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    Altered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation in a GM1-gangliosidosis model
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    Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model
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    PRODH safeguards human naive pluripotency by limiting mitochondrial oxidative phosphorylation and reactive oxygen species production
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    ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion
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  6. Apr 2024
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    Overexpression of α-Klotho isoforms promotes distinct Effects on BDNF-Induced Alterations in Dendritic Morphology
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    CircTMEM165 facilitates endothelial repair by modulating mitochondrial fission via miR-192/SCP2 in vitro and in vivo
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    Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding
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    The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle
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    A light-controlled phospholipase C for imaging of lipid dynamics and controlling neural plasticity
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    Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome
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  13. Mar 2024
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    Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L
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    Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion
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    FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis
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    TGR5-mediated lateral hypothalamus-dCA3-dorsolateral septum circuit regulates depressive-like behavior in male mice
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    Epithelial-derived interleukin-23 promotes oral mucosal immunopathology
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    Conditioned medium from induced pluripotent stem cell-derived mesenchymal stem cells accelerates cutaneous wound healing through enhanced angiogenesis
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    Foretinib is effective in acute myeloid leukemia by inhibiting FLT3 and overcoming secondary mutations that drive resistance to quizartinib and gilteritinib
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    Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis
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    A gut-derived hormone regulates cholesterol metabolism
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    Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats
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    Sialyltransferase ST3GAL4 confers osimertinib resistance and offers strategies to overcome resistance in non-small cell lung cancer
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    VISTA promotes the metabolism and differentiation of myeloid-derived suppressor cells by STAT3 and polyamine-dependent mechanisms
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    Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer
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    PDGFRα+ITGA11+ fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay
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  28. Feb 2024
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    Fluoroquinolones upregulate insulin-like growth factor–binding protein 3, inhibit cell growth and insulin-like growth factor signaling
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    An integrative proteomics approach identifies tyrosine kinase KIT as a therapeutic target for SPINK1-positive prostate cancer
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    Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin α2β1
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    A small-molecule degrader selectively inhibits the growth of ALK-rearranged lung cancer with ceritinib resistance
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    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
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    Allosteric inhibitor of SHP2 enhances macrophage endocytosis and bacteria elimination by increasing caveolae activation and protects against bacterial sepsis
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    OVOL2 induces autophagy-mediated epithelial-mesenchymal transition by the ERK1/2 MAPK signaling in lung adenocarcinoma
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    Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR
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    Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists
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    Gut-liver axis calibrates intestinal stem cell fitness
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  39. Jan 2024
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    Tumor cell–intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling
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      DOI: 10.1126/sciadv.adi2012

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    Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
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    MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning
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    O6-Methylguanine DNA Methyltransferase Regulates β-glucan-induced Trained Immunity of Macrophages via Farnesoid X Receptor and AMPK
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    CHTOP Alleviates Cerebral Ischemia/Reperfusion-Induced Injury by Regulating RNA Alternative Splicing
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    Casein kinase-2 inhibition promotes retinal ganglion cell survival after acute intraocular pressure elevation
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    A reversible epigenetic memory of inflammatory injury controls lineage plasticity and tumor initiation in the mouse pancreas
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    Econazole selectively induces cell death in NF1-homozygous mutant tumor cells
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    ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells
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  53. Nov 2023
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    Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
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    Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer
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    The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability
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    Blockade of CCR5 suppresses paclitaxel-induced peripheral neuropathic pain caused by increased deoxycholic acid
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    A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment
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    HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B
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    Repositioning of Montelukast to inhibit proliferation of mutated KRAS pancreatic cancer through a novel mechanism that interfere the binding between KRAS and GTP/GDP
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    ANKRD49 promotes the metastasis of NSCLC via activating JNK-ATF2/c-Jun-MMP-2/9 axis
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    Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer
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    A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
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    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
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    ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer
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    Metformin Improves the Prerequisites for FGF21 Signaling in Patients with Type 2 Diabetes
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    Tyrosine hydroxylase phosphorylation is under the control of serine 40
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    ERK1-mediated immunomodulation of mesenchymal stem cells ameliorates inflammatory disorders
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    Neutrophil extracellular traps enhance S. aureus skin colonization by oxidative stress induction and downregulation of epidermal barrier genes
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    MAPK-ERK-CREB signaling pathway upregulates Nav1.6 in oxaliplatin-induced neuropathic pain in the rat
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    Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis
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    URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease.
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    CGK733 alleviates ovariectomy-induced bone loss through blocking RANKL-mediated Ca2+ oscillations and NF-κB/MAPK signaling pathways
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    The MORC2 p.S87L mutation reduces proliferation of pluripotent stem cells derived from a patient with the spinal muscular atrophy-like phenotype by inhibiting proliferation-related signaling pathways
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    Glucose Transporter-2 Regulation of Male versus Female Hypothalamic Astrocyte MAPK Expression and Activation: Impact of Glucose
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    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
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    Apical extrusion prevents apoptosis from activating an acute inflammatory program in epithelia
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    ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
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    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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    Tumoral P2Y2 receptor modulates tumor growth and host anti-tumor immune responses in a syngeneic murine model of oral cancer
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  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine
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    Targeting CD36 determines nicotine derivative NNK-induced lung adenocarcinoma carcinogenesis
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    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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    Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
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    Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
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    PARP2 downregulation in T cells ameliorates lipopolysaccharide-induced inflammation of the large intestine
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    Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer
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    Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH
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    TOPK mediates immune evasion of Renal Cell Carcinoma via upregulating the expression of PD-L1
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    SHP2 participates in decidualization by activating ERK to maintain normal nuclear localization of progesterone receptor
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    The nucleotide receptor STING translocates to the phagosomes to negatively regulate anti-fungal immunity
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    Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway
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    Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design
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    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
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    UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders
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    How aberrant N-glycosylation can alter protein functionality and ligand binding: An atomistic view
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    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
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    Discovery of a Selective and Orally Bioavailable FGFR2 Degrader for Treating Gastric Cancer
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    USP10 regulates ZEB1 ubiquitination and protein stability to inhibit ZEB1-mediated colorectal cancer metastasis
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    A Drosophila model of diabetic neuropathy reveals a role of proteasome activity in the glia
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    N6-methyl-2′-deoxyadenosine promotes self-renewal of BFU-E progenitor in erythropoiesis
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    IRAK1 inhibition blocks the HIV-1 RNA mediated pro-inflammatory cytokine response from microglia
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    New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
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    Evaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters
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  128. aacrjournals.org aacrjournals.org
    RBM10 loss promotes EGFR-driven lung cancer and confers sensitivity to spliceosome inhibition
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    Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis
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  130. academic.oup.com academic.oup.com
    Casein kinase 1α regulates testosterone synthesis and testis development in adult mice
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    Cadmium-induced Sertoli cell injury through p38-MAPK and related signaling proteins – a study by RNA sequencing
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  132. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    Targeting formyl peptide receptor 1 by anteiso-C13-surfactin for neutrophil-dominant acute respiratory distress syndrome
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  135. May 2023
  136. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C
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    Targeting of Annexin A1 in Tumor-associated Macrophages as a Therapeutic Strategy for Hepatocellular Carcinoma
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    Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway
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    Salivary gland cancer organoids are valid for preclinical genotype-oriented medical precision trials
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    cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway
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    VEGFR-3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection
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  143. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  144. aacrjournals.org aacrjournals.org
    RASGRF1 Fusions Activate Oncogenic RAS Signaling and Confer Sensitivity to MEK Inhibition
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    Mechanisms of estradiol-induced EGF-like factor expression and oocyte maturation via G protein-coupled estrogen receptor
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    Cross-activation of FGF, NODAL, and WNT pathways constrains BMP-signaling-mediated induction of the totipotent state in mouse embryonic stem cells
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  147. Apr 2023
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    Regulation of sertoli cell function by planar cell polarity (PCP) protein Fjx1
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  149. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Amphiregulin blockade decreases the levodopa-induced dyskinesia in a 6-hydroxydopamine Parkinson's disease mouse model
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  150. www.biorxiv.org www.biorxiv.org
    ANKRD49 promotes the metastasis of NCI-H1299 and NCI-H1703 cells via activating JNK-ATF2/c-Jun-MMP-2/9 axis
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    IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma
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  152. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors
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  153. www.nature.com www.nature.com
    Single targeting of MET in EGFR-mutated and MET-amplified non-small cell lung cancer
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  154. www.embopress.org www.embopress.org
    RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis
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    Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells
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    INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model
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    ERK Inhibition Promotes Engraftment of Allografts by Reprogramming T-Cell Metabolism
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    Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer
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    Histone H3 phospho-regulation by KimH3 in both interphase and mitosis
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    IFNγ blockade in capillary leak site improves tumour chemotherapy by inhibiting lactate-induced endocytosis of vascular endothelial-cadherins
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    Epithelial cells activate fibroblasts to promote esophageal cancer development
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    Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo
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    Sulforaphane attenuates cancer cell-induced atrophy of C2C12 myotubes
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  165. journals.physiology.org journals.physiology.org
    Sulforaphane attenuates cancer cell-induced atrophy of C2C12 myotubes
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  166. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical Function of DPP4 Promotes Cognitive Impairment through ERp29-associated Mitochondrial Calcium Overload in Diabetes
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  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metformin Prevents Endothelial Oxidative Stress and Microvascular Insulin Resistance during Obesity Development in Male Rats
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    Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer
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    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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  170. Feb 2023
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    CAR-T cells targeting HLA-G as potent therapeutic strategy for EGFR mutated and overexpressed oral cancer
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    Repositioning Lomitapide to block ZDHHC5-dependant palmitoylation on SSTR5 leads to anti-proliferation effect in preclinical pancreatic cancer models
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    Identification of Genes Associated with Liver Metastasis in Pancreatic Cancer Reveals PCSK6 as a Crucial Mediator
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