com/science/article/pii/S1567576924009214
  15. link.springer.com link.springer.com
    Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease
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    1. scibot 06 Jun 2024
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      DOI: 10.1038/s41594-024-01320-8

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    link.springer.com/article/10.1038/s41594-024-01320-8
  16. May 2024
  17. www.sciencedirect.com www.sciencedirect.com
    Heterochromatic 3D genome organization is directed by HP1a- and H3K9-dependent and independent mechanisms
    1
    1. scibot 30 May 2024
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      DOI: 10.1016/j.molcel.2024.05.002

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    sciencedirect.com/science/article/pii/S1097276524003952
  18. 52.53.155.43 52.53.155.43
    2024.02.25.581951v1.full-html.html
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      DOI: 10.1038/nature12362

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    52.53.155.43/3cbbb6c4022cb0d94766603ef526c2fd13dcbc89/2024.02.25.581951v1.full-html.html
  19. Apr 2024
  20. rupress.org rupress.org
    Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization
    4
    1. scibot 25 Apr 2024
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      DOI: 10.1083/jcb.202307026

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    rupress.org/jcb/article/223/4/e202307026/276570/Tunable-DNMT1-degradation-reveals-DNMT1-DNMT3B
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    SAFB restricts contact domain boundaries associated with L1 chimeric transcription
    1
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    sciencedirect.com/science/article/pii/S1097276524002314
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    Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer
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      DOI: 10.1016/j.ccell.2024.03.005

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    sciencedirect.com/science/article/pii/S1535610824000904
  23. Mar 2024
  24. www.sciencedirect.com www.sciencedirect.com
    Mitotic chromosomes are self-entangled and disentangle through a topoisomerase-II-dependent two-stage exit from mitosis
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    1. scibot 27 Mar 2024
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      DOI: 10.1016/j.molcel.2024.02.025

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    sciencedirect.com/science/article/pii/S1097276524001448
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Engineered FSHD mutations results in D4Z4 heterochromatin disruption and feedforward DUX4 network activation
    1
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      DOI: 10.1016/j.isci.2024.109357

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    ncbi.nlm.nih.gov/pmc/articles/PMC10951985/
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    The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA
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      DOI: 10.1016/j.devcel.2024.02.008

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    sciencedirect.com/science/article/pii/S1534580724001072
  27. www.sciencedirect.com www.sciencedirect.com
    ApoE maintains neuronal integrity via miRNA and H3K27me3-mediated repression.
    2
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      DOI: 10.1016/j.isci.2024.109231

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    sciencedirect.com/science/article/pii/S2589004224004528
  28. www.sciencedirect.com www.sciencedirect.com
    Cellular senescence is associated with the spatial evolution toward a higher metastatic phenotype in colorectal cancer
    2
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    sciencedirect.com/science/article/pii/S2211124724002407
  29. Feb 2024
  30. www.cell.com www.cell.com
    Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma
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      DOI: 10.1016/j.cmet.2024.01.018

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    cell.com/cell-metabolism/abstract/S1550-4131(24)00018-4
  31. 52.53.155.43 52.53.155.43
    The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells
    2
    1. scibot 22 Feb 2024
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      DOI: 10.1152/ajpcell.00293.2023

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      DOI: 10.1152/ajpcell.00293.2023

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    52.53.155.43/d532629e4f1cf755a6f5c302a21018f2c97350c4/reisbeck-et-al-2023-the-iron-chelator-and-oxphos-inhibitor-vlx600-induces-mitophagy-and-an-autophagy-dependent-type-of (1)-html.html
  32. journals.physiology.org journals.physiology.org
    The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells
    2
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      DOI: 10.1152/ajpcell.00293.2023

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      DOI: 10.1152/ajpcell.00293.2023

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    journals.physiology.org/doi/10.1152/ajpcell.00293.2023
  33. www.sciencedirect.com www.sciencedirect.com
    FOXA1 forms biomolecular condensates that unpack condensed chromatin to function as a pioneer factor
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      DOI: 10.1016/j.molcel.2023.11.020

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    sciencedirect.com/science/article/abs/pii/S1097276523009656
  34. Jan 2024
  35. www.sciencedirect.com www.sciencedirect.com
    PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression
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      DOI: 10.1016/j.devcel.2023.12.015

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    sciencedirect.com/science/article/pii/S1534580723006962
  36. www.sciencedirect.com www.sciencedirect.com
    XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells
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      DOI: 10.1016/j.cell.2023.11.033

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    sciencedirect.com/science/article/pii/S0092867423013193
  37. Dec 2023
  38. www.sciencedirect.com www.sciencedirect.com
    A histone deacetylase network regulates epigenetic reprogramming and viral silencing in HIV-infected cells
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      DOI: 10.1016/j.chembiol.2023.11.009

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    sciencedirect.com/science/article/pii/S2451945623004245
  39. www.sciencedirect.com www.sciencedirect.com
    Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome
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      DOI: 10.1016/j.cell.2023.11.019

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    sciencedirect.com/science/article/pii/S0092867423012734
  40. www.sciencedirect.com www.sciencedirect.com
    Pluripotency state transition of embryonic stem cells requires the turnover of histone chaperone FACT on chromatin
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      DOI: 10.1016/j.isci.2023.108537

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    sciencedirect.com/science/article/pii/S2589004223026147
  41. www.sciencedirect.com www.sciencedirect.com
    Cell stretching activates an ATM mechano-transduction pathway that remodels cytoskeleton and chromatin
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    sciencedirect.com/science/article/pii/S221112472301567X
  42. Nov 2023
  43. www.sciencedirect.com www.sciencedirect.com
    Nuclear RNA catabolism controls endogenous retroviruses, gene expression asymmetry, and dedifferentiation
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      DOI: 10.1016/j.molcel.2023.10.036

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    sciencedirect.com/science/article/pii/S1097276523009036
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Centromere innovations within a mouse species
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      DOI: 10.1126/sciadv.adi5764

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    ncbi.nlm.nih.gov/pmc/articles/PMC10651114/
  45. www.biorxiv.org www.biorxiv.org
    Endonucleosis mediates internalization of cytoplasm into the nucleus in senescent cells
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      DOI: 10.1101/2023.11.12.566736

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    biorxiv.org/content/10.1101/2023.11.12.566736v1
  46. Oct 2023
  47. www.sciencedirect.com www.sciencedirect.com
    Maternally inherited siRNAs initiate piRNA cluster formation
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    The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr
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  92. Oct 2022
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    Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development
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    Inhibition of DYRK1A, via histone modification, promotes cardiomyocyte cell cycle activation and cardiac repair after myocardial infarction
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    Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1
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    An Inducible CRISPR/Cas9 Screen Identifies DTX2 as a Transcriptional Regulator of Human Telomerase
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    SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers
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    Defects in Emerin-nucleoskeleton binding disrupt nuclear structure and promote breast cancer cell motility and metastasis
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  126. Dec 2021
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    SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity
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    Loss of sister kinetochore co-orientation and peri-centromeric cohesin protection after meiosis I depends on cleavage of centromeric REC8
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    Global chromatin relabeling accompanies spatial inversion of chromatin in rod photoreceptors
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    Defining Proximity Proteomics of Histone Modifications by Antibody-mediated Protein A-APEX2 Labeling
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    Aging-Dependent Downregulation of SUV39H1 Histone Methyltransferase Increases Susceptibility to Stress-Induced Depressive Behavior
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    Interrogation of the dynamic properties of higher-order heterochromatin using CRISPR-dCas9
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    A loss-of-function variant in SUV39H2 identified in autism-spectrum disorder causes altered H3K9 trimethylation and dysregulation of protocadherin β-cluster genes in the developing brain
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    Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer
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    Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation
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    Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules
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    C. elegans Heterochromatin Factor SET-32 Plays an Essential Role in Transgenerational Establishment of Nuclear RNAi-Mediated Epigenetic Silencing
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    Aging increases vulnerability to stress-induced depression via upregulation of NADPH oxidase in mice
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  203. Jan 2021
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    Deleting Mecp2 from the cerebellum rather than its neuronal subtypes causes a delay in motor learning in mice
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    The Essential Function of SETDB1 in Homologous Chromosome Pairing and Synapsis during Meiosis
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  208. Nov 2020
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    H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation
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    Formation of the CenH3-Deficient Holocentromere in Lepidoptera Avoids Active Chromatin
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    TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
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    Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres
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    Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence
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    Systematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation
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    Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria
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    Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation
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    Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
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    Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis
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    CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma
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    Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage
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    Aging increases vulnerability to stress-induced depression via upregulation of NADPH oxidase in mice
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    Co-dependent Assembly of Drosophila piRNA Precursor Complexes and piRNA Cluster Heterochromatin
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      Rabbit anti H3K9me3

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    Loss of Dystroglycan Drives Cellular Senescence via Defective Mitosis-Mediated Genomic Instability
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    LINE-1 specific nuclear organization in mice olfactory sensory neurons
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    The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis
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    Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells
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    ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures
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    SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States
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    Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors
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    Piwi/PRG-1 Argonaute and TGF-β Mediate Transgenerational Learned Pathogenic Avoidance
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    Sphingomyelin Synthase 2 Inhibition Ameliorates Cerebral Ischemic Reperfusion Injury Through Reducing the Recruitment of Toll‐Like Receptor 4 to Lipid Rafts
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