414 Matching Annotations
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    ARNTL2 promotes metastatic phenotypes through SERPINE1 transcription in KRAS G12D pancreatic cancer
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    sciencedirect.com/science/article/pii/S2589004226028580
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting PRMT5 inhibitor-induced adaptation in pancreatic cancer with the RBM39 degrader indisulam
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    pmc.ncbi.nlm.nih.gov/articles/PMC13530115/
  4. Aug 2026
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mitophagy-Competent Cancer-Associated Fibroblasts Fuel Chemoresistance by Rewiring Pyrimidine Metabolism in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13473869/
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    Targeting addiction to HMGB2-driven transcriptional programs in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2211124726007278
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    Engineered mechanosensitive MSCs enable synthetic radiotheranostic targeting across tumor types
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    sciencedirect.com/science/article/pii/S1934590926002754
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    Chrysosplenetin-induced TMED3 aggregation triggers unfolded protein response in pancreatic cancer
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    link.springer.com/article/10.1038/s44321-026-00506-5
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ERO1L induces macrophage infiltration to potentiate KrasG12D and inflammation-induced pancreatic tumorigenesis via oxidative protein folding of CCL2
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    pmc.ncbi.nlm.nih.gov/articles/PMC13479891/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Scalable MNase-seq Framework for Reproducible Nucleosome Profiling across Pluripotent Stem Cell and Cardiomyocyte Models
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    pmc.ncbi.nlm.nih.gov/articles/PMC13438036/
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    A stress-adaptive lipid kinase axis defines metabolic vulnerabilities in neuroendocrine prostate cancer
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    sciencedirect.com/science/article/pii/S1535610826003120
  12. Jul 2026
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acquisition of resistance to RAS inhibition is associated with the upregulation of macropinocytosis through both PI3K-dependent and -independent signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC13410306/
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    A single-component optogenetic toolkit for reversible visualization and programmable control of microtubule dynamics
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    sciencedirect.com/science/article/pii/S266723752600233X
  15. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    <fc>MicroRNA</fc>‐15a/16 regulate protein metabolism and are associated with clinical outcomes in pancreatic ductal adenocarcinoma
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    physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.71015
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    Mitochondria-targeted metformin analogs activate the ER stress-unfolded protein response pathway to drive apoptosis in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13372815/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ATM Deficiency Induces TGFβ-Mediated Stromal Programming in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13370118/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13343314/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibiting Fatty Acid Oxidation Reverses Autophagy-Mediated Acquired Chemotherapy Resistance in Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13324344/
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    Single-Cell and Multiomics Characterization of p21 in Cancer Progression and Therapeutic Sensitivity
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    onlinelibrary.wiley.com/doi/10.1155/humu/5598948
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    Exosomal microRNA-4800-3p in portal vein blood promotes liver metastasis in pancreatic cancer by targeting PLAA
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    nature.com/articles/s41598-026-48779-7
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    Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors
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    sciencedirect.com/science/article/pii/S1074761326002578
  23. 54.241.53.176 54.241.53.176
    koe-et-al-2026-n-linked-glycosylation-regulates-snat2-trafficking-and-stability-in-pancreatic-ductal-adenocarcinoma-html.html
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  24. Jun 2026
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    Mutant KRAS-driven selective mRNA translation reveals mechanisms and therapeutic vulnerabilities in cancer
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    sciencedirect.com/science/article/pii/S221112472600598X
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    The CD49b (ITGA2) collagen receptor excludes CD8+ T cell infiltration in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S2589004226018754
  27. aacrjournals.org aacrjournals.org
    Overcoming adaptive resistance to KRASG12D blockade in pancreatic cancer through vertical pathway inhibition
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    aacrjournals.org/clincancerres/article/32/11/2279/785357/Overcoming-Adaptive-Resistance-to-KRASG12D
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    Pancreatic cancer organoids recapitulate chemotherapy response and identify a potent cytotoxic T cell population
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    aacrjournals.org/clincancerres/article/32/3/596/772037/Pancreatic-Cancer-Organoids-Recapitulate
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A malignant subpopulation of H2AFZ+ cells interacts with myeloid cells to promote an anti-inflammatory microenvironment and drive hepatic metastasis, revealing an immunotherapeutic strategy for pancreatic ductal adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13266339/
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.70378
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    Mapping cell type-resolved transcriptomic profiles to patient survival in pancreatic cancer
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    sciencedirect.com/science/article/pii/S1535610826002576
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Protein Phosphatase Inhibitor LB100 Targets the Mesenchymal Lineage of Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13243779/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting HAS2 to enhance anti-tumor immunity in pancreatic cancer via PD-L1 regulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13237160/
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    SLC22A3/OCT3 drives serotonin-mediated stemness in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2211124726004651
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas
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    pmc.ncbi.nlm.nih.gov/articles/PMC13227558/
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    Pyrazolo-quinolinone suppresses epithelial–mesenchymal transition by targeting the CXCR4/NF-κB axis in human pancreatic cancer cells
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    sciencedirect.com/science/article/pii/S0344033826002001
  37. May 2026
  38. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Tumor-Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202520029
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    The Host Cell Factor Phosphatase-2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type-1
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202523697
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    Integrative multi-omics analysis identifies ATAD1 as a potential regulator of metastasis in pancreatic cancer
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    nature.com/articles/s41598-026-52051-3
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multiomics and Genomic Alteration Characterization Identifies VDAC1 as a Mitochondrial‐Associated Biomarker in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13150345/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RBM15-Mediated m6A Modification Regulates Proliferation and Migration of Pancreatic Cancer Cells via the lncRNA LINC01320/miR-1287-5p/FBXO11 Axis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13149094/
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    CFIm25-dependent alternative polyadenylation in AKT2 mRNA programs macrophage polarization
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    sciencedirect.com/science/article/pii/S2589004226011661
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    Vorinostat Potentiates Chemoimmunotherapy in Immune-Enriched Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202521844
  45. Apr 2026
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Engineering functionality-optimized fully human B7-H3 CAR T cells for enhanced solid tumor therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13198247/
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    GLIS3 marks a neural-like progenitor cell state that drives metastasis in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S221112472600392X
  48. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The Vitamin D3 Analog Calcipotriol Attenuates Pancreatic Cancer Malignancy via Downregulating Thrombospondin 1 in Pancreatic Stellate Cells
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    onlinelibrary.wiley.com/doi/10.1155/mi/2632235
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70455
  50. www.biorxiv.org www.biorxiv.org
    Mutant KRAS promotes NF-κB driven CCL20 chemokine expression in pancreatic ductal adenocarcinoma
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    biorxiv.org/content/10.64898/2026.04.13.717530v1
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    Loss of Regulator of G protein signaling 11 promotes pro-tumorigenic features in pancreatic cancer
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    aacrjournals.org/mcr/article/24/1/34/771151/Loss-of-Regulator-of-G-Protein-Signaling-11
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    mTORC1 activity suppresses ferroptosis through a SCARB1-dependent HDL-tocopherol uptake pathway
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    sciencedirect.com/science/article/pii/S1097276526001954
  53. 54.241.53.176 54.241.53.176
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  54. Mar 2026
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    Targeting PI3Kδ suppresses pancreatic cancer by dual disruption of fibrosis and immune evasion
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    sciencedirect.com/science/article/pii/S2211124726002664
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    A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy
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    sciencedirect.com/science/article/pii/S0092867426002692
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR-Drug Combinatorial Screening Identifies Effective Combination Treatments for MTAP-deleted cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13014710/
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    Cancer cell-derived sialylated IgG interacting with Siglec-7/9/10 is a potential immunotherapeutic target in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126000777
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Wild-type RAS signaling is an essential therapeutic target in RAS-mutated cancers
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    pmc.ncbi.nlm.nih.gov/articles/PMC12983336/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12970238/
  61. Feb 2026
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Placing purines in precision medicine: Targeting a metabolic reliance in KRAS-mutant tumors
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  63. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    An Insulin-Exosome-TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202515606
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    Syndecan-1-targeted therapeutic antibody impairs macropinocytosis and elicits antitumor immunity in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126000303
  65. 54.241.53.176 54.241.53.176
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  66. www.biorxiv.org www.biorxiv.org
    ADT-030, a novel PDE10 inhibitor, demonstrates potent antitumor activity in pancreatic ductal adenocarcinoma
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    biorxiv.org/content/10.64898/2026.02.11.705411v1
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    Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux
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    SERPINA3 mediates liver cancer cells escape from chemotherapy-induced neutrophil extracellular trap killing
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    sciencedirect.com/science/article/pii/S2211124726000343
  69. pubs.acs.org pubs.acs.org
    5′-NucA-SMCC-DM1 and 5′-NucA-SPDMV-DM1 are Potent Aptamer–Drug Conjugates against Pancreatic Cancer
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    pubs.acs.org/doi/full/10.1021/acsomega.5c11364
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Covalent modification of a glutamic acid inspired by HaloTag technology
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    pmc.ncbi.nlm.nih.gov/articles/PMC12864978/
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Synthesis of Benzopyrans and Quinolines with Nitrogenated Chain and Their Cytotoxicity Against Human Cancer Cell Lines
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    pmc.ncbi.nlm.nih.gov/articles/PMC12860552/
  72. Jan 2026
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CK2-mediated HDAC5 shuttling regulates DNA end resection through Ku70 deacetylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12846757/
  74. www.sciencedirect.com www.sciencedirect.com
    Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD+ to eradicate KRAS-driven AML
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    sciencedirect.com/science/article/pii/S155041312600001X
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Simultaneous targeting of KRAS and CDK4 synergistically induces durable growth arrest in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12847887/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combined action of suicide gene exosomes from pancreatic cancer-associated fibroblasts and from mesenchymal stem cells as a pancreatic ductal adenocarcinoma treatment approach
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    pmc.ncbi.nlm.nih.gov/articles/PMC12831315/
  77. www.sciencedirect.com www.sciencedirect.com
    Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers
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    sciencedirect.com/science/article/pii/S2666379125006500
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Circ72309 modulates gemcitabine metabolism and gemcitabine sensitivity in pancreatic cancer: Serum Circ72309 levels as a potential predictor of treatment response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12823056/
  79. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Basroparib inhibits YAP-driven cancers by stabilizing angiomotin
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70209
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    Multimodal profiling of pancreatic cancer reveals a TIMP-1-dominated secretory profile determining pro-tumor immunoinstruction in human cancers
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    sciencedirect.com/science/article/pii/S2666379125006196
  81. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Metabolic Reprogramming of T Cells by Dual UCP2 and IL-17 Blockade Enhances Immunity Against Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202513020
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting a Glutamic Acid in PDEδ with Fluoromethyl-Aryl Electrophiles Impairs K-Ras Signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC12833852/
  83. www.nature.com www.nature.com
    SLC6A14-mediated glutamine promotes SYTL4–CXCL8 axis activation to drive gemcitabine resistance and immune evasion in pancreatic cancer
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    nature.com/articles/s12276-025-01596-w
  84. Dec 2025
  85. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Mitochondrial VHL rewires cell metabolism in hypoxia
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    Anti-mitotic agent SB-216 overcomes taxane resistance in castration-resistant prostate cancer and exhibits anti-tumour efficacy in pancreatic cancer
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70294
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    Deprivation of EGFR signal causes senolysis in PDAC with CDK4/6 inhibition
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    nature.com/articles/s41418-025-01634-0
  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RAS mutation–specific responses to paralog- and state-selective RAS inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12710464/
  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Niclosamide nanoparticles enhance pancreatic cancer sensitivity to gemcitabine via HIF-1α inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12704315/
  90. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage
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    pmc.ncbi.nlm.nih.gov/articles/PMC12700215/
  91. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Study of the blood–brain barrier-penetrating KRAS G12C inhibitor JMKX1899 in KRAS G12C-mutated NSCLC with brain metastases
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    sciencedirect.com:5037/science/article/pii/S266700542500122X
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  189. Oct 2024
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  216. May 2024
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  224. Apr 2024
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