88 Matching Annotations
  1. May 2022
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    Intracellular infection and immune system cues rewire adipocytes to acquire immune function
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    1. scibot 05 May 2022
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    sciencedirect.com/science/article/pii/S1550413122001358
  3. Apr 2022
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    Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques
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    1. scibot 20 Apr 2022
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      DOI: 10.1016/j.immuni.2022.03.018

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    sciencedirect.com/science/article/pii/S1074761322001418
  5. Mar 2022
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    PTIP governs NAD+ metabolism by regulating CD38 expression to drive macrophage inflammation
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    1. scibot 31 Mar 2022
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    sciencedirect.com/science/article/pii/S2211124722003515
  7. journals.lww.com journals.lww.com
    Ruxolitinib attenuates secondary injury after traumatic spinal cord injury
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    1. scibot 10 Mar 2022
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      DOI: 10.4103/1673-5374.335165

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    journals.lww.com/nrronline/Fulltext/2022/17090/Ruxolitinib_attenuates_secondary_injury_after.35.aspx
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    Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages
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    1. scibot 02 Mar 2022
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    sciencedirect.com/science/article/pii/S1550413122000468
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    Abi1 mediates airway smooth muscle cell proliferation and airway remodeling via Jak2/STAT3 signaling
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    sciencedirect.com/science/article/pii/S2589004222001031
  10. Feb 2022
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    Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
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    1. scibot 23 Feb 2022
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      DOI: 10.1016/j.chom.2022.01.014

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    sciencedirect.com/science/article/pii/S1931312822000506
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    Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo
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      DOI: 10.1038/s41375-020-01077-1

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    nature.com/articles/s41375-020-01077-1
  13. Jan 2022
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    Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription
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    1. scibot 26 Jan 2022
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    sciencedirect.com/science/article/pii/S2211124722000146
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    Vitamin D receptor, STAT3, and TET2 cooperate to establish tolerogenesis
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    1. scibot 19 Jan 2022
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      DOI: 10.1016/j.celrep.2021.110244

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    sciencedirect.com/science/article/pii/S2211124721017538
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    Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells
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    1. scibot 16 Jan 2022
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    sciencedirect.com/science/article/pii/S2211124721017459
  17. Dec 2021
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    EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion
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    1. scibot 28 Dec 2021
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    sciencedirect.com/science/article/pii/S0092867421014276
  19. www.nature.com www.nature.com
    Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance
    1
    1. scibot 11 Dec 2021
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      DOI: 10.1038/s41467-021-27349-7

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    nature.com/articles/s41467-021-27349-7
  20. Nov 2021
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells
    1
    1. scibot 24 Nov 2021
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      DOI: 10.1016/j.isci.2021.103348

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    ncbi.nlm.nih.gov/pmc/articles/PMC8593563/
  22. www.sciencedirect.com www.sciencedirect.com
    Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors
    1
    1. scibot 03 Nov 2021
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      DOI: 10.1016/j.celrep.2021.109955

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    sciencedirect.com/science/article/pii/S2211124721014327
  23. Oct 2021
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway
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    1. scibot 23 Oct 2021
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      DOI: 10.1016/j.isci.2021.103173

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    ncbi.nlm.nih.gov/pmc/articles/PMC8517841/
  25. Sep 2021
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    PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis
    1
    1. scibot 24 Sep 2021
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      DOI: 10.1016/j.molcel.2021.08.039

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    sciencedirect.com/science/article/pii/S1097276521007292
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    Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma
    1
    1. scibot 15 Sep 2021
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      DOI: 10.1016/j.xcrm.2021.100399

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    sciencedirect.com/science/article/pii/S2666379121002573
  28. www.sciencedirect.com www.sciencedirect.com
    Activating a collaborative innate-adaptive immune response to control metastasis
    1
    1. scibot 03 Sep 2021
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      DOI: 10.1016/j.ccell.2021.08.005

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    sciencedirect.com/science/article/pii/S1535610821004451
  29. Aug 2021
  30. www.sciencedirect.com www.sciencedirect.com
    Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes
    1
    1. scibot 25 Aug 2021
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      DOI: 10.1016/j.celrep.2021.109613

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    sciencedirect.com/science/article/pii/S2211124721010512
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CXCL10/CXCR3 signaling contributes to an inflammatory microenvironment and its blockade enhances progression of murine pancreatic precancerous lesions
    1
    1. scibot 19 Aug 2021
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      DOI: 10.7554/eLife.60646

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    ncbi.nlm.nih.gov/pmc/articles/PMC8360647/
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Studying immunotherapy resistance in a melanoma autologous humanized mouse xenograft.
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    1. scibot 15 Aug 2021
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      DOI: 10.1158/1541-7786.MCR-20-0686

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    ncbi.nlm.nih.gov/pmc/articles/PMC7864867/
  33. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 10 Aug 2021
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      DOI: 10.1016/j.immuni.2018.10.008

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    sciencedirect.com/science/article/pii/S1074761318304497
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    Untitled document
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    sciencedirect.com/science/article/pii/S107476131830428X
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    FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection
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    1. scibot 09 Aug 2021
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      DOI: 10.1016/j.chom.2018.10.006

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    sciencedirect.com/science/article/pii/S1931312818305444
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    Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death
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    1. scibot 07 Aug 2021
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      DOI: 10.1016/j.cell.2021.07.026

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    sciencedirect.com/science/article/pii/S0092867421008850
  37. www.sciencedirect.com www.sciencedirect.com
    Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome
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    1. scibot 01 Aug 2021
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      DOI: 10.1016/j.celrep.2019.10.038

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    sciencedirect.com/science/article/pii/S221112471931352X
  38. Jul 2021
  39. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Interleukin 35 ameliorates myocardial ischemia‐reperfusion injury by activating the gp130‐STAT3 axis
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    1. scibot 30 Jul 2021
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      DOI: 10.1096/fj.201901718RR

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    onlinelibrary.wiley.com/doi/10.1096/fj.201901718RR
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    Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC
    1
    1. scibot 30 Jul 2021
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      DOI: 10.1016/j.cell.2018.09.053

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    sciencedirect.com/science/article/pii/S0092867418313047
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    Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING
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      DOI: 10.1016/j.celrep.2021.109412

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    sciencedirect.com/science/article/pii/S2211124721008251
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    PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity
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      DOI: 10.1016/j.ccell.2021.06.018

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    sciencedirect.com/science/article/pii/S1535610821003408
  43. www.nature.com www.nature.com
    Necroptotic virotherapy of oncolytic alphavirus M1 cooperated with Doxorubicin displays promising therapeutic efficacy in TNBC
    1
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      DOI: 10.1038/s41388-021-01869-4

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    nature.com/articles/s41388-021-01869-4
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    Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell
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    sciencedirect.com/science/article/pii/S2211124721007622
  45. Jun 2021
  46. www.hindawi.com www.hindawi.com
    Table 2 | Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition
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    hindawi.com/journals/mi/2021/6687089/tab2/
  47. www.frontiersin.org www.frontiersin.org
    Promotion of Bone Lesions Through the Myeloma Integrin α6-Mediated Osteolytic Signaling
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      DOI: 10.3389/fonc.2021.692190

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    frontiersin.org/article/10.3389/fonc.2021.692190/full
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    Translation stress and collided ribosomes are co-activators of cGAS
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      DOI: 10.1016/j.molcel.2021.05.018

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    sciencedirect.com/science/article/pii/S1097276521004020
  49. May 2021
  50. www.sciencedirect.com www.sciencedirect.com
    Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses
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      DOI: 10.1016/j.isci.2021.102477

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    sciencedirect.com/science/article/pii/S2589004221004454
  51. www.sciencedirect.com www.sciencedirect.com
    Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities
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      DOI: 10.1016/j.celrep.2021.109126

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    sciencedirect.com/science/article/pii/S2211124721004654
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    Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology
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      DOI: 10.1016/j.neuron.2021.02.010

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    sciencedirect.com/science/article/pii/S0896627321000842
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    Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation
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      DOI: 10.1016/j.molcel.2021.01.010

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    Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function
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    Combination of CHEK1/2 inhibition and ionizing radiation results in abscopal tumor response through increased micronuclei formation
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    Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling
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    An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer
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    Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome
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    Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and III Interferons
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    STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production
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    A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
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    Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense
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    Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions
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    IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners
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    RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer
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    A Bacterial Expression Platform for Production of Therapeutic Proteins Containing Human-like O-Linked Glycans
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    Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus
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    Permeability analyses and three dimensional imaging of interferon gamma-induced barrier disintegration in intestinal organoids
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    Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING
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    IFIT1 Exerts Opposing Regulatory Effects on the Inflammatory and Interferon Gene Programs in LPS-Activated Human Macrophages
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    The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors
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    Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping
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    By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation
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  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Efficacy of the Interferon Alpha/Beta Response versus Arboviruses Is Temperature Dependent
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    Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection
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    Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1
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    Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress
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    The control of oligodendrocyte bioenergetics by interferon-gamma (IFN-γ) and Src homology region 2 domain-containing phosphatase-1 (SHP-1)
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    A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader
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    Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade
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    Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation
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