374 Matching Annotations
  1. Last 7 days
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    The ULK1 effector BAG2 regulates autophagy initiation by modulating AMBRA1 localization
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    1. scibot 13 Sep 2024
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      DOI: 10.1016/j.celrep.2024.114689

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    sciencedirect.com/science/article/pii/S2211124724010404
  3. Sep 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11364545/
  5. Aug 2024
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    Blockage of BCL-XL overcomes venetoclax resistance across BCL2+ lymphoid malignancies irrespective of BIM status
    1
    1. scibot 26 Aug 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11261020/
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    Functions of PMS2 and MLH1 important for regulation of divergent repeat-mediated deletions
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    1. scibot 26 Aug 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11326157/
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    Single-nucleosome imaging unveils that condensins and nucleosome–nucleosome interactions differentially constrain chromatin to organize mitotic chromosomes
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    1. scibot 26 Aug 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11339268/
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    Molecular Basis for the Calcium-Dependent Activation of the Ribonuclease EndoU
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    1. scibot 26 Aug 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11275989/
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    RECON gene disruption enhances host resistance to enable genome-wide evaluation of intracellular pathogen fitness during infection
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    BEAM: A combinatorial recombinase toolbox for binary gene expression and mosaic genetic analysis
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    sciencedirect.com/science/article/pii/S2211124724010015
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    MYC and p53 alterations cooperate through VEGF signaling to repress cytotoxic T cell and immunotherapy responses in prostate cancer
    1
    1. scibot 22 Aug 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11291169/
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    Rapid phagosome isolation enables unbiased multiomic analysis of human microglial phagosomes
    1
    1. scibot 22 Aug 2024
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    sciencedirect.com/science/article/pii/S1074761324003686
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    Generation of a fluorescent hESC reporter line (Kle033-A-1) for the isolation of distinct midbrain progenitor cell types
    1
    1. scibot 21 Aug 2024
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    sciencedirect.com/science/article/pii/S1873506124002216
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    Axo-axonic synaptic input drives homeostatic plasticity by tuning the axon initial segment structurally and functionally
    1
    1. scibot 19 Aug 2024
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      DOI: 10.1126/sciadv.adk4331

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  16. onlinelibrary.wiley.com onlinelibrary.wiley.com
    SNX32 Regulates Sorting and Trafficking of Activated EGFR to the Lysosomal Degradation Pathway
    1
    1. scibot 19 Aug 2024
      plasmid_42230

      DOI: 10.1111/tra.12952

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  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis
    1
    1. scibot 18 Aug 2024
      42230

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  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A mechanistic study on the tolerance of PAM distal end mismatch by SpCas9
    1
    1. scibot 18 Aug 2024
      plasmid_42230

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  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel chemical genetic approach reveals paralog-specific role of ERK1/2 in mouse embryonic stem cell fate control
    1
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      plasmid_42230

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  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kinesins regulate the heterogeneity in centrosome clustering after whole-genome duplication
    1
    1. scibot 18 Aug 2024
      plasmid_42230

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  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Golgi pH homeostasis stabilizes the lysosomal membrane through N-glycosylation of membrane proteins
    1
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      42230

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  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ki-67 is necessary during DNA replication for fork protection and genome stability
    1
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      42230

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  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity
    2
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  24. 52.53.155.43 52.53.155.43
    Method of Monitoring 26S Proteasome in the Cells Revealed the Crucial Role of PSMA3 C-terminus in 26S Integrity
    1
    1. scibot 02 Aug 2024
      RRID:  Addgene_42230

      DOI: 10.20944/preprints202305.1610.v1

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  25. Jul 2024
  26. www.sciencedirect.com www.sciencedirect.com
    Generation of MBP-tdTomato reporter human induced pluripotent stem cell line for live myelin visualization
    1
    1. scibot 19 Jul 2024
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    FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition
    2
    1. scibot 17 Jul 2024
      AddgeneCat# 42230

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    sciencedirect.com/science/article/pii/S2211124724007939
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9
    1
    1. scibot 12 Jul 2024
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      DOI: 10.7554/eLife.92764

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  29. Jun 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A temperature-sensitive and interferon-silent Sendai virus vector for CRISPR-Cas9 delivery and gene editing in primary human cells
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  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells
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      plasmid_42230

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  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation of DNA-binding domains of CLOCK–BMAL1 complex for PER-dependent inhibition in circadian clock of mammalian cells
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  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mode of SUV420H2 heterochromatin localization through multiple HP1 binding motifs in the heterochromatic targeting module
    1
    1. scibot 15 Jun 2024
      42,230

      DOI: 10.1111/gtc.13109

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  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An antifouling membrane-fusogenic liposome for effective intracellular delivery in vivo
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11106281/
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ciliary tip actin dynamics regulate photoreceptor outer segment integrity
    1
    1. scibot 07 Jun 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11109262/
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A global gene regulatory program and its region-specific regulator partition neurons into commissural and ipsilateral projection types
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11114196/
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11126719/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pseudopregnant mice generated from Piwil1 deficiency sterile mice
    1
    1. scibot 07 Jun 2024
      Plasmid_42230

      DOI: 10.1371/journal.pone.0296414

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    ncbi.nlm.nih.gov/pmc/articles/PMC11108164/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FokI-RYdCas9 Mediates Nearly PAM-Less and High-Precise Gene Editing in Human Cells
    1
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      plasmid_42230

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  40. 52.53.155.43 52.53.155.43
    2024.05.31.596483v1.full-html.html
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  41. www.sciencedirect.com www.sciencedirect.com
    Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression
    2
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    sciencedirect.com/science/article/pii/S1534580724003307
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic movement of the Golgi unit and its glycosylation enzyme zones
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    ncbi.nlm.nih.gov/pmc/articles/PMC11130159/
  43. May 2024
  44. www.biorxiv.org www.biorxiv.org
    Proteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer
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      plasmid_42230

      DOI: 10.1101/2024.03.05.583460

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    biorxiv.org/content/10.1101/2024.03.05.583460v1
  45. www.sciencedirect.com www.sciencedirect.com
    Bag1 protein loss sensitizes mouse embryonic fibroblasts to glutathione depletion
    2
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      plasmid_42230

      DOI: 10.1016/j.cstres.2024.05.003

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      RRID:Addgene_4223031

      DOI: 10.1016/j.cstres.2024.05.003

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    sciencedirect.com/science/article/pii/S1355814524000750
  46. www.biorxiv.org www.biorxiv.org
    Mammalian RNAi represses pericentromeric lncRNAs to maintain genome stability
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      RRID:Addgene_42230

      DOI: 10.1101/2024.05.09.593425

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    biorxiv.org/content/10.1101/2024.05.09.593425v1
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CD74 supports accumulation and function of regulatory T cells in tumors
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  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HIF-1α participates in the regulation of S100A16-HRD1-GSK3β/CK1α pathway in renal hypoxia injury
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  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The factor inhibiting HIF regulates T cell differentiation and anti-tumour efficacy
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  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Coregulation of NDC80 Complex Subunits Determines the Fidelity of the Spindle-Assembly Checkpoint and Mitosis
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  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    WNT5B drives osteosarcoma stemness, chemoresistance and metastasis
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  52. Apr 2024
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Linear interaction between replication and transcription shapes DNA break dynamics at recurrent DNA break Clusters
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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Endogenous BAX and BAK form mosaic rings of variable size and composition on apoptotic mitochondria
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  55. rupress.org rupress.org
    Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization
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  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptomic profiling across human serotonin neuron differentiation via the FEV reporter system
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  57. www.nature.com www.nature.com
    Luciferase- and HaloTag-based reporter assays to measure small-molecule-induced degradation pathway in living cells
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  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IntAct: A nondisruptive internal tagging strategy to study the organization and function of actin isoforms
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  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL
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  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma
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  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular basis promoting centriole triplet microtubule assembly
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  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oligomerization mediated by the D2 domain of DTX3L is critical for DTX3L‐PARP9 reading function of mono‐ADP‐ribosylated androgen receptor
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    ER-export and ARFRP1/AP-1–dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication
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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons
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  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure and tethering mechanism of dynein-2 intermediate chains in intraflagellar transport
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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells
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  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The impact of canonical Wnt transcriptional repressors TLE3 and TLE4 on postsynaptic transcription at the neuromuscular junction
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  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer’s Disease
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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
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  70. www.sciencedirect.com www.sciencedirect.com
    Generation of human cerebral organoids with a structured outer subventricular zone
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  71. Mar 2024
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure and function of Semaphorin-5A glycosaminoglycan interactions
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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mycobacterium tuberculosis inhibits METTL14-mediated m6A methylation of Nox2 mRNA and suppresses anti-TB immunity
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  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The genetically modified human foreskin fibroblast cell line (YhFF#8) stably expressing Cas9 gene: A lab resource report
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  75. onlinelibrary.wiley.com onlinelibrary.wiley.com
    An oocyte-specific Cas9-expressing mouse for germline CRISPR/Cas9-mediated genome editing
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  76. link.springer.com link.springer.com
    Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism
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  77. www.nature.com www.nature.com
    Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species
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  78. www.sciencedirect.com www.sciencedirect.com
    Generation of a homozygous ALX1 knockout human embryonic stem cell line (WAe001-A-060) by a CRISPR/Cas9 system
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  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Engineered FSHD mutations results in D4Z4 heterochromatin disruption and feedforward DUX4 network activation
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  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of Fel d 1 chain 2 genome-edited cats by CRISPR-Cas9 system
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    The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function
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    Prediction and validation of circulating G-quadruplexes as a novel biomarker in colorectal cancer
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  83. www.nature.com www.nature.com
    Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis
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  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DJ-1 protects proteins from acylation by catalyzing the hydrolysis of highly reactive cyclic 3-phosphoglyceric anhydride
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  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of protein kinase C increases Prdm14 level to promote self-renewal of embryonic stem cells through reducing Suv39h-induced H3K9 methylation
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  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The transcription factor ChREBP Orchestrates liver carcinogenesis by coordinating the PI3K/AKT signaling and cancer metabolism
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    SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions
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  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A humanized mouse model for adeno-associated viral gene therapy
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  90. www.sciencedirect.com www.sciencedirect.com
    LncRNA Litchi is a Regulator for Harmonizing Maturity and Resilient Functionality in Spinal Motor Neurons
    2
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  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
    1
    1. scibot 06 Mar 2024
      RRID:Addgene_42230

      DOI: 10.1038/s41467-024-45947-z

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  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TREX2 deficiency suppresses spontaneous and genotoxin-associated mutagenesis
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10883656/
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC10899107/
  94. Feb 2024
  95. www.biorxiv.org www.biorxiv.org
    Sparse CBX2 nucleates many Polycomb proteins to promote facultative heterochromatinization of Polycomb target genes
    1
    1. scibot 29 Feb 2024
      pX330-U6-Chimeric_BB-CBh-hSpCas9

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    biorxiv.org/content/10.1101/2024.02.05.578969v1
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Undetectable off-target effects induced by FokI catalytic domain in mouse embryos
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      plasmid_42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC10877887/
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence
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      pX330-U6-Chimeric_BB-CBh-hSpCas9

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    ncbi.nlm.nih.gov/pmc/articles/PMC10873425/
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA m6A modification regulates L1 retrotransposons in human spermatogonial stem cell differentiation in vitro and in vivo
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  99. www.sciencedirect.com www.sciencedirect.com
    Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting
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  100. www.biorxiv.org www.biorxiv.org
    Post-synaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles
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    1. scibot 15 Feb 2024
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    biorxiv.org/content/10.1101/2023.12.21.572751v1
  101. www.biorxiv.org www.biorxiv.org
    DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin
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    1. scibot 15 Feb 2024
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    biorxiv.org/content/10.1101/2024.02.06.579191v1
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BCL-XL regulates the timing of mitotic apoptosis independently of BCL2 and MCL1 compensation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10764939/
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An ovalbumin fusion strategy to increase recombinant protein secretion in chicken eggs
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      plasmid_42230

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    ncbi.nlm.nih.gov/pmc/articles/PMC10785457/
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations
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    ncbi.nlm.nih.gov/pmc/articles/PMC10784283/
  105. www.sciencedirect.com www.sciencedirect.com
    CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs
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      plasmid_42230

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    sciencedirect.com/science/article/pii/S1097276524000078
  106. Jan 2024
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Methodology to Create Auxin-Inducible Degron Tagging System to Control Expression of a Target Protein in Mammalian Cell Lines
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      https://www.addgene.org/42230/

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  108. www.sciencedirect.com www.sciencedirect.com
    Generation of a patient-specific iPSC cell line with cardiac arrhythmias and dilated cardiomyopathy (CBRCULi016-A), an isogenic control (CBRCULi016-A-1), and a paternal control (CBRCULi017-A)
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      Addgene_42230

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    sciencedirect.com/science/article/pii/S1873506124000060
  109. Dec 2023
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Altered Phenotypes of Breast Epithelial × Breast Cancer Hybrids after ZEB1 Knock-Out
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    1. scibot 28 Dec 2023
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      DOI: 10.3390/ijms242417310

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    ncbi.nlm.nih.gov/pmc/articles/PMC10744253/
  111. www.sciencedirect.com www.sciencedirect.com
    Highly cooperative chimeric super-SOX induces naive pluripotency across species
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    1. scibot 23 Dec 2023
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  112. link.springer.com link.springer.com
    Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation
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      RRID:Addgene_42230

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  113. Nov 2023
  114. www.sciencedirect.com www.sciencedirect.com
    Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth
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    1. scibot 22 Nov 2023
      plasmid_42230

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    sciencedirect.com/science/article/pii/S0092867423011777
  115. Oct 2023
  116. www.sciencedirect.com www.sciencedirect.com
    The intrinsically disordered region of eIF5B stimulates IRES usage and nucleates biological granule formation
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      plasmid_42230

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    sciencedirect.com/science/article/pii/S2211124723012950
  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for auxin-inducible depletion of the RNA-binding protein PTBP1 in mouse embryonic stem cells
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  118. dx.doi.org dx.doi.org
    Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction
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  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LINE-1 activation in the cerebellum drives ataxia
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    1. scibot 20 Oct 2023
      Addgene #42230

      DOI: 10.1016/j.neuron.2022.08.011

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      DOI: 10.1016/j.neuron.2022.08.011

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    ncbi.nlm.nih.gov/pmc/articles/PMC9588660/
  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model
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    ncbi.nlm.nih.gov/pmc/articles/PMC10521973/
  121. www.sciencedirect.com www.sciencedirect.com
    ZEB2 and MEIS1 independently contribute to hematopoiesis via early hematopoietic enhancer activation
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    sciencedirect.com/science/article/pii/S2589004223019703
  122. Sep 2023
  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The autophagic protein FYCO1 controls TNFRSF10/TRAIL receptor induced apoptosis and is inactivated by CASP8 (caspase 8)
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      RRID:Addgene_42230

      DOI: 10.1080/15548627.2023.2229656

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    ncbi.nlm.nih.gov/pmc/articles/PMC10472876/
  124. Aug 2023
  125. www.embopress.org www.embopress.org
    Myddosome clustering in IL-1 receptor signaling regulates the formation of an NF-kB activating signalosome
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      Plasmid_42230

      DOI: 10.15252/embr.202357233

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    embopress.org/doi/10.15252/embr.202357233
  126. www.sciencedirect.com www.sciencedirect.com
    Integrating single-cell imaging and RNA sequencing datasets links differentiation and morphogenetic dynamics of human pancreatic endocrine progenitors
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  127. www.biorxiv.org www.biorxiv.org
    Ubiquitin phosphorylation accelerates protein aggregation and promotes neurodegeneration in the aging brain
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    1. scibot 16 Aug 2023
      plasmid_42230

      DOI: 10.1101/2023.08.10.552882

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    biorxiv.org/content/10.1101/2023.08.10.552882v1
  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The mitochondrial succinate dehydrogenase complex controls the STAT3-IL-10 pathway in inflammatory macrophages
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    ncbi.nlm.nih.gov/pmc/articles/PMC10416071/
  129. Jul 2023
  130. www.sciencedirect.com www.sciencedirect.com
    Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation
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      RRID:Addgene_42230

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    sciencedirect.com/science/article/pii/S1534580723003313
  131. www.sciencedirect.com www.sciencedirect.com
    Optimized CRISPR/Cas9 System for Gene Knockout in Chicken DF1 Cells
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      plasmid_42230

      DOI: 10.1016/j.psj.2023.102970

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    sciencedirect.com/science/article/pii/S0032579123004893
  132. www.sciencedirect.com www.sciencedirect.com
    mRNA stability and m6A are major determinants of subcellular mRNA localization in neurons
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    1. scibot 14 Jul 2023
      Addgene_42230

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  133. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic analysis of the molecular and biophysical properties of key DNA damage response factors
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    1. scibot 06 Jul 2023
      RRID:Addgene_42230

      DOI: 10.7554/eLife.87086

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    ncbi.nlm.nih.gov/pmc/articles/PMC10319438/
  134. Jun 2023
  135. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Method of Monitoring 26S Proteasome in Cells Revealed the Crucial Role of PSMA3 C-Terminus in 26S Integrity
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    1. scibot 30 Jun 2023
      RRID:Addgene_42230

      DOI: 10.3390/biom13060992

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  136. www.sciencedirect.com www.sciencedirect.com
    Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization
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  137. www.sciencedirect.com www.sciencedirect.com
    Coordinated linear and rotational movements of endothelial cells compartmentalized by VE-cadherin drive angiogenic sprouting
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    sciencedirect.com/science/article/pii/S2589004223011288
  138. www.sciencedirect.com www.sciencedirect.com
    Centromere/kinetochore is assembled through CENP-C oligomerization
    2
    1. scibot 09 Jun 2023
      Plasmid_42230

      DOI: 10.1016/j.molcel.2023.05.023

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      plasmid_422350

      DOI: 10.1016/j.molcel.2023.05.023

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    sciencedirect.com/science/article/pii/S1097276523003799
  139. www.sciencedirect.com www.sciencedirect.com
    Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer
    1
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      plasmid_42230

      DOI: 10.1016/j.ccell.2023.05.004

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    sciencedirect.com/science/article/pii/S1535610823001721
  140. May 2023
  141. www.sciencedirect.com www.sciencedirect.com
    ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis
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    Protocol for biallelic tagging of an endogenous gene using CRISPR-Cas9 in human cells
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    Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex
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    Methylated histones on mitotic chromosomes promote Topoisomerase IIα function for high fidelity chromosome segregation.
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  145. Apr 2023
  146. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Knock-In Rat Lines with Cre Recombinase at the Dopamine D1 and Adenosine 2a Receptor Loci
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    Mitochondrial dynamics define muscle fiber type by modulating cellular metabolic pathways
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  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of PARP7 Creates a Vulnerability for Growth Inhibition by RBN2397 in Prostate Cancer Cells
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  149. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear Cell Renal Cell Carcinoma
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  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
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    Synergistic effects of combined immunotherapy strategies in a model of multifocal hepatocellular carcinoma
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    Characterizing the differential distribution and targets of Sumo1 and Sumo2 in the mouse brain
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  153. Mar 2023
  154. aacrjournals.org aacrjournals.org
    Rlf–Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer
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  155. www.nature.com www.nature.com
    FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation
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  156. academic.oup.com academic.oup.com
    INO80 promotes H2A.Z occupancy to regulate cell fate transition in pluripotent stem cells
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    Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma
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    hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung’s disease
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  159. Feb 2023
  160. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HER2-driven breast cancer suppression by the JNK signaling pathway
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  161. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression
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    Phase separation of an actin nucleator by junctional microtubules regulates epithelial function
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  163. www.biorxiv.org www.biorxiv.org
    The Glucocorticoid Receptor is Required for Efficient Aldosterone-Induced Transcription by the Mineralocorticoid Receptor
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    RIF1 suppresses the formation of single-stranded ultrafine anaphase bridges via protein phosphatase 1
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  165. Jan 2023
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    Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis
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    Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
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    Myddosome clustering in IL-1 receptor signaling regulates the formation of an NF-kB activating signalosome
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    PTBP1-activated co-transcriptional splicing controls epigenetic status of pluripotent stem cells
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    Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging
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    Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome
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  172. journals.plos.org journals.plos.org
    In vitro genome editing activity of Cas9 in somatic cells after random and transposon-based genomic Cas9 integration
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  173. Dec 2022
  174. www.sciencedirect.com www.sciencedirect.com
    The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER
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    Self-cleaving guide RNAs enable pharmacological selection of precise gene editing events in vivo
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    Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals
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  177. Nov 2022
  178. www.science.org www.science.org
    Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo
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    TEMPO enables sequential genetic labeling and manipulation of vertebrate cell lineages
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    Α γ-tubulin complex-dependent pathway suppresses ciliogenesis by promoting cilia disassembly
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    Transcription factor antagonism regulates heterogeneity in embryonic stem cell states
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    Erratic and blood vessel-guided migration of astrocyte progenitors in the cerebral cortex
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    WNK kinases sense molecular crowding and rescue cell volume via phase separation
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  184. Oct 2022
  185. www.nature.com www.nature.com
    Divergent regulation of basement membrane trafficking by human macrophages and cancer cells
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    A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants
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  187. Sep 2022
  188. www.sciencedirect.com www.sciencedirect.com
    Latent HIV-1 provirus in vitro suppression using combinatorial CRISPR/Cas9 strategy
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  189. academic.oup.com academic.oup.com
    Nesprin-1 LINC complexes recruit microtubule cytoskeleton proteins and drive pathology in Lmna mutant striated muscle
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  190. www.sciencedirect.com www.sciencedirect.com
    Targeted protein degradation reveals RNA Pol II heterogeneity and functional diversity
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    sciencedirect.com/science/article/pii/S1097276522008127
  191. link.springer.com link.springer.com
    Generation of corrected hiPSC clones from a Cornelia de Lange Syndrome (CdLS) patient through CRISPR-Cas-based technology
    1
    1. scibot 07 Sep 2022
      Addgene_42230

      DOI: 10.1186/s13287-022-03135-0

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    link.springer.com/article/10.1186/s13287-022-03135-0
  192. Aug 2022
  193. 52.53.155.43 52.53.155.43
    cd-21-0925-html.html
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    1. scibot 27 Aug 2022
      Addgene_42230

      DOI: 10.1158/2159-8290.CD-21-0925

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    52.53.155.43/e9cb0f5c6481209473760646202430887dd48d19/cd-21-0925-html.html
  194. www.sciencedirect.com www.sciencedirect.com
    NF-κB memory coordinates transcriptional responses to dynamic inflammatory stimuli
    1
    1. scibot 17 Aug 2022
      Plasmid_42230

      DOI: 10.1016/j.celrep.2022.111159

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    sciencedirect.com/science/article/pii/S2211124722009688
  195. Jul 2022
  196. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Method for In Situ Reverse Genetic Analysis of Proteins Involved mtDNA Replication
    1
    1. scibot 31 Jul 2022
      RRID:Addgene_42230

      DOI: 10.3390/cells11142168

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    ncbi.nlm.nih.gov/pmc/articles/PMC9316749/
  197. www.sciencedirect.com www.sciencedirect.com
    Template-independent genome editing in the Pcdh15av−3j mouse, a model of human DFNB23 nonsyndromic deafness
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    1. scibot 13 Jul 2022
      AddgeneCat#42230

      DOI: 10.1016/j.celrep.2022.111061

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    sciencedirect.com/science/article/pii/S2211124722008592
  198. link.springer.com link.springer.com
    Generation of Pigs that Produce Single Sex Progeny
    1
    1. scibot 09 Jul 2022
      RRID:Addgene_42230

      DOI: 10.1007/978-1-0716-2301-5_15

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    link.springer.com/protocol/10.1007/978-1-0716-2301-5_15
  199. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age
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    1. scibot 06 Jul 2022
      RRID:Addgene_42230

      DOI: 10.1371/journal.pone.0269404

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    ncbi.nlm.nih.gov/pmc/articles/PMC9246188/
  200. Jun 2022
  201. www.sciencedirect.com www.sciencedirect.com
    Cholesterol and matrisome pathways dysregulated in astrocytes and microglia
    1
    1. scibot 24 Jun 2022
      RRID:Addgene_42230

      DOI: 10.1016/j.cell.2022.05.017

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    sciencedirect.com/science/article/pii/S0092867422006481
  202. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Poliovirus non-permissive CD155 knockout cells derived from RD cell line for handling poliovirus potentially infectious materials in virology laboratories
    2
    1. scibot 17 Jun 2022
      plasmid_42230

      DOI: 10.1002/jmv.27897

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      RRID:Addgene:42230

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    onlinelibrary.wiley.com/doi/10.1002/jmv.27897
  203. www.sciencedirect.com www.sciencedirect.com
    Deciphering the origins and fates of steroidogenic lineages in the mouse testis
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    1. scibot 15 Jun 2022
      RRID:Addgene_42230

      DOI: 10.1016/j.celrep.2022.110935

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    sciencedirect.com/science/article/pii/S2211124722007173
  204. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Understanding the Mechanism of Dysglycemia in a Fanconi-Bickel Syndrome Patient
    1
    1. scibot 04 Jun 2022
      plasmid_42230

      DOI: 10.3389/fendo.2022.841788

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    ncbi.nlm.nih.gov/pmc/articles/PMC9159359/
  205. May 2022
  206. www.researchsquare.com www.researchsquare.com
    Home
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    1. scibot 20 May 2022
      Addgene_42230

      DOI: 10.21203/rs.3.rs-658360/v1

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    researchsquare.com/article/rs-2787982/v1
  207. www.sciencedirect.com www.sciencedirect.com
    BAG6 prevents the aggregation of neurodegeneration-associated fragments of TDP43
    2
    1. scibot 05 May 2022
      Addgene Cat#42230

      DOI: 10.1016/j.isci.2022.104273

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      plasmid_42230

      DOI: 10.1016/j.isci.2022.104273

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    sciencedirect.com/science/article/pii/S2589004222005430
  208. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective requirement of MYB for oncogenic hyperactivation of a translocated enhancer in leukemia
    1
    1. scibot 03 May 2022
      RRID:Addgene_42230

      DOI: 10.1158/2159-8290.CD-20-1793

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    ncbi.nlm.nih.gov/pmc/articles/PMC8563373/
  209. Apr 2022
  210. www.sciencedirect.com www.sciencedirect.com
    Interferons limit autoantigen-specific CD8+ T-cell expansion in the non-obese diabetic mouse
    1
    1. scibot 27 Apr 2022
      Addgene plasmid # 42,230

      DOI: 10.1016/j.celrep.2022.110747

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    sciencedirect.com/science/article/pii/S2211124722005113
  211. www.sciencedirect.com www.sciencedirect.com
    Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS
    1
    1. scibot 27 Apr 2022
      Addgene_42230

      DOI: 10.1016/j.molcel.2022.03.034

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    sciencedirect.com/science/article/pii/S1097276522002908
  212. www.embopress.org www.embopress.org
    Mammalian UPF3A and UPF3B can activate nonsense-mediated mRNA decay independently of their exon junction complex binding
    1
    1. scibot 27 Apr 2022
      RRID:Addgene_42230

      DOI: 10.15252/embj.2021109202

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    embopress.org/doi/abs/10.15252/embj.2021109202
  213. www.sciencedirect.com www.sciencedirect.com
    CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair
    1
    1. scibot 21 Apr 2022
      Addgene_42230

      DOI: 10.1016/j.molcel.2022.03.031

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    sciencedirect.com/science/article/pii/S1097276522002696
  214. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Dual SHOX2:GFP; MYH6:mCherry Knock-in hESC Reporter Line for Derivation of Human SAN-like Cells
    1
    1. scibot 19 Apr 2022
      plasmid_42230

      DOI: 10.1016/j.isci.2022.104153

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    ncbi.nlm.nih.gov/pmc/articles/PMC9010642/
  215. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region
    1
    1. scibot 15 Apr 2022
      Addgene_42230

      DOI: 10.7554/eLife.75047

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    ncbi.nlm.nih.gov/pmc/articles/PMC9007588/
  216. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of Il6 expression by single CpG methylation in downstream of Il6 transcription initiation site
    1
    1. scibot 08 Apr 2022
      Addgene_42230

      DOI: 10.1016/j.isci.2022.104118

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    ncbi.nlm.nih.gov/pmc/articles/PMC8983349/
  217. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A new mouse model of Ehlers-Danlos syndrome generated using CRISPR/Cas9-mediated genomic editing
    1
    1. scibot 07 Apr 2022
      plasmid_42230

      DOI: 10.1242/dmm.048963

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    ncbi.nlm.nih.gov/pmc/articles/PMC8713987/
  218. www.sciencedirect.com www.sciencedirect.com
    CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories
    1
    1. scibot 06 Apr 2022
      RRID:Addgene_42230

      DOI: 10.1016/j.celrep.2022.110615

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    sciencedirect.com/science/article/pii/S2211124722003631
  219. Mar 2022
  220. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Entamoeba histolytica Develops Resistance to Complement Deposition and Lysis after Acquisition of Human Complement-Regulatory Proteins through Trogocytosis
    1
    1. scibot 26 Mar 2022
      RRID:Addgene_42230

      DOI: 10.1128/mbio.03163-21

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    ncbi.nlm.nih.gov/pmc/articles/PMC8941920/