251 Matching Annotations
  1. May 2026
  2. www.nature.com www.nature.com
    Integrative multi-omics analysis identifies ATAD1 as a potential regulator of metastasis in pancreatic cancer
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    nature.com/articles/s41598-026-52051-3
  3. www.sciencedirect.com www.sciencedirect.com
    Glypican-1-targeted antibody-drug conjugate shows therapeutic efficacy in lung squamous cell carcinoma
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    sciencedirect.com/science/article/pii/S0169500226004927
  4. Apr 2026
  5. www.sciencedirect.com www.sciencedirect.com
    GLIS3 marks a neural-like progenitor cell state that drives metastasis in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S221112472600392X
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Moderate-Affinity Antibody–Drug Conjugate Targeting B7-H3 Exerts Potent Antitumor Efficacy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13118972/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Base Editing of TIGIT Reprograms CD155 Signaling in Natural Killer Cells to Enhance Cancer Immunotherapy Efficacy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13080321/
  8. www.sciencedirect.com www.sciencedirect.com
    Epithelial barrier DUOX2 serves as early immune defense in intestinal pathogen control
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    sciencedirect.com/science/article/pii/S1933021926000413
  9. aacrjournals.org aacrjournals.org
    Identification of Small-Molecule Inhibitors that Block the GTP-Binding Pocket of K-Ras and Other Members of the Ras Superfamily of Small GTPases
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    aacrjournals.org/mct/article/25/1/84/771280/Identification-of-Small-Molecule-Inhibitors-that
  10. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Efficacy and immunogenic effects of Tumor Treating Fields (TTFields) in preclinical models of pancreatic ductal adenocarcinoma, with and without gemcitabine/nab-paclitaxel
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    onlinelibrary.wiley.com/doi/10.1002/ijc.70408
  11. Mar 2026
  12. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Lactate Facilitates the Survival and Invasion of Pancreatic Cancer Cells Under Glucose Deprivation
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202503162RR
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    Targeting PI3Kδ suppresses pancreatic cancer by dual disruption of fibrosis and immune evasion
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    sciencedirect.com/science/article/pii/S2211124726002664
  14. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202517184
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    A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy
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    sciencedirect.com/science/article/pii/S0092867426002692
  16. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear-induced Death During Hematogenous Dissemination
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202523112
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Trop-2.2 directed radioimmunotherapy with 177Lu, 225Ac, and 212Pb in a pancreatic cancer model
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    pmc.ncbi.nlm.nih.gov/articles/PMC13011061/
  18. www.sciencedirect.com www.sciencedirect.com
    A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126001059
  19. www.biorxiv.org www.biorxiv.org
    Membrane Curvature Activates Src kinase and Promotes Metastatic Cancer Cell Survival
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    biorxiv.org/content/10.64898/2026.03.03.709279v1
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12970238/
  21. www.sciencedirect.com www.sciencedirect.com
    Reconstruction of T cell infiltration in an osteosarcoma PDX-organoid interactive biobank for personalized immunotherapy
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    sciencedirect.com/science/article/pii/S2666379126000613
  22. Feb 2026
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Resveratrol amplifies the anti-tumor effect of α-PD-1 by altering the intestinal microbiome and PGD2 content
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    pmc.ncbi.nlm.nih.gov/articles/PMC12931716/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Placing purines in precision medicine: Targeting a metabolic reliance in KRAS-mutant tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12937152/
  25. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    An Insulin-Exosome-TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202515606
  26. www.biorxiv.org www.biorxiv.org
    ADT-030, a novel PDE10 inhibitor, demonstrates potent antitumor activity in pancreatic ductal adenocarcinoma
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    biorxiv.org/content/10.64898/2026.02.11.705411v1
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Covalent modification of a glutamic acid inspired by HaloTag technology
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    pmc.ncbi.nlm.nih.gov/articles/PMC12864978/
  28. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Deep Learning-Powered Scalable Cancer Organ Chip for Cancer Precision Medicine
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202516660
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Target-Specific Locked Nucleic Acid Gapmer Decreases Growth and Metastases of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12316562/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Interruption of cross-communication pathways alters the immune cell signature of pancreatic cancer and decreases tumor growth
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    pmc.ncbi.nlm.nih.gov/articles/PMC12859874/
  31. Jan 2026
  32. www.sciencedirect.com www.sciencedirect.com
    Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD+ to eradicate KRAS-driven AML
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    sciencedirect.com/science/article/pii/S155041312600001X
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combined action of suicide gene exosomes from pancreatic cancer-associated fibroblasts and from mesenchymal stem cells as a pancreatic ductal adenocarcinoma treatment approach
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    pmc.ncbi.nlm.nih.gov/articles/PMC12831315/
  34. www.sciencedirect.com www.sciencedirect.com
    Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers
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    sciencedirect.com/science/article/pii/S2666379125006500
  35. www.biorxiv.org www.biorxiv.org
    The combination of BCL-xL PROTAC and mTOR inhibitor sensitizes pancreatic ductal adenocarcinoma to KRASG12D inhibitor treatment by enhancing apoptosis induction
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    biorxiv.org/content/10.64898/2026.01.05.697773v1
  36. pubs.acs.org pubs.acs.org
    Icosahedral Carborane: A Safe Albumin Binder for Augmenting Radiopharmaceuticals’ Tumor Uptake and Retention
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    pubs.acs.org/doi/full/10.1021/acs.jmedchem.5c03169
  37. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202514136
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting a Glutamic Acid in PDEδ with Fluoromethyl-Aryl Electrophiles Impairs K-Ras Signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12833852/
  39. www.mdpi.com www.mdpi.com
    A Novel Quinolone JH62 (E-2-(Tridec-4-en-1-yl)-quinolin-4(1H)-one) from Pseudomonas aeruginosa Exhibits Potent Anticancer Activity
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    mdpi.com/2076-2607/14/1/78
  40. www.nature.com www.nature.com
    SLC6A14-mediated glutamine promotes SYTL4–CXCL8 axis activation to drive gemcitabine resistance and immune evasion in pancreatic cancer
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    nature.com/articles/s12276-025-01596-w
  41. Dec 2025
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    D3-GPC2-directed CAR T cells are safe and efficacious in preclinical models of neuroblastoma and small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12699724/
  43. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Integrated Multiomics Unravels Hedgehog (HH) Signaling Characteristics in Pancreatic Cancer (PC) and DCBLD2 Regulates HH Signaling to Drive PC Progression
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    onlinelibrary.wiley.com/doi/full/10.1155/humu/4806397
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Baseline AHR expression shapes immune response to pharmacological modulation in PBMCs from pancreatic cancer patients
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    pmc.ncbi.nlm.nih.gov/articles/PMC12675361/
  45. www.nature.com www.nature.com
    RASH3D19 mediates RAS activation through a positive feedback loop in KRAS-mutant cancer
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    nature.com/articles/s41556-025-01816-5
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Interactions between Siglec-10 and α3β1 Integrin Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12671567/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IFN-γ-driven UBE2D3 upregulation impairs antigen presentation pathways and anti-tumor immunity in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12663187/
  48. Nov 2025
  49. www.nature.com www.nature.com
    A moonlighting function of tumoral interleukin-1β precursor promotes metastasis via RACK1-mediated actin remodeling
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    nature.com/articles/s41467-025-65220-1
  50. www.nature.com www.nature.com
    KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2
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    nature.com/articles/s41467-025-66007-0
  51. www.sciencedirect.com www.sciencedirect.com
    Dynasore as a dual modulator of lipid rafts and cell death in pancreatic cancer
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    sciencedirect.com/science/article/pii/S1476558625001344
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sequestration and suppressed synthesis of oncogenic HMGA1 using engineered adenoviruses decreases human pancreatic and breast cancer cell characteristics
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    pmc.ncbi.nlm.nih.gov/articles/PMC12582467/
  53. Oct 2025
  54. www.sciencedirect.com www.sciencedirect.com
    Plakophilin 3 drives acinar cell transformation and promotes cancer initiation and progression in pancreas
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    sciencedirect.com/science/article/pii/S2211124725012586
  55. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202513552
  56. www.sciencedirect.com www.sciencedirect.com
    Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity
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    sciencedirect.com/science/article/pii/S2211124725012045
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12484808/
  58. Sep 2025
  59. link.springer.com link.springer.com
    STYK1 as a targetable vulnerability enhances the efficacy of anti-PD-L1 therapy in pancreatic cancer
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    link.springer.com/article/10.1007/s00535-025-02291-3
  60. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202511726
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of Sorting Nexin 10 accelerates KRAS-induced pancreatic tumorigenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12415682/
  62. www.sciencedirect.com www.sciencedirect.com
    Targeting the IRS1 macromolecular signaling node by Trienomycin a triggers cytoprotective autophagy in pancreatic adenocarcinoma
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    sciencedirect.com/science/article/pii/S0141813025081048
  63. link.springer.com link.springer.com
    RACK1 attenuates pancreatic tumorigenesis by suppressing acinar-to-ductal metaplasia through inflammatory signaling modulation
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    link.springer.com/article/10.1007/s13402-025-01084-3
  64. Aug 2025
  65. www.sciencedirect.com www.sciencedirect.com
    Integrative genomic identification of therapeutic targets for pancreatic cancer
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    sciencedirect.com/science/article/pii/S2211124725009623
  66. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    SP1-Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202510071
  67. pubs.acs.org pubs.acs.org
    A Nucleoside Analogue Featuring a C3′-Stereogenic All-Carbon Quaternary Center as a Bioenergetic Disruptor of KRAS-Mutated Pancreatic Cancer Cells
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    pubs.acs.org/doi/10.1021/acsmedchemlett.5c00378
  68. www.sciencedirect.com www.sciencedirect.com
    A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S2666379125003659
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11584292/
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Differential control of growth and identity by HNF4α isoforms in pancreatic ductal adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12333154/
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12322234/
  72. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70080
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Trametinib thwarts activation of survival pathways induced by pro-ferroptotic drug conjugate ACXT-3102 resulting in enhanced pancreatic cancer cell death
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    pmc.ncbi.nlm.nih.gov/articles/PMC12307273/
  74. Jul 2025
  75. www.nature.com www.nature.com
    Spatiotemporal H2O2 flashes coordinate actin cytoskeletal remodeling and regulate cell migration and wound healing
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    nature.com/articles/s41467-025-62272-1
  76. www.sciencedirect.com www.sciencedirect.com
    A STAT3/integrin axis accelerates pancreatic cancer initiation and progression
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    sciencedirect.com/science/article/pii/S2211124725007818
  77. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    SenExo-cCCT2 Reprograms Senescence Response and Anti-Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202508431
  78. www.nature.com www.nature.com
    The transcriptomic fingerprint of cancer response to Tumor Treating Fields (TTFields)
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    nature.com/articles/s41420-025-02615-5
  79. 52.53.155.43 52.53.155.43
    Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma
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    52.53.155.43/90f14ef8571e843cb9aa796393ce7ca58a75c077/1-s2.0-S2589004225013148-main-html.html
  80. Jun 2025
  81. journals.lww.com journals.lww.com
    Six weeks into the 2019 coronavirus disease (COVID-19)... : Chinese Medical Journal
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    journals.lww.com/cmj/fulltext/2025/10050/novel_cd19_fast_car_t_cells_vs__cd19_conventional.10.aspx
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    Pre-clinical characterization of novel multi-client inhibitors of Sec61 with broad anti-tumor activity
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    sciencedirect.com/science/article/pii/S0022356525398472
  83. 52.53.155.43 52.53.155.43
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  84. May 2025
  85. www.nature.com www.nature.com
    HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity
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    nature.com/articles/s41467-025-60129-1
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    E‐Cadherin Is a Structuring Component of Invadopodia in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12077114/
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Efficacy of Targeted Monoclonal IgA Antibodies Against Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12071589/
  88. Apr 2025
  89. www.sciencedirect.com www.sciencedirect.com
    CD44 Identified as a Diagnostic Biomarker for Highly Malignant CA19-9 Negative Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S0304383525002794
  90. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    VAX014 Activates Tumor-Intrinsic STING and RIG-I to Promote the Development of Antitumor Immunity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962400/
  91. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Novel Amanitin-Based Antibody–Drug Conjugates Targeting TROP2 for the Treatment of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962393/
  92. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    PPY-Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202413432
  93. Feb 2025
  94. www.sciencedirect.com www.sciencedirect.com
    SQLE-catalyzed squalene metabolism promotes mitochondrial biogenesis and tumor development in K-ras-driven cancer
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    sciencedirect.com/science/article/pii/S0304383525001508
  95. www.sciencedirect.com www.sciencedirect.com
    Small-molecule inhibitor BAY synergizes with gemcitabine through AHR inhibition in pancreatic cancer cells
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    sciencedirect.com/science/article/pii/S0006295225000607
  96. www.sciencedirect.com www.sciencedirect.com
    Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2
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    sciencedirect.com/science/article/pii/S0092867425000947
  97. Jan 2025
  98. www.sciencedirect.com www.sciencedirect.com
    Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis
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    sciencedirect.com/science/article/pii/S2666379125000011
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  166. Dec 2023
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  178. Sep 2023
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  185. Jul 2023
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    Sialyl-Tn Antigen-Imprinted Dual Fluorescent Core–Shell Nanoparticles for Ratiometric Sialyl-Tn Antigen Detection and Dual-Color Labeling of Cancer Cells
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  204. Oct 2022
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  206. Sep 2022
  207. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Original research: Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression
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  208. Aug 2022
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    Axon guidance receptor ROBO3 modulates subtype identity and prognosis via AXL-associated inflammatory network in pancreatic cancer
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    Concurrent inhibition of IGF1R and ERK increases pancreatic cancer sensitivity to autophagy inhibitors
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  211. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    CDK7 inhibition augments response to multidrug chemotherapy in pancreatic cancer
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  214. Jul 2022
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    KRAS mutant-driven SUMOylation controls extracellular vesicle transmission to trigger lymphangiogenesis in pancreatic cancer
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    Lipocalin-2 inhibits pancreatic cancer stemness via the AKT/c-Jun pathway
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  219. Jun 2022
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    GPR120 promotes metastasis but inhibits tumor growth in pancreatic ductal adenocarcinoma
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  221. May 2022
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    Generation of human parallel chimeric antigen receptor (pCAR) T cells to achieve synergistic T cell co-stimulation
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    SRSF3-mediated regulation of N6-methyladenosine modification-related lncRNA ANRIL splicing promotes resistance of pancreatic cancer to gemcitabine
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    Optical magnetic multimodality imaging of plectin-1-targeted imaging agent for the precise detection of orthotopic pancreatic ductal adenocarcinoma in mice
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  227. Apr 2022
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  233. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    UHMK1 Is a Novel Marker for Personalized Prediction of Pancreatic Cancer Prognosis
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  234. Mar 2022
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    Analysis of capecitabine metabolites in conjunction with digital autoradiography in a murine model of pancreatic cancer suggests extensive drug penetration through the tumor
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    Heterodimeric RGD-NGR PET Tracer for the Early Detection of Pancreatic Cancer
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  237. Jan 2022
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    Mechanosensitive Channel Piezo1 Induces Cell Apoptosis in Pancreatic Cancer by Ultrasound with Microbubbles
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  239. journals.sagepub.com journals.sagepub.com
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  240. Dec 2021
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    Protein modifications throughout the lung cancer proteome unravel the cancer-specific regulation of glycolysis
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  242. journals.sagepub.com journals.sagepub.com
    Complex Tumor Spheroids, a Tissue-Mimicking Tumor Model, for Drug Discovery and Precision Medicine - Gurmeet Kaur, David M. Evans, Beverly A. Teicher, Nathan P. Coussens, 2021
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  243. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glutamine deprivation triggers NAGK-dependent hexosamine salvage
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