290 Matching Annotations
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    Hangeshashinto Induces Apoptosis and Suppresses Colorectal Cancer Growth In Vitro and In Vivo
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    mdpi.com/1422-0067/27/20/9310
  3. Oct 2026
  4. www.sciencedirect.com www.sciencedirect.com
    Integrative genomics and experimental validation identify a mechanosensitive gene signature associated with colorectal cancer liver metastasis
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    sciencedirect.com/science/article/pii/S2589004226033092
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    Deoxysphingolipids activate cGAS-STING and enhance antitumor immunity
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    sciencedirect.com/science/article/pii/S221112472601168X
  6. Sep 2026
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protocol for robust gene knockout and reliable validation in human cell lines using quad-guide RNA vectors
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    pmc.ncbi.nlm.nih.gov/articles/PMC13597292/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ALDH2 regulates oxaliplatin sensitivity via PDE4B in p53-mutant colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13539918/
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    Bacteroides acidifaciens enriched by KRAS mutation promotes colorectal tumorigenesis
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    sciencedirect.com/science/article/pii/S1931312826003525
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PRKN mediates the ubiquitination of SCAF8 to reduce the mRNA stability of KLF5 and its transcriptional activation of EFNA3 in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13523511/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Programmable protein degraders enable selective knockdown of pathogenic β-catenin subpopulations in vitro and in vivo
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    pmc.ncbi.nlm.nih.gov/articles/PMC13524019/
  12. Aug 2026
  13. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    A Novel tRNA Half mt-5’-tiRNA-Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.77042
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    Excess intracellular lactate represses mRNA translation and tumor progression through lactate-tRNA charging
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    sciencedirect.com/science/article/pii/S1097276526005125
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting colorectal cancer with pyrazolo[4,3-e][1,2,4]triazine and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides: comprehensive in vitro evaluation
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    Iron-addicted colorectal cancers exploit heme-complex II axis to resist oxidative cell death
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    pmc.ncbi.nlm.nih.gov/articles/PMC13401815/
  17. Jul 2026
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    DHODH is a synthetic lethal target in PIK3CA-mutant colorectal cancer
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    sciencedirect.com/science/article/pii/S2211124726007977
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    Granular component sub-phases direct ribosome biogenesis in the nucleolus
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    sciencedirect.com/science/article/pii/S1097276526004247
  20. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Eu(III), Tb(III), and Gd(III) Complexes With Dual Ligand Architecture: Synthesis, Characterization, Photoluminescence, Cytotoxic, and Molecular Docking Studies
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    onlinelibrary.wiley.com/doi/10.1002/cbdv.71502
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    SOCS5 suppresses antitumor immunity in colorectal cancer by promoting IFNAR1 ubiquitylation and type I interferon response
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    sciencedirect.com/science/article/pii/S0925443926002309
  22. gut.bmj.com gut.bmj.com
    Extrinsic lipids are absorbed and accumulate in colorectal cancer
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    gut.bmj.com/content/early/2026/06/16/gutjnl-2025-336377
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CIP2A recruits SLX4-MUS81-XPF in mitosis and protects against replication stress
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    Framework for evaluating in vitro vasculogenic mimicry using structural and metabolic parameters
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    Pyrazole-linked quinoline hydrazone derivatives: Design, synthesis, antimicrobial and antiproliferative activity via dihydrofolate reductase inhibition
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    sciencedirect.com/science/article/pii/S0022286026016947
  26. Jun 2026
  27. onlinelibrary.wiley.com onlinelibrary.wiley.com
    AIEgen Targets the STAT3‒SUCLG2 Axis to Regulate Metabolism for Colorectal Cancer Theranostics
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    onlinelibrary.wiley.com/doi/10.1002/agt2.70383
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acquired resistance to the PRMT5 inhibitor confers collateral sensitivity to MEK inhibition in MTAP-null non-small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13131504/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DDR1 Promotes Immune Evasion in Colorectal Cancer by Orchestrating IL33-Mediated M2-like Polarization of Tumor-Associated Macrophages
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    pmc.ncbi.nlm.nih.gov/articles/PMC13227095/
  30. May 2026
  31. www.sciencedirect.com www.sciencedirect.com
    Targeting ADAR1 p150 triggers tumor inhibition and antitumor immunity to overcome immunotherapy resistance
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    Metabolic stress conditions dictate MAPKAPK2-dependent efficiency of MEK1/2 inhibition in colorectal carcinoma
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  33. aacrjournals.org aacrjournals.org
    Lipid Nanoparticle-Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T Cell Infiltration
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    aacrjournals.org/cancerres/article/85/19/3706/765871/Lipid-Nanoparticle-Encapsulated-mRNAs-Encoding
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cell and Nuclear Size Is Associated with Chromosomal Instability and Tumorigenicity in Cancer Cells That Undergo Whole Genome Doubling
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  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ASCC3 promotes chemosensitivity in colorectal cancer cells
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  36. www.biorxiv.org www.biorxiv.org
    Comparison studies between Cesium-137 and X-ray irradiators in epithelial injury using in vitro and in vivo models
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    biorxiv.org/content/10.64898/2026.04.17.719248v1
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acquired resistance to the PRMT5 inhibitor confers collateral sensitivity to MEK inhibition in MTAP-null non-small cell lung cancer
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  38. Apr 2026
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ASCL2 drives colorectal cancer metastasis through transcriptional activation of TDGF1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13096262/
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70256
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    Mosperafenib, a novel paradox breaker BRAF inhibitor with potent preclinical activity in BRAF mutated colorectal cancer
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    Transgelin Expression in Activated Cancer-Associated Fibroblasts Regulates Stromal Contractility and Promotes Colon Cancer Progression
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    onlinelibrary.wiley.com/doi/10.1002/cam4.71789
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AURKA-mediated destabilization of SAPS3 drives ferroptosis evasion via 7-dehydrocholesterol biosynthesis in colorectal cancer
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    Phosphorylation-driven Targeted Protein Degradation of Oncogenic β-catenin
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  45. Mar 2026
  46. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202516557
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    A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy
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    Intratumoral microbiota and host genotype cooperatively shape neutrophil cytotoxic functions in colorectal cancer
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  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    m1A‐Dependent TRMT6/61A‐ARG2 Axis Drives Protumorigenic Senescence by Remodeling the Tumor Microenvironment
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  50. 54.241.53.176 54.241.53.176
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  51. Feb 2026
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Placing purines in precision medicine: Targeting a metabolic reliance in KRAS-mutant tumors
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    BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes
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  54. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A comprehensive review of anti-colorectal cancer alkaloids from traditional Chinese medicine: Sources, chemical structures, mechanisms and therapeutic applications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70343
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Colorectal cancer-derived osteopontin rewires macrophages into a pro-metastatic M2 state via the PI3K/AKT/CSF1-CSF1R axis
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    Functional characterization of CASP, a CUX1 isoform, reveals its tumor-promoting role in colorectal cancer via TRIM21-mediated signaling
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    SERPINA3 mediates liver cancer cells escape from chemotherapy-induced neutrophil extracellular trap killing
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  58. Jan 2026
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Thimerosal Inhibits Tumor Malignant Progression through Direct Action and Enhancing the Efficacy of PD-1-Based Immunotherapy
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    Basroparib inhibits YAP-driven cancers by stabilizing angiomotin
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70209
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Distinct Regulation of the ARF and TAp73 Tumor Suppressor Genes by the Transcription Factor E2F1 Enables Discrimination of Cancer Cells from Normal Growing Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12785935/
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    HMMR/RHAMM recruits SACK1D/FAM83D-CK1α complex at the mitotic spindle to control spindle alignment
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    BRD2 bridges TFIID and MOF-H4K16ac-containing nucleosomes to promote transcriptional initiation
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    Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer
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  65. Dec 2025
  66. www.sciencedirect.com www.sciencedirect.com
    A TRIM21–UCHL3–ITCH–SIPA1 axis promotes colorectal cancer growth and metastasis
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    sciencedirect.com/science/article/pii/S0304383525007931
  67. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Mitochondrial VHL rewires cell metabolism in hypoxia
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  69. www.nature.com www.nature.com
    KRT81 promotes metastasis of colorectal cancer by acting as a protein scaffold for ezrin
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  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RAS mutation–specific responses to paralog- and state-selective RAS inhibitors
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  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel β-carboline alkaloid derivative targeting MDM2-p53 pathway suppresses colorectal cancer progression
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  72. Nov 2025
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Colorectal cancer cell-derived exosomes induce metabolic reprogramming of cancer-associated fibroblasts to promote colorectal cancer growth
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  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cytoplasmic HMGB1 promotes and interacts with BECN1 through ZNF460 to induce autophagy and accelerate radioresistance in colorectal cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12558843/
  76. Oct 2025
  77. www.sciencedirect.com www.sciencedirect.com
    Purinergic Ecto-Enzyme CD73 is a Context-Dependent Tumor Suppressor in Colorectal Cancer
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    sciencedirect.com/science/article/pii/S0021925825027164
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    CANDiT: A machine learning framework for differentiation therapy in colorectal cancer
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  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MM-129 Counteracts 5-Fluorouracil-Induced Cellular Senescence in Colon Cancer via SIRT1/STAT3 Signaling Pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12524155/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cancer-associated fibroblasts expressing FSTL3 promote vasculogenic mimicry formation and drive colon cancer malignancy
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    Extracellular Vesicle-Packaged circTAX1BP1 from Cancer-Associated Fibroblasts Regulates RNA m6A Modification through Lactylation of VIRMA in Colorectal Cancer Cells
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202514008
  83. Sep 2025
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FET fusion oncoproteins enrich SWI/SNF complex subtypes and interaction partners
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    Knockdown of translocon-associated protein subunit beta (TRAPβ) stimulates cell cycle arrest and apoptosis in human colorectal cancer cells
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    Chemotherapy modulation by a cancer-associated microbiota metabolite
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  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875910/
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    SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer
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    sciencedirect.com/science/article/pii/S2211124725009106
  90. Aug 2025
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    TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation
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    Cyclin-dependent kinase 9 inhibitors as oncogene signaling modulators in combination with targeted therapy for the treatment of colorectal cancer
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    biorxiv.org/content/10.1101/2025.08.13.669992v1
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    Characterizing Compounds Targeting Colorectal Cancer Derived From Monastrol Using High-Through Screening of an Extensive Combinatorial Library
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    biorxiv.org/content/10.1101/2025.08.07.667829v1
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    Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance
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    Combined MEK and PARP inhibition enhances radiation response in rectal cancer
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  96. www.cell.com www.cell.com
    Systematic screening for functional exon-skipping isoforms using the CRISPR-RfxCas13d system
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    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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  98. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  202. Aug 2023
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    Epigenetic regulation in colorectal cancer: The susceptibility of microRNAs 145, 143 and 133b to DNA demethylation and histone deacetylase inhibitors
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    MHC Class II is Induced by IFNγ and Follows Three Distinct Patterns of Expression in Colorectal Cancer Organoids
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    DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype
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  206. Jul 2023
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    Activation of autophagy depends on Atg1/Ulk1-mediated phosphorylation and inhibition of the Hsp90 chaperone machinery
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    Prognosis of colon cancer patients based on enhancer RNAs-related genes
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    LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3
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    Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors
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  211. Jun 2023
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    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
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    Minor intron splicing is critical for survival of lethal prostate cancer
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    Venetoclax is a potent hepsin inhibitor that reduces the metastatic and prothrombotic phenotypes of hepsin-expressing colorectal cancer cells
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  215. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer
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  216. May 2023
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    A novel EGFR Inhibitor, HNPMI regulates apoptosis and oncogenesis by modulating BCL-2/BAX and p53 in colon cancer
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  218. Apr 2023
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    Fanconi anemia-associated chromosomal radial formation is dependent on POLθ-mediated alternative end joining
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    Bromodomain protein BRD8 regulates cell cycle progression in colorectal cancer cells through a TIP60-independent regulation of the pre-RC complex
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    Histone H3 phospho-regulation by KimH3 in both interphase and mitosis
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  222. Mar 2023
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    Drug–gene Interaction Screens Coupled to Tumor Data Analyses Identify the Most Clinically Relevant Cancer Vulnerabilities Driving Sensitivity to PARP Inhibition
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    Overexpression of synaptic vesicle protein Rab GTPase 3C promotes vesicular exocytosis and drug resistance in colorectal cancer cells
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    Transcriptional Regulation of Liver-Type OATP1B3 (Lt-OATP1B3) and Cancer-Type OATP1B3 (Ct-OATP1B3) Studied in Hepatocyte-Derived and Colon Cancer-Derived Cell Lines
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  226. Feb 2023
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    Downregulation of iNOS/NO Promotes Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer
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  228. Jan 2023
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    The regulatory role of the CD2AP/TKS4 interaction in EMT and its potential as a biomarker for colon cancer
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    ANGPTL4-Mediated Promotion of Glycolysis Facilitates the Colonization of Fusobacterium nucleatum in Colorectal Cancer
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    Human Endogenous Retroviruses in Cancer: Oncogenesis mechanisms and Clinical Implications
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    Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer
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  235. Dec 2022
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    Cancer cell-derived type I interferons instruct tumor monocyte polarization
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    Table 1 Tumor cell lines used to set up common subcutaneous mouse tumor models
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  238. Nov 2022
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    Downregulation of protein kinase C gamma reduces epithelial property and enhances malignant phenotypes in colorectal cancer cells
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    AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity
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  241. Sep 2022
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    De novo sphingolipid biosynthesis necessitates detoxification in cancer cells
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