492 Matching Annotations
  1. Nov 2024
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intra-tumoral YAP and TAZ heterogeneity drives collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981
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    1. scibot 15 Nov 2024
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      DOI: 10.1016/j.isci.2024.111133

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    pmc.ncbi.nlm.nih.gov/articles/PMC11544388/
  3. Oct 2024
  4. aacrjournals.org aacrjournals.org
    NK Receptor Signaling Lowers TCR Activation Threshold, Enhancing Selective Recognition of Cancer Cells by TAA-Specific CTLs
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    1. scibot 08 Oct 2024
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      DOI: 10.1158/2326-6066.CIR-24-0061

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    aacrjournals.org/cancerimmunolres/article/12/10/1421/748722/NK-Receptor-Signaling-Lowers-TCR-Activation
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Verapamil Prevents Decline of IGF-I in Subjects With Type 1 Diabetes and Promotes β-Cell IGF-I Signaling
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    1. scibot 03 Oct 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10545554/
  6. www.sciencedirect.com www.sciencedirect.com
    Voluntary exercise suppresses inflammation and improves insulin resistance in the arcuate nucleus and ventral tegmental area in mice on a high-fat diet
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    1. scibot 02 Oct 2024
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    sciencedirect.com/science/article/pii/S0031938424002518
  7. www.sciencedirect.com www.sciencedirect.com
    Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition
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    sciencedirect.com/science/article/pii/S2666379124004828
  8. www.nature.com www.nature.com
    QSOX2 Deficiency-induced short stature, gastrointestinal dysmotility and immune dysfunction
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    1. scibot 01 Oct 2024
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      DOI: 10.1038/s41467-024-52587-w

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  9. Sep 2024
  10. dx.doi.org dx.doi.org
    Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels
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    1. scibot 27 Sep 2024
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      DOI: 10.1093/hmg/ddae135

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    dx.doi.org/10.1093/hmg/ddae135
  11. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A novel inhibitor of class IIa histone deacetylases attenuates collagen-induced arthritis
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    1. scibot 27 Sep 2024
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17306
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription
    1
    1. scibot 26 Sep 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11387499/
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer
    1
    1. scibot 25 Sep 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11410950/
  14. www.sciencedirect.com www.sciencedirect.com
    IGFBP7 is upregulated in islets from T2D donors and reduces insulin secretion
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    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S2589004224019928
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    Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity
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    sciencedirect.com/science/article/pii/S2211124724011136
  16. www.sciencedirect.com www.sciencedirect.com
    Endothelial metabolic control of insulin sensitivity through resident macrophages
    1
    1. scibot 13 Sep 2024
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    sciencedirect.com/science/article/pii/S1550413124003358
  17. www.nature.com www.nature.com
    Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer
    1
    1. scibot 13 Sep 2024
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    nature.com/articles/s41467-024-51831-7
  18. www.sciencedirect.com www.sciencedirect.com
    H3K9 lactylation in malignant cells facilitates CD8+ T cell dysfunction and poor immunotherapy response
    1
    1. scibot 04 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724010374
  19. www.sciencedirect.com www.sciencedirect.com
    Aldehydes alter TGF-β signaling and induce obesity and cancer
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    1. scibot 04 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724010271
  20. Aug 2024
  21. www.sciencedirect.com www.sciencedirect.com
    Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression
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    1. scibot 28 Aug 2024
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    sciencedirect.com/science/article/pii/S1534580724004866
  22. link.springer.com link.springer.com
    Contactin -Associated protein1 Regulates Autophagy by Modulating the PI3K/AKT/mTOR Signaling Pathway and ATG4B Levels in Vitro and in Vivo
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    1. scibot 25 Aug 2024
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    link.springer.com/article/10.1007/s12035-024-04425-9
  23. www.sciencedirect.com www.sciencedirect.com
    Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila
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    1. scibot 22 Aug 2024
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    sciencedirect.com/science/article/pii/S2211124721001893
  24. www.sciencedirect.com www.sciencedirect.com
    Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions
    1
    1. scibot 22 Aug 2024
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  25. www.cell.com www.cell.com
    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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    1. scibot 22 Aug 2024
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      DOI: 10.1016/j.cell.2020.02.019

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    cell.com/cell/fulltext/S0092-8674(20)30163-X
  26. www.sciencedirect.com www.sciencedirect.com
    Sex-Dimorphic Effects of Glucose Transporter-2 Gene Knockdown on Hypothalamic Primary Astrocyte Phosphoinositide-3-kinase (PI3K)/Protein Kinase B (PKB/Akt)/Mammalian Target of Rapamycin (mTOR) Cascade Protein Expression and Phosphorylation
    1
    1. scibot 21 Aug 2024
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    sciencedirect.com/science/article/pii/S0303720724001977
  27. www.sciencedirect.com www.sciencedirect.com
    Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies
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    1. scibot 20 Aug 2024
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      DOI: 10.1016/j.chembiol.2024.07.005

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    sciencedirect.com/science/article/pii/S2451945624003076
  28. www.researchsquare.com www.researchsquare.com
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      DOI: 10.21203/rs.3.rs-1945681/v1

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    researchsquare.com/article/rs-156250/v1
  29. journals.physiology.org journals.physiology.org
    mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology
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      DOI: 10.1152/ajpcell.00385.2020

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  30. Jul 2024
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration
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    1. scibot 24 Jul 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC8328392/
  32. www.sciencedirect.com www.sciencedirect.com
    Canagliflozin Attenuates Post-Resuscitation Myocardial Dysfunction in Diabetic Rats by Inhibiting Autophagy through the PI3K/Akt/mTOR Pathway
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    1. scibot 19 Jul 2024
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  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance
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  34. www.sciencedirect.com www.sciencedirect.com
    PIK3CA mutations enhance the adipogenesis of ADSCs in facial infiltrating lipomatosis through TRPV1
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  35. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    Multi-step regulation of microRNA expression and secretion into small extracellular vesicles by insulin
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  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Insulin Potentiates JAK/STAT Signaling to Broadly Inhibit Flavivirus Replication in Insect Vectors
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    ncbi.nlm.nih.gov/pmc/articles/PMC6871768/
  38. Jun 2024
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acetyl-NPKY of Integrin-beta 1 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity.
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  40. www.cell.com www.cell.com
    Oxygen tension-dependent variability in the cancer cell kinome impacts signaling pathways and response to targeted therapies
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    cell.com/iscience/abstract/S2589-0042(24)01293-8
  41. www.sciencedirect.com www.sciencedirect.com
    PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer
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  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-tumor effects of tirbanibulin in squamous cell carcinoma cells are mediated via disruption of tubulin-polymerization
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    ncbi.nlm.nih.gov/pmc/articles/PMC11161541/
  43. 52.53.155.43 52.53.155.43
    Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency
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      DOI: 10.1101/2024.02.09.579580

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    52.53.155.43/be49547c4f9e1293474726024249294abe2db848/2024.02.09.579580v1.full-html.html
  44. May 2024
  45. www.science.org www.science.org
    eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer
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      DOI: 10.1126/scisignal.adh4475

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  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Repurposing homoharringtonine for thyroid cancer treatment through TIMP1/FAK/PI3K/AKT signaling pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC11103377/
  47. www.sciencedirect.com www.sciencedirect.com
    Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation
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      DOI: 10.1016/j.immuni.2024.04.023

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    Development of stemness-related signature to optimize prognosis prediction and identify XMD8-85 as a novel therapeutic compound for glioma
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    Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance
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  51. 52.53.155.43 52.53.155.43
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  52. journals.physiology.org journals.physiology.org
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    A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1
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  57. www.sciencedirect.com www.sciencedirect.com
    Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer
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    Cancer-associated fibroblasts promote enzalutamide resistance and PD-L1 expression in prostate cancer through CCL5-CCR5 paracrine axis
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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Sialyltransferase ST3GAL4 confers osimertinib resistance and offers strategies to overcome resistance in non-small cell lung cancer
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    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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    Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans
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  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors
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    SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells
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    Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development
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  92. Dec 2023
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    Glucose restriction enhances oxidative fiber formation: A multi-omic signal network involving AMPK and CaMK2
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    ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells
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    Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia
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    Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway
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    Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
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    The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency
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    Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer
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    The myocardium utilizes a platelet-derived growth factor receptor alpha (Pdgfra)–phosphoinositide 3-kinase (PI3K) signaling cascade to steer toward the midline during zebrafish heart tube formation
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    FUS-dependent microRNA deregulations identify TRIB2 as a druggable target for ALS motor neurons
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  113. Oct 2023
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    Collagen 1-mediated CXCL1 secretion in tumor cells activates fibroblasts to promote radioresistance of esophageal cancer
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    N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes
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  120. Sep 2023
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    Mechanism of Hyperproteinemia-Induced Damage to Female Reproduction in a Genetic Silkworm Model
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    Different sensitivity to diet-induced hyperinsulinemia and hyperglycemia between mice with global or bone marrow-specific apoE receptor-2 deficiency
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    The MORC2 p.S87L mutation reduces proliferation of pluripotent stem cells derived from a patient with the spinal muscular atrophy-like phenotype by inhibiting proliferation-related signaling pathways
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    mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway
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    Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties
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  137. Jul 2023
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    Increased Cardiac PFK-2 Protects Against High-Fat Diet-Induced Cardiomyopathy and Mediates Beneficial Systemic Metabolic Effects
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    UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders
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    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
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    Transcriptional repression by FoxM1 suppresses tumor differentiation and promotes metastasis of breast cancer
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  171. Apr 2023
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    Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration
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    Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells
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    A human skeletal muscle stem/myotube model reveals multiple signaling targets of cancer secretome in skeletal muscle
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    VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma
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    CHD1 promotes sensitivity to Aurora kinase inhibitors by suppressing interaction of AURKA with its coactivator TPX2
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    Echinocystic acid alleviated hypoxic-ischemic brain damage in neonatal mice by activating the PI3K/Akt/Nrf2 signaling pathway
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    Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise
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    STRA6 promotes thyroid carcinoma progression via activation of the ILK/AKT/mTOR axis in cells and female nude mice
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    PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6
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    Development of a bispecific DNA-aptamer-based lysosome-targeting chimera for HER2 protein degradation
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    Pseudo-temporal dynamics of chemoresistant triple negative breast cancer cells reveal EGFR/HER2 inhibition as synthetic lethal during mid-neoadjuvant chemotherapy
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    HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease
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    The TGR5 Agonist INT-777 Promotes Peripheral Nerve Regeneration by Activating cAMP-dependent Protein Kinase A in Schwann Cells
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    Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis
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    Selaginella tamariscina Inhibits Glutamate-Induced Autophagic Cell Death by Activating the PI3K/AKT/mTOR Signaling Pathways
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    The Neuroprotective Effects of Arecae Pericarpium against Glutamate-Induced HT22 Cell Cytotoxicity
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    Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells
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    Reelin regulates the migration of late-born hippocampal CA1 neurons via cofilin phosphorylation
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    Ketone Body Infusion abrogates Growth Hormone Induced Lipolysis and Insulin Resistance
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    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
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    RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation
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    Platelet p110β mediates platelet-leukocyte interaction and curtails bacterial dissemination in pneumococcal pneumonia
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