181 Matching Annotations
  1. Nov 2024
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Deciphering the composition and key driver genes of breast invasive micropapillary carcinoma by multi-omics analysis
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    1. scibot 14 Nov 2024
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      DOI: 10.1016/j.isci.2024.111178

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    pmc.ncbi.nlm.nih.gov/articles/PMC11549989/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antagonistic roles of cGAS/STING signaling in colorectal cancer chemotherapy
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    1. scibot 07 Nov 2024
      RRID:AB_561284

      DOI: 10.3389/fonc.2024.1441935

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    pmc.ncbi.nlm.nih.gov/articles/PMC11513249/
  4. Oct 2024
  5. www.sciencedirect.com www.sciencedirect.com
    Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon
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    1. scibot 04 Oct 2024
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    sciencedirect.com/science/article/pii/S1550413124003668
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    Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model
    1
    1. scibot 02 Oct 2024
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      DOI: 10.1016/j.neuron.2024.09.006

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    sciencedirect.com/science/article/pii/S0896627324006548
  7. www.nature.com www.nature.com
    QSOX2 Deficiency-induced short stature, gastrointestinal dysmotility and immune dysfunction
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    1. scibot 01 Oct 2024
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      DOI: 10.1038/s41467-024-52587-w

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    nature.com/articles/s41467-024-52587-w
  8. Sep 2024
  9. www.sciencedirect.com www.sciencedirect.com
    CXCR4 orchestrates the TOX-programmed exhausted phenotype of CD8+ T cells via JAK2/STAT3 pathway
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    1. scibot 26 Sep 2024
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      DOI: 10.1016/j.xgen.2024.100659

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    sciencedirect.com/science/article/pii/S2666979X24002702
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PDIA3 orchestrates effector T cell program by serving as a chaperone to facilitate the non-canonical nuclear import of STAT1 and PKM2
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    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.ymthe.2024.05.038

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    ncbi.nlm.nih.gov/pmc/articles/PMC11405166/
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    Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium
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    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S1931312824003202
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    Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses
    1
    1. scibot 25 Sep 2024
      RRID:AB_10860071

      DOI: 10.1016/j.celrep.2020.108080

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      Curator comments: Rabbit Anti-Stat1, phospho (Tyr701) Monoclonal Antibody, Unconjugated, Clone 58D6 Cell Signaling Technology Cat# 9167

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    sciencedirect.com/science/article/pii/S2211124720310652
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    Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring
    1
    1. scibot 25 Sep 2024
      RRID:AB_10859888

      DOI: 10.1016/j.cmet.2019.10.004

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    sciencedirect.com/science/article/pii/S1550413119305595
  14. Aug 2024
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Role of Forkhead Box P3 in Interferon γ-mediated PD-L1 Expression and Bladder Cancer Epithelial-to-Mesenchymal Transition
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    1. scibot 28 Aug 2024
      RRID:AB_561284

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    ncbi.nlm.nih.gov/pmc/articles/PMC11345674/
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    Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells
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    1. scibot 21 Aug 2024
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    sciencedirect.com/science/article/pii/S2211124724009379
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    Interleukin-21 engineering enhances NK cell activity against glioblastoma via CEBPD
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    1. scibot 21 Aug 2024
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    sciencedirect.com/science/article/pii/S1535610824002721
  18. jbiomedsci.biomedcentral.com jbiomedsci.biomedcentral.com
    Proteasome inhibitors restore the STAT1 pathway and enhance the expression of MHC class I on human colon cancer cells
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    1. scibot 02 Aug 2024
      9167

      DOI: 10.1186/s12929-021-00769-9

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    jbiomedsci.biomedcentral.com/articles/10.1186/s12929-021-00769-9
  19. Jul 2024
  20. www.sciencedirect.com www.sciencedirect.com
    Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity
    1
    1. scibot 24 Jul 2024
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    sciencedirect.com/science/article/pii/S1074761324002796
  21. Jun 2024
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic control of gene expression by ISGF3 and IRF1 during IFNβ and IFNγ signaling
    1
    1. scibot 08 Jun 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11148166/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity
    1
    1. scibot 04 Jun 2024
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      DOI: 10.1016/j.celrep.2024.114289

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    ncbi.nlm.nih.gov/pmc/articles/PMC11315447/
  24. May 2024
  25. www.sciencedirect.com www.sciencedirect.com
    Distinct roles of TREM2 in central nervous system cancers and peripheral cancers
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    1. scibot 24 May 2024
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    sciencedirect.com/science/article/pii/S1535610824001624
  26. aacrjournals.org aacrjournals.org
    TREX1 inactivation unleashes cancer cell STING-interferon signaling and promotes anti-tumor immunity
    2
    1. scibot 23 May 2024
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      DOI: 10.1158/2159-8290.CD-23-0700

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      DOI: 10.1158/2159-8290.CD-23-0700

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    aacrjournals.org/cancerdiscovery/article/14/5/752/745044/TREX1-Inactivation-Unleashes-Cancer-Cell-STING
  27. www.sciencedirect.com www.sciencedirect.com
    Trophoblastic signals facilitate endometrial interferon response and lipid metabolism, ensuring normal decidualization
    1
    1. scibot 21 May 2024
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      DOI: 10.1016/j.celrep.2024.114246

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    sciencedirect.com/science/article/pii/S2211124724005746
  28. www.biorxiv.org www.biorxiv.org
    Viral mimicry and memory deficits upon microglial deletion of ATRX
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    1. scibot 16 May 2024
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      DOI: 10.1101/2024.05.07.592875

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    biorxiv.org/content/10.1101/2024.05.07.592875v1
  29. www.biorxiv.org www.biorxiv.org
    Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model
    1
    1. scibot 10 May 2024
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      DOI: 10.1101/2024.01.24.577107

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    biorxiv.org/content/10.1101/2024.01.24.577107v1
  30. Apr 2024
  31. www.sciencedirect.com www.sciencedirect.com
    Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity
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    1. scibot 30 Apr 2024
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      DOI: 10.1016/j.xcrm.2024.101528

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    sciencedirect.com/science/article/pii/S2666379124001976
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer immunotherapy via synergistic co-activation of myeloid receptors CD40 and Dectin-1
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    1. scibot 24 Apr 2024
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      DOI: 10.1126/sciimmunol.adj5097

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    ncbi.nlm.nih.gov/pmc/articles/PMC11034815/
  33. www.sciencedirect.com www.sciencedirect.com
    ISGylation by HERCs facilitates STING activation
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      DOI: 10.1016/j.celrep.2024.114135

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    sciencedirect.com/science/article/pii/S2211124724004637
  34. www.sciencedirect.com www.sciencedirect.com
    Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21
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    1. scibot 19 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114095

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    sciencedirect.com/science/article/pii/S2211124724004236
  35. www.sciencedirect.com www.sciencedirect.com
    Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
    1
    1. scibot 16 Apr 2024
      RRID:AB_3096118

      DOI: 10.1016/j.celrep.2024.114111

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    sciencedirect.com/science/article/pii/S221112472400439X
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/β-Catenin/PD-L1 axis
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    1. scibot 10 Apr 2024
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      DOI: 10.1016/j.isci.2024.109533

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    ncbi.nlm.nih.gov/pmc/articles/PMC11000115/
  37. Mar 2024
  38. www.sciencedirect.com www.sciencedirect.com
    Housekeeping U1 snRNA facilitates antiviral innate immunity by promoting TRIM25-mediated RIG-I activation
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      DOI: 10.1016/j.celrep.2024.113945

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    sciencedirect.com/science/article/pii/S2211124724002730
  39. Feb 2024
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription
    1
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      Cell Signaling9167S

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    ncbi.nlm.nih.gov/pmc/articles/PMC11056844/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gut-Brain Axis Interplay via STAT3 pathway: Implications of Helicobacter pylori derived secretome on inflammation and Alzheimer's disease
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      DOI: 10.1080/21505594.2024.2303853

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    ncbi.nlm.nih.gov/pmc/articles/PMC10854367/
  42. www.sciencedirect.com www.sciencedirect.com
    Extracellular-vesicle-packaged S100A11 from osteosarcoma cells mediates lung premetastatic niche formation by recruiting gMDSCs
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    sciencedirect.com/science/article/pii/S2211124724000792
  43. 52.53.155.43 52.53.155.43
    Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates
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    52.53.155.43/d3d22b34dc913e3c2adad8dc51a7839208721c99/PIIS2589004224003213-html.html
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Subsets of interferon signaling predict response to immune checkpoint blockade in melanoma patients
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      DOI: 10.1158/1078-0432.CCR-23-0215

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    ncbi.nlm.nih.gov/pmc/articles/PMC10524955/
  45. www.sciencedirect.com www.sciencedirect.com
    SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion
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    sciencedirect.com/science/article/pii/S0092867424000102
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutations in the non-catalytic polyproline motif destabilize TREX1 and amplify cGAS-STING signaling
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      DOI: 10.1101/2024.01.04.574136

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    ncbi.nlm.nih.gov/pmc/articles/PMC10802300/
  47. Jan 2024
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells
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      DOI: 10.1016/j.celrep.2023.113600

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    ncbi.nlm.nih.gov/pmc/articles/PMC10989277/
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pdgfrβ is required for embryonic specification and confinement of the adult white adipose lineage
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      DOI: 10.1016/j.isci.2023.108682

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    ncbi.nlm.nih.gov/pmc/articles/PMC10792241/
  50. www.sciencedirect.com www.sciencedirect.com
    Predicting gene-level sensitivity to JAK-STAT signaling perturbation using a mechanistic-to-machine learning framework
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  51. Dec 2023
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    IL-21-armored B7H3 CAR-iNKT cells exert potent antitumor effects
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    The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer
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    Cancer immunotherapy via synergistic coactivation of myeloid receptors CD40 and Dectin-1
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  55. Nov 2023
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    SIX4 Controls Anti-PD-1 Efficacy by Regulating STING Expression
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    Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity
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  58. Oct 2023
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    Serotonin reduction in post-acute sequelae of viral infection
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    Endocrine Therapy Synergizes with SMAC Mimetics to Potentiate Antigen Presentation and Tumor Regression in Hormone Receptor–Positive Breast Cancer
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    Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
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    In vivo modeling of CLL transformation to Richter’s syndrome reveals convergent evolutionary paths and therapeutic vulnerabilities
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    NLRP11 is a pattern recognition receptor for bacterial lipopolysaccharide in the cytosol of human macrophages
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    ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
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    Hedgehog receptors exert immune-surveillance roles in the epidermis across species
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    Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model
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    MEF2A suppresses stress responses that trigger DDX41-dependent IFN production
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    Derivation of CD8+ T-cell Infiltration Potentiators in Non-Small Cell Lung Cancer Through Tumor Microenvironment Analysis
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    Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH
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  74. Jun 2023
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    Interferon hyperactivity impairs cardiogenesis in Down syndrome via downregulation of canonical Wnt signaling
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  76. May 2023
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    MYO10 regulates genome stability and cancer inflammation through mediating mitosis
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    Human papillomavirus E5 suppresses immunity via inhibition of the immunoproteasome and STING pathway
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    Innate immune pathway modulator screen identifies STING pathway activation as a strategy to inhibit multiple families of arbo and respiratory viruses
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    Early immune pressure initiated by tissue-resident memory T cells sculpts tumor evolution in non-small cell lung cancer
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    Conserved and cell type-specific transcriptional responses to IFN-γ in the ventral midbrain
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    N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+ T cell responsiveness.
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    MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer
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    Restricting genomic actions of innate immune mediators on fetal hematopoietic progenitor cells
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  89. Feb 2023
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    Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity
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    SECTM1 is upregulated in immuno-hot tumors and predicts immunotherapeutic efficacy in multiple cancers
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  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity
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  95. Jan 2023
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    Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner
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    Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy
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    Immunoediting instructs tumor metabolic reprogramming to support immune evasion
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    COMPREHENSIVE DRUG RESPONSE PROFILING AND PAN-OMIC ANALYSIS IDENTIFIED THERAPEUTIC CANDIDATES AND PROGNOSTIC BIOMARKERS FOR ASIAN CHOLANGIOCARCINOMA
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    Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription
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    FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection
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  158. Jul 2021
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    Interleukin 35 ameliorates myocardial ischemia‐reperfusion injury by activating the gp130‐STAT3 axis
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    Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC
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    Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING
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    Necroptotic virotherapy of oncolytic alphavirus M1 cooperated with Doxorubicin displays promising therapeutic efficacy in TNBC
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  165. Jun 2021
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    Table 2 | Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition
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    Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses
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    Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities
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    Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus
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    MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
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    The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design
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  178. Mar 2021
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    Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication
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  185. Jan 2021
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    MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells
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    Interferon-λ Enhances the Differentiation of Naive B Cells into Plasmablasts via the mTORC1 Pathway
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  192. Sep 2020
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    Combination of CHEK1/2 inhibition and ionizing radiation results in abscopal tumor response through increased micronuclei formation
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    Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling
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    An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer
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    Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome
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    Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and III Interferons
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    STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production
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    A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
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    CCN1 interlinks integrin and Hippo pathway to autoregulate tip cell activity
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    Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy
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    Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions
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    IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners
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    A Bacterial Expression Platform for Production of Therapeutic Proteins Containing Human-like O-Linked Glycans
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    Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus
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    Permeability analyses and three dimensional imaging of interferon gamma-induced barrier disintegration in intestinal organoids
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    Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING
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  217. Nov 2018
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    IFIT1 Exerts Opposing Regulatory Effects on the Inflammatory and Interferon Gene Programs in LPS-Activated Human Macrophages
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    The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors
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    Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping
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    By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation
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    The Efficacy of the Interferon Alpha/Beta Response versus Arboviruses Is Temperature Dependent
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    Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection
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    Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1
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    Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress
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    The control of oligodendrocyte bioenergetics by interferon-gamma (IFN-γ) and Src homology region 2 domain-containing phosphatase-1 (SHP-1)
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  228. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader
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  229. Nov 2017
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    Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade
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    Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation
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