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    Microglia-derived ADAM9 promote GHRH neurons pyroptosis by Mad2L2-JNK-caspase-1 pathway in subarachnoid hemorrhage
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  3. Nov 2024
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    Bilateral regulation of EGFR activity and local PI(4,5)P2 dynamics in mammalian cells observed with superresolution microscopy
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    USP7 deubiquitinates KRAS and promotes non-small cell lung cancer
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    Insulin Mediates Lipopolysaccharide-Induced Inflammatory Responses and Oxidative Stress in BV2 Microglia
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    Bidirectional signals generated by Siglec-7 and its crucial ligand tri-sialylated T to escape of cancer cells from immune surveillance
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  9. Oct 2024
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    Neuregulin 1 signaling attenuates tumor necrosis factor-α induced female rat luteal cell death
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    NK Receptor Signaling Lowers TCR Activation Threshold, Enhancing Selective Recognition of Cancer Cells by TAA-Specific CTLs
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    Combination of JAKi and HDACi Exerts Antiangiogenic Potential in Cutaneous T-Cell Lymphoma
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  13. Sep 2024
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    TRPV4 Blockage Inhibits the Neurogenesis in the Adult Hippocampal Dentate Gyrus Following Pilocarpine‑Induced Status Epilepticus
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    A novel inhibitor of class IIa histone deacetylases attenuates collagen-induced arthritis
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    IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1
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    Customised design of antisense oligonucleotides targeting EGFR driver mutants for personalised treatment of non-small cell lung cancer
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    Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene
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    FNIP1 suppresses colorectal cancer progression through inhibiting STAT3 phosphorylation and nuclear translocation
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    Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity
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    Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling
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    Cancer cell – fibroblast crosstalk via HB-EGF/EGFR/MEK signaling promotes expression of macrophage chemo-attractants in squamous cell carcinoma
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    Aged fibroblast-derived extracellular vesicles promote angiogenesis in melanoma
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    Phosphodiesterase 4 is overexpressed in keloid epidermal scars and its inhibition reduces keratinocyte fibrotic alterations
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    A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib
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    H3K9 lactylation in malignant cells facilitates CD8+ T cell dysfunction and poor immunotherapy response
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  27. Aug 2024
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    FRA1 controls acinar cell plasticity during murine KrasG12D-induced pancreatic acinar to ductal metaplasia
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    LIFR regulates cholesterol-driven bidirectional hepatocyte–neutrophil cross-talk to promote liver regeneration
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    Multiplex Spatial Omics Reveals Changes in Immune-Epithelial Crosstalk During Inflammation and Dysplasia Development in Chronic IBD Patients
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    Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers
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    Neuropeptide Y receptor activation preserves inner retinal integrity through PI3K/Akt signaling in a glaucoma mouse model
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    Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease
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    Andrographolide Attenuates Established Pulmonary Hypertension via Rescue of Vascular Remodeling
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    Quantitative phosphoproteomic analysis reveals chemoresistance-related proteins and signaling pathways induced by rhIL-6 in human osteosarcoma cells
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  37. Jul 2024
  38. www.cell.com www.cell.com
    Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK
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    Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation
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    Cancer-associated endocrine cells participate in pancreatic carcinogenesis
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    Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation
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    TERT activation targets DNA methylation and multiple aging hallmarks
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  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration
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    wang-et-al-2024-lilrb1-hla-g-axis-defines-a-checkpoint-driving-natural-killer-cell-exhaustion-in-tuberculosis-html.html
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    LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis
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    Netrin signaling mediates survival of dormant epithelial ovarian cancer cells
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    Dietary fiber alleviates alcoholic liver injury via Bacteroides acidifaciens and subsequent ammonia detoxification
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    A Tetravalent Bispecific Antibody Selectively Inhibits Diverse FGFR3 Oncogenic Variants
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    Spatial transcriptomics analysis identifies a tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease
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  57. Jun 2024
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency
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    Analyzing efficiency of a lentiviral shRNA knockdown system in human enteroids using western blot and flow cytometry
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    Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations
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    Metabolic reprogramming of hypoxic tumour-associated macrophages through CSF-1R targeting favours treatment efficiency in colorectal cancers
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    EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells
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    Altered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation in a GM1-gangliosidosis model
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    Overexpression of α-Klotho isoforms promotes distinct Effects on BDNF-Induced Alterations in Dendritic Morphology
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    CircTMEM165 facilitates endothelial repair by modulating mitochondrial fission via miR-192/SCP2 in vitro and in vivo
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    The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle
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    Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome
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  91. Mar 2024
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    Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L
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    Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion
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    FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis
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    TGR5-mediated lateral hypothalamus-dCA3-dorsolateral septum circuit regulates depressive-like behavior in male mice
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    Conditioned medium from induced pluripotent stem cell-derived mesenchymal stem cells accelerates cutaneous wound healing through enhanced angiogenesis
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  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Foretinib is effective in acute myeloid leukemia by inhibiting FLT3 and overcoming secondary mutations that drive resistance to quizartinib and gilteritinib
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    Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats
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    Sialyltransferase ST3GAL4 confers osimertinib resistance and offers strategies to overcome resistance in non-small cell lung cancer
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    Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer
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    PDGFRα+ITGA11+ fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay
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  106. Feb 2024
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    Fluoroquinolones upregulate insulin-like growth factor–binding protein 3, inhibit cell growth and insulin-like growth factor signaling
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    An integrative proteomics approach identifies tyrosine kinase KIT as a therapeutic target for SPINK1-positive prostate cancer
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    Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin α2β1
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    Allosteric inhibitor of SHP2 enhances macrophage endocytosis and bacteria elimination by increasing caveolae activation and protects against bacterial sepsis
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    Tumor cell–intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling
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  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning
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    O6-Methylguanine DNA Methyltransferase Regulates β-glucan-induced Trained Immunity of Macrophages via Farnesoid X Receptor and AMPK
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  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TNIK drives Castration-Resistant Prostate Cancer via phosphorylating EGFR
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    CHTOP Alleviates Cerebral Ischemia/Reperfusion-Induced Injury by Regulating RNA Alternative Splicing
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  124. Dec 2023
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    Casein kinase-2 inhibition promotes retinal ganglion cell survival after acute intraocular pressure elevation
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    A reversible epigenetic memory of inflammatory injury controls lineage plasticity and tumor initiation in the mouse pancreas
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    Econazole selectively induces cell death in NF1-homozygous mutant tumor cells
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    pERK-mediated IL8 secretion can enhance the migration, invasion, and cisplatin resistance of CD10-positive oral cancer cells
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    ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells
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  131. Nov 2023
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    Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
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    Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer
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    The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability
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    Blockade of CCR5 suppresses paclitaxel-induced peripheral neuropathic pain caused by increased deoxycholic acid
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    A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment
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    Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration
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    HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B
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    Repositioning of Montelukast to inhibit proliferation of mutated KRAS pancreatic cancer through a novel mechanism that interfere the binding between KRAS and GTP/GDP
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    ANKRD49 promotes the metastasis of NSCLC via activating JNK-ATF2/c-Jun-MMP-2/9 axis
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    Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk
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    Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish
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    Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer
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  144. Oct 2023
  145. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
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    Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis
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    Protocol for auxin-inducible depletion of the RNA-binding protein PTBP1 in mouse embryonic stem cells
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    MEK inhibitors increase the mortality rate in mice with LPS-induced inflammation through IL-12-NO signaling
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    Peroxisomal ERK mediates Akh/glucagon action and glycemic control
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    Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor
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    Activation of the JNK/COX-2/HIF-1α axis promotes M1 macrophage via glycolytic shift in HIV-1 infection
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    Minichromosome maintenance 6 protects against renal fibrogenesis by regulating DUSP6-mediated ERK/GSK-3β/Snail1 signaling
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    Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
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    Methylation of KRAS by SETD7 promotes KRAS degradation in non-small cell lung cancer
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    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
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    ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer
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    Metformin Improves the Prerequisites for FGF21 Signaling in Patients with Type 2 Diabetes
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    Tyrosine hydroxylase phosphorylation is under the control of serine 40
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    ERK1-mediated immunomodulation of mesenchymal stem cells ameliorates inflammatory disorders
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    MAPK-ERK-CREB signaling pathway upregulates Nav1.6 in oxaliplatin-induced neuropathic pain in the rat
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    Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis
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    URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease.
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    CGK733 alleviates ovariectomy-induced bone loss through blocking RANKL-mediated Ca2+ oscillations and NF-κB/MAPK signaling pathways
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    The MORC2 p.S87L mutation reduces proliferation of pluripotent stem cells derived from a patient with the spinal muscular atrophy-like phenotype by inhibiting proliferation-related signaling pathways
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    Glucose Transporter-2 Regulation of Male versus Female Hypothalamic Astrocyte MAPK Expression and Activation: Impact of Glucose
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    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
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    Apical extrusion prevents apoptosis from activating an acute inflammatory program in epithelia
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    ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
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    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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    Tumoral P2Y2 receptor modulates tumor growth and host anti-tumor immune responses in a syngeneic murine model of oral cancer
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  175. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine
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    Targeting CD36 determines nicotine derivative NNK-induced lung adenocarcinoma carcinogenesis
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    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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    Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
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    Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer
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    TOPK mediates immune evasion of Renal Cell Carcinoma via upregulating the expression of PD-L1
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    SHP2 participates in decidualization by activating ERK to maintain normal nuclear localization of progesterone receptor
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    Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway
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    Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design
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    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
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    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
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    Discovery of a Selective and Orally Bioavailable FGFR2 Degrader for Treating Gastric Cancer
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  200. aacrjournals.org aacrjournals.org
    USP10 regulates ZEB1 ubiquitination and protein stability to inhibit ZEB1-mediated colorectal cancer metastasis
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    A Drosophila model of diabetic neuropathy reveals a role of proteasome activity in the glia
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    IRAK1 inhibition blocks the HIV-1 RNA mediated pro-inflammatory cytokine response from microglia
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    New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
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    Evaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters
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    RBM10 loss promotes EGFR-driven lung cancer and confers sensitivity to spliceosome inhibition
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