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  1. Last 7 days
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation of DNA-binding domains of CLOCK–BMAL1 complex for PER-dependent inhibition in circadian clock of mammalian cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11161756/
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    Mode of SUV420H2 heterochromatin localization through multiple HP1 binding motifs in the heterochromatic targeting module
    1
    1. scibot 15 Jun 2024
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  4. Jun 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An antifouling membrane-fusogenic liposome for effective intracellular delivery in vivo
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    Ciliary tip actin dynamics regulate photoreceptor outer segment integrity
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    A global gene regulatory program and its region-specific regulator partition neurons into commissural and ipsilateral projection types
    1
    1. scibot 07 Jun 2024
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    H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours
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    Pseudopregnant mice generated from Piwil1 deficiency sterile mice
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    1. scibot 07 Jun 2024
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    FokI-RYdCas9 Mediates Nearly PAM-Less and High-Precise Gene Editing in Human Cells
    1
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  11. 52.53.155.43 52.53.155.43
    2024.05.31.596483v1.full-html.html
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    Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression
    2
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    Dynamic movement of the Golgi unit and its glycosylation enzyme zones
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    1. scibot 03 Jun 2024
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  14. May 2024
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    Proteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer
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    1. scibot 23 May 2024
      plasmid_42230

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    Bag1 protein loss sensitizes mouse embryonic fibroblasts to glutathione depletion
    2
    1. scibot 21 May 2024
      plasmid_42230

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      RRID:Addgene_4223031

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    Mammalian RNAi represses pericentromeric lncRNAs to maintain genome stability
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    CD74 supports accumulation and function of regulatory T cells in tumors
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  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HIF-1α participates in the regulation of S100A16-HRD1-GSK3β/CK1α pathway in renal hypoxia injury
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  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The factor inhibiting HIF regulates T cell differentiation and anti-tumour efficacy
    1
    1. scibot 05 May 2024
      42230

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  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Coregulation of NDC80 Complex Subunits Determines the Fidelity of the Spindle-Assembly Checkpoint and Mitosis
    1
    1. scibot 05 May 2024
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  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    WNT5B drives osteosarcoma stemness, chemoresistance and metastasis
    1
    1. scibot 03 May 2024
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  23. Apr 2024
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Linear interaction between replication and transcription shapes DNA break dynamics at recurrent DNA break Clusters
    1
    1. scibot 30 Apr 2024
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  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Endogenous BAX and BAK form mosaic rings of variable size and composition on apoptotic mitochondria
    1
    1. scibot 29 Apr 2024
      plasmid_42230

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  26. rupress.org rupress.org
    Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization
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    1. scibot 25 Apr 2024
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  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptomic profiling across human serotonin neuron differentiation via the FEV reporter system
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    1. scibot 23 Apr 2024
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  28. link.springer.com link.springer.com
    Luciferase- and HaloTag-based reporter assays to measure small-molecule-induced degradation pathway in living cells
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  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IntAct: A nondisruptive internal tagging strategy to study the organization and function of actin isoforms
    1
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  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL
    1
    1. scibot 15 Apr 2024
      pX330-U6-Chimeric_BB-CBh-hSpCas9

      DOI: 10.1084/jem.20230941

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  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma
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  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular basis promoting centriole triplet microtubule assembly
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  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oligomerization mediated by the D2 domain of DTX3L is critical for DTX3L‐PARP9 reading function of mono‐ADP‐ribosylated androgen receptor
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    ER-export and ARFRP1/AP-1–dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication
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    PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons
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  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure and tethering mechanism of dynein-2 intermediate chains in intraflagellar transport
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  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells
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  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The impact of canonical Wnt transcriptional repressors TLE3 and TLE4 on postsynaptic transcription at the neuromuscular junction
    1
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  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer’s Disease
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  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
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  41. www.sciencedirect.com www.sciencedirect.com
    Generation of human cerebral organoids with a structured outer subventricular zone
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    1. scibot 09 Apr 2024
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  42. Mar 2024
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure and function of Semaphorin-5A glycosaminoglycan interactions
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  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mycobacterium tuberculosis inhibits METTL14-mediated m6A methylation of Nox2 mRNA and suppresses anti-TB immunity
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  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The genetically modified human foreskin fibroblast cell line (YhFF#8) stably expressing Cas9 gene: A lab resource report
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    1. scibot 28 Mar 2024
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      DOI: 10.18502/ijrm.v22i1.15243

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  46. onlinelibrary.wiley.com onlinelibrary.wiley.com
    An oocyte-specific Cas9-expressing mouse for germline CRISPR/Cas9-mediated genome editing
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    Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism
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  48. www.nature.com www.nature.com
    Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species
    1
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      RRID:Addgene_42230

      DOI: 10.1038/s41418-024-01280-y

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  49. www.sciencedirect.com www.sciencedirect.com
    Generation of a homozygous ALX1 knockout human embryonic stem cell line (WAe001-A-060) by a CRISPR/Cas9 system
    1
    1. scibot 25 Mar 2024
      RRID:Addgene_42230

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  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Engineered FSHD mutations results in D4Z4 heterochromatin disruption and feedforward DUX4 network activation
    1
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      RRID:Addgene_42230

      DOI: 10.1016/j.isci.2024.109357

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    ncbi.nlm.nih.gov/pmc/articles/PMC10951985/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of Fel d 1 chain 2 genome-edited cats by CRISPR-Cas9 system
    1
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      42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC10904870/
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function
    1
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      DOI: 10.7554/eLife.91010

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    ncbi.nlm.nih.gov/pmc/articles/PMC10942629/
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prediction and validation of circulating G-quadruplexes as a novel biomarker in colorectal cancer
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      plasmid_42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC10932654/
  54. www.nature.com www.nature.com
    Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis
    1
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      RRID:Addgene_42230

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  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DJ-1 protects proteins from acylation by catalyzing the hydrolysis of highly reactive cyclic 3-phosphoglyceric anhydride
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      42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC10915168/
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells
    1
    1. scibot 08 Mar 2024
      pX330-U6-Chimeric_BB-CBh-hSpCas9

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  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of protein kinase C increases Prdm14 level to promote self-renewal of embryonic stem cells through reducing Suv39h-induced H3K9 methylation
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    1. scibot 08 Mar 2024
      pX330-U6-Chimeric_BB-CBh-hSpCas9

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  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The transcription factor ChREBP Orchestrates liver carcinogenesis by coordinating the PI3K/AKT signaling and cancer metabolism
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  59. www.sciencedirect.com www.sciencedirect.com
    SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions
    2
    1. scibot 08 Mar 2024
      Addgene_42230

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  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A humanized mouse model for adeno-associated viral gene therapy
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      plasmid_42230

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  61. www.sciencedirect.com www.sciencedirect.com
    LncRNA Litchi is a Regulator for Harmonizing Maturity and Resilient Functionality in Spinal Motor Neurons
    2
    1. scibot 07 Mar 2024
      RRID:Addgene_42230

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  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
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    ncbi.nlm.nih.gov/pmc/articles/PMC10908796/
  63. www.sciencedirect.com www.sciencedirect.com
    TREX2 deficiency suppresses spontaneous and genotoxin-associated mutagenesis
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    sciencedirect.com/science/article/pii/S2211124723016480
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC10899107/
  65. Feb 2024
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sparse CBX2 nucleates many Polycomb proteins to promote facultative heterochromatinization of Polycomb target genes
    1
    1. scibot 29 Feb 2024
      pX330-U6-Chimeric_BB-CBh-hSpCas9

      DOI: 10.1101/2024.02.05.578969

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    ncbi.nlm.nih.gov/pmc/articles/PMC10871256/
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Undetectable off-target effects induced by FokI catalytic domain in mouse embryos
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      plasmid_42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC10877887/
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence
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      pX330-U6-Chimeric_BB-CBh-hSpCas9

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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA m6A modification regulates L1 retrotransposons in human spermatogonial stem cell differentiation in vitro and in vivo
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      42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC10873452/
  70. www.sciencedirect.com www.sciencedirect.com
    Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting
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      DOI: 10.1016/j.molcel.2024.01.022

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    sciencedirect.com/science/article/pii/S1097276524000893
  71. www.biorxiv.org www.biorxiv.org
    Post-synaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles
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      plasmid_42230

      DOI: 10.1101/2023.12.21.572751

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    biorxiv.org/content/10.1101/2023.12.21.572751v1
  72. www.biorxiv.org www.biorxiv.org
    DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin
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      DOI: 10.1101/2024.02.06.579191

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    biorxiv.org/content/10.1101/2024.02.06.579191v1
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BCL-XL regulates the timing of mitotic apoptosis independently of BCL2 and MCL1 compensation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10764939/
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An ovalbumin fusion strategy to increase recombinant protein secretion in chicken eggs
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      plasmid_42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC10785457/
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations
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    ncbi.nlm.nih.gov/pmc/articles/PMC10784283/
  76. www.sciencedirect.com www.sciencedirect.com
    CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs
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      plasmid_42230

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  77. Jan 2024
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Methodology to Create Auxin-Inducible Degron Tagging System to Control Expression of a Target Protein in Mammalian Cell Lines
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      https://www.addgene.org/42230/

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  79. www.sciencedirect.com www.sciencedirect.com
    Generation of a patient-specific iPSC cell line with cardiac arrhythmias and dilated cardiomyopathy (CBRCULi016-A), an isogenic control (CBRCULi016-A-1), and a paternal control (CBRCULi017-A)
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    sciencedirect.com/science/article/pii/S1873506124000060
  80. Dec 2023
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Altered Phenotypes of Breast Epithelial × Breast Cancer Hybrids after ZEB1 Knock-Out
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      DOI: 10.3390/ijms242417310

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  82. www.sciencedirect.com www.sciencedirect.com
    Highly cooperative chimeric super-SOX induces naive pluripotency across species
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  83. link.springer.com link.springer.com
    Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation
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  84. Nov 2023
  85. www.sciencedirect.com www.sciencedirect.com
    Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth
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      plasmid_42230

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  86. Oct 2023
  87. www.sciencedirect.com www.sciencedirect.com
    The intrinsically disordered region of eIF5B stimulates IRES usage and nucleates biological granule formation
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  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for auxin-inducible depletion of the RNA-binding protein PTBP1 in mouse embryonic stem cells
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  89. dx.doi.org dx.doi.org
    Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction
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      DOI: 10.1093/nar/gkad863

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  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LINE-1 activation in the cerebellum drives ataxia
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      Addgene #42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC9588660/
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model
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  92. www.sciencedirect.com www.sciencedirect.com
    ZEB2 and MEIS1 independently contribute to hematopoiesis via early hematopoietic enhancer activation
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  93. Sep 2023
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The autophagic protein FYCO1 controls TNFRSF10/TRAIL receptor induced apoptosis and is inactivated by CASP8 (caspase 8)
    1
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  95. Aug 2023
  96. www.embopress.org www.embopress.org
    Myddosome clustering in IL-1 receptor signaling regulates the formation of an NF-kB activating signalosome
    1
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  97. www.sciencedirect.com www.sciencedirect.com
    Integrating single-cell imaging and RNA sequencing datasets links differentiation and morphogenetic dynamics of human pancreatic endocrine progenitors
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  98. www.biorxiv.org www.biorxiv.org
    Ubiquitin phosphorylation accelerates protein aggregation and promotes neurodegeneration in the aging brain
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    biorxiv.org/content/10.1101/2023.08.10.552882v1
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The mitochondrial succinate dehydrogenase complex controls the STAT3-IL-10 pathway in inflammatory macrophages
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  100. Jul 2023
  101. www.sciencedirect.com www.sciencedirect.com
    Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation
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  102. www.sciencedirect.com www.sciencedirect.com
    Optimized CRISPR/Cas9 System for Gene Knockout in Chicken DF1 Cells
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    mRNA stability and m6A are major determinants of subcellular mRNA localization in neurons
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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic analysis of the molecular and biophysical properties of key DNA damage response factors
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  105. Jun 2023
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Method of Monitoring 26S Proteasome in Cells Revealed the Crucial Role of PSMA3 C-Terminus in 26S Integrity
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  107. www.sciencedirect.com www.sciencedirect.com
    Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization
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  108. www.sciencedirect.com www.sciencedirect.com
    Coordinated linear and rotational movements of endothelial cells compartmentalized by VE-cadherin drive angiogenic sprouting
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  109. www.sciencedirect.com www.sciencedirect.com
    Centromere/kinetochore is assembled through CENP-C oligomerization
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  110. www.sciencedirect.com www.sciencedirect.com
    Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer
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  111. May 2023
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    ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis
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    Protocol for biallelic tagging of an endogenous gene using CRISPR-Cas9 in human cells
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    Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex
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  115. www.sciencedirect.com www.sciencedirect.com
    Methylated histones on mitotic chromosomes promote Topoisomerase IIα function for high fidelity chromosome segregation.
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  116. Apr 2023
  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Knock-In Rat Lines with Cre Recombinase at the Dopamine D1 and Adenosine 2a Receptor Loci
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  118. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial dynamics define muscle fiber type by modulating cellular metabolic pathways
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  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of PARP7 Creates a Vulnerability for Growth Inhibition by RBN2397 in Prostate Cancer Cells
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  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear Cell Renal Cell Carcinoma
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  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
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    Synergistic effects of combined immunotherapy strategies in a model of multifocal hepatocellular carcinoma
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  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Characterizing the differential distribution and targets of Sumo1 and Sumo2 in the mouse brain
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  124. Mar 2023
  125. aacrjournals.org aacrjournals.org
    Rlf–Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer
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    aacrjournals.org/cancerdiscovery/article/11/12/3214/674718/Rlf-Mycl-Gene-Fusion-Drives-Tumorigenesis-and
  126. www.nature.com www.nature.com
    FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation
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  127. academic.oup.com academic.oup.com
    INO80 promotes H2A.Z occupancy to regulate cell fate transition in pluripotent stem cells
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  128. www.sciencedirect.com www.sciencedirect.com
    Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma
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    hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung’s disease
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      DOI: 10.1016/j.stem.2023.02.003

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  130. Feb 2023
  131. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HER2-driven breast cancer suppression by the JNK signaling pathway
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  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression
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  133. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phase separation of an actin nucleator by junctional microtubules regulates epithelial function
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  134. www.biorxiv.org www.biorxiv.org
    The Glucocorticoid Receptor is Required for Efficient Aldosterone-Induced Transcription by the Mineralocorticoid Receptor
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    RIF1 suppresses the formation of single-stranded ultrafine anaphase bridges via protein phosphatase 1
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  136. Jan 2023
  137. www.sciencedirect.com www.sciencedirect.com
    Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis
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    Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
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      DOI: 10.1007/s00125-022-05856-6

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  139. www.biorxiv.org www.biorxiv.org
    Myddosome clustering in IL-1 receptor signaling regulates the formation of an NF-kB activating signalosome
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    PTBP1-activated co-transcriptional splicing controls epigenetic status of pluripotent stem cells
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  141. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging
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  142. www.sciencedirect.com www.sciencedirect.com
    Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome
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  143. journals.plos.org journals.plos.org
    In vitro genome editing activity of Cas9 in somatic cells after random and transposon-based genomic Cas9 integration
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      DOI: 10.1371/journal.pone.0279123

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    journals.plos.org/plosone/article
  144. Dec 2022
  145. www.sciencedirect.com www.sciencedirect.com
    The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER
    1
    1. scibot 24 Dec 2022
      Addgene_42230

      DOI: 10.1016/j.celrep.2022.111868

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    sciencedirect.com/science/article/pii/S2211124722017648
  146. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Self-cleaving guide RNAs enable pharmacological selection of precise gene editing events in vivo
    1
    1. scibot 03 Dec 2022
      RRID:Addgene_42230

      DOI: 10.1038/s41467-022-35097-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC9712609/
  147. elifesciences.org elifesciences.org
    Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals
    1
    1. scibot 02 Dec 2022
      Addgene_42230

      DOI: 10.7554/eLife.79712

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    elifesciences.org/articles/79712
  148. Nov 2022
  149. www.science.org www.science.org
    Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo
    1
    1. scibot 29 Nov 2022
      plasmid_42230

      DOI: 10.1126/sciadv.abq6324

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    science.org/doi/10.1126/sciadv.abq6324
  150. www.sciencedirect.com www.sciencedirect.com
    TEMPO enables sequential genetic labeling and manipulation of vertebrate cell lineages
    2
    1. scibot 24 Nov 2022
      RRID:Addgene_42230

      DOI: 10.1016/j.neuron.2022.10.035

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    sciencedirect.com/science/article/pii/S0896627322009953
  151. www.sciencedirect.com www.sciencedirect.com
    Α γ-tubulin complex-dependent pathway suppresses ciliogenesis by promoting cilia disassembly
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    1. scibot 16 Nov 2022
      plasmid_42230

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    sciencedirect.com/science/article/pii/S2211124722015133
  152. www.sciencedirect.com www.sciencedirect.com
    Transcription factor antagonism regulates heterogeneity in embryonic stem cell states
    1
    1. scibot 10 Nov 2022
      Addgene_42230

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    sciencedirect.com/science/article/pii/S109727652201022X
  153. www.nature.com www.nature.com
    Erratic and blood vessel-guided migration of astrocyte progenitors in the cerebral cortex
    1
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      plasmid_42230

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    nature.com/articles/s41467-022-34184-x
  154. www.sciencedirect.com www.sciencedirect.com
    WNK kinases sense molecular crowding and rescue cell volume via phase separation
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    sciencedirect.com/science/article/pii/S0092867422012612
  155. Oct 2022
  156. www.nature.com www.nature.com
    Divergent regulation of basement membrane trafficking by human macrophages and cancer cells
    1
    1. scibot 28 Oct 2022
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    nature.com/articles/s41467-022-34087-x
  157. www.sciencedirect.com www.sciencedirect.com
    A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants
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    1. scibot 07 Oct 2022
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    sciencedirect.com/science/article/pii/S193459092200385X
  158. Sep 2022
  159. www.sciencedirect.com www.sciencedirect.com
    Latent HIV-1 provirus in vitro suppression using combinatorial CRISPR/Cas9 strategy
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    1. scibot 21 Sep 2022
      plasmid_42230

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    sciencedirect.com/science/article/pii/S2452014422001947
  160. academic.oup.com academic.oup.com
    Nesprin-1 LINC complexes recruit microtubule cytoskeleton proteins and drive pathology in Lmna mutant striated muscle
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    1. scibot 17 Sep 2022
      RRID:Addgene_42230

      DOI: 10.1093/hmg/ddac179

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    academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddac179/6655857
  161. www.sciencedirect.com www.sciencedirect.com
    Targeted protein degradation reveals RNA Pol II heterogeneity and functional diversity
    2
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      Cat#42230

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    sciencedirect.com/science/article/pii/S1097276522008127
  162. link.springer.com link.springer.com
    Generation of corrected hiPSC clones from a Cornelia de Lange Syndrome (CdLS) patient through CRISPR-Cas-based technology
    1
    1. scibot 07 Sep 2022
      Addgene_42230

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    link.springer.com/article/10.1186/s13287-022-03135-0
  163. Aug 2022
  164. 52.53.155.43 52.53.155.43
    cd-21-0925-html.html
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    1. scibot 27 Aug 2022
      Addgene_42230

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    52.53.155.43/e9cb0f5c6481209473760646202430887dd48d19/cd-21-0925-html.html
  165. www.sciencedirect.com www.sciencedirect.com
    NF-κB memory coordinates transcriptional responses to dynamic inflammatory stimuli
    1
    1. scibot 17 Aug 2022
      Plasmid_42230

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    sciencedirect.com/science/article/pii/S2211124722009688
  166. Jul 2022
  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Method for In Situ Reverse Genetic Analysis of Proteins Involved mtDNA Replication
    1
    1. scibot 31 Jul 2022
      RRID:Addgene_42230

      DOI: 10.3390/cells11142168

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    ncbi.nlm.nih.gov/pmc/articles/PMC9316749/
  168. www.sciencedirect.com www.sciencedirect.com
    Template-independent genome editing in the Pcdh15av−3j mouse, a model of human DFNB23 nonsyndromic deafness
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    1. scibot 13 Jul 2022
      AddgeneCat#42230

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    sciencedirect.com/science/article/pii/S2211124722008592
  169. link.springer.com link.springer.com
    Generation of Pigs that Produce Single Sex Progeny
    1
    1. scibot 09 Jul 2022
      RRID:Addgene_42230

      DOI: 10.1007/978-1-0716-2301-5_15

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    link.springer.com/protocol/10.1007/978-1-0716-2301-5_15
  170. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age
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    1. scibot 06 Jul 2022
      RRID:Addgene_42230

      DOI: 10.1371/journal.pone.0269404

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    ncbi.nlm.nih.gov/pmc/articles/PMC9246188/
  171. Jun 2022
  172. www.sciencedirect.com www.sciencedirect.com
    Cholesterol and matrisome pathways dysregulated in astrocytes and microglia
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    1. scibot 24 Jun 2022
      RRID:Addgene_42230

      DOI: 10.1016/j.cell.2022.05.017

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    sciencedirect.com/science/article/pii/S0092867422006481
  173. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Poliovirus non-permissive CD155 knockout cells derived from RD cell line for handling poliovirus potentially infectious materials in virology laboratories
    2
    1. scibot 17 Jun 2022
      plasmid_42230

      DOI: 10.1002/jmv.27897

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    onlinelibrary.wiley.com/doi/10.1002/jmv.27897
  174. www.sciencedirect.com www.sciencedirect.com
    Deciphering the origins and fates of steroidogenic lineages in the mouse testis
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      RRID:Addgene_42230

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    sciencedirect.com/science/article/pii/S2211124722007173
  175. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Understanding the Mechanism of Dysglycemia in a Fanconi-Bickel Syndrome Patient
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    1. scibot 04 Jun 2022
      plasmid_42230

      DOI: 10.3389/fendo.2022.841788

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    ncbi.nlm.nih.gov/pmc/articles/PMC9159359/
  176. May 2022
  177. www.researchsquare.com www.researchsquare.com
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      DOI: 10.21203/rs.3.rs-658360/v1

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    researchsquare.com/article/rs-2787982/v1
  178. www.sciencedirect.com www.sciencedirect.com
    BAG6 prevents the aggregation of neurodegeneration-associated fragments of TDP43
    2
    1. scibot 05 May 2022
      Addgene Cat#42230

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    sciencedirect.com/science/article/pii/S2589004222005430
  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective requirement of MYB for oncogenic hyperactivation of a translocated enhancer in leukemia
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    1. scibot 03 May 2022
      RRID:Addgene_42230

      DOI: 10.1158/2159-8290.CD-20-1793

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    ncbi.nlm.nih.gov/pmc/articles/PMC8563373/
  180. Apr 2022
  181. www.sciencedirect.com www.sciencedirect.com
    Interferons limit autoantigen-specific CD8+ T-cell expansion in the non-obese diabetic mouse
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    1. scibot 27 Apr 2022
      Addgene plasmid # 42,230

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    sciencedirect.com/science/article/pii/S2211124722005113
  182. www.sciencedirect.com www.sciencedirect.com
    Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS
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    sciencedirect.com/science/article/pii/S1097276522002908
  183. www.embopress.org www.embopress.org
    Mammalian UPF3A and UPF3B can activate nonsense-mediated mRNA decay independently of their exon junction complex binding
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      RRID:Addgene_42230

      DOI: 10.15252/embj.2021109202

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    embopress.org/doi/abs/10.15252/embj.2021109202
  184. www.sciencedirect.com www.sciencedirect.com
    CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair
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    sciencedirect.com/science/article/pii/S1097276522002696
  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Dual SHOX2:GFP; MYH6:mCherry Knock-in hESC Reporter Line for Derivation of Human SAN-like Cells
    1
    1. scibot 19 Apr 2022
      plasmid_42230

      DOI: 10.1016/j.isci.2022.104153

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    ncbi.nlm.nih.gov/pmc/articles/PMC9010642/
  186. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region
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      DOI: 10.7554/eLife.75047

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    ncbi.nlm.nih.gov/pmc/articles/PMC9007588/
  187. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of Il6 expression by single CpG methylation in downstream of Il6 transcription initiation site
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      Addgene_42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC8983349/
  188. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A new mouse model of Ehlers-Danlos syndrome generated using CRISPR/Cas9-mediated genomic editing
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    1. scibot 07 Apr 2022
      plasmid_42230

      DOI: 10.1242/dmm.048963

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    ncbi.nlm.nih.gov/pmc/articles/PMC8713987/
  189. www.sciencedirect.com www.sciencedirect.com
    CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories
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      RRID:Addgene_42230

      DOI: 10.1016/j.celrep.2022.110615

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    sciencedirect.com/science/article/pii/S2211124722003631
  190. Mar 2022
  191. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Entamoeba histolytica Develops Resistance to Complement Deposition and Lysis after Acquisition of Human Complement-Regulatory Proteins through Trogocytosis
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    1. scibot 26 Mar 2022
      RRID:Addgene_42230

      DOI: 10.1128/mbio.03163-21

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    ncbi.nlm.nih.gov/pmc/articles/PMC8941920/
  192. www.sciencedirect.com www.sciencedirect.com
    A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
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    1. scibot 16 Mar 2022
      AddgeneCat# 42230

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    sciencedirect.com/science/article/pii/S2211124722002583
  193. www.nature.com www.nature.com
    Rap1 prevents colitogenic Th17 cell expansion and facilitates Treg cell differentiation and distal TCR signaling
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    1. scibot 10 Mar 2022
      RRID:Addgene_42230

      DOI: 10.1038/s42003-022-03129-x

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    nature.com/articles/s42003-022-03129-x
  194. www.sciencedirect.com www.sciencedirect.com
    A simple protocol to isolate a single human cell PRDX1 knockout generated by CRISPR-Cas9 system
    1
    1. scibot 09 Mar 2022
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      DOI: 10.1016/j.xpro.2022.101216

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    sciencedirect.com/science/article/pii/S266616672200096X
  195. www.jneurosci.org www.jneurosci.org
    Involvement of denervated midbrain-derived factors in the formation of ectopic cortico-mesencephalic projection after hemispherectomy
    1
    1. scibot 08 Mar 2022
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      DOI: 10.1523/JNEUROSCI.1371-21.2021

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    jneurosci.org/content/42/5/749
  196. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antiviral Targeting of Varicella Zoster Virus Replication and Neuronal Reactivation Using CRISPR/Cas9 Cleavage of the Duplicated Open Reading Frames 62/71
    1
    1. scibot 04 Mar 2022
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    ncbi.nlm.nih.gov/pmc/articles/PMC8880005/
  197. Feb 2022
  198. www.sciencedirect.com www.sciencedirect.com
    Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells
    2
    1. scibot 11 Feb 2022
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      DOI: 10.1016/j.stem.2022.01.010

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    sciencedirect.com/science/article/pii/S1934590922000108
  199. www.sciencedirect.com www.sciencedirect.com
    Suppression of premature transcription termination leads to reduced mRNA isoform diversity and neurodegeneration
    2
    1. scibot 11 Feb 2022
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      DOI: 10.1016/j.neuron.2022.01.018

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    sciencedirect.com/science/article/pii/S0896627322000575
  200. www.sciencedirect.com www.sciencedirect.com
    Mapping the invisible chromatin transactions of prophase chromosome remodeling
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    1. scibot 02 Feb 2022
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    sciencedirect.com/science/article/pii/S1097276521011461
  201. Jan 2022
  202. www.sciencedirect.com www.sciencedirect.com
    CRISPitope: A generic platform to model target antigens for adoptive T cell transfer therapy in mouse tumor models
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    1. scibot 08 Jan 2022
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      DOI: 10.1016/j.xpro.2021.101038

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    sciencedirect.com/science/article/pii/S2666166721007449
  203. Dec 2021
  204. www.sciencedirect.com www.sciencedirect.com
    Association of RanGAP to nuclear pore complex component, RanBP2/Nup358, is required for pupal development in Drosophila
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    1. scibot 29 Dec 2021
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    sciencedirect.com/science/article/pii/S2211124721016478
  205. www.sciencedirect.com www.sciencedirect.com
    Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus
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    sciencedirect.com/science/article/pii/S109727652101025X
  206. www.sciencedirect.com www.sciencedirect.com
    14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure thresholds in mice
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    sciencedirect.com/science/article/pii/S2211124721016016
  207. www.cell.com www.cell.com
    MYC assembles and stimulates topoisomerases 1 and 2 in a “topoisome”
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    cell.com/molecular-cell/fulltext/S1097-2765(21)00996-5
  208. Nov 2021
  209. elifesciences.org elifesciences.org
    Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion
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    1. scibot 24 Nov 2021
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      DOI: 10.7554/eLife.66721

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    elifesciences.org/articles/66721
  210. www.sciencedirect.com www.sciencedirect.com
    The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair
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    1. scibot 24 Nov 2021
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      DOI: 10.1016/j.devcel.2021.10.022

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    sciencedirect.com/science/article/pii/S1534580721008534
  211. www.cell.com www.cell.com
    Sterols lower energetic barriers of membrane bending and fission necessary for efficient clathrin-mediated endocytosis
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    cell.com/cell-reports/fulltext/S2211-1247(21)01486-8
  212. link.springer.com link.springer.com
    Alternative splicing of NF-YA promotes prostate cancer aggressiveness and represents a new molecular marker for clinical stratification of patients
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      DOI: 10.1186/s13046-021-02166-4

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    link.springer.com/article/10.1186/s13046-021-02166-4
  213. www.sciencedirect.com www.sciencedirect.com
    Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1
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    sciencedirect.com/science/article/pii/S1097276521009072
  214. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay
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      DOI: 10.7554/eLife.71966

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    ncbi.nlm.nih.gov/pmc/articles/PMC8553338/
  215. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific NaV1.7 regulation in the pathogenesis of chronic neuropathic pain
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    1. scibot 05 Nov 2021
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      DOI: 10.1097/j.pain.0000000000001951

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    ncbi.nlm.nih.gov/pmc/articles/PMC7572581/
  216. www.sciencedirect.com www.sciencedirect.com
    MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal
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    1. scibot 03 Nov 2021
      RRID:Addgene_42230

      DOI: 10.1016/j.celrep.2021.109949

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    sciencedirect.com/science/article/pii/S2211124721014261
  217. Oct 2021
  218. www.sciencedirect.com www.sciencedirect.com
    A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus
    1
    1. scibot 28 Oct 2021
      Plasmid_42230

      DOI: 10.1016/j.devcel.2021.10.004

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    sciencedirect.com/science/article/pii/S1534580721008054
  219. www.sciencedirect.com www.sciencedirect.com
    Exocyst complex mediates recycling of internal cilia
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      DOI: 10.1016/j.cub.2021.09.067

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    sciencedirect.com/science/article/pii/S0960982221013233
  220. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Tumor cell intrinsic TLR4 signaling promotes melanoma progression and metastatic dissemination
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    1. scibot 15 Oct 2021
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      DOI: 10.1002/ijc.33804

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    onlinelibrary.wiley.com/doi/10.1002/ijc.33804
  221. www.sciencedirect.com www.sciencedirect.com
    RAG2 abolishes RAG1 aggregation to facilitate V(D)J recombination
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    1. scibot 13 Oct 2021
      42230

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    sciencedirect.com/science/article/pii/S2211124721012882
  222. Sep 2021
  223. academic.oup.com academic.oup.com
    CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase
    1
    1. scibot 24 Sep 2021
      RRID:Addgene_42230

      DOI: 10.1093/nar/gkab805

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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab805/6371977