646 Matching Annotations
  1. Oct 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuregulin 1 signaling attenuates tumor necrosis factor-α induced female rat luteal cell death
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    1. scibot 09 Oct 2024
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      DOI: 10.1210/endocr/bqae129

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    ncbi.nlm.nih.gov/pmc/articles/PMC11456883/
  3. aacrjournals.org aacrjournals.org
    NK Receptor Signaling Lowers TCR Activation Threshold, Enhancing Selective Recognition of Cancer Cells by TAA-Specific CTLs
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    1. scibot 08 Oct 2024
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      DOI: 10.1158/2326-6066.CIR-24-0061

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    aacrjournals.org/cancerimmunolres/article/12/10/1421/748722/NK-Receptor-Signaling-Lowers-TCR-Activation
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combination of JAKi and HDACi Exerts Antiangiogenic Potential in Cutaneous T-Cell Lymphoma
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    1. scibot 02 Oct 2024
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      DOI: 10.3390/cancers16183176

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    ncbi.nlm.nih.gov/pmc/articles/PMC11430229/
  5. Sep 2024
  6. link.springer.com link.springer.com
    TRPV4 Blockage Inhibits the Neurogenesis in the Adult Hippocampal Dentate Gyrus Following Pilocarpine‑Induced Status Epilepticus
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    1. scibot 27 Sep 2024
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      DOI: 10.1007/s12035-024-04504-x

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    link.springer.com/article/10.1007/s12035-024-04504-x
  7. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A novel inhibitor of class IIa histone deacetylases attenuates collagen-induced arthritis
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    1. scibot 27 Sep 2024
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      DOI: 10.1111/bph.17306

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17306
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1
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    1. scibot 26 Sep 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11387596/
  9. www.sciencedirect.com www.sciencedirect.com
    Customised design of antisense oligonucleotides targeting EGFR driver mutants for personalised treatment of non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S235239642400392X
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene
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    1. scibot 25 Sep 2024
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  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FNIP1 suppresses colorectal cancer progression through inhibiting STAT3 phosphorylation and nuclear translocation
    1
    1. scibot 25 Sep 2024
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    Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity
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    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724011136
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    Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling
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    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.celrep.2019.11.036

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    sciencedirect.com/science/article/pii/S2211124719315189
  14. www.sciencedirect.com www.sciencedirect.com
    Cancer cell – fibroblast crosstalk via HB-EGF/EGFR/MEK signaling promotes expression of macrophage chemo-attractants in squamous cell carcinoma
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    1. scibot 17 Sep 2024
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    sciencedirect.com/science/article/pii/S2589004224018601
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    Aged fibroblast-derived extracellular vesicles promote angiogenesis in melanoma
    1
    1. scibot 12 Sep 2024
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  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphodiesterase 4 is overexpressed in keloid epidermal scars and its inhibition reduces keratinocyte fibrotic alterations
    1
    1. scibot 05 Sep 2024
      RRID:AB_390779

      DOI: 10.1186/s10020-024-00906-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC11370283/
  17. www.sciencedirect.com www.sciencedirect.com
    A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib
    1
    1. scibot 04 Sep 2024
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    sciencedirect.com/science/article/pii/S2666379124004245
  18. www.sciencedirect.com www.sciencedirect.com
    H3K9 lactylation in malignant cells facilitates CD8+ T cell dysfunction and poor immunotherapy response
    1
    1. scibot 04 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724010374
  19. Aug 2024
  20. www.sciencedirect.com www.sciencedirect.com
    FRA1 controls acinar cell plasticity during murine KrasG12D-induced pancreatic acinar to ductal metaplasia
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    1. scibot 23 Aug 2024
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      DOI: 10.1016/j.devcel.2024.07.021

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    sciencedirect.com/science/article/pii/S1534580724004830
  21. www.nature.com www.nature.com
    LIFR regulates cholesterol-driven bidirectional hepatocyte–neutrophil cross-talk to promote liver regeneration
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    1. scibot 23 Aug 2024
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      DOI: 10.1038/s42255-024-01110-y

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    nature.com/articles/s42255-024-01110-y
  22. www.sciencedirect.com www.sciencedirect.com
    Multiplex Spatial Omics Reveals Changes in Immune-Epithelial Crosstalk During Inflammation and Dysplasia Development in Chronic IBD Patients
    1
    1. scibot 21 Aug 2024
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    sciencedirect.com/science/article/pii/S2589004224017759
  23. www.sciencedirect.com www.sciencedirect.com
    Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers
    1
    1. scibot 21 Aug 2024
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    sciencedirect.com/science/article/pii/S1535610824002708
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuropeptide Y receptor activation preserves inner retinal integrity through PI3K/Akt signaling in a glaucoma mouse model
    1
    1. scibot 21 Aug 2024
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      DOI: 10.1093/pnasnexus/pgae299

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    ncbi.nlm.nih.gov/pmc/articles/PMC11305140/
  25. www.sciencedirect.com www.sciencedirect.com
    Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease
    1
    1. scibot 19 Aug 2024
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      DOI: 10.1016/j.celrep.2024.114589

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    sciencedirect.com/science/article/pii/S2211124724009185
  26. www.researchsquare.com www.researchsquare.com
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      DOI: 10.21203/rs.3.rs-1945681/v1

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  27. www.mdpi.com www.mdpi.com
    Andrographolide Attenuates Established Pulmonary Hypertension via Rescue of Vascular Remodeling
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    1. scibot 02 Aug 2024
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    mdpi.com/2218-273X/11/12/1801/htm
  28. cancerci.biomedcentral.com cancerci.biomedcentral.com
    Quantitative phosphoproteomic analysis reveals chemoresistance-related proteins and signaling pathways induced by rhIL-6 in human osteosarcoma cells
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      DOI: 10.1186/s12935-021-02286-z

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    cancerci.biomedcentral.com/articles/10.1186/s12935-021-02286-z
  29. Jul 2024
  30. www.cell.com www.cell.com
    Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK
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    1. scibot 30 Jul 2024
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    cell.com/cell-host-microbe/abstract/S1931-3128(24)00254-3
  31. www.sciencedirect.com www.sciencedirect.com
    Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation
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    1. scibot 27 Jul 2024
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      DOI: 10.1016/j.celrep.2021.108862

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  32. 52.53.155.43 52.53.155.43
    Cancer-associated endocrine cells participate in pancreatic carcinogenesis
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    Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation
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  34. www.sciencedirect.com www.sciencedirect.com
    TERT activation targets DNA methylation and multiple aging hallmarks
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      DOI: 10.1016/j.cell.2024.05.048

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  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration
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  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    wang-et-al-2024-lilrb1-hla-g-axis-defines-a-checkpoint-driving-natural-killer-cell-exhaustion-in-tuberculosis-html.html
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  37. www.embopress.org www.embopress.org
    LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis
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  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Netrin signaling mediates survival of dormant epithelial ovarian cancer cells
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      DOI: 10.7554/eLife.91766

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    A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model
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    Dietary fiber alleviates alcoholic liver injury via Bacteroides acidifaciens and subsequent ammonia detoxification
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  41. www.science.org www.science.org
    In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss
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      DOI: 10.1126/sciadv.adk2299

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  42. aacrjournals.org aacrjournals.org
    A Tetravalent Bispecific Antibody Selectively Inhibits Diverse FGFR3 Oncogenic Variants
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      DOI: 10.1158/0008-5472.CAN-23-3195

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    aacrjournals.org/cancerres/article/84/13/2169/746134/A-Tetravalent-Bispecific-Antibody-Selectively
  43. www.cell.com www.cell.com
    Anti-tumor efficacy of HRS-4642 and its potential combination with proteasome inhibition in KRAS G12D-mutant cancer
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    cell.com/cancer-cell/fulltext/S1535-6108(24)00226-5
  44. www.cell.com www.cell.com
    TSPAN4 influences glioblastoma progression through regulating EGFR stability
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  45. www.sciencedirect.com www.sciencedirect.com
    Multi-step regulation of microRNA expression and secretion into small extracellular vesicles by insulin
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    Spatial transcriptomics analysis identifies a tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease
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  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Combination of ß-Hydroxybutyrate and Citrate Ameliorates Disease Progression in a Rat Model of Polycystic Kidney Disease
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  49. Jun 2024
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    Acetyl-NPKY of Integrin-beta 1 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity.
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    Oxygen tension-dependent variability in the cancer cell kinome impacts signaling pathways and response to targeted therapies
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    In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss
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    Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency
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    Endonucleolytic RNA cleavage drives changes in gene expression during the innate immune response
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  56. May 2024
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    FGD5 in basal cells induces CXCL14 secretion that initiates a feedback loop to promote murine mammary epithelial growth and differentiation
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    Analyzing efficiency of a lentiviral shRNA knockdown system in human enteroids using western blot and flow cytometry
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    TUDCA alleviates atherosclerosis by inhibiting AIM2 inflammasome and enhancing cholesterol efflux capacity in macrophage
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    Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations
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    Metabolic reprogramming of hypoxic tumour-associated macrophages through CSF-1R targeting favours treatment efficiency in colorectal cancers
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  65. onlinelibrary.wiley.com onlinelibrary.wiley.com
    EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells
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  67. www.cell.com www.cell.com
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    Identification of novel and distinct FGF23 signaling in a Klotho-dependent and -independent manner
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  70. Apr 2024
  71. www.embopress.org www.embopress.org
    PRODH safeguards human naive pluripotency by limiting mitochondrial oxidative phosphorylation and reactive oxygen species production
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    Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer
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    Altered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation in a GM1-gangliosidosis model
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  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Overexpression of α-Klotho isoforms promotes distinct Effects on BDNF-Induced Alterations in Dendritic Morphology
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    CircTMEM165 facilitates endothelial repair by modulating mitochondrial fission via miR-192/SCP2 in vitro and in vivo
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    A light-controlled phospholipase C for imaging of lipid dynamics and controlling neural plasticity
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    Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome
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  84. www.sciencedirect.com www.sciencedirect.com
    Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L
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    Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion
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    FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis
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    Conditioned medium from induced pluripotent stem cell-derived mesenchymal stem cells accelerates cutaneous wound healing through enhanced angiogenesis
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  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Foretinib is effective in acute myeloid leukemia by inhibiting FLT3 and overcoming secondary mutations that drive resistance to quizartinib and gilteritinib
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  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis
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  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats
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    Sialyltransferase ST3GAL4 confers osimertinib resistance and offers strategies to overcome resistance in non-small cell lung cancer
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  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer
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    PDGFRα+ITGA11+ fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay
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    Fluoroquinolones upregulate insulin-like growth factor–binding protein 3, inhibit cell growth and insulin-like growth factor signaling
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    Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin α2β1
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    Allosteric inhibitor of SHP2 enhances macrophage endocytosis and bacteria elimination by increasing caveolae activation and protects against bacterial sepsis
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    O6-Methylguanine DNA Methyltransferase Regulates β-glucan-induced Trained Immunity of Macrophages via Farnesoid X Receptor and AMPK
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    CHTOP Alleviates Cerebral Ischemia/Reperfusion-Induced Injury by Regulating RNA Alternative Splicing
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    Casein kinase-2 inhibition promotes retinal ganglion cell survival after acute intraocular pressure elevation
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    pERK-mediated IL8 secretion can enhance the migration, invasion, and cisplatin resistance of CD10-positive oral cancer cells
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  123. Nov 2023
  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
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    Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer
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    The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability
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    Blockade of CCR5 suppresses paclitaxel-induced peripheral neuropathic pain caused by increased deoxycholic acid
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    A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment
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    HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B
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    Repositioning of Montelukast to inhibit proliferation of mutated KRAS pancreatic cancer through a novel mechanism that interfere the binding between KRAS and GTP/GDP
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    ANKRD49 promotes the metastasis of NSCLC via activating JNK-ATF2/c-Jun-MMP-2/9 axis
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    A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
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    Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis
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    Metformin Improves the Prerequisites for FGF21 Signaling in Patients with Type 2 Diabetes
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    MAPK-ERK-CREB signaling pathway upregulates Nav1.6 in oxaliplatin-induced neuropathic pain in the rat
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    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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    Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine
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  172. Jul 2023
  173. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
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    Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer
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    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
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    Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH
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    TOPK mediates immune evasion of Renal Cell Carcinoma via upregulating the expression of PD-L1
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  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SHP2 participates in decidualization by activating ERK to maintain normal nuclear localization of progesterone receptor
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    Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway
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    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
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    Discovery of a Selective and Orally Bioavailable FGFR2 Degrader for Treating Gastric Cancer
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    New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
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    Evaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters
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    RBM10 loss promotes EGFR-driven lung cancer and confers sensitivity to spliceosome inhibition
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    Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis
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    Targeting formyl peptide receptor 1 by anteiso-C13-surfactin for neutrophil-dominant acute respiratory distress syndrome
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