320 Matching Annotations
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    p53 activates chaperone-mediated autophagy to remodel metabolism and suppress tumorigenesis
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  3. Nov 2026
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    The VCPIP1-UBE3A Deubiquitination-Ubiquitination Cascade Contributes to Castration-Resistant Prostate Cancer Progression
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    UFSP2 constitutes a targetable vulnerability via deUFMylation-dependent activation of AKT oncogenic signaling
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    Oxidative DNA damage drives centromere fragility and chromosome instability
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    A common germline 3′ UTR variant controls DDIT4 translation efficiency and stress responses in cancer cells
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    ΔNp73 isoform defines a TP53-mutant-like poor-risk subgroup of acute myeloid leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12866144/
  10. Sep 2026
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    Cancers modulate processing and presentation of p53 neoantigens to evade T cell detection
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  12. Aug 2026
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    IRE1 activity is prognostic in localised and metastatic prostate cancer and affects epithelial lineage states
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    link.springer.com/article/10.1038/s44321-026-00490-w
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    MDM2 binds and suppresses RNA polymerase III to restrain the innate immune response to cytosolic DNA
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    Genotoxic antibody-drug conjugates combined with BCL-XL inhibitors enhance therapeutic efficacy in metastatic castration-resistant prostate cancer
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  16. Jul 2026
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    A bivalent molecular glue linking lysine acetyltransferases to oncogene-induced cell death
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  19. Jun 2026
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    Resident mesenchymal progenitor cells require autocrine IGF-I in homeostatic and regenerating skeletal muscle
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    Baicalein Inhibits Proliferation, Migration, and Invasion of Mesothelioma Cells Through the p53–FOXM1 Signaling Axis
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  22. May 2026
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    mTOR-NAA10-C7orf50 axis senses nutritional status to coordinate ribosome biogenesis and autophagy
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    Human pancreatic progenitor organoids define genetic and epigenetic barriers to early PDAC transformation
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    mTOR-NAA10-C7orf50 axis senses nutritional status to coordinate ribosome biogenesis and autophagy
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    Ribosomal RNA processing impairments in a B cell immunodeficient patient with WDR75 variants
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    A personalized therapeutic approach for liver cancers expressing the African-centric P47S variant of TP53
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    PARP1 suppression drives ROS resistance in aneuploid cancer cells
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  29. Apr 2026
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    Activation of T cell-intrinsic p53 by acetylation elicits antitumor immunity to boost cancer immunotherapy
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    EYA4 promotes cellular senescence by enhancing P21 transcription through interaction with SIX2
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  35. Mar 2026
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    Chemoradiation Reprograms Tumor Cells and the Immune Microenvironment in Cervical Cancer
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    Loss of p53 exacerbates autoimmunity by reprogramming propionyl-CoA metabolism and histone modifications in Treg cells
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    Genomic enrichment and functional impact of TP53 and CYLD alterations in recurrent and metastatic HPV-associated head and neck cancer
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  39. Feb 2026
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  41. Jan 2026
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    Isoquercitrin induces melanogenesis in B16F10 melanoma cells and zebrafish via the p38 and PKA/CREB signaling pathways: an experimental study
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  46. Dec 2025
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    Elevated expression and secretion of TGF-α contribute to Temozolomide resistance in human glioblastoma cells
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  50. Nov 2025
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    ARID1A stabilizes non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin
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    Genotoxic antibody-drug conjugates combined with Bcl-xL inhibitors enhance therapeutic efficacy in metastatic castration-resistant prostate cancer
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  58. Sep 2025
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    Disrupting the interaction between androgen receptor and its coregulator WDR77 delays the growth of treatment-resistant prostate cancer
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  68. Aug 2025
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    Retinoic acid disrupts an NPM1c/ROS/SENP3/ARF oncogenic axis in acute myeloid leukemia
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  73. Jul 2025
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    Divergent sex-specific effects on a ketogenic diet: Male, but not female, mice exhibit oxidative stress and cellular senescence
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  76. Jun 2025
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  80. May 2025
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    Trichosanthes kirilowii Maxim. and Bioactive Compound Cucurbitacin D Alleviate Cisplatin-Induced Peripheral Neuropathy In Vitro and In Vivo
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    IMPDH inhibition induces DNA replication stress and ATR sensitivity in Merkel cell carcinoma
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    ALDH4A1 functions as an active component of the MPC complex maintaining mitochondrial pyruvate import for TCA cycle entry and tumour suppression
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  85. Apr 2025
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    Downregulation of rRNA synthesis by BCL-2 induces chemoresistance in diffuse large B cell lymphoma
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    p53 regulates DREAM complex-mediated repression in a p21-independent manner
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    A Novel Mechanism of the p53 Isoform Δ40p53α in Regulating Collagen III Expression in TGFβ1-Induced LX-2 Human Hepatic Stellate Cells
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    Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity
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    Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution
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  91. Mar 2025
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    Role of TRIM24 in the regulation of proteasome-autophagy crosstalk in bortezomib-resistant mantle cell lymphoma
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    p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells
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  95. Feb 2025
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    Designer polyQ fusion proteins sequester USP7/HDM2 for modulating P53 functionality
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    OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival
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    Combined inhibition of ribonucleotide reductase and WEE1 induces synergistic anticancer activity in Ewing’s sarcoma cells
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  100. Jan 2025
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    Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders
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  102. Dec 2024
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    Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents
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    MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics
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    Control of cell proliferation by memories of mitosis
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    Transcriptional and functional regulation of cell cycle and UV response by PPARβ in human skin epidermal cells
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    p53 induces circFRMD4A to suppress cancer development through glycolytic reprogramming and cuproptosis
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    Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer
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  109. Nov 2024
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  220. Aug 2022
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  224. Jul 2022
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  231. May 2022
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  233. Apr 2022
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  239. Feb 2022
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  243. Dec 2021
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  245. Nov 2021
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  249. Oct 2021
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