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Inhibiting KRAS with CD47 and immune checkpoint overcomes intrinsic resistance to combined KRAS and immune checkpoint inhibitor therapy

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1. scibot 30 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102317
  
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sciencedirect.com/science/article/pii/S2666379125003908
Aug 2025
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The kinase ERK plays a conserved dominant role in the heterogeneity of epithelial-mesenchymal transition in pancreatic cancer cells

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1. scibot 20 Aug 2025
  
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  DOI: 10.1126/scisignal.ads7002
  
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science.org/doi/10.1126/scisignal.ads7002
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Nitroxoline upregulates low-density lipoprotein receptors expression, enhances lipid metabolism, and reduces hepatic steatosis and atherosclerosis in Apoe−/− mice

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1. scibot 19 Aug 2025
  
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Pharmacologic inhibition of CSF-1R suppresses intrinsic tumor cell growth in osteosarcoma with CSF-1R overexpression

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1. scibot 14 Aug 2025
  
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  DOI: 10.1186/s12967-025-06920-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12341233/
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Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR-TKI resistance and metastasis

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1. scibot 14 Aug 2025
  
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  DOI: 10.1016/j.devcel.2025.07.014
  
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Conditional deletion of TRPC1 channel modulates synaptic plasticity, long term depression, and memory extinction in Fragile X Syndrome mice.

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1. scibot 12 Aug 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12329558/
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Early Life Social Isolation Dysregulates Social Reward Processing, BDNF Signaling, and Intracellular Vesicular Sorting in the Nucleus Accumbens of Male and Female Rats

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1. scibot 07 Aug 2025
  
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  DOI: 10.1111/jnc.70181
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12323299/
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A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression

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1. scibot 05 Aug 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-4774
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12317733/
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Pentagalloyl glucose inhibits monosodium urate-induced inflammation and NLRP3 inflammasome formation via TAK1 | American Journal of Physiology-Cell Physiology | American Physiological Society

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1. scibot 05 Aug 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12318505/
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Plasma extracellular vesicle surface-located GAS6/PROS1 and CD39/CD73 attenuate inflammation

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1. scibot 05 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116096
  
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sciencedirect.com/science/article/pii/S2211124725008678
Jul 2025
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P75NTR activation limits CD21lo B cell subsets expansion in response to autoimmune-inducing challenges

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1. scibot 30 Jul 2025
  
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  DOI: 10.1016/j.isci.2025.113055
  
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FGF-induced phospholipase Cγ signaling regulates lacrimal gland branching by competing with PI3K in phosphoinositide metabolism

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1. scibot 30 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116046
  
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cell.com/cell-reports/abstract/S2211-1247(25)00817-4
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Opsin 5 mediates violet light-accelerated wound healing in mammalian corneas

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1. scibot 30 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116045
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00816-2
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RIT1 Drives Oncogenic Transformation and is an Actionable Target in Lung Adenocarcinoma

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1. scibot 25 Jul 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-3819
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12281470/
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Impaired BDNF-TrkB trafficking and signalling in Down syndrome basal forebrain neurons

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1. scibot 25 Jul 2025
  
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  DOI: 10.1101/2025.07.15.664857
  
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biorxiv.org/content/10.1101/2025.07.15.664857v1
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1-s2.0-S2589004225014555-main-html.html

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1. scibot 25 Jul 2025
  
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  DOI: 10.1016/j.isci.2025.113194
  
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52.53.155.43/644b847ccbd9fd7a361f652a83914faf17916b63/1-s2.0-S2589004225014555-main-html.html
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Alistipes finegoldii augments the efficacy of immunotherapy against solid tumors

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1. scibot 25 Jul 2025
  
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  DOI: 10.1016/j.ccell.2025.07.002
  
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Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer

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1. scibot 25 Jul 2025
  
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  DOI: 10.1016/j.ccell.2025.06.021
  
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Periodontal Ligaments Enhance Neurite Outgrowth in Trigeminal Ganglion Neurons through Wnt5a Production Induced by Mechanical Stimulation

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1. scibot 22 Jul 2025
  
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  DOI: 10.1152/ajpcell.00302.2022
  
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52.53.155.43/f8df4eb8a5eedcbd3583132b5c32fd671a443179/takahashi-et-al-2022-periodontal-ligaments-enhance-neurite-outgrowth-in-trigeminal-ganglion-neurons-through-wnt5a-html.html
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BRAFV600E augments WNT signaling in colorectal cancer via aberrant DNA methylation

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1. scibot 20 Jul 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12272824/
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PHGDH Induction by MAPK is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability

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  DOI: 10.1158/0008-5472.CAN-24-2471
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11735329/
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RANKL/PD-1 dual blockade demonstrates survival benefit for patients with advanced lung adenocarcinoma harboring KRAS mutations

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TBK1 phagosomal recruitment enhances antifungal immunity via positive feedback regulation with SRC

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1. scibot 15 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.115972
  
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cell.com/cell-reports/abstract/S2211-1247(25)00743-0
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1-s2.0-S258900422501346X-main-html.html

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1. scibot 15 Jul 2025
  
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52.53.155.43/e8a33482a6cb41aff5e8ce2ac737d9b3a4cc1b78/1-s2.0-S258900422501346X-main-html.html
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Using computational pharmacology and experimental verification to decode mechanism of Qing-Wei-San in treating periodontitis

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1. scibot 10 Jul 2025
  
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  DOI: 10.1186/s12906-025-04967-y
  
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A Rac-specific competitive inhibitor of guanine nucleotide binding reduces metastasis in triple-negative breast cancer

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1. scibot 09 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102233
  
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NOD1 promotes leukocyte clearance and limits inflammation in female mice during obesity‐associated acute lung injury

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1. scibot 08 Jul 2025
  
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  DOI: 10.14814/phy2.70446
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12227658/
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Neutrophil extracellular trap gene expression signatures identify prognostic and targetable signaling axes for inhibiting pancreatic tumour metastasis

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  DOI: 10.1038/s42003-025-08440-x
  
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nature.com/articles/s42003-025-08440-x
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High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA

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  DOI: 10.1016/j.celrep.2025.115947
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00718-1
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Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps

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The planar cell polarity (PCP) protein Fat 1 in Sertoli cell function

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  DOI: 10.1210/endocr/bqae041
  
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dx.doi.org/10.1210/endocr/bqae041
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VCPIP1 potentiates innate immune responses by non-catalytically reducing the ubiquitination of IRAK1/2

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  DOI: 10.1016/j.celrep.2025.115931
  
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EGFR TKIs suppress MUC1 glycosylation through the PI3K/AKT/SP1/C1GALT1 pathway to enhance TnMUC1 CAR-T efficacy in EGFR-mutant NSCLC

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1. scibot 25 Jun 2025
  
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  DOI: 10.1016/j.xcrm.2025.102199
  
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Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer

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1. scibot 24 Jun 2025
  
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  DOI: 10.1002/advs.202503322
  
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advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202503322
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Deficiency of Fibroblast Growth Factor 2 Promotes Contractile Phenotype of Pericytes in Ascending Thoracic Aortic Aneurysm

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1. scibot 18 Jun 2025
  
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  DOI: 10.1152/ajpheart.00834.2024
  
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Tumor-derived ligands trigger tumor growth and host wasting via differential MEK activation

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PTEN protein phosphatase activity regulates metastasis by targeting PKCδ

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Nerve growth factor signaling tunes axon maintenance protein abundance and kinetics of Wallerian degeneration

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PIN1 serves as a prognostic and therapeutic biomarker in lung adenocarcinoma

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Efflux of N1-acetylspermidine from hepatoma fosters macrophage-mediated immune suppression to dampen immunotherapeutic efficacy

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Bromodomain-containing protein 4 knockdown promotes... : Neural Regeneration Research

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KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation

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Preclinical Activity of the Type II RAF Inhibitor Tovorafenib in Tumor Models Harboring Either a BRAF Fusion or an NF1 Loss-of-Function Mutation

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Hepato-cardiac interorgan communication controls cardiac hypertrophy via combined endocrine-autocrine FGF21 signaling

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1-s2.0-S2589004225009125-main-html.html

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A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons

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Growth Hormone Promotes Lipolysis and Impairs Insulin Sensitivity by Activating the ERK/HSL Signaling Pathway in Bovine Adipocytes

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Interleukin-33 (IL-33) promotes DNA damage-resistance in lung cancer

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Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage

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PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma

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Bro1 proteins determine tumor immune evasion and metastasis by controlling secretion or degradation of multivesicular bodies

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Xuebijing injection alleviates septic acute kidney injury by modulating inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress

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Scutellaria barbata ameliorates acute respiratory distress syndrome by inhibiting neutrophil-mediated inflammatory responses

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Lipid-metabolism-focused CRISPR screens identify enzymes of the mevalonate pathway as essential for prostate cancer growth

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GEF-H1 drives breast cancer cells to tumor progression

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Macrophage-specific PHGDH protects against MAFLD by suppressing TAK1

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TTC7A-ALK, a novel ALK fusion variant identified in a patient with metastatic lung adenocarcinoma, exhibits excellent response to crizotinib

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Monocytes from patients with myelodysplastic syndrome inhibit natural killer cell-mediated antitumor function through the CD200/CD200R pathway

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ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity

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Septin 3 regulates memory and L-LTP-dependent extension of endoplasmic reticulum into spines

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MIF-ACKR3 causes irreversible fat loss by impairing adipogenesis in cancer cachexia

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Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP

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Akt is a mediator of artery specification during zebrafish development

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The TSH receptor antibody reactome contributes to retro-orbital inflammation

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Relaxin Modulates the Genomic Actions and Biological Effects of Estrogen in the Myometrium

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Identification of Meibomian gland stem cell populations and mechanisms of aging

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Lipid droplet efferocytosis attenuates proinflammatory signaling in macrophages via TREM2- and MS4A7-dependent mechanisms

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TGF-β antagonizes IFN-γ-mediated adaptive immune evasion via activation of the AKT-Smad3-SHP1 axis in lung adenocarcinoma

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pH-sensing GPR68 inhibits vascular smooth muscle cell proliferation through Rap1A

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SMAD4 and KRAS Status Shape Cancer Cell-Stromal Crosstalk and Therapeutic Response in Pancreatic Cancer

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Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy

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AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis

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OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth

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Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity

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Nuclear adenine activates hnRNPA2B1 to enhance antibacterial innate immunity

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bqaf001-html.html

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Histone acetylation alteration by KAT6A inhibitor WM-1119 suppresses IgE-mediated mast cell activation and allergic inflammation via reduction in AP-1 signaling

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The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A

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Calcineurin: An essential regulator of sleep revealed by biochemical, chemical biological, and genetic approaches

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Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL-10

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1-s2.0-S2589004224028967-main-html.html

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A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor

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Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma

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Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery

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AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection

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HucMSCs can alleviate abnormal vasculogenesis induced by high glucose through the MAPK signaling pathway

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ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion

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Microglia-derived ADAM9 promote GHRH neurons pyroptosis by Mad2L2-JNK-caspase-1 pathway in subarachnoid hemorrhage

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Bilateral regulation of EGFR activity and local PI(4,5)P2 dynamics in mammalian cells observed with superresolution microscopy

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can-24-1817-html.html

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USP7 deubiquitinates KRAS and promotes non-small cell lung cancer

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Insulin Mediates Lipopolysaccharide-Induced Inflammatory Responses and Oxidative Stress in BV2 Microglia

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Bidirectional signals generated by Siglec-7 and its crucial ligand tri-sialylated T to escape of cancer cells from immune surveillance

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Neuregulin 1 signaling attenuates tumor necrosis factor-α induced female rat luteal cell death

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NK Receptor Signaling Lowers TCR Activation Threshold, Enhancing Selective Recognition of Cancer Cells by TAA-Specific CTLs

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Combination of JAKi and HDACi Exerts Antiangiogenic Potential in Cutaneous T-Cell Lymphoma

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TRPV4 Blockage Inhibits the Neurogenesis in the Adult Hippocampal Dentate Gyrus Following Pilocarpine‑Induced Status Epilepticus

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A novel inhibitor of class IIa histone deacetylases attenuates collagen-induced arthritis

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IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1

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Customised design of antisense oligonucleotides targeting EGFR driver mutants for personalised treatment of non-small cell lung cancer

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Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene

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FNIP1 suppresses colorectal cancer progression through inhibiting STAT3 phosphorylation and nuclear translocation

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Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity

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Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling

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Cancer cell – fibroblast crosstalk via HB-EGF/EGFR/MEK signaling promotes expression of macrophage chemo-attractants in squamous cell carcinoma

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Aged fibroblast-derived extracellular vesicles promote angiogenesis in melanoma

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Phosphodiesterase 4 is overexpressed in keloid epidermal scars and its inhibition reduces keratinocyte fibrotic alterations

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A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib

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H3K9 lactylation in malignant cells facilitates CD8+ T cell dysfunction and poor immunotherapy response

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FRA1 controls acinar cell plasticity during murine KrasG12D-induced pancreatic acinar to ductal metaplasia

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LIFR regulates cholesterol-driven bidirectional hepatocyte–neutrophil cross-talk to promote liver regeneration

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Multiplex Spatial Omics Reveals Changes in Immune-Epithelial Crosstalk During Inflammation and Dysplasia Development in Chronic IBD Patients

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Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers

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Neuropeptide Y receptor activation preserves inner retinal integrity through PI3K/Akt signaling in a glaucoma mouse model

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Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease

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Andrographolide Attenuates Established Pulmonary Hypertension via Rescue of Vascular Remodeling

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Quantitative phosphoproteomic analysis reveals chemoresistance-related proteins and signaling pathways induced by rhIL-6 in human osteosarcoma cells

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Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK

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Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation

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Cancer-associated endocrine cells participate in pancreatic carcinogenesis

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Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation

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TERT activation targets DNA methylation and multiple aging hallmarks

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Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration

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wang-et-al-2024-lilrb1-hla-g-axis-defines-a-checkpoint-driving-natural-killer-cell-exhaustion-in-tuberculosis-html.html

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LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis

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Netrin signaling mediates survival of dormant epithelial ovarian cancer cells

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A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model

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Dietary fiber alleviates alcoholic liver injury via Bacteroides acidifaciens and subsequent ammonia detoxification

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In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss

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A Tetravalent Bispecific Antibody Selectively Inhibits Diverse FGFR3 Oncogenic Variants

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Anti-tumor efficacy of HRS-4642 and its potential combination with proteasome inhibition in KRAS G12D-mutant cancer

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TSPAN4 influences glioblastoma progression through regulating EGFR stability

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Multi-step regulation of microRNA expression and secretion into small extracellular vesicles by insulin

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Spatial transcriptomics analysis identifies a tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease

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Insulin Potentiates JAK/STAT Signaling to Broadly Inhibit Flavivirus Replication in Insect Vectors

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A Combination of ß-Hydroxybutyrate and Citrate Ameliorates Disease Progression in a Rat Model of Polycystic Kidney Disease

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Acetyl-NPKY of Integrin-beta 1 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity.

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Oxygen tension-dependent variability in the cancer cell kinome impacts signaling pathways and response to targeted therapies

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In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss

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Anti-tumor effects of tirbanibulin in squamous cell carcinoma cells are mediated via disruption of tubulin-polymerization

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Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency

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Endonucleolytic RNA cleavage drives changes in gene expression during the innate immune response

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FGD5 in basal cells induces CXCL14 secretion that initiates a feedback loop to promote murine mammary epithelial growth and differentiation

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Analyzing efficiency of a lentiviral shRNA knockdown system in human enteroids using western blot and flow cytometry

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TUDCA alleviates atherosclerosis by inhibiting AIM2 inflammasome and enhancing cholesterol efflux capacity in macrophage

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Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations

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Alarmin S100A8 imparts chemoresistance of esophageal cancer by reprogramming cancer-associated fibroblasts

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Deficiency of UCHL1 results in insufficient decidualization accompanied by impaired dNK modulation and eventually miscarriage

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Direct interrogation of context-dependent GPCR activity with a universal biosensor platform

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Metabolic reprogramming of hypoxic tumour-associated macrophages through CSF-1R targeting favours treatment efficiency in colorectal cancers

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EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells

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2024.02.09.579580v1.full-html.html

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Discovery of SOCS7 as a versatile E3 ligase for protein-based degraders

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Nurr1 overexpression in the primary motor cortex alleviates motor dysfunction induced by intracerebral hemorrhage in the striatum in mice

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Identification of novel and distinct FGF23 signaling in a Klotho-dependent and -independent manner

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PRODH safeguards human naive pluripotency by limiting mitochondrial oxidative phosphorylation and reactive oxygen species production

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PRODH safeguards human naive pluripotency by limiting mitochondrial oxidative phosphorylation and reactive oxygen species production

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Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer

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Altered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation in a GM1-gangliosidosis model

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Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model

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ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion

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Overexpression of α-Klotho isoforms promotes distinct Effects on BDNF-Induced Alterations in Dendritic Morphology

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CircTMEM165 facilitates endothelial repair by modulating mitochondrial fission via miR-192/SCP2 in vitro and in vivo

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Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding

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The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle

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A light-controlled phospholipase C for imaging of lipid dynamics and controlling neural plasticity

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Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome

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Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L

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Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion

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FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis

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TGR5-mediated lateral hypothalamus-dCA3-dorsolateral septum circuit regulates depressive-like behavior in male mice

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Epithelial-derived interleukin-23 promotes oral mucosal immunopathology

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Conditioned medium from induced pluripotent stem cell-derived mesenchymal stem cells accelerates cutaneous wound healing through enhanced angiogenesis

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  anti-ERK1/2
  
  DOI: 10.1186/s13287-021-02366-x
  
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Foretinib is effective in acute myeloid leukemia by inhibiting FLT3 and overcoming secondary mutations that drive resistance to quizartinib and gilteritinib

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  RRID:AB_390779
  
  DOI: 10.1158/0008-5472.CAN-23-1534
  
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Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis

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  DOI: 10.1038/s41467-024-46602-3
  
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A gut-derived hormone regulates cholesterol metabolism

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  RRID:AB_390779
  
  DOI: 10.1016/j.cell.2024.02.024
  
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  DOI: 10.1016/j.cell.2024.02.024
  
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Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats

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  AB_390779
  
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Sialyltransferase ST3GAL4 confers osimertinib resistance and offers strategies to overcome resistance in non-small cell lung cancer

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VISTA promotes the metabolism and differentiation of myeloid-derived suppressor cells by STAT3 and polyamine-dependent mechanisms

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  RRID:AB_390779
  
  DOI: 10.1016/j.celrep.2023.113661
  
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Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer

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PDGFRα+ITGA11+ fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay

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  RRID:AB_390779
  
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Fluoroquinolones upregulate insulin-like growth factor–binding protein 3, inhibit cell growth and insulin-like growth factor signaling

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  AB_390
  
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An integrative proteomics approach identifies tyrosine kinase KIT as a therapeutic target for SPINK1-positive prostate cancer

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  RRID:AB_390779
  
  DOI: 10.1016/j.isci.2024.108794
  
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Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin α2β1

1
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  RRID:AB_390779
  
  DOI: 10.1016/j.cmet.2024.01.014
  
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A small-molecule degrader selectively inhibits the growth of ALK-rearranged lung cancer with ceritinib resistance

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  RRID:AB_390779
  
  DOI: 10.1016/j.isci.2024.109015
  
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EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis

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  RRID:AB_390779
  
  DOI: 10.1016/j.celrep.2024.113714
  
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Allosteric inhibitor of SHP2 enhances macrophage endocytosis and bacteria elimination by increasing caveolae activation and protects against bacterial sepsis

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  RRID:AB_390779
  
  DOI: 10.1016/j.phrs.2024.107096
  
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OVOL2 induces autophagy-mediated epithelial-mesenchymal transition by the ERK1/2 MAPK signaling in lung adenocarcinoma

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  RRID:AB_390779
  
  DOI: 10.1016/j.isci.2024.108873
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10838806/
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Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR

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  RRID:AB_390779
  
  DOI: 10.1016/j.devcel.2024.01.010
  
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