219 Matching Annotations
  1. Aug 2025
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    Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer
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    sciencedirect.com/science/article/pii/S153458072500499X
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    Type I interferon signaling promotes kainic acid-induced seizures through mTOR activation
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    sciencedirect.com/science/article/pii/S0028390825003429
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    Overcoming ovarian cancer resistance and evasion to CAR-T cell therapy by harnessing allogeneic CAR-NKT cells
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    sciencedirect.com/science/article/pii/S2666634025002314
  6. Jul 2025
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    Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer
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    sciencedirect.com/science/article/pii/S2666379125003246
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The proteoglycan decorin does not influence adiposity, glucose tolerance, or aerobic exercise capacity in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12227656/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Riluzole Enhancing anti-PD-1 Efficacy by Activating cGAS/STING Signaling in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695182/
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    Early innate immune response and evolution of a SARS-CoV-2 furin cleavage site inactive variant in bat cells
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    sciencedirect.com/science/article/pii/S2211124725007004
  11. Jun 2025
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Immune targeting of triple-negative breast cancer through a clinically actionable STING agonist-CAR T cell platform
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    pmc.ncbi.nlm.nih.gov/articles/PMC12281382/
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    The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis
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    sciencedirect.com/science/article/pii/S0092867425006166
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel loss-of-function variant in STAT1 causes Mendelian susceptibility to mycobacterial disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12146302/
  15. May 2025
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Phase transition of WTAP regulates m6A modification of interferon-stimulated genes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12113268/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4+ T cells through STAT1-related epigenetic mechanisms
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    pmc.ncbi.nlm.nih.gov/articles/PMC12077877/
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    Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice
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    sciencedirect.com/science/article/pii/S2352396425001781
  19. Apr 2025
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    Cannabinoid CB2 receptor controls chronic itch by regulating spinal microglial activation and synaptic transmission
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    Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway
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  22. Mar 2025
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    Bilirubin metabolism in the liver orchestrates antiviral innate immunity in the body
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    Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome
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    pmc.ncbi.nlm.nih.gov/articles/PMC11927619/
  25. www.science.org www.science.org
    Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome
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    science.org/doi/10.1126/sciadv.adi9885
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    AGO2 mediates immunotherapy failure via suppressing tumor IFN-gamma response-dependent CD8+ T cell immunity
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    IL-24 promotes atopic dermatitis-like inflammation through driving MRSA-induced allergic responses
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  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Determining the Bordetella LPS structural features that influence TLR4 downstream signaling
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    The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis
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    Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy
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    Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response
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  32. Feb 2025
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance
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    Lipid droplet efferocytosis attenuates proinflammatory signaling in macrophages via TREM2- and MS4A7-dependent mechanisms
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  35. 52.53.155.43 52.53.155.43
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  36. Jan 2025
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acquired resistance to PD-L1 inhibition enhances a type I IFN-regulated secretory program in tumors
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    Longitudinal single-cell profiles of lung regeneration after viral infection reveal persistent injury-associated cell states
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  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pan-inhibition of super-enhancer-driven oncogenic transcription by next-generation synthetic ecteinascidins yields potent anti-cancer activity
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    Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation
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    JAK inhibition decreases the autoimmune burden in Down syndrome
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  42. Dec 2024
  43. www.sciencedirect.com www.sciencedirect.com
    RNA sensing induced by chromosome missegregation augments anti-tumor immunity
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    Pressure to evade cell-autonomous innate sensing reveals interplay between mitophagy, IFN signaling, and SARS-CoV-2 evolution
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    Regulation of human interferon signaling by transposon exonization
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    Neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ pathway
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  47. 52.53.155.43 52.53.155.43
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  48. Nov 2024
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Deciphering the composition and key driver genes of breast invasive micropapillary carcinoma by multi-omics analysis
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  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antagonistic roles of cGAS/STING signaling in colorectal cancer chemotherapy
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  51. Oct 2024
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    Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon
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    Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model
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    sciencedirect.com/science/article/pii/S0896627324006548
  54. www.nature.com www.nature.com
    QSOX2 Deficiency-induced short stature, gastrointestinal dysmotility and immune dysfunction
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    nature.com/articles/s41467-024-52587-w
  55. Sep 2024
  56. www.sciencedirect.com www.sciencedirect.com
    CXCR4 orchestrates the TOX-programmed exhausted phenotype of CD8+ T cells via JAK2/STAT3 pathway
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  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PDIA3 orchestrates effector T cell program by serving as a chaperone to facilitate the non-canonical nuclear import of STAT1 and PKM2
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    ncbi.nlm.nih.gov/pmc/articles/PMC11405166/
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    Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium
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    Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses
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    Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring
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  61. Aug 2024
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Role of Forkhead Box P3 in Interferon γ-mediated PD-L1 Expression and Bladder Cancer Epithelial-to-Mesenchymal Transition
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    Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells
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    Interleukin-21 engineering enhances NK cell activity against glioblastoma via CEBPD
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  65. jbiomedsci.biomedcentral.com jbiomedsci.biomedcentral.com
    Proteasome inhibitors restore the STAT1 pathway and enhance the expression of MHC class I on human colon cancer cells
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    jbiomedsci.biomedcentral.com/articles/10.1186/s12929-021-00769-9
  66. Jul 2024
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    Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity
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  68. Jun 2024
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic control of gene expression by ISGF3 and IRF1 during IFNβ and IFNγ signaling
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  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11315447/
  71. May 2024
  72. www.sciencedirect.com www.sciencedirect.com
    Distinct roles of TREM2 in central nervous system cancers and peripheral cancers
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  73. aacrjournals.org aacrjournals.org
    TREX1 inactivation unleashes cancer cell STING-interferon signaling and promotes anti-tumor immunity
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    aacrjournals.org/cancerdiscovery/article/14/5/752/745044/TREX1-Inactivation-Unleashes-Cancer-Cell-STING
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    Trophoblastic signals facilitate endometrial interferon response and lipid metabolism, ensuring normal decidualization
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  75. www.biorxiv.org www.biorxiv.org
    Viral mimicry and memory deficits upon microglial deletion of ATRX
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    biorxiv.org/content/10.1101/2024.05.07.592875v1
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    Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model
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    biorxiv.org/content/10.1101/2024.01.24.577107v1
  77. Apr 2024
  78. www.sciencedirect.com www.sciencedirect.com
    Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity
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  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer immunotherapy via synergistic co-activation of myeloid receptors CD40 and Dectin-1
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    ISGylation by HERCs facilitates STING activation
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    Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21
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    Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
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  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/β-Catenin/PD-L1 axis
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  84. Mar 2024
  85. www.sciencedirect.com www.sciencedirect.com
    Housekeeping U1 snRNA facilitates antiviral innate immunity by promoting TRIM25-mediated RIG-I activation
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  86. Feb 2024
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription
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    ncbi.nlm.nih.gov/pmc/articles/PMC11056844/
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gut-Brain Axis Interplay via STAT3 pathway: Implications of Helicobacter pylori derived secretome on inflammation and Alzheimer's disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC10854367/
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    Extracellular-vesicle-packaged S100A11 from osteosarcoma cells mediates lung premetastatic niche formation by recruiting gMDSCs
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    Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates
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    Subsets of interferon signaling predict response to immune checkpoint blockade in melanoma patients
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    SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion
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  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutations in the non-catalytic polyproline motif destabilize TREX1 and amplify cGAS-STING signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC10802300/
  94. Jan 2024
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10989277/
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pdgfrβ is required for embryonic specification and confinement of the adult white adipose lineage
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    Predicting gene-level sensitivity to JAK-STAT signaling perturbation using a mechanistic-to-machine learning framework
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  98. Dec 2023
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    IL-21-armored B7H3 CAR-iNKT cells exert potent antitumor effects
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    The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer
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  101. www.science.org www.science.org
    Cancer immunotherapy via synergistic coactivation of myeloid receptors CD40 and Dectin-1
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    science.org/doi/10.1126/sciimmunol.adj5097
  102. Nov 2023
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SIX4 Controls Anti-PD-1 Efficacy by Regulating STING Expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10680432/
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    Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity
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    sciencedirect.com/science/article/abs/pii/S107476132300417X
  105. Oct 2023
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    Serotonin reduction in post-acute sequelae of viral infection
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  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Endocrine Therapy Synergizes with SMAC Mimetics to Potentiate Antigen Presentation and Tumor Regression in Hormone Receptor–Positive Breast Cancer
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  222. Apr 2021
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    The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design
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  225. Mar 2021
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    Comparative Cell Surface Proteomic Analysis of the Primary Human T Cell and Monocyte Responses to Type I Interferon
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  229. Feb 2021
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    Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes
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    Functional heterogeneity of lymphocytic patterns in primary melanoma dissected through single-cell multiplexing
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  232. Jan 2021
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    MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells
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  235. Dec 2020
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    Endothelial Reprogramming by Disturbed Flow Revealed by Single-Cell RNA and Chromatin Accessibility Study
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  237. Oct 2020
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    Interferon-λ Enhances the Differentiation of Naive B Cells into Plasmablasts via the mTORC1 Pathway
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  239. Sep 2020
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    Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages
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    Systemic Type I IFN Inflammation in Human ISG15 Deficiency Leads to Necrotizing Skin Lesions
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    Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function
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    Decoding the Transcriptional Response to Ischemic Stroke in Young and Aged Mouse Brain
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    Combination of CHEK1/2 inhibition and ionizing radiation results in abscopal tumor response through increased micronuclei formation
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    Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling
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  246. Jan 2020
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    An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer
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    Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome
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    Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and III Interferons
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    STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production
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    A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
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    Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense
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    Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions
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