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Repurposing Nelfinavir: AIM2 inflammasome-associated anti-tumor effects in Glioblastoma

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1. scibot 23 Aug 2026
  
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  DOI: 10.1016/j.bbadis.2026.168428
  
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Reassessment of the roles of coronin proteins as actin effectors and in signaling

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1. scibot 22 Aug 2026
  
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  DOI: 10.1371/journal.pbio.3003904
  
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Modulating the sialic acid content of endothelial cells affects their adhesion and barrier permeability

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1. scibot 22 Aug 2026
  
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Mitochondrial stress activates ELT-2–dependent lysosomal proteostasis to extend lifespan in C. elegans

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1. scibot 20 Aug 2026
  
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  DOI: 10.1126/sciadv.aeh0657
  
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CDK8/19 inhibition prevents adaptive resistance to CDK4/6 inhibitors in vitro and in vivo

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Gut microbiota generate dinitrosyl iron complexes with cardiometabolic benefits

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  DOI: 10.1016/j.cell.2026.07.055
  
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ER-liquid condensate contacts sequester FAM134B/C and RhoA to govern cell morphology

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  DOI: 10.1016/j.molcel.2026.07.027
  
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Targeting the CHD3 chromatin remodeler exploits a synthetic lethal vulnerability in dual SMARCA4/SMARCA2-deficient cancers via derepression of PARD3B

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1. scibot 15 Aug 2026
  
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3β-HSD1-mediated steroid back-conversion can maintain androgen signaling in prostate cancer

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1. scibot 14 Aug 2026
  
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IL-4-Primed Microglial Extracellular Vesicles Attenuate Rotenone-Induced Cell Death in SH-SY5Y Cells: A Contributory Role for miR-191-5p

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1. scibot 13 Aug 2026
  
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  DOI: 10.1080/17590914.2026.2712448
  
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Cofilin1-driven cytoskeletal remodeling modulates pan-cancer CD8+ T cell immunotherapy responses

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1. scibot 13 Aug 2026
  
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  DOI: 10.1016/j.xcrm.2026.102984
  
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Hyodeoxycholic acid suppresses hepatic steatosis in a PPARα-dependent manner via distinct GLP-1- and iNKT cell-mediated pathways

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1. scibot 10 Aug 2026
  
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Virus-induced deconjugation of ISG15 dysregulates innate immunity and cellular metabolism

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1. scibot 09 Aug 2026
  
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  DOI: 10.1016/j.immuni.2026.07.007
  
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Biomarker-guided responses in patient-derived organoids predict effective therapies in breast cancer

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1. scibot 08 Aug 2026
  
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  DOI: 10.1016/j.xcrm.2026.102973
  
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A macrophage-intestinal organoid co-culture model captures balanced epithelial homeostasis and inflammation

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  DOI: 10.1016/j.stemcr.2026.103045
  
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FKBP52 dictates the dual role of p53 in hepatocellular carcinoma: mutation-specific prognostic stratification and therapeutic implications

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1. scibot 08 Aug 2026
  
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  DOI: 10.1016/j.jbc.2026.113390
  
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Inhibitory TIGIT signaling is dependent on T cell receptor activation

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  DOI: 10.1016/j.celrep.2026.117787
  
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LZTFL1 rewires NADPH-glutathione metabolism to amplify ferroptosis

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1. scibot 06 Aug 2026
  
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  DOI: 10.1016/j.molcel.2026.07.018
  
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Mycoplasma infection drives EGFR-TKI resistance through convergent transcriptomic reprogramming in non-small cell lung cancer

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Iron-addicted colorectal cancers exploit heme-complex II axis to resist oxidative cell death

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Resolving the subcellular redox landscape of Coenzyme Q

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Enhanced dopamine transporter binding is associated with species-specific 2C-B-induced reinforcement in marmosets, but not in mice

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An antibody-PROTAC conjugate targets BRD4/c-Myc/PD-L1 to enhance immunotherapy efficacy in triple-negative breast cancer

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1. scibot 31 Jul 2026
  
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Spatiotemporal organisation of residual disease in mouse and human BRCA1-deficient mammary tumours and breast cancer

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  DOI: 10.1038/s41467-026-74125-6
  
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Microbial metabolite hyodeoxycholic acid induces macrophage immunometabolic reprogramming and alleviates ulcerative colitis

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GBP6 maintains mitochondrial bioenergetics to promote immune evasion from NK cells in cervical cancer

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1. scibot 29 Jul 2026
  
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Asprosin expression and its role in regulating proliferation, cell cycle, and apoptosis in mouse hippocampal HT-22 cells

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1. scibot 27 Jul 2026
  
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Human GBP4 promotes TRIM21-BIP-dependent autophagy to restrict M. tuberculosis infection by preventing SORT1-mediated progranulin degradation

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A self-amplifying nerve-fibroblast circuit drives colorectal cancer progression

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Dual roles of SBSN in renal cancer progression and tumor thrombus: Cell-autonomous NF-κB-CD44 axis and IFI6-driven paracrine angiogenesis

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The requirement of MALT1 activity for the growth of adult T cell leukemia/lymphoma

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The vaccine candidate Liver Stage Antigen 3 is exported during Plasmodium falciparum infection and required for liver-stage development

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  DOI: 10.7554/eLife.108524.2
  
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Iron overload suppresses LKB1 and induces IL36G anti-tumor immunity in PDAC metastasis

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  DOI: 10.1126/sciadv.adz8681
  
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Temporal control of macrophage pro-inflammatory phenotype by a biphasic HIF-1α regulatory program

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ACSS2 is required for colorectal cancer progression and a druggable target for colorectal cancer treatment

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Iron overload suppresses LKB1 and induces IL36G anti-tumor immunity in PDAC metastasis

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1. scibot 21 Jul 2026
  
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A genome-wide functional analysis of conserved intronic regions reveals essential roles for speckle-associated retained introns

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A Bright Ratiometric Dipyrene Probe for Functional Imaging of Condensate Microenvironments in Living Cells

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αKG-mediated carnitine synthesis drives DNA repair via histone acetylation

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Localized mRNAs and protein synthesis in cortical layer 1

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TGF-β signaling promotes astroglial activation and TDP-43 proteinopathy in organoid models of frontotemporal lobar degeneration

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Targeted antibody-drug conjugates for rhabdomyosarcoma and other FGFR4-expressing cancers

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TMEM97 regulates cholesterol biosynthesis and mitochondrial metabolism in gastric carcinoma

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TRF2 enriched cytoplasmic chromatin drives cGAS-STAT1-mediated inflammation in senescence

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TNIK overexpression is sufficient for chemoradiation resistance in limited-stage small cell lung cancer

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The tRNA-Derived Fragment tRF-E Promotes Ferroptosis in Hepatocellular Carcinoma to Suppress Tumor Progression

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IDH1 Reprograms Nucleotide Metabolism by Inducing Chromatin Remodeling and DHODH Transcription to Drive Chemoresistance in Nasopharyngeal Carcinoma

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Aryl Aldehyde-Anchored Small Molecules Recruit FBXO22 for Targeted Degradation of NSD2

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Intratumoral Lactobacillus johnsonii Enhances Sensitivity to PD-1 Blockade by Inducing CD8+ T Cell Expansion in Hepatocellular Carcinoma

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HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell-Like Phenotype in Head and Neck Squamous Cell Carcinoma

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Combining PD-L1 blockade with a second-generation HSP110 inhibitor enhances antitumor immunity in colorectal cancer

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TP53 mutations in triple-negative breast cancer cells confer sensitivity to ASCT2 inhibition via arginine uptake

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PRDM16 modulates aspects of cell cycle dynamics and maturation in human iPSC-derived cardiomyocytes

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HDAC-driven autophagy repression aids macrophage immune evasion by K. pneumoniae strains displaying classical, MDR, and hypervirulent phenotypes

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PUMILIO proteins maintain lineage balance via post-transcriptional repression of germline fate and promotion of somatic differentiation

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chattergoon-et-al-2026-b-raf-is-required-for-normal-murine-cardiac-development-and-function-html.html

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A druggable ATP13A3–antizyme switch controls adaptive polyamine uptake in cancer

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Protocol for quantifying cellular drug-target engagement across a temperature series using the MICRO-TAG enzyme complementation assay

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Thyroid cancer-associated EZH1 Q571R mutation drives chromatin compaction and H3K27me3 invasion into active chromatin

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Hippocampal ERK2 dimerization regulates inhibitory avoidance memory reconsolidation and synaptic plasticity

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Targeting cholesterol esterification sensitizes liver cancer to CD8+ T cell attack by impairing metabolic and redox resilience

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Supra-additive neuroprotective effects of berberine–metformin combination in diabetic encephalopathy: Chou–Talalay synergy quantification, AMPK–Nrf2 axis modulation, and pharmacokinetic verification

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RelB drives integrin-mediated stress tolerance and relapse in high-grade serous ovarian cancer

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An IGF2BP3-dependent metabolic circuit governs macrophage recruitment and immunosuppression in glioblastoma

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Atg5 deficiency alters myofibroblast accumulation and alveolar regeneration in lung fibrosis

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Chronic glucocorticoid exposure disrupts lactate homeostasis and hippocampal neurogenesis by reducing cerebrovascular monocarboxylate transporter 1, leading to behavioral abnormalities in mice

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TGF-β1-induced endothelial transcytosis drives blood-brain barrier leakage during aging

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Otopetrin 1 protects against adipose tissue wasting during cancer cachexia progression

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Gut commensal Bacteroides-derived pantothenic acid alleviates metabolic syndrome

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koe-et-al-2026-n-linked-glycosylation-regulates-snat2-trafficking-and-stability-in-pancreatic-ductal-adenocarcinoma-html.html

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Hydrostatic pressure reduces the mechanosensitivity of cell migration

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Dual Targeting of Orphan Nuclear Receptors NR4A1 and NR4A2 for Non-Hormonal Endometriosis Therapy

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Thyroid Hormone Receptor Beta Suppresses Cancer Cell Activity by Differential Regulation of Glycogen Metabolism

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Targeting SUV4-20H Epigenetic Enzymes Enhances Topoisomerase II Poisoning in Prostate Cancer

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Identification of FXYD5 as an oncogene in pediatric papillary thyroid cancer

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IGF2BP3 is essential for the growth heterogeneity of colorectal adenoma cells by regulating MYC

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Structures of the PI3Kα/KRas complex on lipid bilayers reveal molecular mechanisms of PI3Kα activation

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The ALS- and FTD-associated proteins annexin A11 and CHMP2B act sequentially in plasma membrane repair

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Recurrent ZC3H18 mutations stabilize oncogenic endogenous retroviral RNA

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A Three-subtype Molecular model of Cervical Cancer: Multiple PI3K Pathway inhibitors suppress growth and cooperate with HPV-directed immunotherapy

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Commensal Cutibacterium acnes-derived indolelactic acid safeguards skin barrier function through the aryl hydrocarbon receptor

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Lineage plasticity driven by GATA6 loss fuels colorectal cancer metastasis

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Methionine-supplemented longevity diet increases growth hormone, GLP-1, and FGF21; reduces frailty; and promotes healthspan

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Lipid droplet-mitochondria tethering releases MAVS inhibition to potentiate antiviral immunity

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In vivo visualization of bioactive iron and oxygen using LiON, the labile iron and oxygen notifier

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HMGA2 regulates fear and growth: Canine GWAS and functional evidence

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The novel immunocompetent Eµ-SOX11CCND1 mouse model phenotypically and molecularly resembles human mantle cell lymphoma

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A CHK1-mediated phosphorylation switch suppresses human Topoisomerase 1-associated genomic instability

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Enhancing Proteasome Activity in T Cells Alleviates Exhaustion and Improves Antitumor Immunity

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VISTA neutralization by immunization reprograms immunosuppression and augments vaccine efficacy in renal carcinoma

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Hypoxia-activated PROTAC for dual inhibition of FAK and EGFR enables synergistic mechano-chemical cancer therapy

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FANCA-dependent FEN1 recruitment suppresses transcription-replication conflicts and PARPi sensitivity

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A Wireless 3D Magneto-Mechanical Stimulation Platform Drives In Situ Chondrogenic Commitment of Endogenous MSCs

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RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription

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Coordinated regulation of mRNA translation and stability by ZC3H7A and ZC3H7B RNA-binding proteins

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The C-terminal region of TENT5 proteins drives ER-associated mRNA polyadenylation via FNDC3 interaction

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CFP1 promotes B cell class switch recombination through the regulation of S region germline transcription and proliferation

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Redirection of SARS-CoV-2 to phagocytes by intranasal sACE2-Fc as a universal decoy confers complete prophylactic protection

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RAB5c orchestrates LC3-associated phagocytosis to promote microbicidal function of macrophages

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Uric acid promotes dietary lipid absorption through microbiome and metabolomic remodeling via a liver-gut endocrine axis

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An orally active dual CBP/p300 degrader targets core dependencies of multiple myeloma

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FGF21 suppresses hepatocellular carcinoma by driving competitive cell-cell interactions

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BPS Publications

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FEBS Press

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Bmal1 regulates thermogenic function by modulation of lipolytic and OXPHOS gene expression in male mice brown adipocytes

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Placental Pathology and HTRA4-Mediated Autophagic Flux Disruption in Selective Fetal Growth Restriction Types I and III: A Morphological and Transcriptomic Study

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YY1 Binding Motif at Upstream of Rep/Cap Increases AAV Yield and Full Capsids

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2026.05.15.725565.full-html.html

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Ferroptosis susceptibility in hippocampal neural precursor cells influences neurogenesis and memory across aging

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Lipid Nanoparticle-Delivered Circ_0017866 Alleviates Cerebral Ischemia-Reperfusion Injury by Suppressing Endothelial-Mesenchymal Transition via the miR-124-3p/CLDND1 Axis

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Delivery of ATSP-7041 by Minimally Invasive Nasal Depot (MIND) to Target Diffuse Intrinsic Pontine Glioma

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CTSZ-dependent anoikis resistance enhances malignant characters of glioblastoma via NF-κB signaling

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ALDH1A3 promotes the lung metastatic organotropism of pancreatic ductal adenocarcinoma through semaphorin signaling

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NAPRT expression and epigenetic regulation in pediatric rhabdomyosarcoma as a potential biomarker for NAMPT inhibition

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The impact of cannabidiol (CBD) in hyperglycemic zebrafish (Danio rerio)

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Adrenomedullin restores the human cortical interneurons migration defects induced by hypoxia

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A reabsorption mechanism in Drosophila renal tubules maintains amino acid homeostasis

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Coronavirus protein interaction mapping in bat and human cells reveals network rewiring governing immune evasion and zoonotic potential

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Transcription and cohesin direct domain boundary spatial positioning and are linked to Friedreich’s ataxia

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Loss of the autoimmune risk gene TREX1 reveals a convergence of mechanisms promoting immune tolerance loss and antitumor immunity

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Celecoxib potentiates ribociclib-induced apoptosis and anti-tumor activity by co-targeting COX-2/NF-κB and PI3K/AKT/mTOR pathways in hormone receptor-positive/HER2-negative breast cancer

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2026.04.28.721421.full-html.html

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chattergoon-et-al-2026-b-raf-is-required-for-normal-murine-cardiac-development-and-function-html.html

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A peritumoral microenvironment engaged by Reg-EXTL3 axis fosters nerve-cancer interactions in pancreatic ductal adenocarcinoma

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Healthy young human plasma-derived exosomes enhance neural stem cell therapy by suppressing pyroptosis via TXNIP/NLRP3 after intracerebral hemorrhage

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Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and HMGB1 secretion

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Virological characteristics of SARS-CoV-2-related coronaviruses dynamically circulating in Southeast Asia

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BPS Publications

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Damage-induced i-loops generate eccDNA from repetitive elements

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Combination treatment with synthetic gRNA/Cas12a and gRNA/Cas9 ribonucleoproteins disrupts HIV replication and expression

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Mechanism by which a linoleic acid metabolite suppresses cancer cell growth by inhibiting mTOR

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Activated T cell extracellular vesicle DNA transfer enhances antigen presentation and anti-tumor immunity

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NAD-dependent redox control enables endothelial quiescence and vascular stabilization during angiogenesis

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The long isoform of ZAP coordinates multiple enzymes to mediate complete decay of target transcripts

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BPS Publications

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QW-5-70 targets the colchicine site and demonstrates antitumor activity in P-gp–overexpressing cancer models

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LARS promotes osteosarcoma proliferation through leucine-dependent PRIM2 translation and DNA replication activation

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SFPQ prevents MDA5-mediated activation of innate immunity and preserves cell viability

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Engineered commensals for metabolic modulation of the gut-liver-brain axis

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Intracellular sclerostin promotes tumor progression and metastasis as a potential therapeutic target in triple-negative breast cancer

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AAV-based gene therapy with modified HEXB confers lasting therapeutic benefits in GM2 gangliosidosis models

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Tuning the sensitivity of mechanosensory receptors through histidine scanning

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Immunotherapy Inhibits Tumor Cholesterol Synthesis via the IFN-γ-ΙRF1-SREBF2 Axis

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BPS Publications

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ISGylation is disrupted by UBA7 gene variants identified in individuals with neurodevelopmental disorder phenotypes

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Generalizable, high-throughput image analysis of subcellular structures using dispersion indices

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B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism

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ARID1A deficiency unleashes centromeric RNA transcription to drive chromosomal instability and boosts PKMYT1 inhibitor efficacy via RNA sensing

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E3 Ubiquitin Ligase Nedd4‐2 Exacerbates Seizure‐Induced Mitochondrial Defects in an Alzheimer's Disease Mouse Model

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Optineurin modulates mTORC2/AKT/STAT3 signaling to control MHC class II expression and adaptive immunity against HSV-1

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PIK3CA mutant cervical cancer is selectively suppressed by PI3Kα inhibition (Alpelisib/BYL-719 and Inavolisib/GDC-0077) and cooperates with HPV directed T cell therapy

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SCD1 and SCD5 modulate PARP-dependent DNA repair via fatty acid desaturation in glioblastoma

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SNAT1 (SLC38A1) Is Not the Main Glutamine Transporter in Melanoma, but Controls Metabolism via Glutamine-Dependent Activation of P62 (SQSTM1)/cMYC-Axis

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Sex-specific effects of acetylation on tauopathy in aging htau mice

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Tumor metabolic adaptation induced by L-asparaginase reveals a vulnerability to PARP1/2 inhibitor in B-cell lymphomas

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A hotspot phosphorylation site on SHP2 drives oncoprotein activation and drug resistance

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Mosperafenib, a novel paradox breaker BRAF inhibitor with potent preclinical activity in BRAF mutated colorectal cancer

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TNF alpha unmasks enteric malate aspartate shuttle dysfunction bridging Parkinson disease and intestinal inflammation

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1-s2.0-S2589004226010862-main-html.html

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A Rasa3-Gαi signaling axis orchestrates B lymphocyte trafficking into and through lymphoid organs

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Species-specific cleavage of the autophagy adaptor p62 dictates responses to TNF

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An interactome-based framework for DDB1- and CUL4-associated factor prioritization in targeted protein degradation

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Selective degradation of TBK1 uncovers mechanistic insights into blocking ccRCC progression

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Host microRNA-31-5p regulates KHDRBS3 expression and modulates viral gene expression during KSHV lytic reactivation

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Postnatal plasticity in the paralaminar nucleus of the pallial amygdala in juvenile swine brain

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Patient-derived kidney organoids recapitulate ADPKD and facilitate the identification of Rho pathway inhibitors as candidate therapeutics

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Integrating interferon gamma receptor pathways, antigenicity, and immune contexture as predictors of immunotherapeutic strategies for mucosal melanomas

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THC and CBD Induce Heme Oxygenase-1-Dependent Cell Death and Trigger Mitochondrial Dysfunction in Human Melanoma and Cutaneous Squamous Cell Carcinoma Cells

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The aryl hydrocarbon receptor (AHR) drives human leukocyte antigen (HLA)-II expression in human melanoma

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Innate Immune Receptor NLRX1: Potential Modulator of Glioblastoma Pathophysiology

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Early-stage multi-cancer detection through a plasma extracellular vesicle protein signature

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Targeting the energy metabolism of melanoma cells: FX-11 acts as a mitochondrial uncoupler

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1-s2.0-S2589004226008114-main-html.html

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Autoinhibitory control of MLKL governs pseudokinase domain phosphorylation and oligomerization during necroptosis

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1. scibot 24 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117130
  
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Panx1 deficiency exacerbates GAN diet-induced obesity by destabilizing β-catenin via GSK3β

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  DOI: 10.1016/j.isci.2026.115098
  
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ZNFX1 uses two-component ubiquitin circuitry to quarantine viral RNA

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  DOI: 10.1016/j.molcel.2026.02.015
  
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Optimized laminin surfaces induce spontaneous myelination by neonate mice dorsal root ganglia

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  DOI: 10.1016/j.mcn.2026.104089
  
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2026.03.11.711019.full-html.html

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  DOI: 10.64898/2026.03.11.711019
  
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Young Regulatory T Cell-Derived Extracellular Vesicles Improve Mitochondrial Function and Angiogenesis and Suppress Inflammation in Senescent Brain and Heart

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1. scibot 19 Mar 2026
  
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MiR-34a deficiency enhances nucleic acid sensing and type I IFN signaling in a mouse model of Alzheimer’s disease

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1. scibot 18 Mar 2026
  
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  DOI: 10.3389/fimmu.2026.1694824
  
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Bioorthogonal catalytic centres engineered for gastrointestinal stabilization provide oral delivery for the treatment of gastric cancer

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1. scibot 18 Mar 2026
  
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  DOI: 10.1186/s12951-026-04065-2
  
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Medium-Chain Fatty Acid Receptor GPR84 Modulates Cytotoxic CD8 T cells Antitumor Immunity Through Metabolic Reprogramming

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  DOI: 10.1158/2326-6066.CIR-25-0695
  
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RRAS and RRAS2 mutations are recurrent oncogenic drivers in lung cancer and are sensitive to the pan-RAS inhibitor RMC-6236

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  DOI: 10.1158/1078-0432.CCR-25-2734
  
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A multivalent adaptor mechanism drives the nuclear import of proteasomes

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  DOI: 10.1038/s41467-026-69162-0
  
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Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration

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  DOI: 10.1016/j.stem.2025.12.019
  
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Divergent proteome tolerance against gain and loss of chromosome arms

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1. scibot 18 Mar 2026
  
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  DOI: 10.1016/j.molcel.2025.10.023
  
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MRCKα Is a Suppressor of GEF-H1/RhoA/MRTF Signaling in Tubular Cells

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  DOI: 10.3390/cells15050447
  
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Targeting pre-existing club-like cells in prostate cancer potentiates androgen deprivation therapy

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  DOI: 10.1038/s44321-026-00375-y
  
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In vivo CAR-Tfh cell reprogramming restores tolerance in a mouse model of autoimmune hepatitis

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  DOI: 10.1016/j.stem.2026.02.006
  
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Unified phase separation drives DNA-induced inflammasome activation of the AIM2-like receptors

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  DOI: 10.1016/j.celrep.2026.117065
  
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CREB2 Functions as a Central Mediator of Oxidative Neuronal Death Triggered by Microglial Glutamate Release Under Neuroinflammatory Conditions

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1. scibot 17 Mar 2026
  
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  DOI: 10.1007/s10571-026-01695-w
  
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CircRNA-encoded RIPK1-98 protein drives lung adenocarcinoma progression

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1. scibot 13 Mar 2026
  
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  DOI: 10.1016/j.devcel.2026.02.014
  
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Insulin receptor trafficking and interactions in muscle cells

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  DOI: 10.1210/jendso/bvag020
  
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Lack of GPNMB Is Associated With Altered Lipid and Glucose Metabolism and Disrupted Diurnal Hepatic Glycogen Regulation

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miR-181d coordinates homologous recombination and anti-tumor immune responses in glioblastoma

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  DOI: 10.1016/j.isci.2026.115077
  
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NAD+ hydrolysis catalyzed by SelO is required for mitochondrial homeostasis

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1. scibot 10 Mar 2026
  
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  DOI: 10.1016/j.cell.2026.01.033
  
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ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition

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1. scibot 05 Mar 2026
  
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  DOI: 10.1002/ijc.70400
  
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THC and CBD Induce Heme Oxygenase-1-Dependent Cell Death and Trigger Mitochondrial Dysfunction in Human Melanoma and Cutaneous Squamous Cell Carcinoma Cells

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1. scibot 03 Mar 2026
  
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  DOI: 10.3390/antiox15030286
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13024539/
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Prenatal and postnatal atrazine-induced endocrine and ovarian chemical biotransformation protein disruption in offspring

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pmc.ncbi.nlm.nih.gov/articles/PMC12946850/

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