229 Matching Annotations
  1. Last 7 days
  2. www.thelancet.com www.thelancet.com
    Discovery of a peptide proteolysis-targeting chimera (PROTAC) drug of p300 for prostate cancer therapy
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      DOI: 10.1016/j.ebiom.2024.105212

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    thelancet.com/journals/ebiom/article/PIIS2352-3964(24)00247-0/abstract
  3. Jul 2024
  4. www.cell.com www.cell.com
    A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence
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    cell.com/cell/abstract/S0092-8674(24)00693-7
  5. www.sciencedirect.com www.sciencedirect.com
    Incense-burning smoke ingredient Auramine enhances lincRNA-p21 expression for chemosensitization in p53-mutated non-small cell lung cancer
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    1. scibot 11 Jul 2024
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      DOI: 10.1016/j.jhazmat.2024.135105

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    sciencedirect.com/science/article/pii/S0304389424016844
  6. Jun 2024
  7. www.sciencedirect.com www.sciencedirect.com
    The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress
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    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.celrep.2024.114366

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    sciencedirect.com/science/article/pii/S2211124724006946
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    TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons
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    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.cell.2024.05.030

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    sciencedirect.com/science/article/pii/S0092867424005750
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ESR1 and p53 Interactome Alteration Defines Mechanisms of Tamoxifen Response in Luminal Breast Cancer
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    1. scibot 14 Jun 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11166704/
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IRX4204 Induces Senescence and Cell Death in HER2-positive Breast Cancer and Synergizes with Anti-HER2 Therapy
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    1. scibot 07 Jun 2024
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      DOI: 10.1158/1078-0432.CCR-23-3839

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    ncbi.nlm.nih.gov/pmc/articles/PMC11145169/
  11. May 2024
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cell Competition Eliminates Aneuploid Human Pluripotent Stem Cells
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      DOI: 10.1101/2024.05.08.593217

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      DOI: 10.1101/2024.05.08.593217

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    ncbi.nlm.nih.gov/pmc/articles/PMC11100710/
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fatal COVID-19 pulmonary disease involves ferroptosis
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    1. scibot 23 May 2024
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      DOI: 10.1038/s41467-024-48055-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC11106344/
  14. elifesciences.org elifesciences.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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    1. scibot 03 May 2024
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      DOI: 10.7554/eLife.90683

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    elifesciences.org/articles/90683
  15. Apr 2024
  16. www.sciencedirect.com www.sciencedirect.com
    Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers
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    1. scibot 26 Apr 2024
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    sciencedirect.com/science/article/pii/S1535610824001284
  17. www.sciencedirect.com www.sciencedirect.com
    Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis
    1
    1. scibot 23 Apr 2024
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      DOI: 10.1016/j.cell.2024.04.002

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    sciencedirect.com/science/article/pii/S0092867424003970
  18. www.sciencedirect.com www.sciencedirect.com
    RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells
    2
    1. scibot 19 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114116

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      DOI: 10.1016/j.celrep.2024.114116

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    sciencedirect.com/science/article/pii/S2211124724004443
  19. www.sciencedirect.com www.sciencedirect.com
    A senescence restriction point acting on chromatin integrates oncogenic signals
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    sciencedirect.com/science/article/pii/S2211124724003723
  20. Mar 2024
  21. www.sciencedirect.com www.sciencedirect.com
    Dual-specificity tyrosine-regulated kinase 2 exerts anti-tumor effects by induction of G1 arrest in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S0304416524000436
  22. www.sciencedirect.com www.sciencedirect.com
    A unique chaperoning mechanism in class A JDPs recognizes and stabilizes mutant p53
    2
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    sciencedirect.com/science/article/pii/S1097276524001370
  23. Feb 2024
  24. www.sciencedirect.com www.sciencedirect.com
    Apoptosis due to after-effects of acute ethanol exposure in brain cortex: Intrinsic and extrinsic signaling pathways
    2
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      DOI: 10.1016/j.neuroscience.2024.02.022

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      DOI: 10.1016/j.neuroscience.2024.02.022

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    sciencedirect.com/science/article/pii/S0306452224000861
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PPM1G promotes cell proliferation via modulating mutant GOF p53 protein expression in hepatocellular carcinoma
    1
    1. scibot 28 Feb 2024
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      DOI: 10.1016/j.isci.2024.109116

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    ncbi.nlm.nih.gov/pmc/articles/PMC10879691/
  26. www.cell.com www.cell.com
    Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma
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    1. scibot 23 Feb 2024
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    cell.com/cell-metabolism/abstract/S1550-4131(24)00018-4
  27. www.sciencedirect.com www.sciencedirect.com
    A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers
    1
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      DOI: 10.1016/j.xcrm.2024.101434

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    sciencedirect.com/science/article/pii/S2666379124000570
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of a First-in-Class Small Molecule Inhibitor of the eIF4E-RBM38 Complex that Enhances wild-type p53 Protein Translation for Tumor Growth Suppression
    1
    1. scibot 16 Feb 2024
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      DOI: 10.1158/1535-7163.MCT-22-0627

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    ncbi.nlm.nih.gov/pmc/articles/PMC10866396/
  29. Jan 2024
  30. www.cell.com www.cell.com
    p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP
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    1. scibot 25 Jan 2024
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      DOI: 10.1016/j.celrep.2023.113426

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    cell.com/cell-reports/abstract/S2211-1247(23)01438-9
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unique transcriptional profiles underlie osteosarcomagenesis driven by different p53 mutants
    1
    1. scibot 18 Jan 2024
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      DOI: 10.1158/0008-5472.CAN-22-3464

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    ncbi.nlm.nih.gov/pmc/articles/PMC10524763/
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner
    1
    1. scibot 10 Jan 2024
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      DOI: 10.1158/1078-0432.CCR-23-0964

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    ncbi.nlm.nih.gov/pmc/articles/PMC10767302/
  33. Dec 2023
  34. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation
    1
    1. scibot 29 Dec 2023
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      DOI: 10.1002/advs.202305620

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    onlinelibrary.wiley.com/doi/10.1002/advs.202305620
  35. www.sciencedirect.com www.sciencedirect.com
    Unified framework for patient-derived, tumor-organoid-based predictive testing of standard-of-care therapies in metastatic colorectal cancer
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      DOI: 10.1016/j.xcrm.2023.101335

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    sciencedirect.com/science/article/pii/S2666379123005529
  36. www.sciencedirect.com www.sciencedirect.com
    FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination
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      DOI: 10.1016/j.celrep.2023.113523

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    sciencedirect.com/science/article/pii/S2211124723015358
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquiton—An inducible, linkage-specific polyubiquitylation tool
    1
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      DOI: 10.1016/j.molcel.2023.11.016

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    ncbi.nlm.nih.gov/pmc/articles/PMC10804999/
  38. Nov 2023
  39. www.sciencedirect.com www.sciencedirect.com
    Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest
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      DOI: 10.1016/j.chembiol.2023.10.011

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    sciencedirect.com/science/article/abs/pii/S2451945623003720
  40. www.cell.com www.cell.com
    Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest
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    cell.com/molecular-cell/fulltext/S1097-2765(23)00857-2
  41. www.sciencedirect.com www.sciencedirect.com
    An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant
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    sciencedirect.com/science/article/pii/S2211124723014961
  42. www.sciencedirect.com www.sciencedirect.com
    Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53
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      DOI: 10.1016/j.celrep.2023.113478

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    sciencedirect.com/science/article/pii/S2211124723014900
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antitumor effects of PRMT5 inhibition in sarcomas
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      DOI: 10.1158/2767-9764.CRC-23-0239

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    ncbi.nlm.nih.gov/pmc/articles/PMC10621483/
  44. Oct 2023
  45. www.nature.com www.nature.com
    SIRT1 is an actionable target to restore p53 function in HPV-associated cancer therapy
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      DOI: 10.1038/s41416-023-02465-x

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    nature.com/articles/s41416-023-02465-x
  46. Sep 2023
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    circELMOD3 increases and stabilizes TRIM13 by sponging miR-6864-5p and direct binding to inhibit HCC progression
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      DOI: 10.1016/j.isci.2023.107818

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    ncbi.nlm.nih.gov/pmc/articles/PMC10518715/
  48. www.nature.com www.nature.com
    Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
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      DOI: 10.1038/s41422-023-00874-4

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    A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression
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    Endothelial SIRT-1 has a critical role for the maintenance of capillarization in brown adipose tissue
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  97. www.sciencedirect.com www.sciencedirect.com
    m6A modification confers thermal vulnerability to HPV E7 oncotranscripts via reverse regulation of its reader protein IGF2BP1 upon heat stress
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    Decreased DNA damage and improved p53 specificity of RITA analogs
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    Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors
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    Control of ribosomal RNA synthesis by hematopoietic transcription factors
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    A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice
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  103. Aug 2022
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    SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis
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    Targeting HOTAIRM1 ameliorates glioblastoma by disrupting mitochondrial oxidative phosphorylation and serine metabolism
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  107. Jul 2022
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    Self-assembly of pericentriolar material in interphase cells lacking centrioles
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    MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma
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    Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
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    Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia
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    MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression
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  114. May 2022
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    Mutations in DNA binding domain of p53 impede RSL1D1-p53 interaction to escape from degradation in human colorectal cancer cells
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  116. Apr 2022
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    Targeting the miR-34a/LRPPRC/MDR1 axis collapse the chemoresistance in P53 inactive colorectal cancer
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    Suppression of p53 response by targeting p53-Mediator binding with a stapled peptide
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  119. Mar 2022
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    Chk1 dynamics in G2 phase upon replication stress predict daughter cell outcome
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    Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis
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  122. Feb 2022
  123. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Tau nuclear translocation is a leading step in tau pathology process through P53 stabilization and nucleolar dispersion
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  124. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling
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    SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage
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  126. Dec 2021
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    Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis
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  128. Nov 2021
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    LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity
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    Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells
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  132. Oct 2021
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    Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models
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    Shift in MSL1 alternative polyadenylation in response to DNA damage protects cancer cells from chemotherapeutic agent-induced apoptosis
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    USP7 and VCPFAF1 define the SUMO/Ubiquitin landscape at the DNA replication fork
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    ERα determines the chemoresistant function of mutant p53 involving the switch between lincRNA-p21 and DDB2 expressions
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    A hydride transfer complex reprograms NAD metabolism and bypasses senescence
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    ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction
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    HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis
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  141. Aug 2021
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    Serine/threonine ligation-assisted chemical synthesis of HMGA1a protein with site-specific post-translational modifications
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    Entosis is induced by UV radiation.
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    Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm
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    Ribosomal L1 domain-containing protein 1 coordinates with HDM2 to negatively regulate p53 in human colorectal Cancer cells
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    Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion
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    Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion
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  149. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  151. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53
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  153. journals.biologists.com journals.biologists.com
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  155. Jul 2021
  156. onlinelibrary.wiley.com onlinelibrary.wiley.com
    CBX4 promotes the proliferation and metastasis via regulating BMI‐1 in lung cancer
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    Effects of the Antifungal Agent Ciclopirox in HPV‐Positive Cancer Cells: Repression of Viral E6/E7 Oncogene Expression and Induction of Senescence and Apoptosis
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    A Molecular Signature in Blood Reveals a Role for p53 in Regulating Malaria-Induced Inflammation
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      anti-human p53 Alexa Fluor 647 clone DO-1

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  159. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed Cancers
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    A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer
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    Selective Anti-tumor Activity of wogonin targeting the Warburg Effect through stablizing p53
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    CETSA interaction proteomics define specific RNA-modification pathways as key components of fluorouracil-based cancer drug cytotoxicity
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    CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cells
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      sc-126

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    Deletion of RBMX RGG/RG motif in Shashi-XLID syndrome leads to aberrant p53 activation and neuronal differentiation defects
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  166. Jun 2021
  167. www.cell.com www.cell.com
    p53 mitigates the effects of oncogenic HRAS in urothelial cells via the repression of MCOLN1
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    Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library
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  169. May 2021
  170. rupress.org rupress.org
    Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis
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  171. www.sciencedirect.com www.sciencedirect.com
    AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation
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    POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status
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    The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia
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    Centrosomal Localization of RXRα Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability
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  175. Apr 2021
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    Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation
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  178. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  184. Mar 2021
  185. www.sciencedirect.com www.sciencedirect.com
    Phosphorylation-regulated HMGA1a-P53 interaction unveils the function of HMGA1a acidic tail phosphorylations via synthetic proteins
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  186. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    The tumor suppressor LATS2 reduces v‐Src‐induced membrane blebs in a kinase activity‐independent manner
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      anti‐p53

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    Ectopically expressed olfactory receptors OR51E1 and OR51E2 suppress proliferation and promote cell death in a prostate cancer cell line
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      Anti-p53

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  188. Feb 2021
  189. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  190. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Combination of the M2 Muscarinic Receptor Agonist and Chemotherapy Affects Drug Resistance in Neuroblastoma Cells
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      DOI: 10.3390/ijms21228433

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  191. www.nature.com www.nature.com
    Altered Adhesion and Migration of Human Mesenchymal Stromal Cells under Febrile Temperature Stress Involves NF-κβ Pathway
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      DOI: 10.1038/s41598-020-61361-z

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  192. www.sciencedirect.com www.sciencedirect.com
    Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype
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  193. Jan 2021
  194. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRD4-mediated repression of p53 is a target for combination therapy in AML
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      DOI: 10.1038/s41467-020-20378-8

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  195. Oct 2020
  196. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Rucaparib Treatment Alters p53 Oscillations in Single Cells to Enhance DNA-Double-Strand-Break-Induced Cell Cycle Arrest
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