245 Matching Annotations
  1. Last 7 days
  2. aacrjournals.org aacrjournals.org
    Identification of Small-Molecule Inhibitors that Block the GTP-Binding Pocket of K-Ras and Other Members of the Ras Superfamily of Small GTPases
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    aacrjournals.org/mct/article/25/1/84/771280/Identification-of-Small-Molecule-Inhibitors-that
  3. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Efficacy and immunogenic effects of Tumor Treating Fields (TTFields) in preclinical models of pancreatic ductal adenocarcinoma, with and without gemcitabine/nab-paclitaxel
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    onlinelibrary.wiley.com/doi/10.1002/ijc.70408
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    Lactate Facilitates the Survival and Invasion of Pancreatic Cancer Cells Under Glucose Deprivation
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202503162RR
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    Targeting PI3Kδ suppresses pancreatic cancer by dual disruption of fibrosis and immune evasion
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    sciencedirect.com/science/article/pii/S2211124726002664
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    Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202517184
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    A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy
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    sciencedirect.com/science/article/pii/S0092867426002692
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    Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear-induced Death During Hematogenous Dissemination
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202523112
  9. Mar 2026
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Trop-2.2 directed radioimmunotherapy with 177Lu, 225Ac, and 212Pb in a pancreatic cancer model
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    pmc.ncbi.nlm.nih.gov/articles/PMC13011061/
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    A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126001059
  12. www.biorxiv.org www.biorxiv.org
    Membrane Curvature Activates Src kinase and Promotes Metastatic Cancer Cell Survival
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    biorxiv.org/content/10.64898/2026.03.03.709279v1
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12970238/
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    Reconstruction of T cell infiltration in an osteosarcoma PDX-organoid interactive biobank for personalized immunotherapy
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    sciencedirect.com/science/article/pii/S2666379126000613
  15. Feb 2026
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Resveratrol amplifies the anti-tumor effect of α-PD-1 by altering the intestinal microbiome and PGD2 content
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    pmc.ncbi.nlm.nih.gov/articles/PMC12931716/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Placing purines in precision medicine: Targeting a metabolic reliance in KRAS-mutant tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12937152/
  18. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    An Insulin-Exosome-TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202515606
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    ADT-030, a novel PDE10 inhibitor, demonstrates potent antitumor activity in pancreatic ductal adenocarcinoma
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    biorxiv.org/content/10.64898/2026.02.11.705411v1
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Covalent modification of a glutamic acid inspired by HaloTag technology
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    pmc.ncbi.nlm.nih.gov/articles/PMC12864978/
  21. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Deep Learning-Powered Scalable Cancer Organ Chip for Cancer Precision Medicine
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202516660
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Target-Specific Locked Nucleic Acid Gapmer Decreases Growth and Metastases of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12316562/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Interruption of cross-communication pathways alters the immune cell signature of pancreatic cancer and decreases tumor growth
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    pmc.ncbi.nlm.nih.gov/articles/PMC12859874/
  24. Jan 2026
  25. www.sciencedirect.com www.sciencedirect.com
    Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD+ to eradicate KRAS-driven AML
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    sciencedirect.com/science/article/pii/S155041312600001X
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combined action of suicide gene exosomes from pancreatic cancer-associated fibroblasts and from mesenchymal stem cells as a pancreatic ductal adenocarcinoma treatment approach
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    pmc.ncbi.nlm.nih.gov/articles/PMC12831315/
  27. www.sciencedirect.com www.sciencedirect.com
    Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers
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    sciencedirect.com/science/article/pii/S2666379125006500
  28. www.biorxiv.org www.biorxiv.org
    The combination of BCL-xL PROTAC and mTOR inhibitor sensitizes pancreatic ductal adenocarcinoma to KRASG12D inhibitor treatment by enhancing apoptosis induction
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    biorxiv.org/content/10.64898/2026.01.05.697773v1
  29. pubs.acs.org pubs.acs.org
    Icosahedral Carborane: A Safe Albumin Binder for Augmenting Radiopharmaceuticals’ Tumor Uptake and Retention
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    pubs.acs.org/doi/full/10.1021/acs.jmedchem.5c03169
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    Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development
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  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting a Glutamic Acid in PDEδ with Fluoromethyl-Aryl Electrophiles Impairs K-Ras Signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12833852/
  32. www.mdpi.com www.mdpi.com
    A Novel Quinolone JH62 (E-2-(Tridec-4-en-1-yl)-quinolin-4(1H)-one) from Pseudomonas aeruginosa Exhibits Potent Anticancer Activity
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  33. www.nature.com www.nature.com
    SLC6A14-mediated glutamine promotes SYTL4–CXCL8 axis activation to drive gemcitabine resistance and immune evasion in pancreatic cancer
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    nature.com/articles/s12276-025-01596-w
  34. Dec 2025
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    D3-GPC2-directed CAR T cells are safe and efficacious in preclinical models of neuroblastoma and small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12699724/
  36. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Integrated Multiomics Unravels Hedgehog (HH) Signaling Characteristics in Pancreatic Cancer (PC) and DCBLD2 Regulates HH Signaling to Drive PC Progression
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    onlinelibrary.wiley.com/doi/full/10.1155/humu/4806397
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Baseline AHR expression shapes immune response to pharmacological modulation in PBMCs from pancreatic cancer patients
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    pmc.ncbi.nlm.nih.gov/articles/PMC12675361/
  38. www.nature.com www.nature.com
    RASH3D19 mediates RAS activation through a positive feedback loop in KRAS-mutant cancer
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    nature.com/articles/s41556-025-01816-5
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Interactions between Siglec-10 and α3β1 Integrin Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12671567/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IFN-γ-driven UBE2D3 upregulation impairs antigen presentation pathways and anti-tumor immunity in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12663187/
  41. Nov 2025
  42. www.nature.com www.nature.com
    A moonlighting function of tumoral interleukin-1β precursor promotes metastasis via RACK1-mediated actin remodeling
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    nature.com/articles/s41467-025-65220-1
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    KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2
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    nature.com/articles/s41467-025-66007-0
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    Dynasore as a dual modulator of lipid rafts and cell death in pancreatic cancer
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    sciencedirect.com/science/article/pii/S1476558625001344
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sequestration and suppressed synthesis of oncogenic HMGA1 using engineered adenoviruses decreases human pancreatic and breast cancer cell characteristics
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    pmc.ncbi.nlm.nih.gov/articles/PMC12582467/
  46. Oct 2025
  47. www.sciencedirect.com www.sciencedirect.com
    Plakophilin 3 drives acinar cell transformation and promotes cancer initiation and progression in pancreas
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    sciencedirect.com/science/article/pii/S2211124725012586
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    MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202513552
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    Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity
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  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12484808/
  51. Sep 2025
  52. link.springer.com link.springer.com
    STYK1 as a targetable vulnerability enhances the efficacy of anti-PD-L1 therapy in pancreatic cancer
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    link.springer.com/article/10.1007/s00535-025-02291-3
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    Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202511726
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of Sorting Nexin 10 accelerates KRAS-induced pancreatic tumorigenesis
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    Targeting the IRS1 macromolecular signaling node by Trienomycin a triggers cytoprotective autophagy in pancreatic adenocarcinoma
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    sciencedirect.com/science/article/pii/S0141813025081048
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    RACK1 attenuates pancreatic tumorigenesis by suppressing acinar-to-ductal metaplasia through inflammatory signaling modulation
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    link.springer.com/article/10.1007/s13402-025-01084-3
  57. Aug 2025
  58. www.sciencedirect.com www.sciencedirect.com
    Integrative genomic identification of therapeutic targets for pancreatic cancer
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    sciencedirect.com/science/article/pii/S2211124725009623
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    SP1-Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202510071
  60. pubs.acs.org pubs.acs.org
    A Nucleoside Analogue Featuring a C3′-Stereogenic All-Carbon Quaternary Center as a Bioenergetic Disruptor of KRAS-Mutated Pancreatic Cancer Cells
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    A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma
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  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11584292/
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Differential control of growth and identity by HNF4α isoforms in pancreatic ductal adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12333154/
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70080
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Trametinib thwarts activation of survival pathways induced by pro-ferroptotic drug conjugate ACXT-3102 resulting in enhanced pancreatic cancer cell death
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    pmc.ncbi.nlm.nih.gov/articles/PMC12307273/
  67. Jul 2025
  68. www.nature.com www.nature.com
    Spatiotemporal H2O2 flashes coordinate actin cytoskeletal remodeling and regulate cell migration and wound healing
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    A STAT3/integrin axis accelerates pancreatic cancer initiation and progression
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    sciencedirect.com/science/article/pii/S2211124725007818
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    SenExo-cCCT2 Reprograms Senescence Response and Anti-Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202508431
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    The transcriptomic fingerprint of cancer response to Tumor Treating Fields (TTFields)
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    nature.com/articles/s41420-025-02615-5
  72. 52.53.155.43 52.53.155.43
    Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma
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  73. Jun 2025
  74. journals.lww.com journals.lww.com
    Six weeks into the 2019 coronavirus disease (COVID-19)... : Chinese Medical Journal
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    Pre-clinical characterization of novel multi-client inhibitors of Sec61 with broad anti-tumor activity
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    sciencedirect.com/science/article/pii/S0022356525398472
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  77. May 2025
  78. www.nature.com www.nature.com
    HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity
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    nature.com/articles/s41467-025-60129-1
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    E‐Cadherin Is a Structuring Component of Invadopodia in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12077114/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Efficacy of Targeted Monoclonal IgA Antibodies Against Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12071589/
  81. Apr 2025
  82. www.sciencedirect.com www.sciencedirect.com
    CD44 Identified as a Diagnostic Biomarker for Highly Malignant CA19-9 Negative Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S0304383525002794
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    VAX014 Activates Tumor-Intrinsic STING and RIG-I to Promote the Development of Antitumor Immunity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962400/
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Novel Amanitin-Based Antibody–Drug Conjugates Targeting TROP2 for the Treatment of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962393/
  85. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    PPY-Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202413432
  86. Feb 2025
  87. www.sciencedirect.com www.sciencedirect.com
    SQLE-catalyzed squalene metabolism promotes mitochondrial biogenesis and tumor development in K-ras-driven cancer
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    sciencedirect.com/science/article/pii/S0304383525001508
  88. www.sciencedirect.com www.sciencedirect.com
    Small-molecule inhibitor BAY synergizes with gemcitabine through AHR inhibition in pancreatic cancer cells
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    sciencedirect.com/science/article/pii/S0006295225000607
  89. www.sciencedirect.com www.sciencedirect.com
    Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2
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    sciencedirect.com/science/article/pii/S0092867425000947
  90. Jan 2025
  91. www.sciencedirect.com www.sciencedirect.com
    Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis
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    sciencedirect.com/science/article/pii/S2666379125000011
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.17374
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    Revealing the role of cancer-associated fibroblast senescence in prognosis and immune landscape in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2589004224028396
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    Resveratrol amplifies the anti-tumor effect of α-PD-1 by altering the intestinal microbiome and PGD2 content
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    tandfonline.com/doi/full/10.1080/19490976.2024.2447821
  96. Dec 2024
  97. 52.53.155.43 52.53.155.43
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    NCF-1 plays a pivotal role in the survival of adenocarcinoma cells of pancreatic and gastric origins
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  159. Dec 2023
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  165. Nov 2023
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  169. Oct 2023
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  171. Sep 2023
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  176. Aug 2023
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  178. Jul 2023
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  180. Jun 2023
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  188. Dec 2022
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  193. Nov 2022
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  197. Oct 2022
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  199. Sep 2022
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  201. Aug 2022
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  207. Jul 2022
  208. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KRAS mutant-driven SUMOylation controls extracellular vesicle transmission to trigger lymphangiogenesis in pancreatic cancer
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    Lipocalin-2 inhibits pancreatic cancer stemness via the AKT/c-Jun pathway
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  212. Jun 2022
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  214. May 2022
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    Interleukin 6/gp130 axis promotes neural invasion in pancreatic cancer
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  220. Apr 2022
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    ATX/LPA axis regulates FAK activation, cell proliferation, apoptosis, and motility in human pancreatic cancer cells
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    Novel hybridization- and tag-based error-corrected method for sensitive ctDNA mutation detection using ion semiconductor sequencing
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    UHMK1 Is a Novel Marker for Personalized Prediction of Pancreatic Cancer Prognosis
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  227. Mar 2022
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    Analysis of capecitabine metabolites in conjunction with digital autoradiography in a murine model of pancreatic cancer suggests extensive drug penetration through the tumor
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  230. Jan 2022
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    Mechanosensitive Channel Piezo1 Induces Cell Apoptosis in Pancreatic Cancer by Ultrasound with Microbubbles
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  233. Dec 2021
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    Protein modifications throughout the lung cancer proteome unravel the cancer-specific regulation of glycolysis
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    CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
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  239. Nov 2021
  240. elifesciences.org elifesciences.org
    Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion
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    A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer
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  242. journals.sagepub.com journals.sagepub.com
    Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine - Gurmeet Kaur, David M. Evans, Beverly A. Teicher, Nathan P. Coussens, 2021
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