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    CTNND2 moderates the pace of synaptic maturation and links human evolution to synaptic neoteny
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    sciencedirect.com/science/article/pii/S2211124724011483
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    K128 ubiquitination constrains RAS activity by expanding its binding interface with GAP proteins
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      Addgene

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    ncbi.nlm.nih.gov/pmc/articles/PMC11251195/
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    TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis
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      PX330

      DOI: 10.7554/eLife.92195

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    Fatty acid–binding proteins 3, 7, and 8 bind cholesterol and facilitate its egress from lysosomes
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      42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC10909654/
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    Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2
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      pX-330

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    Distinct functions of PAXX and MRI during chromosomal end joining
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    Inhibition of the ITGB1 gene attenuates crystalline silica-induced pulmonary fibrosis via epithelial-mesenchymal transformation
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      pX330-U6-Chimeric_BB-CBh-hSpCas9

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    CyCoNP lncRNA establishes cis and trans RNA–RNA interactions to supervise neuron physiology
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      PX330

      DOI: 10.1093/nar/gkae590

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    ncbi.nlm.nih.gov/pmc/articles/PMC11381359/
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    Dual-specificity phosphatases 13 and 27 as key switches in muscle stem cell transition from proliferation to differentiation
    1
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      px330-U6-Chimeric_BB-CBh-hSpCas9

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    ncbi.nlm.nih.gov/pmc/articles/PMC11384902/
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    Hyper-recombination in ribosomal DNA is driven by long-range resection-independent RAD51 accumulation
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      plasmid_42230

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    When less is more – a fast TurboID knock-in approach for high-sensitivity endogenous interactome mapping
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      plasmid_42230

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    HSF1 is required for cellular adaptation to daily temperature fluctuations
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      42230

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    Tuberculosis in otherwise healthy adults with inherited TNF deficiency
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      42230

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    Electrophysiology of Human iPSC-derived Vascular Smooth Muscle Cells and Cell-autonomous Consequences of Cantú Syndrome Mutations
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      Addgene_42230

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    A suite of genome-engineered hepatic cells provides novel insights into the spatiotemporal metabolism of apolipoprotein B and apolipoprotein B–containing lipoprotein secretion
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    Senataxin RNA/DNA helicase promotes replication restart at co-transcriptional R-loops to prevent MUS81-dependent fork degradation
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      plasmid_42

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    Characterising replisome disassembly in human cells
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    Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator
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    Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation
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      Cat# 42230

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    CRISPRi with barcoded expression reporters dissects regulatory networks in human cells
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    Activation of the NLRP1B inflammasome by caspase-8
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      plasmid_42230

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    Alternative splicing coupled to nonsense-mediated decay coordinates downregulation of non-neuronal genes in developing mouse neurons
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      plasmid_42

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    The ULK1 effector BAG2 regulates autophagy initiation by modulating AMBRA1 localization
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    FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation
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      Addgene, #42230

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    Blockage of BCL-XL overcomes venetoclax resistance across BCL2+ lymphoid malignancies irrespective of BIM status
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    Functions of PMS2 and MLH1 important for regulation of divergent repeat-mediated deletions
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      42230

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    Single-nucleosome imaging unveils that condensins and nucleosome–nucleosome interactions differentially constrain chromatin to organize mitotic chromosomes
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    Molecular Basis for the Calcium-Dependent Activation of the Ribonuclease EndoU
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      Addgene_42230

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    RECON gene disruption enhances host resistance to enable genome-wide evaluation of intracellular pathogen fitness during infection
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      Addgene_42230

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    BEAM: A combinatorial recombinase toolbox for binary gene expression and mosaic genetic analysis
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      Addgene_42230

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    MYC and p53 alterations cooperate through VEGF signaling to repress cytotoxic T cell and immunotherapy responses in prostate cancer
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    Rapid phagosome isolation enables unbiased multiomic analysis of human microglial phagosomes
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    Generation of a fluorescent hESC reporter line (Kle033-A-1) for the isolation of distinct midbrain progenitor cell types
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    Axo-axonic synaptic input drives homeostatic plasticity by tuning the axon initial segment structurally and functionally
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      DOI: 10.1126/sciadv.adk4331

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    SNX32 Regulates Sorting and Trafficking of Activated EGFR to the Lysosomal Degradation Pathway
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      plasmid_42230

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  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis
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  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A mechanistic study on the tolerance of PAM distal end mismatch by SpCas9
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      plasmid_42230

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  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel chemical genetic approach reveals paralog-specific role of ERK1/2 in mouse embryonic stem cell fate control
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      plasmid_42230

      DOI: 10.3389/fcell.2024.1415621

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  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kinesins regulate the heterogeneity in centrosome clustering after whole-genome duplication
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      plasmid_42230

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  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Golgi pH homeostasis stabilizes the lysosomal membrane through N-glycosylation of membrane proteins
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    Ki-67 is necessary during DNA replication for fork protection and genome stability
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    Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity
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  46. 52.53.155.43 52.53.155.43
    Method of Monitoring 26S Proteasome in the Cells Revealed the Crucial Role of PSMA3 C-terminus in 26S Integrity
    1
    1. scibot 02 Aug 2024
      RRID:  Addgene_42230

      DOI: 10.20944/preprints202305.1610.v1

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  47. Jul 2024
  48. www.sciencedirect.com www.sciencedirect.com
    Generation of MBP-tdTomato reporter human induced pluripotent stem cell line for live myelin visualization
    1
    1. scibot 19 Jul 2024
      RRID:Addgene_42230

      DOI: 10.1016/j.scr.2024.103493

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  49. www.sciencedirect.com www.sciencedirect.com
    FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition
    2
    1. scibot 17 Jul 2024
      AddgeneCat# 42230

      DOI: 10.1016/j.celrep.2024.114464

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  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9
    1
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      RRID:Addgene_42230

      DOI: 10.7554/eLife.92764

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    ncbi.nlm.nih.gov/pmc/articles/PMC11230626/
  51. Jun 2024
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A temperature-sensitive and interferon-silent Sendai virus vector for CRISPR-Cas9 delivery and gene editing in primary human cells
    1
    1. scibot 21 Jun 2024
      42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC11092779/
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells
    1
    1. scibot 21 Jun 2024
      plasmid_42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC11142080/
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation of DNA-binding domains of CLOCK–BMAL1 complex for PER-dependent inhibition in circadian clock of mammalian cells
    1
    1. scibot 15 Jun 2024
      42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC11161756/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mode of SUV420H2 heterochromatin localization through multiple HP1 binding motifs in the heterochromatic targeting module
    1
    1. scibot 15 Jun 2024
      42,230

      DOI: 10.1111/gtc.13109

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    ncbi.nlm.nih.gov/pmc/articles/PMC11163940/
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An antifouling membrane-fusogenic liposome for effective intracellular delivery in vivo
    1
    1. scibot 07 Jun 2024
      42230

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  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ciliary tip actin dynamics regulate photoreceptor outer segment integrity
    1
    1. scibot 07 Jun 2024
      42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC11109262/
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A global gene regulatory program and its region-specific regulator partition neurons into commissural and ipsilateral projection types
    1
    1. scibot 07 Jun 2024
      42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC11114196/
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours
    1
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      42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC11126719/
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pseudopregnant mice generated from Piwil1 deficiency sterile mice
    1
    1. scibot 07 Jun 2024
      Plasmid_42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC11108164/
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FokI-RYdCas9 Mediates Nearly PAM-Less and High-Precise Gene Editing in Human Cells
    1
    1. scibot 07 Jun 2024
      plasmid_42230

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  62. 52.53.155.43 52.53.155.43
    2024.05.31.596483v1.full-html.html
    1
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      Addgene_42230

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  63. www.sciencedirect.com www.sciencedirect.com
    Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression
    2
    1. scibot 04 Jun 2024
      Addgene_42230

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    sciencedirect.com/science/article/pii/S1534580724003307
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic movement of the Golgi unit and its glycosylation enzyme zones
    1
    1. scibot 03 Jun 2024
      Addgene_42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC11130159/
  65. May 2024
  66. www.biorxiv.org www.biorxiv.org
    Proteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer
    1
    1. scibot 23 May 2024
      plasmid_42230

      DOI: 10.1101/2024.03.05.583460

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    biorxiv.org/content/10.1101/2024.03.05.583460v1
  67. www.sciencedirect.com www.sciencedirect.com
    Bag1 protein loss sensitizes mouse embryonic fibroblasts to glutathione depletion
    2
    1. scibot 21 May 2024
      plasmid_42230

      DOI: 10.1016/j.cstres.2024.05.003

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      RRID:Addgene_4223031

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    sciencedirect.com/science/article/pii/S1355814524000750
  68. www.biorxiv.org www.biorxiv.org
    Mammalian RNAi represses pericentromeric lncRNAs to maintain genome stability
    1
    1. scibot 17 May 2024
      RRID:Addgene_42230

      DOI: 10.1101/2024.05.09.593425

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    biorxiv.org/content/10.1101/2024.05.09.593425v1
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CD74 supports accumulation and function of regulatory T cells in tumors
    1
    1. scibot 12 May 2024
      42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC11068745/
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HIF-1α participates in the regulation of S100A16-HRD1-GSK3β/CK1α pathway in renal hypoxia injury
    1
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      42230

      DOI: 10.1038/s41419-024-06696-5

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  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The factor inhibiting HIF regulates T cell differentiation and anti-tumour efficacy
    1
    1. scibot 05 May 2024
      42230

      DOI: 10.3389/fimmu.2024.1293723

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    ncbi.nlm.nih.gov/pmc/articles/PMC11058823/
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Coregulation of NDC80 Complex Subunits Determines the Fidelity of the Spindle-Assembly Checkpoint and Mitosis
    1
    1. scibot 05 May 2024
      Addgene_42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC11063766/
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    WNT5B drives osteosarcoma stemness, chemoresistance and metastasis
    1
    1. scibot 03 May 2024
      RRID:Addgene_42230

      DOI: 10.1002/ctm2.1670

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    ncbi.nlm.nih.gov/pmc/articles/PMC11061378/
  74. Apr 2024
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Linear interaction between replication and transcription shapes DNA break dynamics at recurrent DNA break Clusters
    1
    1. scibot 30 Apr 2024
      Addgene_42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC11055891/
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Endogenous BAX and BAK form mosaic rings of variable size and composition on apoptotic mitochondria
    1
    1. scibot 29 Apr 2024
      plasmid_42230

      DOI: 10.1038/s41418-024-01273-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC11043412/
  77. rupress.org rupress.org
    Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization
    1
    1. scibot 25 Apr 2024
      42230; Addgene

      DOI: 10.1083/jcb.202307026

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    rupress.org/jcb/article/223/4/e202307026/276570/Tunable-DNMT1-degradation-reveals-DNMT1-DNMT3B
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptomic profiling across human serotonin neuron differentiation via the FEV reporter system
    1
    1. scibot 23 Apr 2024
      Addgene_42230

      DOI: 10.1186/s13287-024-03728-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC11027224/
  79. www.nature.com www.nature.com
    Luciferase- and HaloTag-based reporter assays to measure small-molecule-induced degradation pathway in living cells
    1
    1. scibot 19 Apr 2024
      RRID:Addgene_42230

      DOI: 10.1038/s41596-024-00979-z

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    nature.com/articles/s41596-024-00979-z
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IntAct: A nondisruptive internal tagging strategy to study the organization and function of actin isoforms
    1
    1. scibot 15 Apr 2024
      42230

      DOI: 10.1371/journal.pbio.3002551

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    ncbi.nlm.nih.gov/pmc/articles/PMC10957077/
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL
    1
    1. scibot 15 Apr 2024
      pX330-U6-Chimeric_BB-CBh-hSpCas9

      DOI: 10.1084/jem.20230941

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    ncbi.nlm.nih.gov/pmc/articles/PMC10959178/
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma
    1
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      42230

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  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular basis promoting centriole triplet microtubule assembly
    1
    1. scibot 15 Apr 2024
      42230

      DOI: 10.1038/s41467-024-46454-x

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  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oligomerization mediated by the D2 domain of DTX3L is critical for DTX3L‐PARP9 reading function of mono‐ADP‐ribosylated androgen receptor
    1
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  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ER-export and ARFRP1/AP-1–dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication
    1
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      42230

      DOI: 10.1126/sciadv.adl5012

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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons
    1
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      42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC11001582/
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure and tethering mechanism of dynein-2 intermediate chains in intraflagellar transport
    1
    1. scibot 13 Apr 2024
      plasmid_42230

      DOI: 10.1038/s44318-024-00060-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10987677/
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells
    1
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      Addgene_42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC10997609/
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The impact of canonical Wnt transcriptional repressors TLE3 and TLE4 on postsynaptic transcription at the neuromuscular junction
    1
    1. scibot 13 Apr 2024
      plasmid_42230

      DOI: 10.3389/fnmol.2024.1360368

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    ncbi.nlm.nih.gov/pmc/articles/PMC11004254/
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer’s Disease
    1
    1. scibot 11 Apr 2024
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  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
    1
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  92. www.sciencedirect.com www.sciencedirect.com
    Generation of human cerebral organoids with a structured outer subventricular zone
    1
    1. scibot 09 Apr 2024
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    sciencedirect.com/science/article/pii/S2211124724003590
  93. Mar 2024
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure and function of Semaphorin-5A glycosaminoglycan interactions
    1
    1. scibot 31 Mar 2024
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  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mycobacterium tuberculosis inhibits METTL14-mediated m6A methylation of Nox2 mRNA and suppresses anti-TB immunity
    1
    1. scibot 31 Mar 2024
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  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The genetically modified human foreskin fibroblast cell line (YhFF#8) stably expressing Cas9 gene: A lab resource report
    1
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  97. onlinelibrary.wiley.com onlinelibrary.wiley.com
    An oocyte-specific Cas9-expressing mouse for germline CRISPR/Cas9-mediated genome editing
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    1. scibot 26 Mar 2024
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    onlinelibrary.wiley.com/doi/10.1002/dvg.23589
  98. link.springer.com link.springer.com
    Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism
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  99. www.nature.com www.nature.com
    Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species
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  100. www.sciencedirect.com www.sciencedirect.com
    Generation of a homozygous ALX1 knockout human embryonic stem cell line (WAe001-A-060) by a CRISPR/Cas9 system
    1
    1. scibot 25 Mar 2024
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  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Engineered FSHD mutations results in D4Z4 heterochromatin disruption and feedforward DUX4 network activation
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  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of Fel d 1 chain 2 genome-edited cats by CRISPR-Cas9 system
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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function
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    1. scibot 17 Mar 2024
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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prediction and validation of circulating G-quadruplexes as a novel biomarker in colorectal cancer
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  105. www.nature.com www.nature.com
    Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis
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    1. scibot 14 Mar 2024
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  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DJ-1 protects proteins from acylation by catalyzing the hydrolysis of highly reactive cyclic 3-phosphoglyceric anhydride
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  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells
    1
    1. scibot 08 Mar 2024
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  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of protein kinase C increases Prdm14 level to promote self-renewal of embryonic stem cells through reducing Suv39h-induced H3K9 methylation
    1
    1. scibot 08 Mar 2024
      pX330-U6-Chimeric_BB-CBh-hSpCas9

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  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The transcription factor ChREBP Orchestrates liver carcinogenesis by coordinating the PI3K/AKT signaling and cancer metabolism
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  110. www.sciencedirect.com www.sciencedirect.com
    SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions
    2
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  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A humanized mouse model for adeno-associated viral gene therapy
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  112. www.sciencedirect.com www.sciencedirect.com
    LncRNA Litchi is a Regulator for Harmonizing Maturity and Resilient Functionality in Spinal Motor Neurons
    2
    1. scibot 07 Mar 2024
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  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
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  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TREX2 deficiency suppresses spontaneous and genotoxin-associated mutagenesis
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  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease
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  116. Feb 2024
  117. www.biorxiv.org www.biorxiv.org
    Sparse CBX2 nucleates many Polycomb proteins to promote facultative heterochromatinization of Polycomb target genes
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    1. scibot 29 Feb 2024
      pX330-U6-Chimeric_BB-CBh-hSpCas9

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    biorxiv.org/content/10.1101/2024.02.05.578969v1
  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Undetectable off-target effects induced by FokI catalytic domain in mouse embryos
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  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence
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  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA m6A modification regulates L1 retrotransposons in human spermatogonial stem cell differentiation in vitro and in vivo
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  121. www.sciencedirect.com www.sciencedirect.com
    Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting
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  122. www.biorxiv.org www.biorxiv.org
    Post-synaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles
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  123. www.biorxiv.org www.biorxiv.org
    DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin
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      DOI: 10.1101/2024.02.06.579191

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  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BCL-XL regulates the timing of mitotic apoptosis independently of BCL2 and MCL1 compensation
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  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An ovalbumin fusion strategy to increase recombinant protein secretion in chicken eggs
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  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations
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  127. www.sciencedirect.com www.sciencedirect.com
    CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs
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  128. Jan 2024
  129. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Methodology to Create Auxin-Inducible Degron Tagging System to Control Expression of a Target Protein in Mammalian Cell Lines
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      https://www.addgene.org/42230/

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  130. www.sciencedirect.com www.sciencedirect.com
    Generation of a patient-specific iPSC cell line with cardiac arrhythmias and dilated cardiomyopathy (CBRCULi016-A), an isogenic control (CBRCULi016-A-1), and a paternal control (CBRCULi017-A)
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  131. Dec 2023
  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Altered Phenotypes of Breast Epithelial × Breast Cancer Hybrids after ZEB1 Knock-Out
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      DOI: 10.3390/ijms242417310

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  133. www.sciencedirect.com www.sciencedirect.com
    Highly cooperative chimeric super-SOX induces naive pluripotency across species
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  134. link.springer.com link.springer.com
    Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation
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    link.springer.com/article/10.1038/s41467-023-43896-7
  135. Nov 2023
  136. www.sciencedirect.com www.sciencedirect.com
    Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth
    1
    1. scibot 22 Nov 2023
      plasmid_42230

      DOI: 10.1016/j.cell.2023.10.026

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    sciencedirect.com/science/article/pii/S0092867423011777
  137. Oct 2023
  138. www.sciencedirect.com www.sciencedirect.com
    The intrinsically disordered region of eIF5B stimulates IRES usage and nucleates biological granule formation
    1
    1. scibot 27 Oct 2023
      plasmid_42230

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    sciencedirect.com/science/article/pii/S2211124723012950
  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for auxin-inducible depletion of the RNA-binding protein PTBP1 in mouse embryonic stem cells
    1
    1. scibot 27 Oct 2023
      Addgene_42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC10594634/
  140. dx.doi.org dx.doi.org
    Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction
    1
    1. scibot 27 Oct 2023
      RRID:Addgene_42230

      DOI: 10.1093/nar/gkad863

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    dx.doi.org/10.1093/nar/gkad863
  141. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LINE-1 activation in the cerebellum drives ataxia
    2
    1. scibot 20 Oct 2023
      Addgene #42230

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      RRID:Addgene_42230

      DOI: 10.1016/j.neuron.2022.08.011

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    ncbi.nlm.nih.gov/pmc/articles/PMC9588660/
  142. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model
    1
    1. scibot 06 Oct 2023
      plasmid_42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC10521973/
  143. www.sciencedirect.com www.sciencedirect.com
    ZEB2 and MEIS1 independently contribute to hematopoiesis via early hematopoietic enhancer activation
    1
    1. scibot 01 Oct 2023
      Addgene_42230

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    sciencedirect.com/science/article/pii/S2589004223019703
  144. Sep 2023
  145. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The autophagic protein FYCO1 controls TNFRSF10/TRAIL receptor induced apoptosis and is inactivated by CASP8 (caspase 8)
    1
    1. scibot 07 Sep 2023
      RRID:Addgene_42230

      DOI: 10.1080/15548627.2023.2229656

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    ncbi.nlm.nih.gov/pmc/articles/PMC10472876/
  146. Aug 2023
  147. www.embopress.org www.embopress.org
    Myddosome clustering in IL-1 receptor signaling regulates the formation of an NF-kB activating signalosome
    1
    1. scibot 23 Aug 2023
      Plasmid_42230

      DOI: 10.15252/embr.202357233

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    embopress.org/doi/10.15252/embr.202357233
  148. www.sciencedirect.com www.sciencedirect.com
    Integrating single-cell imaging and RNA sequencing datasets links differentiation and morphogenetic dynamics of human pancreatic endocrine progenitors
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    sciencedirect.com/science/article/pii/S1534580723003660
  149. www.biorxiv.org www.biorxiv.org
    Ubiquitin phosphorylation accelerates protein aggregation and promotes neurodegeneration in the aging brain
    1
    1. scibot 16 Aug 2023
      plasmid_42230

      DOI: 10.1101/2023.08.10.552882

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    biorxiv.org/content/10.1101/2023.08.10.552882v1
  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The mitochondrial succinate dehydrogenase complex controls the STAT3-IL-10 pathway in inflammatory macrophages
    1
    1. scibot 16 Aug 2023
      Plasmid_42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC10416071/
  151. Jul 2023
  152. www.sciencedirect.com www.sciencedirect.com
    Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation
    1
    1. scibot 27 Jul 2023
      RRID:Addgene_42230

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    sciencedirect.com/science/article/pii/S1534580723003313
  153. www.sciencedirect.com www.sciencedirect.com
    Optimized CRISPR/Cas9 System for Gene Knockout in Chicken DF1 Cells
    1
    1. scibot 27 Jul 2023
      plasmid_42230

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    sciencedirect.com/science/article/pii/S0032579123004893
  154. www.sciencedirect.com www.sciencedirect.com
    mRNA stability and m6A are major determinants of subcellular mRNA localization in neurons
    1
    1. scibot 14 Jul 2023
      Addgene_42230

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    sciencedirect.com/science/article/pii/S1097276523004689
  155. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic analysis of the molecular and biophysical properties of key DNA damage response factors
    1
    1. scibot 06 Jul 2023
      RRID:Addgene_42230

      DOI: 10.7554/eLife.87086

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    ncbi.nlm.nih.gov/pmc/articles/PMC10319438/
  156. Jun 2023
  157. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Method of Monitoring 26S Proteasome in Cells Revealed the Crucial Role of PSMA3 C-Terminus in 26S Integrity
    1
    1. scibot 30 Jun 2023
      RRID:Addgene_42230

      DOI: 10.3390/biom13060992

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    ncbi.nlm.nih.gov/pmc/articles/PMC10296302/
  158. www.sciencedirect.com www.sciencedirect.com
    Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization
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    1. scibot 24 Jun 2023
      Addgene_42230

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    sciencedirect.com/science/article/pii/S2451945623001575
  159. www.sciencedirect.com www.sciencedirect.com
    Coordinated linear and rotational movements of endothelial cells compartmentalized by VE-cadherin drive angiogenic sprouting
    1
    1. scibot 23 Jun 2023
      Addgene_42230

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    sciencedirect.com/science/article/pii/S2589004223011288
  160. www.sciencedirect.com www.sciencedirect.com
    Centromere/kinetochore is assembled through CENP-C oligomerization
    2
    1. scibot 09 Jun 2023
      Plasmid_42230

      DOI: 10.1016/j.molcel.2023.05.023

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      plasmid_422350

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    sciencedirect.com/science/article/pii/S1097276523003799
  161. www.sciencedirect.com www.sciencedirect.com
    Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer
    1
    1. scibot 02 Jun 2023
      plasmid_42230

      DOI: 10.1016/j.ccell.2023.05.004

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    sciencedirect.com/science/article/pii/S1535610823001721
  162. May 2023
  163. www.sciencedirect.com www.sciencedirect.com
    ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis
    1
    1. scibot 31 May 2023
      RRID:Addgene_42230

      DOI: 10.1016/j.celrep.2023.112562

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    sciencedirect.com/science/article/pii/S2211124723005739
  164. www.sciencedirect.com www.sciencedirect.com
    Protocol for biallelic tagging of an endogenous gene using CRISPR-Cas9 in human cells
    1
    1. scibot 31 May 2023
      Plasmid_42230

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    sciencedirect.com/science/article/pii/S2666166723002538
  165. www.sciencedirect.com www.sciencedirect.com
    Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex
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    1. scibot 17 May 2023
      Addgene_42230

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    sciencedirect.com/science/article/pii/S1534580723001910
  166. www.sciencedirect.com www.sciencedirect.com
    Methylated histones on mitotic chromosomes promote Topoisomerase IIα function for high fidelity chromosome segregation.
    1
    1. scibot 14 May 2023
      Addgene_42230

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    sciencedirect.com/science/article/pii/S2589004223008209
  167. Apr 2023
  168. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Knock-In Rat Lines with Cre Recombinase at the Dopamine D1 and Adenosine 2a Receptor Loci
    1
    1. scibot 27 Apr 2023
      Addgene_42230

      DOI: 10.1523/ENEURO.0163-19.2019

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    ncbi.nlm.nih.gov/pmc/articles/PMC6776791/
  169. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial dynamics define muscle fiber type by modulating cellular metabolic pathways
    1
    1. scibot 26 Apr 2023
      RRID:Addgene_42230

      DOI: 10.1016/j.celrep.2023.112434

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    sciencedirect.com/science/article/pii/S221112472300445X
  170. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of PARP7 Creates a Vulnerability for Growth Inhibition by RBN2397 in Prostate Cancer Cells
    1
    1. scibot 20 Apr 2023
      RRID:Addgene_42230

      DOI: 10.1158/2767-9764.CRC-23-0086

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    ncbi.nlm.nih.gov/pmc/articles/PMC10108886/
  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear Cell Renal Cell Carcinoma
    1
    1. scibot 12 Apr 2023
      Addgene_42230

      DOI: 10.1158/2159-8290.CD-21-0925

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    ncbi.nlm.nih.gov/pmc/articles/PMC9720541/
  172. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
    1
    1. scibot 12 Apr 2023
      RRID:Addgene_42230

      DOI: 10.1101/2023.03.13.532415

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    ncbi.nlm.nih.gov/pmc/articles/PMC10054921/
  173. www.sciencedirect.com www.sciencedirect.com
    Synergistic effects of combined immunotherapy strategies in a model of multifocal hepatocellular carcinoma
    1
    1. scibot 12 Apr 2023
      plasmid_42230

      DOI: 10.1016/j.xcrm.2023.101009

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    sciencedirect.com/science/article/pii/S2666379123001192
  174. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Characterizing the differential distribution and targets of Sumo1 and Sumo2 in the mouse brain
    1
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      Addgene_42230

      DOI: 10.1016/j.isci.2023.106350

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    ncbi.nlm.nih.gov/pmc/articles/PMC10060683/
  175. Mar 2023
  176. aacrjournals.org aacrjournals.org
    Rlf–Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer
    1
    1. scibot 24 Mar 2023
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      DOI: 10.1158/2159-8290.CD-21-0441

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    aacrjournals.org/cancerdiscovery/article/11/12/3214/674718/Rlf-Mycl-Gene-Fusion-Drives-Tumorigenesis-and
  177. www.nature.com www.nature.com
    FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation
    1
    1. scibot 23 Mar 2023
      plasmid_42230

      DOI: 10.1038/s41586-021-04144-4

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    nature.com/articles/s41586-021-04144-4
  178. academic.oup.com academic.oup.com
    INO80 promotes H2A.Z occupancy to regulate cell fate transition in pluripotent stem cells
    1
    1. scibot 21 Mar 2023
      addgene_42230

      DOI: 10.1093/nar/gkab476

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    academic.oup.com/nar/article/49/12/6739/6303461
  179. www.sciencedirect.com www.sciencedirect.com
    Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma
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    1. scibot 11 Mar 2023
      Plasmid_42230

      DOI: 10.1016/j.celrep.2023.112212

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    sciencedirect.com/science/article/pii/S2211124723002231
  180. www.sciencedirect.com www.sciencedirect.com
    hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung’s disease
    1
    1. scibot 03 Mar 2023
      plasmid_42230

      DOI: 10.1016/j.stem.2023.02.003

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    sciencedirect.com/science/article/pii/S1934590923000401
  181. Feb 2023
  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HER2-driven breast cancer suppression by the JNK signaling pathway
    1
    1. scibot 24 Feb 2023
      RRID:Addgene_42230

      DOI: 10.1073/pnas.2218373120

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    ncbi.nlm.nih.gov/pmc/articles/PMC9942916/
  183. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression
    1
    1. scibot 23 Feb 2023
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      DOI: 10.7554/eLife.83291

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    ncbi.nlm.nih.gov/pmc/articles/PMC9943069/
  184. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phase separation of an actin nucleator by junctional microtubules regulates epithelial function
    1
    1. scibot 17 Feb 2023
      plasmid_42230

      DOI: 10.1126/sciadv.adf6358

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    ncbi.nlm.nih.gov/pmc/articles/PMC9931218/
  185. www.biorxiv.org www.biorxiv.org
    The Glucocorticoid Receptor is Required for Efficient Aldosterone-Induced Transcription by the Mineralocorticoid Receptor
    1
    1. scibot 06 Feb 2023
      plasmid_42230

      DOI: 10.1101/2023.01.26.525745

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    biorxiv.org/content/10.1101/2023.01.26.525745v1
  186. www.sciencedirect.com www.sciencedirect.com
    RIF1 suppresses the formation of single-stranded ultrafine anaphase bridges via protein phosphatase 1
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    sciencedirect.com/science/article/pii/S2211124723000438
  187. Jan 2023
  188. www.sciencedirect.com www.sciencedirect.com
    Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis
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    sciencedirect.com/science/article/pii/S1534580722008723
  189. link.springer.com link.springer.com
    Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
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      DOI: 10.1007/s00125-022-05856-6

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    link.springer.com/article/10.1007/s00125-022-05856-6
  190. www.biorxiv.org www.biorxiv.org
    Myddosome clustering in IL-1 receptor signaling regulates the formation of an NF-kB activating signalosome
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    1. scibot 12 Jan 2023
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    biorxiv.org/content/10.1101/2023.01.06.522894v2
  191. www.sciencedirect.com www.sciencedirect.com
    PTBP1-activated co-transcriptional splicing controls epigenetic status of pluripotent stem cells
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    sciencedirect.com/science/article/pii/S1097276522011716
  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging
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    ncbi.nlm.nih.gov/pmc/articles/PMC9804145/
  193. www.sciencedirect.com www.sciencedirect.com
    Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome
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    sciencedirect.com/science/article/pii/S0969212622004889
  194. journals.plos.org journals.plos.org
    In vitro genome editing activity of Cas9 in somatic cells after random and transposon-based genomic Cas9 integration
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      DOI: 10.1371/journal.pone.0279123

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  195. Dec 2022
  196. www.sciencedirect.com www.sciencedirect.com
    The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER
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    sciencedirect.com/science/article/pii/S2211124722017648
  197. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Self-cleaving guide RNAs enable pharmacological selection of precise gene editing events in vivo
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      DOI: 10.1038/s41467-022-35097-5

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  198. elifesciences.org elifesciences.org
    Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals
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  199. Nov 2022
  200. www.science.org www.science.org
    Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo
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  201. www.sciencedirect.com www.sciencedirect.com
    TEMPO enables sequential genetic labeling and manipulation of vertebrate cell lineages
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      DOI: 10.1016/j.neuron.2022.10.035

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    sciencedirect.com/science/article/pii/S0896627322009953
  202. www.sciencedirect.com www.sciencedirect.com
    Α γ-tubulin complex-dependent pathway suppresses ciliogenesis by promoting cilia disassembly
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    sciencedirect.com/science/article/pii/S2211124722015133
  203. www.sciencedirect.com www.sciencedirect.com
    Transcription factor antagonism regulates heterogeneity in embryonic stem cell states
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    sciencedirect.com/science/article/pii/S109727652201022X
  204. www.nature.com www.nature.com
    Erratic and blood vessel-guided migration of astrocyte progenitors in the cerebral cortex
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  205. www.sciencedirect.com www.sciencedirect.com
    WNK kinases sense molecular crowding and rescue cell volume via phase separation
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    sciencedirect.com/science/article/pii/S0092867422012612
  206. Oct 2022
  207. www.nature.com www.nature.com
    Divergent regulation of basement membrane trafficking by human macrophages and cancer cells
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      DOI: 10.1038/s41467-022-34087-x

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  208. www.sciencedirect.com www.sciencedirect.com
    A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants
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      DOI: 10.1016/j.stem.2022.09.008

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    sciencedirect.com/science/article/pii/S193459092200385X
  209. Sep 2022
  210. www.sciencedirect.com www.sciencedirect.com
    Latent HIV-1 provirus in vitro suppression using combinatorial CRISPR/Cas9 strategy
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      plasmid_42230

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    sciencedirect.com/science/article/pii/S2452014422001947
  211. academic.oup.com academic.oup.com
    Nesprin-1 LINC complexes recruit microtubule cytoskeleton proteins and drive pathology in Lmna mutant striated muscle
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      DOI: 10.1093/hmg/ddac179

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    academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddac179/6655857
  212. www.sciencedirect.com www.sciencedirect.com
    Targeted protein degradation reveals RNA Pol II heterogeneity and functional diversity
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      Cat#42230

      DOI: 10.1016/j.molcel.2022.08.023

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  213. link.springer.com link.springer.com
    Generation of corrected hiPSC clones from a Cornelia de Lange Syndrome (CdLS) patient through CRISPR-Cas-based technology
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      DOI: 10.1186/s13287-022-03135-0

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  214. Aug 2022
  215. 52.53.155.43 52.53.155.43
    cd-21-0925-html.html
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      DOI: 10.1158/2159-8290.CD-21-0925

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  216. www.sciencedirect.com www.sciencedirect.com
    NF-κB memory coordinates transcriptional responses to dynamic inflammatory stimuli
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      DOI: 10.1016/j.celrep.2022.111159

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