318 Matching Annotations
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    MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202513552
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    Integrated spatial morpho-transcriptomics predicts functional traits in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12533583/
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    Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity
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    sciencedirect.com/science/article/pii/S2211124725012045
  5. Oct 2025
  6. 54.241.53.176 54.241.53.176
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    Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S1368764625001153
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    Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer
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    science.org/doi/10.1126/scisignal.adu7145
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    DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12484808/
  10. Sep 2025
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    STYK1 as a targetable vulnerability enhances the efficacy of anti-PD-L1 therapy in pancreatic cancer
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    link.springer.com/article/10.1007/s00535-025-02291-3
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    Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma
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    BOGO: A Proteome-Wide Gene Overexpression Platform for Discovering Rational Cancer Combination Therapies
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    biorxiv.org/content/10.1101/2025.09.02.673780v1
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    c-MYC mRNA destabilization inhibited lethal pancreatic cancer in vivo with significant survival outcomes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12426058/
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    Loss of Sorting Nexin 10 accelerates KRAS-induced pancreatic tumorigenesis
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    Targeting the IRS1 macromolecular signaling node by Trienomycin a triggers cytoprotective autophagy in pancreatic adenocarcinoma
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    sciencedirect.com/science/article/pii/S0141813025081048
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    Multi-parametric magnetic resonance imaging evaluation of a novel ex ovo chick chorioallantoic membrane model for cancer research
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    pmc.ncbi.nlm.nih.gov/articles/PMC12397616/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Stress and obesity signaling converge on CREB phosphorylation to promote pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875952/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HuR-regulated extracellular vesicles promote endothelial cell remodeling in pancreatic cancer
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  20. Aug 2025
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    PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2211124725009702
  22. 52.53.155.43 52.53.155.43
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    SP1-Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202510071
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    Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance
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    ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11584292/
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    NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers
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    Integrated real-time imaging of executioner caspase dynamics, apoptosis-induced proliferation, and immunogenic cell death using a stable fluorescent reporter platform
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    pmc.ncbi.nlm.nih.gov/articles/PMC12328661/
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    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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    Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells
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    The urokinase receptor/uPAR is a major effector of p53 gain-of-function mutations in gemcitabine-treated pancreatic ductal adenocarcinoma
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    KRAS-driven pancreatic ductal adenocarcinoma cell lines harbour putative cancer stem cells
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  34. Jul 2025
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    Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers
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    Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
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    A STAT3/integrin axis accelerates pancreatic cancer initiation and progression
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    SenExo-cCCT2 Reprograms Senescence Response and Anti-Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma
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    CRO-67 has anti-cancer activity in pancreatic tumor cells and stromal cancer-associated fibroblasts
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    TP53 missense–specific transcriptional plasticity drives resistance against cell cycle inhibitors in pancreatic cancer
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    Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma
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    Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy
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  45. Jun 2025
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    Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy
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    EMT-associated bias in the Parsortix® system observed with pancreatic cancer cell lines
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    Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation
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    Efficacy of SOAT1 Inhibitors Against Pancreatic Cancer with TP53 Mutations
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    link.springer.com/article/10.1245/s10434-025-17482-8
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    Mechanism by which the molecular glue-like verteporfin induces IRE1α dimerization and activation to synergize with AKT inhibition in breast cancer
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    sciencedirect.com/science/article/pii/S2451945625001655
  53. May 2025
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    ILF3 mediates lipid metabolism to promote pancreatic cancer development by regulating CPT1A-activated PPARa signaling pathway
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    sciencedirect.com/science/article/pii/S0925443925002674
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    Pharmacologic ascorbate resistant pancreatic cancer demonstrates enhanced metastatic potential
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    sciencedirect.com/science/article/pii/S2213231725002071
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Induced mitochondrial deficit by NDUFS3 transient silencing reduces RAB7 expression and causes lysosomal dysfunction in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12079996/
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glecirasib, a Potent and Selective Covalent KRAS G12C Inhibitor Exhibiting Synergism with Cetuximab or SHP2 Inhibitor JAB-3312
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  60. Apr 2025
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    Cytosolic cytochrome c represses ferroptosis
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    CD44 Identified as a Diagnostic Biomarker for Highly Malignant CA19-9 Negative Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S0304383525002794
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    PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma
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  64. www.nature.com www.nature.com
    Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways
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    nature.com/articles/s41598-025-95766-5
  65. Mar 2025
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    Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202410718
  67. Feb 2025
  68. aacrjournals.org aacrjournals.org
    MR1 gene and protein expression are enhanced by inhibition of the extracellular signal-regulated kinase ERK
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    aacrjournals.org/cancerimmunolres/article/12/10/1452/748716/MR1-Gene-and-Protein-Expression-Are-Enhanced-by
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    The Selective WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Activity with KRASG12C Inhibitors in Preclinical Models
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  71. Jan 2025
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    Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis
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    sciencedirect.com/science/article/pii/S2666379125000011
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    Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11742192/
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    Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response in pancreatic cancer
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    Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation
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    Targeting macrophage circadian rhythms with microcurrent stimulation to activate cancer immunity through phagocytic defense
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  77. Dec 2024
  78. www.cell.com www.cell.com
    Mechanism of enhancing chemotherapy efficacy in pancreatic ductal adenocarcinoma with paricalcitol and hydroxychloroquine
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    cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00652-9
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    MIRO2 promotes cancer invasion and metastasis via MYO9B suppression of RhoA activity
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    cell.com/cell-reports/abstract/S2211-1247(24)01471-2
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    PEG-BCT-100 and Canavanine Synergistically Induce Apoptosis in Arginine Biosynthetic Enzyme-Deficient Pancreatic Cancer
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    aacrjournals.org/cancerrescommun/article/4/12/3180/750649/PEG-BCT-100-and-Canavanine-Synergistically-Induce
  81. Nov 2024
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    Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms
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    Biases in the Parsortix® system observed with pancreatic cancer cell lines
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    biorxiv.org/content/10.1101/2024.11.05.621344v1
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    Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment
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    sciencedirect.com/science/article/pii/S2211124724013238
  85. Oct 2024
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    Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer
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    sciencedirect.com/science/article/pii/S0092867424010729
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Blocking M2-Like Macrophage Polarization Using Decoy Oligodeoxynucleotide-Based Gene Therapy Prevents Immune Evasion for Pancreatic Cancer Treatment
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    ncbi.nlm.nih.gov/pmc/articles/PMC11443249/
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    Dual-hit strategy for therapeutic targeting of pancreatic cancer in patient-derived xenograft tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC11019863/
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    A High-Content Screen Identifies Drugs That Restrict Tumor Cell Extravasation across the Endothelial Barrier
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    aacrjournals.org/cancerres/article/81/3/619/648134/A-High-Content-Screen-Identifies-Drugs-That
  90. Sep 2024
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MicroRNA-26a-5p is a reliable biomarker in the adjuvant setting for pancreatic ductal adenocarcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11407630/
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    Hypoxia Abrogates Tumor-Suppressive Activities of C/EBPδ in Pancreatic Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11394991/
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    A common druggable signature of oncogenic c-Myc, mutant KRAS and mutant p53 reveals functional redundancy and competition among oncogenes in cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11365971/
  95. Aug 2024
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11326289/
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    The role of DPYD and the effects of DPYD suppressor luteolin combined with 5‐FU in pancreatic cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11331593/
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    TAS3681, an androgen receptor antagonist, prevents drug resistance driven by aberrant androgen receptor signaling in prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11306513/
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    A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer
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    HNF1A regulates oxaliplatin resistance in pancreatic cancer by targeting 53BP1
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  200. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  201. www.nature.com www.nature.com
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  202. Feb 2023
  203. www.sciencedirect.com www.sciencedirect.com
    Global profiling of AMG510 modified proteins identified tumor suppressor KEAP1 as an off-target
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  204. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  205. Jan 2023
  206. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  207. www.nature.com www.nature.com
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  208. www.mdpi.com www.mdpi.com
    Identification of Genes Associated with Liver Metastasis in Pancreatic Cancer Reveals PCSK6 as a Crucial Mediator
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  209. Dec 2022
  210. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  211. www.sciencedirect.com www.sciencedirect.com
    The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model
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  212. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  213. Nov 2022
  214. www.sciencedirect.com www.sciencedirect.com
    Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer
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  215. www.sciencedirect.com www.sciencedirect.com
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  216. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  217. Oct 2022
  218. aacrjournals.org aacrjournals.org
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  220. link.springer.com link.springer.com
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  221. Sep 2022
  222. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Original research: Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression
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  223. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EMT-induced gemcitabine resistance in pancreatic cancer involves the functional loss of equilibrative nucleoside transporter 1
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  224. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  225. Aug 2022
  226. insight.jci.org insight.jci.org
    Axon guidance receptor ROBO3 modulates subtype identity and prognosis via AXL-associated inflammatory network in pancreatic cancer
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  228. Jul 2022
  229. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KRAS mutant-driven SUMOylation controls extracellular vesicle transmission to trigger lymphangiogenesis in pancreatic cancer
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  230. onlinelibrary.wiley.com onlinelibrary.wiley.com
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  231. www.researchsquare.com www.researchsquare.com
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    Lipocalin-2 inhibits pancreatic cancer stemness via the AKT/c-Jun pathway
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  234. Jun 2022
  235. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Remediating Desmoplasia with EGFR-Targeted Photoactivable Multi-Inhibitor Liposomes Doubles Overall Survival in Pancreatic Cancer
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