380 Matching Annotations
  1. Last 7 days
  2. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Tumor-Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202520029
  3. May 2026
  4. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    The Host Cell Factor Phosphatase-2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type-1
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202523697
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    Integrative multi-omics analysis identifies ATAD1 as a potential regulator of metastasis in pancreatic cancer
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    nature.com/articles/s41598-026-52051-3
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multiomics and Genomic Alteration Characterization Identifies VDAC1 as a Mitochondrial‐Associated Biomarker in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13150345/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RBM15-Mediated m6A Modification Regulates Proliferation and Migration of Pancreatic Cancer Cells via the lncRNA LINC01320/miR-1287-5p/FBXO11 Axis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13149094/
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    CFIm25-dependent alternative polyadenylation in AKT2 mRNA programs macrophage polarization
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    sciencedirect.com/science/article/pii/S2589004226011661
  9. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Vorinostat Potentiates Chemoimmunotherapy in Immune-Enriched Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202521844
  10. Apr 2026
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    Engineering functionality-optimized fully human B7-H3 CAR T cells for enhanced solid tumor therapy
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    sciencedirect.com/science/article/pii/S2666379126001990
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    GLIS3 marks a neural-like progenitor cell state that drives metastasis in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S221112472600392X
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    The Vitamin D3 Analog Calcipotriol Attenuates Pancreatic Cancer Malignancy via Downregulating Thrombospondin 1 in Pancreatic Stellate Cells
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    onlinelibrary.wiley.com/doi/10.1155/mi/2632235
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    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70455
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    Mutant KRAS promotes NF-κB driven CCL20 chemokine expression in pancreatic ductal adenocarcinoma
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    biorxiv.org/content/10.64898/2026.04.13.717530v1
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    Loss of Regulator of G protein signaling 11 promotes pro-tumorigenic features in pancreatic cancer
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    aacrjournals.org/mcr/article/24/1/34/771151/Loss-of-Regulator-of-G-Protein-Signaling-11
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    mTORC1 activity suppresses ferroptosis through a SCARB1-dependent HDL-tocopherol uptake pathway
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    sciencedirect.com/science/article/pii/S1097276526001954
  18. 54.241.53.176 54.241.53.176
    2026.04.04.716465.full-html.html
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  19. Mar 2026
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    Targeting PI3Kδ suppresses pancreatic cancer by dual disruption of fibrosis and immune evasion
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    sciencedirect.com/science/article/pii/S2211124726002664
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    A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy
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    sciencedirect.com/science/article/pii/S0092867426002692
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR-Drug Combinatorial Screening Identifies Effective Combination Treatments for MTAP-deleted cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13014710/
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    Cancer cell-derived sialylated IgG interacting with Siglec-7/9/10 is a potential immunotherapeutic target in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126000777
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Wild-type RAS signaling is an essential therapeutic target in RAS-mutated cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC12983336/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12970238/
  26. Feb 2026
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Placing purines in precision medicine: Targeting a metabolic reliance in KRAS-mutant tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12937152/
  28. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    An Insulin-Exosome-TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202515606
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    Syndecan-1-targeted therapeutic antibody impairs macropinocytosis and elicits antitumor immunity in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126000303
  30. 54.241.53.176 54.241.53.176
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    ADT-030, a novel PDE10 inhibitor, demonstrates potent antitumor activity in pancreatic ductal adenocarcinoma
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    biorxiv.org/content/10.64898/2026.02.11.705411v1
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    Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux
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    SERPINA3 mediates liver cancer cells escape from chemotherapy-induced neutrophil extracellular trap killing
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    sciencedirect.com/science/article/pii/S2211124726000343
  34. pubs.acs.org pubs.acs.org
    5′-NucA-SMCC-DM1 and 5′-NucA-SPDMV-DM1 are Potent Aptamer–Drug Conjugates against Pancreatic Cancer
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    pubs.acs.org/doi/full/10.1021/acsomega.5c11364
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Covalent modification of a glutamic acid inspired by HaloTag technology
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    pmc.ncbi.nlm.nih.gov/articles/PMC12864978/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Synthesis of Benzopyrans and Quinolines with Nitrogenated Chain and Their Cytotoxicity Against Human Cancer Cell Lines
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    pmc.ncbi.nlm.nih.gov/articles/PMC12860552/
  37. Jan 2026
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CK2-mediated HDAC5 shuttling regulates DNA end resection through Ku70 deacetylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12846757/
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    Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD+ to eradicate KRAS-driven AML
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    sciencedirect.com/science/article/pii/S155041312600001X
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    Simultaneous targeting of KRAS and CDK4 synergistically induces durable growth arrest in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12847887/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combined action of suicide gene exosomes from pancreatic cancer-associated fibroblasts and from mesenchymal stem cells as a pancreatic ductal adenocarcinoma treatment approach
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    pmc.ncbi.nlm.nih.gov/articles/PMC12831315/
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    Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers
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    sciencedirect.com/science/article/pii/S2666379125006500
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Circ72309 modulates gemcitabine metabolism and gemcitabine sensitivity in pancreatic cancer: Serum Circ72309 levels as a potential predictor of treatment response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12823056/
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    Basroparib inhibits YAP-driven cancers by stabilizing angiomotin
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70209
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    Multimodal profiling of pancreatic cancer reveals a TIMP-1-dominated secretory profile determining pro-tumor immunoinstruction in human cancers
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    Metabolic Reprogramming of T Cells by Dual UCP2 and IL-17 Blockade Enhances Immunity Against Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202513020
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting a Glutamic Acid in PDEδ with Fluoromethyl-Aryl Electrophiles Impairs K-Ras Signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12833852/
  48. www.nature.com www.nature.com
    SLC6A14-mediated glutamine promotes SYTL4–CXCL8 axis activation to drive gemcitabine resistance and immune evasion in pancreatic cancer
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    nature.com/articles/s12276-025-01596-w
  49. Dec 2025
  50. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Mitochondrial VHL rewires cell metabolism in hypoxia
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    sciencedirect.com:5037/science/article/pii/S1550413125005273
  51. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Anti-mitotic agent SB-216 overcomes taxane resistance in castration-resistant prostate cancer and exhibits anti-tumour efficacy in pancreatic cancer
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70294
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    Deprivation of EGFR signal causes senolysis in PDAC with CDK4/6 inhibition
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    nature.com/articles/s41418-025-01634-0
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RAS mutation–specific responses to paralog- and state-selective RAS inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12710464/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Niclosamide nanoparticles enhance pancreatic cancer sensitivity to gemcitabine via HIF-1α inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12704315/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage
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    pmc.ncbi.nlm.nih.gov/articles/PMC12700215/
  56. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Study of the blood–brain barrier-penetrating KRAS G12C inhibitor JMKX1899 in KRAS G12C-mutated NSCLC with brain metastases
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    sciencedirect.com:5037/science/article/pii/S266700542500122X
  57. www.biorxiv.org www.biorxiv.org
    DYRK1A regulates cancer cell and cancer-associated fibroblast secretomes to foster an immunosuppressive microenvironment in pancreatic cancer
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    biorxiv.org/content/10.1101/2025.11.26.690756v1
  58. www.nature.com www.nature.com
    RASH3D19 mediates RAS activation through a positive feedback loop in KRAS-mutant cancer
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    nature.com/articles/s41556-025-01816-5
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Interactions between Siglec-10 and α3β1 Integrin Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12671567/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sustained reductions in valine and isoleucine mediate anti-cancer pharmacological effects of inhibiting amino acid transporter LAT1 in cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12673697/
  61. 54.241.53.176 54.241.53.176
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    Extracellular vesicles from obese visceral adipose promote pancreatic cancer development and resistance to immune checkpoint blockade therapy
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  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IFN-γ-driven UBE2D3 upregulation impairs antigen presentation pathways and anti-tumor immunity in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12663187/
  64. Nov 2025
  65. www.sciencedirect.com www.sciencedirect.com
    Dynasore as a dual modulator of lipid rafts and cell death in pancreatic cancer
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    sciencedirect.com/science/article/pii/S1476558625001344
  66. www.nature.com www.nature.com
    KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2
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    nature.com/articles/s41467-025-66007-0
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A pentacyclic triterpene tormentic acid inhibits the proliferation and migration of pancreatic ductal adenocarcinoma cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12605405/
  68. 54.241.53.176 54.241.53.176
    2025.11.06.687028v2.full-html.html
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  70. Oct 2025
  71. www.sciencedirect.com www.sciencedirect.com
    Plakophilin 3 drives acinar cell transformation and promotes cancer initiation and progression in pancreas
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    sciencedirect.com/science/article/pii/S2211124725012586
  72. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202513552
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrated spatial morpho-transcriptomics predicts functional traits in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12533583/
  74. www.sciencedirect.com www.sciencedirect.com
    Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity
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    Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S1368764625001153
  77. www.science.org www.science.org
    Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer
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    science.org/doi/10.1126/scisignal.adu7145
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12484808/
  79. Sep 2025
  80. link.springer.com link.springer.com
    STYK1 as a targetable vulnerability enhances the efficacy of anti-PD-L1 therapy in pancreatic cancer
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    link.springer.com/article/10.1007/s00535-025-02291-3
  81. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202511726
  82. www.biorxiv.org www.biorxiv.org
    BOGO: A Proteome-Wide Gene Overexpression Platform for Discovering Rational Cancer Combination Therapies
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    biorxiv.org/content/10.1101/2025.09.02.673780v1
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    c-MYC mRNA destabilization inhibited lethal pancreatic cancer in vivo with significant survival outcomes
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  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of Sorting Nexin 10 accelerates KRAS-induced pancreatic tumorigenesis
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    Targeting the IRS1 macromolecular signaling node by Trienomycin a triggers cytoprotective autophagy in pancreatic adenocarcinoma
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    sciencedirect.com/science/article/pii/S0141813025081048
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multi-parametric magnetic resonance imaging evaluation of a novel ex ovo chick chorioallantoic membrane model for cancer research
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    pmc.ncbi.nlm.nih.gov/articles/PMC12397616/
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Stress and obesity signaling converge on CREB phosphorylation to promote pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875952/
  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HuR-regulated extracellular vesicles promote endothelial cell remodeling in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12405104/
  89. Aug 2025
  90. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer
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  91. 52.53.155.43 52.53.155.43
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    SP1-Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer
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