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    PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization
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    ARF alters PAF1 complex integrity to selectively repress oncogenic transcription programs upon p53 loss
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    Flow cytometry FRET reveals post-translational modifications drive Protein Phosphatase-5 conformational changes in mammalian cells
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    Structure of the TXNL1-bound proteasome
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    Distinct effects of sacituzumab govitecan and berzosertib on DNA damage response in ovarian cancer
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    Vitamin D alleviates HFD-induced hepatic fibrosis by inhibiting DNMT1 to affect the TGFβ1/Smad3 pathway
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    Porcine NLRC3 specially binds short dsDNA to regulate cGAS activation
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    Dental pulp stem cells promote genioglossus repair and systemic amelioration in chronic intermittent hypoxia
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    A multivalent adaptor mechanism drives the nuclear import of proteasomes
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    SUMOylation of protein phosphatase 5 regulates phosphatase activity and substrate release
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    Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways
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    USP7 deubiquitinates KRAS and promotes non-small cell lung cancer
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    Integrated multiomic analysis identifies TRIP13 as a mediator of alveolar epithelial type II cell dysfunction in idiopathic pulmonary fibrosis
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    CRISPRi/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity
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    SNARE protein SNAP25 regulates the chloride-transporter KCC2 in neurons
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    Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer
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    Hundreds of myosin 10s are pushed to the tips of filopodia and could cause traffic jams on actin
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    Everolimus alleviates CD4+ T cell inflammation by regulating autophagy and cellular redox homeostasis
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    Multi-omic human pancreatic islet endoplasmic reticulum and cytokine stress response mapping provides type 2 diabetes genetic insights
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    Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer
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    Simple aneuploidy evades p53 surveillance and promotes niche factor-independent growth in human intestinal organoids
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    Verapamil Prevents Decline of IGF-I in Subjects With Type 1 Diabetes and Promotes β-Cell IGF-I Signaling
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    RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation
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    Leucine restriction ameliorates Fusobacterium nucleatum-driven malignant progression and radioresistance in nasopharyngeal carcinoma
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    Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming
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  30. Sep 2024
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    HSV-1-induced N6-methyladenosine reprogramming via ICP0-mediated suppression of METTL14 potentiates oncolytic activity in glioma
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    Saturation mutagenesis-reinforced functional assays for disease-related genes
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    Geranylgeranylated SCFFBXO10 regulates selective outer mitochondrial membrane proteostasis and function
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    IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis
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    Colocalization of cancer-associated biomarkers on single extracellular vesicles for early detection of cancer
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    Divergent iron regulatory states contribute to heterogeneity in breast cancer aggressiveness
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    Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development
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    DDI2 protease controls embryonic development and inflammation via TCF11/NRF1
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    Dietary vitamin B3 supplementation induces the antitumor immunity against liver cancer via biased GPR109A signaling in myeloid cell
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    Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy
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    Multi-omics analysis using antibody-based in situ biotinylation technique suggests the mechanism of Cajal body formation
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    A nature-inspired HIF stabilizer derived from a highland-adaptation insertion of plateau pika Epas1 protein
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    Phosphorylation of Piezo1 at a single residue, serine-1612, regulates its mechanosensitivity and in vivo mechanotransduction function
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    Recycled melanoma-secreted melanosomes regulate tumor-associated macrophage diversification
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    Role of AMPA receptors in homocysteine‐NMDAR induced crosstalk between ERK and p38 MAP kinase
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    Generation and characterization of a human iPSC line expressing EGFP-tagged CDH1, KSCBi002-A-3
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    Intestinal epithelium dysfunctions cause IgA deposition in the kidney glomeruli of intestine-specific Ap1m2-deficient mice
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    The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization
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    Differential regulation of G protein-coupled receptor-associated proteins in the caudate and the putamen of cynomolgus macaques following chronic ethanol drinking
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    The E3 ubiquitin-protein ligase UHRF1 promotes adipogenesis and limits fibrosis by suppressing GPNMB-mediated TGF-β signaling
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    Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle
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    Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10
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    Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals
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    Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations
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    ArreSTick motif controls β-arrestin-binding stability and extends phosphorylation-dependent β-arrestin interactions to non-receptor proteins
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