270 Matching Annotations
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    Cancer competition for vitamin B2 creates metabolic checkpoint for T cell ferroptosis
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    sciencedirect.com/science/article/pii/S0092867426011220
  3. Oct 2026
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    FluxAtlas is a pan-cancer metabolic flux atlas that identifies tumor-selective dependencies and prognostic biomarkers
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    sciencedirect.com/science/article/pii/S2211124726011071
  5. Sep 2026
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    ARNTL2 promotes metastatic phenotypes through SERPINE1 transcription in KRAS G12D pancreatic cancer
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    sciencedirect.com/science/article/pii/S2589004226028580
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    Targeting PRMT5 inhibitor-induced adaptation in pancreatic cancer with the RBM39 degrader indisulam
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    pmc.ncbi.nlm.nih.gov/articles/PMC13530115/
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    Targeting CD24 Activates Macrophages to Reduce Tumor Burden in Preclinical Models of Solid Tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC13530989/
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    CPT1A through succinylation regulates the CTCF/LINC01503‒91aa feedback loop to promote gemcitabine resistance in pancreatic ductal adenocarcinoma
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    onlinelibrary.wiley.com/doi/10.1002/ctm2.70776
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    Systematic Targeting of Protein Complexes with Molecular COUPLrs
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    pmc.ncbi.nlm.nih.gov/articles/PMC13527781/
  11. Aug 2026
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    Targeting addiction to HMGB2-driven transcriptional programs in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2211124726007278
  13. Jul 2026
  14. pubs.acs.org pubs.acs.org
    Conformationally Tuned Cyclic RGD Peptides for Integrin-Subtype-Selective PET/CT Imaging
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    pubs.acs.org/doi/full/10.1021/acs.jmedchem.6c00859
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    Tobemstomig, a novel bispecific antibody, preferentially blocks PD-1 and LAG-3 on CD8 TILs to expand stem-like T-cells for sustained tumor control
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    pmc.ncbi.nlm.nih.gov/articles/PMC13347385/
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    Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors
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    sciencedirect.com/science/article/pii/S1074761326002578
  17. Jun 2026
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    Ibrutinib and PD-1 blockade potentiate mesothelin-targeting CAR-T cell therapy in preclinical models of pancreatic cancer
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    aacrjournals.org/clincancerres/article/32/3/611/772036/Ibrutinib-and-PD-1-Blockade-Potentiate-Mesothelin
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    Quantitative Detection of Entotic Cell-In-Cell Structures Using Deformable Segmentation and Deep Learning
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    onlinelibrary.wiley.com/doi/10.1002/cyto.a.70046
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A malignant subpopulation of H2AFZ+ cells interacts with myeloid cells to promote an anti-inflammatory microenvironment and drive hepatic metastasis, revealing an immunotherapeutic strategy for pancreatic ductal adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13266339/
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    Mitochondrial-Localized Keratin 17 Promotes Chemoresistance in Basal-like Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13266344/
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    Optimized Cryoablation and Combinatorial Chemotherapy Overcome Sublethal Survival in Pancreatic Cancer Cells
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    sciencedirect.com/science/article/pii/S0140700726002021
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    Pyrazolo-quinolinone suppresses epithelial–mesenchymal transition by targeting the CXCR4/NF-κB axis in human pancreatic cancer cells
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    sciencedirect.com/science/article/pii/S0344033826002001
  24. May 2026
  25. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Tumor-Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202520029
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    Engineered αvβ6-targeting peptide‒BSH conjugates for boron neutron capture therapy of pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211383526003059
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    Integrative multi-omics analysis identifies ATAD1 as a potential regulator of metastasis in pancreatic cancer
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    Glypican-1-targeted antibody-drug conjugate shows therapeutic efficacy in lung squamous cell carcinoma
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  29. Apr 2026
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    GLIS3 marks a neural-like progenitor cell state that drives metastasis in pancreatic ductal adenocarcinoma
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    A Moderate-Affinity Antibody–Drug Conjugate Targeting B7-H3 Exerts Potent Antitumor Efficacy
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    Base Editing of TIGIT Reprograms CD155 Signaling in Natural Killer Cells to Enhance Cancer Immunotherapy Efficacy
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    Epithelial barrier DUOX2 serves as early immune defense in intestinal pathogen control
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    Identification of Small-Molecule Inhibitors that Block the GTP-Binding Pocket of K-Ras and Other Members of the Ras Superfamily of Small GTPases
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    Efficacy and immunogenic effects of Tumor Treating Fields (TTFields) in preclinical models of pancreatic ductal adenocarcinoma, with and without gemcitabine/nab-paclitaxel
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    onlinelibrary.wiley.com/doi/10.1002/ijc.70408
  36. Mar 2026
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    Lactate Facilitates the Survival and Invasion of Pancreatic Cancer Cells Under Glucose Deprivation
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    Targeting PI3Kδ suppresses pancreatic cancer by dual disruption of fibrosis and immune evasion
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    Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202517184
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    A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy
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    Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear-induced Death During Hematogenous Dissemination
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    Trop-2.2 directed radioimmunotherapy with 177Lu, 225Ac, and 212Pb in a pancreatic cancer model
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    A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer
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    Membrane Curvature Activates Src kinase and Promotes Metastatic Cancer Cell Survival
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    biorxiv.org/content/10.64898/2026.03.03.709279v1
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    GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer
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    Reconstruction of T cell infiltration in an osteosarcoma PDX-organoid interactive biobank for personalized immunotherapy
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  47. Feb 2026
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    Resveratrol amplifies the anti-tumor effect of α-PD-1 by altering the intestinal microbiome and PGD2 content
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    Placing purines in precision medicine: Targeting a metabolic reliance in KRAS-mutant tumors
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    An Insulin-Exosome-TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer
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    ADT-030, a novel PDE10 inhibitor, demonstrates potent antitumor activity in pancreatic ductal adenocarcinoma
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    biorxiv.org/content/10.64898/2026.02.11.705411v1
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    Covalent modification of a glutamic acid inspired by HaloTag technology
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    Deep Learning-Powered Scalable Cancer Organ Chip for Cancer Precision Medicine
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  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Target-Specific Locked Nucleic Acid Gapmer Decreases Growth and Metastases of Pancreatic Cancer
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    Interruption of cross-communication pathways alters the immune cell signature of pancreatic cancer and decreases tumor growth
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  56. Jan 2026
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    Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD+ to eradicate KRAS-driven AML
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    Combined action of suicide gene exosomes from pancreatic cancer-associated fibroblasts and from mesenchymal stem cells as a pancreatic ductal adenocarcinoma treatment approach
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    pmc.ncbi.nlm.nih.gov/articles/PMC12831315/
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    Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers
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    The combination of BCL-xL PROTAC and mTOR inhibitor sensitizes pancreatic ductal adenocarcinoma to KRASG12D inhibitor treatment by enhancing apoptosis induction
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    biorxiv.org/content/10.64898/2026.01.05.697773v1
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    Icosahedral Carborane: A Safe Albumin Binder for Augmenting Radiopharmaceuticals’ Tumor Uptake and Retention
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    Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development
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    Targeting a Glutamic Acid in PDEδ with Fluoromethyl-Aryl Electrophiles Impairs K-Ras Signaling
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    A Novel Quinolone JH62 (E-2-(Tridec-4-en-1-yl)-quinolin-4(1H)-one) from Pseudomonas aeruginosa Exhibits Potent Anticancer Activity
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    SLC6A14-mediated glutamine promotes SYTL4–CXCL8 axis activation to drive gemcitabine resistance and immune evasion in pancreatic cancer
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    nature.com/articles/s12276-025-01596-w
  66. Dec 2025
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    D3-GPC2-directed CAR T cells are safe and efficacious in preclinical models of neuroblastoma and small cell lung cancer
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    Integrated Multiomics Unravels Hedgehog (HH) Signaling Characteristics in Pancreatic Cancer (PC) and DCBLD2 Regulates HH Signaling to Drive PC Progression
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    Baseline AHR expression shapes immune response to pharmacological modulation in PBMCs from pancreatic cancer patients
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    RASH3D19 mediates RAS activation through a positive feedback loop in KRAS-mutant cancer
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    Targeting Interactions between Siglec-10 and α3β1 Integrin Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer
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    IFN-γ-driven UBE2D3 upregulation impairs antigen presentation pathways and anti-tumor immunity in pancreatic cancer
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  73. Nov 2025
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    A moonlighting function of tumoral interleukin-1β precursor promotes metastasis via RACK1-mediated actin remodeling
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    nature.com/articles/s41467-025-65220-1
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    KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2
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    Dynasore as a dual modulator of lipid rafts and cell death in pancreatic cancer
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    Sequestration and suppressed synthesis of oncogenic HMGA1 using engineered adenoviruses decreases human pancreatic and breast cancer cell characteristics
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  78. Oct 2025
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    Plakophilin 3 drives acinar cell transformation and promotes cancer initiation and progression in pancreas
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    MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis
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    Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity
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    DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12484808/
  83. Sep 2025
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    STYK1 as a targetable vulnerability enhances the efficacy of anti-PD-L1 therapy in pancreatic cancer
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    link.springer.com/article/10.1007/s00535-025-02291-3
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    Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202511726
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    Loss of Sorting Nexin 10 accelerates KRAS-induced pancreatic tumorigenesis
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    Targeting the IRS1 macromolecular signaling node by Trienomycin a triggers cytoprotective autophagy in pancreatic adenocarcinoma
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    sciencedirect.com/science/article/pii/S0141813025081048
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    RACK1 attenuates pancreatic tumorigenesis by suppressing acinar-to-ductal metaplasia through inflammatory signaling modulation
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    link.springer.com/article/10.1007/s13402-025-01084-3
  89. Aug 2025
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    Integrative genomic identification of therapeutic targets for pancreatic cancer
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    SP1-Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202510071
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    A Nucleoside Analogue Featuring a C3′-Stereogenic All-Carbon Quaternary Center as a Bioenergetic Disruptor of KRAS-Mutated Pancreatic Cancer Cells
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    pubs.acs.org/doi/10.1021/acsmedchemlett.5c00378
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    A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma
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    ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11584292/
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    Differential control of growth and identity by HNF4α isoforms in pancreatic ductal adenocarcinoma
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    Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells
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  98. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  201. Oct 2023
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  203. Sep 2023
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  208. Aug 2023
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  210. Jul 2023
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  212. Jun 2023
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    Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
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  218. Jan 2023
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  220. Dec 2022
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  223. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  225. Nov 2022
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  229. Oct 2022
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  231. Sep 2022
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  233. Aug 2022
  234. insight.jci.org insight.jci.org
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  236. onlinelibrary.wiley.com onlinelibrary.wiley.com
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  239. Jul 2022
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    KRAS mutant-driven SUMOylation controls extracellular vesicle transmission to trigger lymphangiogenesis in pancreatic cancer
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  244. Jun 2022
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  246. May 2022
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