244 Matching Annotations
  1. Sep 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR screenings identified SMCHD1 as a host-restricting factor for AAV transduction
    1
    1. scibot 29 Sep 2024
      52963

      DOI: 10.1371/journal.ppat.1012344

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    ncbi.nlm.nih.gov/pmc/articles/PMC11257396/
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The histone methyltransferase KMT2D maintains cellular glucocorticoid responsiveness by shielding the glucocorticoid receptor from degradation
    1
    1. scibot 29 Sep 2024
      52963

      DOI: 10.1016/j.jbc.2024.107581

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    ncbi.nlm.nih.gov/pmc/articles/PMC11350265/
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phospholipid scrambling induced by an ion channel/metabolite transporter complex
    1
    1. scibot 29 Sep 2024
      52963

      DOI: 10.1038/s41467-024-51939-w

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    ncbi.nlm.nih.gov/pmc/articles/PMC11366033/
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multi-omic lineage tracing predicts the transcriptional, epigenetic and genetic determinants of cancer evolution
    1
    1. scibot 29 Sep 2024
      52963

      DOI: 10.1038/s41467-024-51424-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC11366763/
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYBL2 Drives Prostate Cancer Plasticity: Inhibiting Its Transcriptional Target CDK2 for RB1-Deficient Neuroendocrine Prostate Cancer
    1
    1. scibot 29 Sep 2024
      52963

      DOI: 10.1158/2767-9764.CRC-24-0069

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    ncbi.nlm.nih.gov/pmc/articles/PMC11368174/
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The V-ATPase complex component RNAseK is required for lysosomal hydrolase delivery and autophagosome degradation
    1
    1. scibot 29 Sep 2024
      plasmid_52963

      DOI: 10.1038/s41467-024-52049-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC11374810/
  8. www.biorxiv.org www.biorxiv.org
    Clustered macrophages cooperate to eliminate tumors via coordinated intrudopodia
    1
    1. scibot 28 Sep 2024
      RRID:Addgene_52963

      DOI: 10.1101/2024.09.19.613918

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    biorxiv.org/content/10.1101/2024.09.19.613918v1
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for in vivo CRISPR screening targeting murine testicular cells
    1
    1. scibot 27 Sep 2024
      52963

      DOI: 10.1016/j.xpro.2024.103306

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    ncbi.nlm.nih.gov/pmc/articles/PMC11416641/
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EspH utilizes phosphoinositide and Rab binding domains to interact with plasma membrane infection sites and Rab GTPases*
    1
    1. scibot 27 Sep 2024
      (https://media.addgene.org

      DOI: 10.1080/19490976.2024.2400575

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    ncbi.nlm.nih.gov/pmc/articles/PMC11421376/
  11. www.sciencedirect.com www.sciencedirect.com
    Saturation mutagenesis-reinforced functional assays for disease-related genes
    1
    1. scibot 27 Sep 2024
      Plasmid_52963

      DOI: 10.1016/j.cell.2024.08.047

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    sciencedirect.com/science/article/pii/S0092867424009760
  12. www.biorxiv.org www.biorxiv.org
    Cytotoxicity of Activator Expression in CRISPR-based Transcriptional Activation Systems
    1
    1. scibot 27 Sep 2024
      plasmid_52963

      DOI: 10.1101/2024.09.23.614524

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    biorxiv.org/content/10.1101/2024.09.23.614524v1
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Atrial fibrillation variant-to-gene prioritization through cross-ancestry eQTL and single-nucleus multiomic analyses
    1
    1. scibot 27 Sep 2024
      Addgene_52963

      DOI: 10.1016/j.isci.2024.110660

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    ncbi.nlm.nih.gov/pmc/articles/PMC11388022/
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites
    1
    1. scibot 26 Sep 2024
      52963

      DOI: 10.1038/s41467-024-50405-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC11271486/
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enhancer activation from transposable elements in extrachromosomal DNA
    1
    1. scibot 26 Sep 2024
      Plasmid_52963

      DOI: 10.1101/2024.09.04.611262

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    ncbi.nlm.nih.gov/pmc/articles/PMC11398463/
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription
    1
    1. scibot 26 Sep 2024
      Addgene_52963

      DOI: 10.1038/s44319-024-00217-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC11387499/
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stem cells tightly regulate dead cell clearance to maintain tissue fitness
    1
    1. scibot 25 Sep 2024
      Addgene_52963

      DOI: 10.1038/s41586-024-07855-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC11390485/
  18. www.sciencedirect.com www.sciencedirect.com
    Protein UFMylation regulates early events during ribosomal DNA-damage response
    1
    1. scibot 17 Sep 2024
      Addgene_52963

      DOI: 10.1016/j.celrep.2024.114738

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    sciencedirect.com/science/article/pii/S2211124724010891
  19. www.sciencedirect.com www.sciencedirect.com
    MIG6 loss increased RET inhibitor tolerant persister cells in RET-rearranged non-small cell lung cancer
    1
    1. scibot 06 Sep 2024
      #52963, Addgene

      DOI: 10.1016/j.canlet.2024.217220

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    sciencedirect.com/science/article/pii/S0304383524006153
  20. Aug 2024
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 screening develops an epigenetic and transcriptional gene signature for risk stratification and target prediction in neuroblastoma
    1
    1. scibot 26 Aug 2024
      52963

      DOI: 10.3389/fcell.2024.1433008

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    ncbi.nlm.nih.gov/pmc/articles/PMC11338898/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Specific multivalent molecules boost CRISPR-mediated transcriptional activation
    1
    1. scibot 26 Aug 2024
      52963

      DOI: 10.1038/s41467-024-51694-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC11341856/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Shifts in receptors during submergence of an encephalitic arbovirus
    1
    1. scibot 26 Aug 2024
      Addgene_52963

      DOI: 10.1038/s41586-024-07740-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC11324528/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR screening uncovers a long-range enhancer for ONECUT1 in pancreatic differentiation and links a diabetes risk variant
    1
    1. scibot 23 Aug 2024
      RRID:Addgene_52963

      DOI: 10.1016/j.celrep.2024.114640

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    ncbi.nlm.nih.gov/pmc/articles/PMC11406439/
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombination at DNA double-strand breaks
    1
    1. scibot 22 Aug 2024
      Addgene_52963

      DOI: 10.1038/s41467-024-51090-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC11329772/
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural basis for VLDLR recognition by eastern equine encephalitis virus
    1
    1. scibot 22 Aug 2024
      Addgene_52963

      DOI: 10.1038/s41467-024-50887-9

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    ncbi.nlm.nih.gov/pmc/articles/PMC11297306/
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The interferon γ pathway enhances pluripotency and X-chromosome reactivation in iPSC reprogramming
    1
    1. scibot 21 Aug 2024
      RRID:Addgene_52963

      DOI: 10.1126/sciadv.adj8862

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    ncbi.nlm.nih.gov/pmc/articles/PMC11305397/
  28. www.biorxiv.org www.biorxiv.org
    An enhanced Eco1 retron editor enables precision genome engineering in human cells from a single-copy integrated lentivirus
    1
    1. scibot 20 Aug 2024
      Addgene_52963

      DOI: 10.1101/2024.08.05.606586

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    biorxiv.org/content/10.1101/2024.08.05.606586v2
  29. www.cell.com www.cell.com
    Calcineurin is an adaptor required for assembly of the TCR signaling complex
    1
    1. scibot 19 Aug 2024
      RRID:Addgene_52963

      DOI: 10.1016/j.celrep.2024.114568

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    cell.com/cell-reports/fulltext/S2211-1247(24)00897-0
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
    1
    1. scibot 18 Aug 2024
      52963

      DOI: 10.1126/science.adk0775

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    ncbi.nlm.nih.gov/pmc/articles/PMC11301402/
  31. www.cell.com www.cell.com
    SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation
    1
    1. scibot 18 Aug 2024
      RRID:Addgene_52963

      DOI: 10.1016/j.celrep.2024.114536

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    cell.com/cell-reports/fulltext/S2211-1247(24)00865-9
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs
    1
    1. scibot 17 Aug 2024
      52963

      DOI: 10.1038/s41551-024-01204-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC11310080/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Library‐Assisted Evolution in Eukaryotic Cells Yield Adenine Base Editors with Enhanced Editing Specificity
    1
    1. scibot 17 Aug 2024
      52963

      DOI: 10.1002/advs.202309004

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    ncbi.nlm.nih.gov/pmc/articles/PMC11321652/
  34. www.nature.com www.nature.com
    3D genomic analysis reveals novel enhancer-hijacking caused by complex structural alterations that drive oncogene overexpression
    1
    1. scibot 13 Aug 2024
      52963

      DOI: 10.1038/s41467-024-50387-w

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    nature.com/articles/s41467-024-50387-w
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A genome-wide CRISPR/Cas9 knockout screen identifies TMEM239 as an important host factor in facilitating African swine fever virus entry into early endosomes
    1
    1. scibot 13 Aug 2024
      52963

      DOI: 10.1371/journal.ppat.1012256

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    ncbi.nlm.nih.gov/pmc/articles/PMC11288436/
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription
    1
    1. scibot 13 Aug 2024
      52963

      DOI: 10.1016/j.celrep.2024.113816

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    ncbi.nlm.nih.gov/pmc/articles/PMC11056844/
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    iNOS is necessary for GBP-mediated T. gondii clearance in murine macrophages via vacuole nitration and intravacuolar network collapse
    1
    1. scibot 13 Aug 2024
      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC10973475/
  38. Jul 2024
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Hippo pathway kinases LATS1 and 2 attenuate cellular responses to heavy metals through phosphorylating MTF1
    1
    1. scibot 27 Jul 2024
      plasmid_52963

      DOI: 10.1038/s41556-021-00813-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC9022944/
  40. www.embopress.org www.embopress.org
    DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer
    1
    1. scibot 18 Jul 2024
      plasmid_52963

      DOI: 10.1038/s44321-024-00088-0

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    embopress.org/doi/10.1038/s44321-024-00088-0
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer
    1
    1. scibot 18 Jul 2024
      plasmid_52963

      DOI: 10.1038/s44321-024-00088-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC11251193/
  42. www.biorxiv.org www.biorxiv.org
    Acute BRCAness Induction and AR Signaling Blockage through CDK12/7/9 Degradation Enhances PARP Inhibitor Sensitivity in Prostate Cancer
    1
    1. scibot 16 Jul 2024
      RRID:Addgene_52963

      DOI: 10.1101/2024.07.09.602803

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    biorxiv.org/content/10.1101/2024.07.09.602803v1
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DUSP4 enhances therapeutic sensitivity in HER2-positive breast cancer by inhibiting the G6PD pathway and ROS metabolism by interacting with ALDOB
    1
    1. scibot 01 Jul 2024
      lentiGuide-Puro

      DOI: 10.1016/j.tranon.2024.102016

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    ncbi.nlm.nih.gov/pmc/articles/PMC11214528/
  44. Jun 2024
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumour-derived Extracellular Vesicle and Particle Reprogramming of Interstitial Macrophages in the Lung Pre-Metastatic Niche Enhances Vascular Permeability and Metastatic Potential
    1
    1. scibot 21 Jun 2024
      52963

      DOI: 10.21203/rs.3.rs-4462139/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11160910/
  46. www.sciencedirect.com www.sciencedirect.com
    An enhancer RNA recruits KMT2A to regulate transcription of Myb
    1
    1. scibot 21 Jun 2024
      plasmid_52963

      DOI: 10.1016/j.celrep.2024.114378

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    sciencedirect.com/science/article/pii/S221112472400706X
  47. www.sciencedirect.com www.sciencedirect.com
    SpRY-mediated screens facilitate functional dissection of non-coding sequences at single-base resolution
    1
    1. scibot 21 Jun 2024
      Addgene_52963

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    sciencedirect.com/science/article/pii/S2666979X24001678
  48. www.sciencedirect.com www.sciencedirect.com
    STING orchestrates the neuronal inflammatory stress response in multiple sclerosis
    1
    1. scibot 21 Jun 2024
      plasmid_52963

      DOI: 10.1016/j.cell.2024.05.031

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    sciencedirect.com/science/article/pii/S0092867424005762
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The CTLH Ubiquitin Ligase Substrates ZMYND19 and MKLN1 Negatively Regulate mTORC1 at the Lysosomal Membrane
    1
    1. scibot 21 Jun 2024
      plasmid_52963

      DOI: 10.21203/rs.3.rs-4259395/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11092817/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The balance between antiviral and antibacterial responses during M. tuberculosis infection is regulated by the ubiquitin ligase CBL
    1
    1. scibot 21 Jun 2024
      Plasmid_52963

      DOI: 10.1101/2024.05.15.594178

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    ncbi.nlm.nih.gov/pmc/articles/PMC11118416/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multi-omic Analysis of Human B-cell Activation Reveals a Key Lysosomal BCAT1 Role in mTOR Hyperactivation by B-cell receptor and TLR9
    1
    1. scibot 21 Jun 2024
      plasmid_52963

      DOI: 10.21203/rs.3.rs-4413958/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11160916/
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation
    1
    1. scibot 20 Jun 2024
      Addgene_52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC11182672/
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The integrin CD11b inhibits MSU-induced NLRP3 inflammasome activation in macrophages and protects mice against MSU-induced joint inflammation
    1
    1. scibot 15 Jun 2024
      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC11165854/
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BCMA/CD47-directed universal CAR-T cells exhibit excellent antitumor activity in multiple myeloma
    1
    1. scibot 07 Jun 2024
      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC11112799/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing therapeutics in RB1-deficient cancer cells
    1
    1. scibot 07 Jun 2024
      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC11114247/
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Large-scale mutational analysis identifies UNC93B1 variants that drive TLR-mediated autoimmunity in mice and humans
    1
    1. scibot 07 Jun 2024
      Plasmid_52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC11116816/
  57. www.sciencedirect.com www.sciencedirect.com
    ΔNp63-restricted viral mimicry response impedes cancer cell viability and remodels tumor microenvironment in esophageal squamous cell carcinoma
    1
    1. scibot 04 Jun 2024
      plasmid_52963

      DOI: 10.1016/j.canlet.2024.216999

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    sciencedirect.com/science/article/pii/S0304383524003938
  58. May 2024
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The nucleic acid binding protein SFPQ represses EBV lytic reactivation by promoting histone H1 expression
    1
    1. scibot 19 May 2024
      Addgene_52963

      DOI: 10.1038/s41467-024-48333-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC11099029/
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Germinal center cytokine driven epigenetic control of Epstein-Barr virus latency gene expression
    1
    1. scibot 12 May 2024
      plasmid_52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC11081508/
  61. www.sciencedirect.com www.sciencedirect.com
    NRP1 is a receptor for mammalian orthoreovirus engaged by distinct capsid subunits
    1
    1. scibot 10 May 2024
      RRID:Addgene_52963

      DOI: 10.1016/j.chom.2024.04.014

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    sciencedirect.com/science/article/pii/S1931312824001343
  62. www.sciencedirect.com www.sciencedirect.com
    Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma
    1
    1. scibot 09 May 2024
      plasmid_52963

      DOI: 10.1016/j.celrep.2024.114211

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    sciencedirect.com/science/article/pii/S2211124724005394
  63. www.sciencedirect.com www.sciencedirect.com
    An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins
    1
    1. scibot 09 May 2024
      Addgene_52963

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    sciencedirect.com/science/article/pii/S1097276524003253
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)
    2
    1. scibot 05 May 2024
      Addgene_52963

      DOI: 10.7554/eLife.94075

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      Addgene_52963

      DOI: 10.7554/eLife.94075

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    ncbi.nlm.nih.gov/pmc/articles/PMC11060711/
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modulation of the microhomology-mediated end joining pathway suppresses large deletions and enhances homology-directed repair following CRISPR-Cas9-induced DNA breaks
    1
    1. scibot 05 May 2024
      52963

      DOI: 10.1186/s12915-024-01896-z

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    ncbi.nlm.nih.gov/pmc/articles/PMC11059712/
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NFATC2IP is a mediator of SUMO-dependent genome integrity
    1
    1. scibot 05 May 2024
      52963

      DOI: 10.1101/gad.350914.123

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    ncbi.nlm.nih.gov/pmc/articles/PMC11065178/
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epstein-Barr-Virus-Driven Cardiolipin Synthesis Sustains Metabolic Remodeling During B-cell Lymphomagenesis
    1
    1. scibot 05 May 2024
      plasmid_52963

      DOI: 10.21203/rs.3.rs-4013392/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11042403/
  68. elifesciences.org elifesciences.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
    1
    1. scibot 03 May 2024
      RRID:Addgene_52963

      DOI: 10.7554/eLife.90683

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    elifesciences.org/articles/90683
  69. www.biorxiv.org www.biorxiv.org
    Epstein–Barr Virus BALF0/1 Subverts the Caveolin and ERAD Pathways to Target B-cell Receptor Complexes for Degradation
    1
    1. scibot 02 May 2024
      RRID:Addgene_52963

      DOI: 10.1101/2024.01.04.574276

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    biorxiv.org/content/10.1101/2024.01.04.574276v1
  70. www.sciencedirect.com www.sciencedirect.com
    Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease
    2
    1. scibot 01 May 2024
      RRID:Addgene_52963

      DOI: 10.1016/j.stem.2024.04.002

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      RRID:Addgene_52963

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    sciencedirect.com/science/article/pii/S1934590924001292
  71. Apr 2024
  72. www.sciencedirect.com www.sciencedirect.com
    GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies
    1
    1. scibot 30 Apr 2024
      Addgene: 52963

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    sciencedirect.com/science/article/pii/S1097276524002843
  73. www.sciencedirect.com www.sciencedirect.com
    Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB
    2
    1. scibot 26 Apr 2024
      Addgene, Cat# 52963

      DOI: 10.1016/j.cell.2024.03.022

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      plasmid_52963

      DOI: 10.1016/j.cell.2024.03.022

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    sciencedirect.com/science/article/pii/S0092867424003131
  74. www.sciencedirect.com www.sciencedirect.com
    IGSF8 is an innate immune checkpoint and cancer immunotherapy target
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    1. scibot 24 Apr 2024
      AddgeneCat# 52963

      DOI: 10.1016/j.cell.2024.03.039

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    sciencedirect.com/science/article/pii/S0092867424003556
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deletion of the TMEM30A gene enables leukemic cell evasion of NK cell cytotoxicity
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    1. scibot 23 Apr 2024
      Addgene_52963

      DOI: 10.1073/pnas.2316447121

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    ncbi.nlm.nih.gov/pmc/articles/PMC11009675/
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-scale pan-cancer interrogation of lncRNA dependencies using CasRx
    1
    1. scibot 23 Apr 2024
      52963

      DOI: 10.1038/s41592-024-02190-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC11009108/
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRPF19 mRNA Encodes a Small Open Reading Frame That Is Important for Viability of Human Cells
    1
    1. scibot 23 Apr 2024
      52963

      DOI: 10.1134/S1607672923700722

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    ncbi.nlm.nih.gov/pmc/articles/PMC11021245/
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Frequent loss of FAM126A expression in colorectal cancer results in selective FAM126B dependency
    1
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      Addgene_52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC11025007/
  79. www.sciencedirect.com www.sciencedirect.com
    Functional genomics identifies N-acetyllactosamine extension of complex N-glycans as a mechanism to evade lysis by natural killer cells
    1
    1. scibot 16 Apr 2024
      plasmid_52963

      DOI: 10.1016/j.celrep.2024.114105

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    sciencedirect.com/science/article/pii/S2211124724004339
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
    1
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      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC11000523/
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Thymidine nucleotide metabolism controls human telomere length
    1
    1. scibot 14 Apr 2024
      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC11000509/
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The PRC2.1 Subcomplex Opposes G1 Progression through Regulation of CCND1 and CCND2
    1
    1. scibot 14 Apr 2024
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  83. www.sciencedirect.com www.sciencedirect.com
    BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response
    2
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      Addgene52963

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  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse
    1
    1. scibot 03 Apr 2024
      AddgeneCat# 52963

      DOI: 10.1016/j.xcrm.2024.101471

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  85. www.sciencedirect.com www.sciencedirect.com
    The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity
    2
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      Plasmid_52963

      DOI: 10.1016/j.cell.2024.03.002

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  86. Mar 2024
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 targeting of passenger single nucleotide variants in haploinsufficient or essential genes expands cancer therapy prospects
    1
    1. scibot 31 Mar 2024
      52,963

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  88. www.sciencedirect.com www.sciencedirect.com
    Pooled CRISPR screening of high-content cellular phenotypes using ghost cytometry
    1
    1. scibot 29 Mar 2024
      Addgene52963

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  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome‐wide loss‐of‐function genetic screen identifies INSIG2 as the vulnerability of hepatitis B virus‐integrated hepatoma cells
    1
    1. scibot 17 Mar 2024
      52963

      DOI: 10.1111/cas.16070

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    ncbi.nlm.nih.gov/pmc/articles/PMC10920982/
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Repeat DNA methylation is modulated by adherens junction signaling
    1
    1. scibot 17 Mar 2024
      Addgene_52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC10920906/
  91. www.sciencedirect.com www.sciencedirect.com
    In vivo CRISPR screening directly targeting testicular cells
    1
    1. scibot 06 Mar 2024
      Addgene: #52963

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    sciencedirect.com/science/article/pii/S2666979X24000375
  92. Feb 2024
  93. www.sciencedirect.com www.sciencedirect.com
    A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis
    1
    1. scibot 29 Feb 2024
      AddgeneCat#52963

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    sciencedirect.com/science/article/pii/S1097276524000984
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The exocyst complex and intracellular vesicles mediate soluble protein trafficking to the primary cilium
    1
    1. scibot 29 Feb 2024
      pLentiGuide-puro

      DOI: 10.1038/s42003-024-05817-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10879184/
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deep learning models incorporating endogenous factors beyond DNA sequences improve the prediction accuracy of base editing outcomes
    1
    1. scibot 29 Feb 2024
      Plasmid_52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC10879117/
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    3D genomic analysis reveals novel enhancer-hijacking caused by complex structural alterations that drive oncogene overexpression
    1
    1. scibot 21 Feb 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10849656/
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through in vivo B cell knockout models
    1
    1. scibot 21 Feb 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10870824/
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons
    1
    1. scibot 15 Feb 2024
      plasmid_52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC10857481/
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance
    1
    1. scibot 13 Feb 2024
      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC10761718/
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aneuploid embryonic stem cells drive teratoma metastasis
    1
    1. scibot 13 Feb 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10844504/
  101. journals.plos.org journals.plos.org
    CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly
    1
    1. scibot 09 Feb 2024
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    journals.plos.org/plosgenetics/article
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection
    1
    1. scibot 08 Feb 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10761986/
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Detection of senescence using machine learning algorithms based on nuclear features
    1
    1. scibot 08 Feb 2024
      52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC10838307/
  104. www.sciencedirect.com www.sciencedirect.com
    Alternative polyadenylation determines the functional landscape of inverted Alu repeats
    1
    1. scibot 06 Feb 2024
      AddgeneCat# 52963

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    sciencedirect.com/science/article/pii/S1097276524000091
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9
    1
    1. scibot 06 Feb 2024
      52,963

      DOI: 10.1186/s13059-023-03149-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC10785552/
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Micronucleus is not a potent inducer of the cGAS/STING pathway
    1
    1. scibot 05 Feb 2024
      52963

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  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Germinal Center Cytokines Driven Epigenetic Control of Epstein-Barr Virus Latency Gene Expression
    1
    1. scibot 05 Feb 2024
      plasmid_52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC10802360/
  108. www.sciencedirect.com www.sciencedirect.com
    Two-step evolution of HIV-1 budding system leading to pandemic in the human population
    1
    1. scibot 02 Feb 2024
      Addgene_52963

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    sciencedirect.com/science/article/pii/S2211124724000251
  109. Jan 2024
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epstein-Barr virus induces germinal center light zone chromatin architecture and promotes survival through enhancer looping at the BCL2A1 locus
    1
    1. scibot 20 Jan 2024
      RRID:Addgene_52963

      DOI: 10.1128/mbio.02444-23

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    ncbi.nlm.nih.gov/pmc/articles/PMC10790771/
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epstein-Barr virus miR-BARTs 7 and 9 modulate viral cycle, cell proliferation, and proteomic profiles in Burkitt lymphoma
    1
    1. scibot 11 Jan 2024
      RRID:Addgene_52963

      DOI: 10.1016/j.tvr.2023.200276

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    ncbi.nlm.nih.gov/pmc/articles/PMC11000110/
  112. Dec 2023
  113. www.sciencedirect.com www.sciencedirect.com
    Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers
    1
    1. scibot 17 Dec 2023
      RRID:Addgene_52963

      DOI: 10.1016/j.immuni.2023.11.008

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    sciencedirect.com/science/article/pii/S1074761323004909
  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
    1
    1. scibot 15 Dec 2023
      RRID:Addgene_52963

      DOI: 10.7554/eLife.87098

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    ncbi.nlm.nih.gov/pmc/articles/PMC10708890/
  115. journals.asm.org journals.asm.org
    Epstein-Barr virus induces germinal center light zone chromatin architecture and promotes survival through enhancer looping at the BCL2A1 locus
    1
    1. scibot 14 Dec 2023
      RRID:Addgene_52963

      DOI: 10.1128/mbio.02444-23

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    journals.asm.org/doi/10.1128/mbio.02444-23
  116. Nov 2023
  117. www.sciencedirect.com www.sciencedirect.com
    Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1
    1
    1. scibot 22 Nov 2023
      Addgene_52963

      DOI: 10.1016/j.xcrm.2023.101282

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    sciencedirect.com/science/article/pii/S2666379123004767
  118. biosignaling.biomedcentral.com biosignaling.biomedcentral.com
    Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival
    1
    1. scibot 18 Nov 2023
      RRID:Addgene_52963

      DOI: 10.1186/s12964-023-01335-6

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    biosignaling.biomedcentral.com/articles/10.1186/s12964-023-01335-6
  119. www.sciencedirect.com www.sciencedirect.com
    HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
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    1. scibot 17 Nov 2023
      RRID:Addgene_52963

      DOI: 10.1016/j.celrep.2023.113352

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    sciencedirect.com/science/article/pii/S2211124723013645
  120. Oct 2023
  121. www.biorxiv.org www.biorxiv.org
    Genome-wide CRISPR/Cas9 screen identifies MAT2A as a critical host factor for BK Polyomavirus
    1
    1. scibot 27 Oct 2023
      RRID:Addgene_52963

      DOI: 10.1101/2023.10.20.563362

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    biorxiv.org/content/10.1101/2023.10.20.563362v1
  122. www.cell.com www.cell.com
    PUF60 promotes cell cycle and lung cancer progression by regulating alternative splicing of CDC25C
    1
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      RRID:Addgene_52963

      DOI: 10.1016/j.celrep.2023.113041

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    cell.com/cell-reports/fulltext/S2211-1247(23)01052-5
  123. Sep 2023
  124. www.nature.com www.nature.com
    CRISPR prime editing for unconstrained correction of oncogenic KRAS variants
    1
    1. scibot 20 Sep 2023
      52963

      DOI: 10.1038/s42003-023-05052-1

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    nature.com/articles/s42003-023-05052-1
  125. www.sciencedirect.com www.sciencedirect.com
    Combined CRISPRi and proteomics screening reveal a cohesin-CTCF-bound allele contributing to increased expression of RUVBL1 and prostate cancer progression
    1
    1. scibot 19 Sep 2023
      RRID:Addgene_52963

      DOI: 10.1016/j.ajhg.2023.07.003

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    sciencedirect.com/science/article/pii/S0002929723002434
  126. www.sciencedirect.com www.sciencedirect.com
    Mitotic perturbation is a key mechanism of action of decitabine in myeloid tumor treatment
    1
    1. scibot 16 Sep 2023
      RRID:Addgene_52963

      DOI: 10.1016/j.celrep.2023.113098

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    sciencedirect.com/science/article/pii/S2211124723011099
  127. Aug 2023
  128. www.biorxiv.org www.biorxiv.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
    1
    1. scibot 16 Aug 2023
      plasmid_52963

      DOI: 10.1101/2023.07.26.550648

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    biorxiv.org/content/10.1101/2023.07.26.550648v2
  129. www.biorxiv.org www.biorxiv.org
    The Interferon γ Pathway Enhances Pluripotency and X-Chromosome Reactivation in iPSC reprogramming
    2
    1. scibot 12 Aug 2023
      plasmids #52963

      DOI: 10.1101/2023.07.31.551297

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      RRID:Addgene_52963

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    biorxiv.org/content/10.1101/2023.07.31.551297v3
  130. Jul 2023
  131. 52.53.155.43 52.53.155.43
    Parallel genome-scale CRISPR screens distinguish pluripotency and self-renewal
    1
    1. scibot 15 Jul 2023
      52963

      DOI: 10.1101/2023.05.03.539283

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    52.53.155.43/8add9715cb6d409825df8305aa589d745e83436f/2023.05.03.539283.full-html.html
  132. Jun 2023
  133. www.sciencedirect.com www.sciencedirect.com
    Generation of Myoglobin (MB)-Knockout human embryonic stem cell (hESC) line (KAIMRCe002- A-1S) using CRISPR/Cas9 technology
    1
    1. scibot 28 Jun 2023
      Addgene_52963

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    sciencedirect.com/science/article/pii/S1873506123001447
  134. www.sciencedirect.com www.sciencedirect.com
    An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets
    1
    1. scibot 23 Jun 2023
      RRID: Addgene_52963

      DOI: 10.1016/j.ccell.2023.06.001

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  135. www.biorxiv.org www.biorxiv.org
    Transcriptional landscape of DTP-DTEP transition reveals DUSP6 as a driver of HER2 inhibitor tolerance via Neuregulin/HER3 axis
    1
    1. scibot 22 Jun 2023
      plasmid_52963

      DOI: 10.1101/2023.06.14.544493

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    biorxiv.org/content/10.1101/2023.06.14.544493v1
  136. www.sciencedirect.com www.sciencedirect.com
    An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation
    1
    1. scibot 16 Jun 2023
      RRID:Addgene_52963

      DOI: 10.1016/j.molcel.2023.05.018

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    sciencedirect.com/science/article/pii/S109727652300374X
  137. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network
    1
    1. scibot 14 Jun 2023
      RRID:Addgene_52963

      DOI: 10.1016/j.immuni.2022.10.021

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    ncbi.nlm.nih.gov/pmc/articles/PMC7614333/
  138. aacrjournals.org aacrjournals.org
    (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers
    1
    1. scibot 10 Jun 2023
      RRID:Addgene_52963

      DOI: 10.1158/2159-8290.CD-22-0825

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    aacrjournals.org/cancerdiscovery/article/13/6/1478/726967/R-2-Hydroxyglutarate-Inhibits-KDM5-Histone-Lysine
  139. aacrjournals.org aacrjournals.org
    RBM10 loss promotes EGFR-driven lung cancer and confers sensitivity to spliceosome inhibition
    1
    1. scibot 03 Jun 2023
      RRID:Addgene_52963

      DOI: 10.1158/0008-5472.CAN-22-1549

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    aacrjournals.org/cancerres/article/83/9/1490/726058/RBM10-Loss-Promotes-EGFR-Driven-Lung-Cancer-and
  140. www.biorxiv.org www.biorxiv.org
    Stem cells tightly regulate dead cell clearance to maintain tissue fitness
    1
    1. scibot 01 Jun 2023
      Addgene_52963

      DOI: 10.1101/2023.05.22.541773

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    biorxiv.org/content/10.1101/2023.05.22.541773v1
  141. May 2023
  142. www.biorxiv.org www.biorxiv.org
    Epstein-Barr virus miR-BARTs 7 and 9 modulate viral cycle, cell proliferation and proteomic profiles in Burkitt lymphoma
    1
    1. scibot 25 May 2023
      RRID:Addgene_52963

      DOI: 10.1101/2023.05.19.538556

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    biorxiv.org/content/10.1101/2023.05.19.538556v1
  143. www.biorxiv.org www.biorxiv.org
    Group comparison based on genetic information reveals lineage-specific therapeutic vulnerabilities in acute myeloid leukemia
    1
    1. scibot 25 May 2023
      RRID:Addgene_52963

      DOI: 10.1101/2023.05.18.541265

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    biorxiv.org/content/10.1101/2023.05.18.541265v1
  144. www.sciencedirect.com www.sciencedirect.com
    Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors
    1
    1. scibot 25 May 2023
      RRID:Addgene_52963

      DOI: 10.1016/j.celrep.2023.112538

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    sciencedirect.com/science/article/pii/S2211124723005491
  145. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis
    1
    1. scibot 25 May 2023
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    ncbi.nlm.nih.gov/pmc/articles/PMC6942053/
  146. Apr 2023
  147. www.sciencedirect.com www.sciencedirect.com
    Proteomic discovery of chemical probes that perturb protein complexes in human cells
    1
    1. scibot 21 Apr 2023
      Addgene_52963

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    sciencedirect.com/science/article/pii/S1097276523002393
  148. Mar 2023
  149. www.nature.com www.nature.com
    The protective role of conjunctival goblet cell mucin sialylation
    1
    1. scibot 18 Mar 2023
      RRID:Addgene_52963

      DOI: 10.1038/s41467-023-37101-y

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    nature.com/articles/s41467-023-37101-y
  150. Feb 2023
  151. www.embopress.org www.embopress.org
    Immune surveillance of brain metastatic cancer cells is mediated by IFITM1
    1
    1. scibot 18 Feb 2023
      RRID:Addgene_52963

      DOI: 10.15252/embj.2022111112

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    embopress.org/doi/10.15252/embj.2022111112
  152. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs
    1
    1. scibot 15 Feb 2023
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      DOI: 10.1371/journal.pbio.3001967

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    ncbi.nlm.nih.gov/pmc/articles/PMC9910744/
  153. Jan 2023
  154. www.sciencedirect.com www.sciencedirect.com
    Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments
    1
    1. scibot 28 Jan 2023
      plasmid_52963

      DOI: 10.1016/j.cmet.2022.12.005

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    sciencedirect.com/science/article/pii/S1550413122005423
  155. www.sciencedirect.com www.sciencedirect.com
    Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation
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    1. scibot 25 Jan 2023
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    sciencedirect.com/science/article/pii/S2211124722018691
  156. www.sciencedirect.com www.sciencedirect.com
    The NLRP1 and CARD8 inflammasomes detect reductive stress
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    1. scibot 19 Jan 2023
      Addgene_52963

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    sciencedirect.com/science/article/pii/S2211124722018708
  157. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of β2 microglobulin, the product of B2M gene, as a Host Factor for Vaccinia Virus Infection by Genome-Wide CRISPR genetic screens
    1
    1. scibot 11 Jan 2023
      RRID:Addgene_52963

      DOI: 10.1371/journal.ppat.1010800

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    ncbi.nlm.nih.gov/pmc/articles/PMC9829182/
  158. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage
    1
    1. scibot 10 Jan 2023
      RRID:Addgene_52963

      DOI: 10.1111/jnc.15751

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15751
  159. www.sciencedirect.com www.sciencedirect.com
    Chimeric efferocytic receptors improve apoptotic cell clearance and alleviate inflammation
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    1. scibot 10 Jan 2023
      plasmid_52963

      DOI: 10.1016/j.cell.2022.11.029

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    sciencedirect.com/science/article/pii/S0092867422015045
  160. Dec 2022
  161. www.embopress.org www.embopress.org
    IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia
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    1. scibot 02 Dec 2022
      Addgene_52963

      DOI: 10.15252/emmm.202115631

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    embopress.org/doi/10.15252/emmm.202115631
  162. Nov 2022
  163. www.sciencedirect.com www.sciencedirect.com
    Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteins
    1
    1. scibot 24 Nov 2022
      Addgene_52963

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    sciencedirect.com/science/article/pii/S2211124722015492
  164. www.sciencedirect.com www.sciencedirect.com
    Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling
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    1. scibot 03 Nov 2022
      Addgene_52963

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    sciencedirect.com/science/article/pii/S2211124722014462
  165. Oct 2022
  166. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The phospholipid flippase ATP8B1 is required for lysosomal fusion in macrophages
    1
    1. scibot 08 Oct 2022
      plasmid_52963

      DOI: 10.1002/cbf.3752

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    onlinelibrary.wiley.com/doi/10.1002/cbf.3752
  167. www.nature.com www.nature.com
    Enzyme-free targeted DNA demethylation using CRISPR–dCas9-based steric hindrance to identify DNA methylation marks causal to altered gene expression
    1
    1. scibot 08 Oct 2022
      plasmid_52963

      DOI: 10.1038/s41596-022-00741-3

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    nature.com/articles/s41596-022-00741-3
  168. Sep 2022
  169. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of insulin-like growth factor-1 receptor enhances eribulin-induced DNA damage in colorectal cancer
    1
    1. scibot 15 Sep 2022
      plasmid_52963

      DOI: 10.1111/cas.15558

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    onlinelibrary.wiley.com/doi/10.1111/cas.15558
  170. www.sciencedirect.com www.sciencedirect.com
    Methionine metabolism controls the B cell EBV epigenome and viral latency
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    1. scibot 07 Sep 2022
      plasmid_52963

      DOI: 10.1016/j.cmet.2022.08.008

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    sciencedirect.com/science/article/pii/S1550413122003515
  171. Aug 2022
  172. www.sciencedirect.com www.sciencedirect.com
    ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain
    1
    1. scibot 31 Aug 2022
      RRID:Addgene_52963

      DOI: 10.1016/j.celrep.2022.111268

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    sciencedirect.com/science/article/pii/S2211124722010865
  173. www.sciencedirect.com www.sciencedirect.com
    Epigenetic reader SP140 loss of function drives Crohn’s disease due to uncontrolled macrophage topoisomerases
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    1. scibot 17 Aug 2022
      Addgene52963

      DOI: 10.1016/j.cell.2022.06.048

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    sciencedirect.com/science/article/pii/S0092867422008418
  174. www.sciencedirect.com www.sciencedirect.com
    Temporal control of PDGFRα regulates the fibroblast-to-myofibroblast transition in wound healing
    1
    1. scibot 17 Aug 2022
      Addgene_52963

      DOI: 10.1016/j.celrep.2022.111192

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    sciencedirect.com/science/article/pii/S2211124722010099
  175. Jun 2022
  176. www.sciencedirect.com www.sciencedirect.com
    Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy
    1
    1. scibot 29 Jun 2022
      Addgene_52963

      DOI: 10.1016/j.celrep.2022.111001

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    sciencedirect.com/science/article/pii/S2211124722007902
  177. www.sciencedirect.com www.sciencedirect.com
    Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability
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    1. scibot 17 Jun 2022
      Addgene_52963

      DOI: 10.1016/j.molcel.2022.05.024

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    sciencedirect.com/science/article/pii/S1097276522004919
  178. www.nature.com www.nature.com
    RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition
    1
    1. scibot 11 Jun 2022
      RRID:Addgene_52963

      DOI: 10.1038/s41467-022-30794-7

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    nature.com/articles/s41467-022-30794-7
  179. May 2022
  180. www.sciencedirect.com www.sciencedirect.com
    A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination
    1
    1. scibot 25 May 2022
      AddgeneCat#52963

      DOI: 10.1016/j.molcel.2022.04.031

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    sciencedirect.com/science/article/pii/S109727652200394X
  181. aacrjournals.org aacrjournals.org
    Melanoma-secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis
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    1. scibot 13 May 2022
      RRID:Addgene_52963

      DOI: 10.1158/2159-8290.CD-21-1006

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    aacrjournals.org/cancerdiscovery/article/12/5/1314/694563/Melanoma-Secreted-Amyloid-Beta-Suppresses
  182. www.sciencedirect.com www.sciencedirect.com
    ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer
    1
    1. scibot 05 May 2022
      Addgene_52963

      DOI: 10.1016/j.devcel.2022.04.014

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    sciencedirect.com/science/article/pii/S1534580722002544
  183. Apr 2022
  184. www.sciencedirect.com www.sciencedirect.com
    Functional elements of the cis-regulatory lincRNA-p21
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    1. scibot 20 Apr 2022
      RRID:Addgene_52963

      DOI: 10.1016/j.celrep.2022.110687

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    sciencedirect.com/science/article/pii/S2211124722004454
  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation
    1
    1. scibot 15 Apr 2022
      plasmid_52963

      DOI: 10.7554/eLife.76963

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    ncbi.nlm.nih.gov/pmc/articles/PMC9007586/
  186. Mar 2022
  187. www.sciencedirect.com www.sciencedirect.com
    Genome-wide CRISPR-Cas9 screening identifies the CYTH2 host gene as a potential therapeutic target of influenza viral infection
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    1. scibot 30 Mar 2022
      RRID:Addgene_52963

      DOI: 10.1016/j.celrep.2022.110559

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    sciencedirect.com/science/article/pii/S2211124722003035
  188. www.sciencedirect.com www.sciencedirect.com
    Epstein-Barr virus BNRF1 destabilizes SMC5/6 cohesin complexes to evade its restriction of replication compartments
    2
    1. scibot 09 Mar 2022
      Addgene_52963

      DOI: 10.1016/j.celrep.2022.110411

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      plasmid_52963

      DOI: 10.1016/j.celrep.2022.110411

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    sciencedirect.com/science/article/pii/S2211124722001358
  189. www.sciencedirect.com www.sciencedirect.com
    Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors
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    1. scibot 09 Mar 2022
      Addgene52963

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    sciencedirect.com/science/article/pii/S0092867422001428
  190. www.sciencedirect.com www.sciencedirect.com
    Targeted intracellular delivery of Cas13 and Cas9 nucleases using bacterial toxin-based platforms
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    sciencedirect.com/science/article/pii/S2211124722002091
  191. www.nature.com www.nature.com
    APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer’s pathology in trisomy 21 neurons
    1
    1. scibot 05 Mar 2022
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      DOI: 10.1038/s41380-022-01454-5

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    nature.com/articles/s41380-022-01454-5
  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective modulation of a pan-essential protein as a therapeutic strategy in cancer
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    1. scibot 04 Mar 2022
      RRID:Addgene_52963

      DOI: 10.1158/2159-8290.CD-20-1213

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    ncbi.nlm.nih.gov/pmc/articles/PMC8419012/
  193. Feb 2022
  194. www.sciencedirect.com www.sciencedirect.com
    A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer
    1
    1. scibot 23 Feb 2022
      Addgene: Cat#52963

      DOI: 10.1016/j.celrep.2022.110417

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    sciencedirect.com/science/article/pii/S2211124722001413
  195. www.sciencedirect.com www.sciencedirect.com
    Listeria toxin promotes phosphorylation of the inflammasome adaptor ASC through Lyn and Syk to exacerbate pathogen expansion
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    1. scibot 23 Feb 2022
      AddgeneCat#: 52963

      DOI: 10.1016/j.celrep.2022.110414

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    sciencedirect.com/science/article/pii/S2211124722001383
  196. www.sciencedirect.com www.sciencedirect.com
    HiCAR is a robust and sensitive method to analyze open-chromatin-associated genome organization
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    1. scibot 23 Feb 2022
      RRID: Addgene_52963

      DOI: 10.1016/j.molcel.2022.01.023

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    sciencedirect.com/science/article/pii/S1097276522000983
  197. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p53 Promotes Cytokine Expression in Melanoma to Regulate Drug Resistance and Migration
    1
    1. scibot 16 Feb 2022
      RRID:Addgene_52963

      DOI: 10.3390/cells11030405

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    ncbi.nlm.nih.gov/pmc/articles/PMC8833998/
  198. www.sciencedirect.com www.sciencedirect.com
    ZEB1-regulated lnc-Nr2f1 promotes the migration and invasion of lung adenocarcinoma cells
    1
    1. scibot 16 Feb 2022
      RRID:Addgene_52963

      DOI: 10.1016/j.canlet.2022.215601

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    sciencedirect.com/science/article/pii/S0304383522000763
  199. www.sciencedirect.com www.sciencedirect.com
    Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells
    2
    1. scibot 11 Feb 2022
      Addgene 52963

      DOI: 10.1016/j.chembiol.2022.01.002

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    2. scibot 11 Feb 2022
      Addgene 52963

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    sciencedirect.com/science/article/pii/S2451945622000022
  200. Jan 2022
  201. www.nature.com www.nature.com
    Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins
    1
    1. scibot 15 Jan 2022
      RRID:Addgene_52963

      DOI: 10.1038/s42003-021-02953-x

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    nature.com/articles/s42003-021-02953-x
  202. Dec 2021
  203. www.sciencedirect.com www.sciencedirect.com
    Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus
    1
    1. scibot 21 Dec 2021
      Plasmid_52963

      DOI: 10.1016/j.molcel.2021.11.023

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    sciencedirect.com/science/article/pii/S109727652101025X
  204. www.sciencedirect.com www.sciencedirect.com
    Chronic calcium signaling in IgE+ B cells limits plasma cell differentiation and survival
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    1. scibot 08 Dec 2021
      RRID:Addgene_52963

      DOI: 10.1016/j.immuni.2021.11.006

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    sciencedirect.com/science/article/pii/S1074761321004970
  205. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetically Edited Hepatic Cells Expressing the NTCP-S267F Variant are Resistant to Hepatitis B Virus Infection
    1
    1. scibot 02 Dec 2021
      RRID:Addgene_52963

      DOI: 10.1016/j.omtm.2021.11.002

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    ncbi.nlm.nih.gov/pmc/articles/PMC8608598/
  206. Sep 2021
  207. www.sciencedirect.com www.sciencedirect.com
    Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps
    1
    1. scibot 23 Sep 2021
      Addgene_52963

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    sciencedirect.com/science/article/pii/S1097276521007395
  208. iovs.arvojournals.org iovs.arvojournals.org
    Using CRISPR Interference as a Therapeutic Approach to Treat TGFβ2-Induced Ocular Hypertension and Glaucoma
    1
    1. scibot 16 Sep 2021
      RRID:Addgene_52963

      DOI: 10.1167/iovs.62.12.7

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    iovs.arvojournals.org/article.aspx
  209. www.sciencedirect.com www.sciencedirect.com
    Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genome
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    1. scibot 02 Sep 2021
      Addgene: 52963

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    sciencedirect.com/science/article/pii/S2211124721010354
  210. Aug 2021
  211. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability
    1
    1. scibot 28 Aug 2021
      RRID:Addgene_52963

      DOI: 10.1186/s13059-021-02460-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC8385949/
  212. www.sciencedirect.com www.sciencedirect.com
    A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells
    1
    1. scibot 25 Aug 2021
      RRID:Addgene_52963

      DOI: 10.1016/j.celrep.2021.109576

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    sciencedirect.com/science/article/pii/S221112472101010X
  213. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network
    1
    1. scibot 14 Aug 2021
      Plasmid_52963

      DOI: 10.1016/j.molcel.2019.03.025

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    ncbi.nlm.nih.gov/pmc/articles/PMC6671628/
  214. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 12 Aug 2021
      Addgene_52963

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    ncbi.nlm.nih.gov/pmc/articles/PMC5639711/
  215. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2
    1
    1. scibot 12 Aug 2021
      Addgene_52963

      DOI: 10.7554/eLife.22540

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    ncbi.nlm.nih.gov/pmc/articles/PMC5241118/
  216. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC5677551/
  217. www.sciencedirect.com www.sciencedirect.com
    The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D
    2
    1. scibot 11 Aug 2021
      Plasmid_52963

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      Plasmid_52963

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    sciencedirect.com/science/article/pii/S155041311730551X
  218. www.sciencedirect.com www.sciencedirect.com
    A UVB-responsive common variant at chromosome band 7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor, AHR
    1
    1. scibot 07 Aug 2021
      RRID:Addgene_52963

      DOI: 10.1016/j.ajhg.2021.07.002

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    sciencedirect.com/science/article/pii/S0002929721002706
  219. www.sciencedirect.com www.sciencedirect.com
    Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States
    1
    1. scibot 06 Aug 2021
      Addgene_52963

      DOI: 10.1016/j.cels.2017.08.002

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    sciencedirect.com/science/article/pii/S2405471217303356
  220. Jul 2021
  221. www.sciencedirect.com www.sciencedirect.com
    Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution
    1
    1. scibot 31 Jul 2021
      RRID:Addgene_52963

      DOI: 10.1016/j.celrep.2021.109460

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    sciencedirect.com/science/article/pii/S2211124721008834
  222. www.sciencedirect.com www.sciencedirect.com
    GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis
    1
    1. scibot 29 Jul 2021
      RRID: Addgene_52963

      DOI: 10.1016/j.cell.2019.10.034

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    sciencedirect.com/science/article/pii/S0092867419312115
  223. mcr.aacrjournals.org mcr.aacrjournals.org
    Intron 1-Mediated Regulation of EGFR Expression In EGFR-Dependent Malignancies is Mediated by AP-1 and BET Proteins
    1
    1. scibot 29 Jul 2021
      Addgene, plasmid #52963

      DOI: 10.1158/1541-7786.MCR-19-0747

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    mcr.aacrjournals.org/content/17/11/2208
  224. www.embopress.org www.embopress.org
    A genome‐wide screen identifies IRF2 as a key regulator of caspase‐4 in human cells
    1
    1. scibot 29 Jul 2021
      lentiGuide‐Puro

      DOI: 10.15252/embr.201948235

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    embopress.org/doi/full/10.15252/embr.201948235
  225. elifesciences.org elifesciences.org
    CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors
    1
    1. scibot 28 Jul 2021
      RRID:Addgene_ 52963

      DOI: 10.7554/eLife.43653

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    elifesciences.org/articles/43653
  226. www.sciencedirect.com www.sciencedirect.com
    Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis
    1
    1. scibot 27 Jul 2021
      RRID_Addgene_52963

      DOI: 10.1016/j.ccell.2019.12.007

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    sciencedirect.com/science/article/pii/S153561081930577X
  227. rupress.org rupress.org
    TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity
    1
    1. scibot 24 Jul 2021
      RRID:Addgene_52963

      DOI: 10.1083/jcb.202010180

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    rupress.org/jcb/article/220/7/e202010180/212098/TRIM37-prevents-formation-of-condensate-organized