553 Matching Annotations
  1. Aug 2025
  2. 52.53.155.43 52.53.155.43
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    Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR-TKI resistance and metastasis
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    sciencedirect.com/science/article/pii/S153458072500471X
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Differential Efficacy of Bevacizumab and Erlotinib in Preclinical Models of Renal Medullary Carcinoma and Fumarate Hydratase–Deficient Renal Cell Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12323885/
  5. Jul 2025
  6. www.science.org www.science.org
    Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling
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    science.org/doi/10.1126/science.adm9805
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    Periodontal Ligaments Enhance Neurite Outgrowth in Trigeminal Ganglion Neurons through Wnt5a Production Induced by Mechanical Stimulation
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    52.53.155.43/f8df4eb8a5eedcbd3583132b5c32fd671a443179/takahashi-et-al-2022-periodontal-ligaments-enhance-neurite-outgrowth-in-trigeminal-ganglion-neurons-through-wnt5a-html.html
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    RANKL/PD-1 dual blockade demonstrates survival benefit for patients with advanced lung adenocarcinoma harboring KRAS mutations
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    sciencedirect.com/science/article/pii/S2666379125003088
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The impact of neuregulin 4 on metabolic dysregulation in lipodystrophy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12236340/
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    Using computational pharmacology and experimental verification to decode mechanism of Qing-Wei-San in treating periodontitis
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    link.springer.com/article/10.1186/s12906-025-04967-y
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    Neuronal PAC1 deletion impairs structural plasticity
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    sciencedirect.com/science/article/pii/S0024320525004783
  14. Jun 2025
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    Bile acids activate cancer-associated fibroblasts and induce an immunosuppressive microenvironment in cholangiocarcinoma
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    sciencedirect.com/science/article/pii/S1535610825002260
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    SETDB1 promotes mammalian liver regeneration by stimulating cytokine CSF3 in hepatocytes
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    sciencedirect.com/science/article/pii/S221112472500614X
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    Overexpression of high affinity Type I adenosine receptors promotes the growth of uterine leiomyomas
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    RNA polymerase II subunit 5-mediating protein limits TLR4-induced innate immune activation in macrophages by inhibiting IKKβ/NF-κB signaling during sepsis
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    link.springer.com/article/10.1186/s12964-025-02278-w
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    PTEN protein phosphatase activity regulates metastasis by targeting PKCδ
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    sciencedirect.com/science/article/pii/S2589004225010028
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    MT-125 inhibits non-muscle myosin IIA and IIB and prolongs survival in glioblastoma
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    sciencedirect.com/science/article/pii/S0092867425005690
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nerve growth factor signaling tunes axon maintenance protein abundance and kinetics of Wallerian degeneration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12005098/
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    PIN1 serves as a prognostic and therapeutic biomarker in lung adenocarcinoma
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    link.springer.com/article/10.1007/s10142-025-01629-7
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    Amiloride synergizes with EGFR PROTACs and inhibitors to overcome therapeutic resistance in NSCLC
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  27. May 2025
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Focal Adhesion Kinase Orchestrates GLUT4 Translocation and Glucose Uptake via Cytoskeletal Turnover in Primary Adipocytes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12093284/
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    Stress-induced pro-inflammatory glioblastoma stem cells secrete TNFAIP6 to enhance tumor growth and induce suppressive macrophages
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  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identifying antisense oligonucleotides for targeted inhibition of insulin receptor isoform A
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    pmc.ncbi.nlm.nih.gov/articles/PMC12038057/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel TRKB-activating internal tandem duplication characterizes a new mechanism of receptor tyrosine kinase activation
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    Semaphorin7A and PD-L1 cooperatively drive immunosuppression during mammary involution and breast cancer
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    sciencedirect.com/science/article/pii/S2211124725004474
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    Inhibition of autotaxin activity with IOA-289 decreases fibrosis in mouse E0771 breast tumors
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    onlinelibrary.wiley.com/doi/10.1002/ijc.35471
  34. Apr 2025
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    PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma
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  39. www.nature.com www.nature.com
    Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways
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    nature.com/articles/s41598-025-95766-5
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    Scutellaria barbata ameliorates acute respiratory distress syndrome by inhibiting neutrophil-mediated inflammatory responses
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  41. Mar 2025
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Induction of Triple-Negative Breast Cancer Cell Death and Chemosensitivity Using mTORC2-Directed RNAi Nanomedicine
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    pmc.ncbi.nlm.nih.gov/articles/PMC11921867/
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    Maternal progesterone and adipose mPRε in pregnancy regulate the embryonic nutritional state
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    Effective targeting of PDGFRA-altered high-grade glioma with avapritinib
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  45. journals.lww.com journals.lww.com
    The compound... : Neural Regeneration Research
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  46. Feb 2025
  47. www.sciencedirect.com www.sciencedirect.com
    FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma
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  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  49. aacrjournals.org aacrjournals.org
    Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer
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    aacrjournals.org/cancerres/article/84/20/3371/749080/Cancer-Associated-Fibroblasts-Expressing-Sulfatase
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    Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling
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    Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melanoma growth and reduces metastases
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    pmc.ncbi.nlm.nih.gov/articles/PMC11866499/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11791202/
  53. 52.53.155.43 52.53.155.43
    The propensity of fructose to induce metabolic dysfunction is dependent on the baseline diet, length of the dietary exposure, and sex of the mice
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    Dab1 expression level controls Reelin-induced PI3K-Akt activation in early GABAergic neurons
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    sciencedirect.com/science/article/pii/S0006291X25001585
  55. Jan 2025
  56. www.sciencedirect.com www.sciencedirect.com
    Lactate homeostasis is maintained through regulation of glycolysis and lipolysis
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    sciencedirect.com/science/article/pii/S1550413124004911
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    Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC11712038/
  58. www.sciencedirect.com www.sciencedirect.com
    Biotransformation of Ganoderma lucidum and Hericium erinaceus for ex vivo gut-brain axis modulation and mood-related outcomes in humans: CREB/BDNF signaling and microbiota-driven synergies
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  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Downregulation of semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11687936/
  60. www.sciencedirect.com www.sciencedirect.com
    Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding
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  61. Dec 2024
  62. www.cell.com www.cell.com
    Adipocyte-derived ferroptotic signaling mitigates obesity
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    cell.com/cell-metabolism/abstract/S1550-4131(24)00456-X
  63. 52.53.155.43 52.53.155.43
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    Antibiotics/coccidiostat exposure induces gut-brain axis remodeling for Akt/mTOR activation and BDNF-mediated neuroprotection in APEC-infected turkeys
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    sciencedirect.com/science/article/pii/S0032579124012148
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    Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery
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    sciencedirect.com/science/article/pii/S1934590924003771
  67. Nov 2024
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MOTS-c modulates skeletal muscle function by directly binding and activating CK2
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  69. www.sciencedirect.com www.sciencedirect.com
    Intra-tumoral YAP and TAZ heterogeneity drives collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981
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  70. Oct 2024
  71. aacrjournals.org aacrjournals.org
    NK Receptor Signaling Lowers TCR Activation Threshold, Enhancing Selective Recognition of Cancer Cells by TAA-Specific CTLs
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    aacrjournals.org/cancerimmunolres/article/12/10/1421/748722/NK-Receptor-Signaling-Lowers-TCR-Activation
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Verapamil Prevents Decline of IGF-I in Subjects With Type 1 Diabetes and Promotes β-Cell IGF-I Signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC10545554/
  73. www.sciencedirect.com www.sciencedirect.com
    Voluntary exercise suppresses inflammation and improves insulin resistance in the arcuate nucleus and ventral tegmental area in mice on a high-fat diet
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  74. www.sciencedirect.com www.sciencedirect.com
    Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition
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    sciencedirect.com/science/article/pii/S2666379124004828
  75. www.nature.com www.nature.com
    QSOX2 Deficiency-induced short stature, gastrointestinal dysmotility and immune dysfunction
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    nature.com/articles/s41467-024-52587-w
  76. Sep 2024
  77. dx.doi.org dx.doi.org
    Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels
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    dx.doi.org/10.1093/hmg/ddae135
  78. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A novel inhibitor of class IIa histone deacetylases attenuates collagen-induced arthritis
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17306
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription
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    ncbi.nlm.nih.gov/pmc/articles/PMC11387499/
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11410950/
  81. www.sciencedirect.com www.sciencedirect.com
    IGFBP7 is upregulated in islets from T2D donors and reduces insulin secretion
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    Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity
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    Endothelial metabolic control of insulin sensitivity through resident macrophages
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  84. www.nature.com www.nature.com
    Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer
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    nature.com/articles/s41467-024-51831-7
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    H3K9 lactylation in malignant cells facilitates CD8+ T cell dysfunction and poor immunotherapy response
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    Aldehydes alter TGF-β signaling and induce obesity and cancer
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  87. Aug 2024
  88. www.sciencedirect.com www.sciencedirect.com
    Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression
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  89. link.springer.com link.springer.com
    Contactin -Associated protein1 Regulates Autophagy by Modulating the PI3K/AKT/mTOR Signaling Pathway and ATG4B Levels in Vitro and in Vivo
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    link.springer.com/article/10.1007/s12035-024-04425-9
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    Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila
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    Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions
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  92. www.cell.com www.cell.com
    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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    cell.com/cell/fulltext/S0092-8674(20)30163-X
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    Sex-Dimorphic Effects of Glucose Transporter-2 Gene Knockdown on Hypothalamic Primary Astrocyte Phosphoinositide-3-kinase (PI3K)/Protein Kinase B (PKB/Akt)/Mammalian Target of Rapamycin (mTOR) Cascade Protein Expression and Phosphorylation
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    Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies
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  95. www.researchsquare.com www.researchsquare.com
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  96. journals.physiology.org journals.physiology.org
    mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology
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    PARP1 inhibition protects mice against Japanese encephalitis virus infection
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  193. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The MORC2 p.S87L mutation reduces proliferation of pluripotent stem cells derived from a patient with the spinal muscular atrophy-like phenotype by inhibiting proliferation-related signaling pathways
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  195. Aug 2023
  196. www.biorxiv.org www.biorxiv.org
    Unraveling Vulnerabilities in Endocrine Therapy-Resistant HER2+/ER+ Breast Cancer
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    mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway
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    Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties
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    Synergy of 5-aminolevulinate supplement and CX3CR1 suppression promotes liver regeneration via elevated IGF-1 signaling
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    FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress
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  201. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
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    Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration
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  204. Jul 2023
  205. dx.doi.org dx.doi.org
    Pigment Epithelium-Derived Factor, a Novel Adipokine, Contributes to Gestational Diabetes Mellitus
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    Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia
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    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
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    Cell Competition Shapes Metastatic Latency and Relapse
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    Increased Cardiac PFK-2 Protects Against High-Fat Diet-Induced Cardiomyopathy and Mediates Beneficial Systemic Metabolic Effects
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    Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH
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