340 Matching Annotations
  1. Last 7 days
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    Targeting a Glutamic Acid in PDEδ with Fluoromethyl-Aryl Electrophiles Impairs K-Ras Signaling
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    pubs.acs.org/doi/10.1021/acs.jmedchem.5c02082
  3. Jan 2026
  4. www.nature.com www.nature.com
    SLC6A14-mediated glutamine promotes SYTL4–CXCL8 axis activation to drive gemcitabine resistance and immune evasion in pancreatic cancer
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    nature.com/articles/s12276-025-01596-w
  5. Dec 2025
  6. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Mitochondrial VHL rewires cell metabolism in hypoxia
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    sciencedirect.com:5037/science/article/pii/S1550413125005273
  7. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Anti-mitotic agent SB-216 overcomes taxane resistance in castration-resistant prostate cancer and exhibits anti-tumour efficacy in pancreatic cancer
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70294
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    Deprivation of EGFR signal causes senolysis in PDAC with CDK4/6 inhibition
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    nature.com/articles/s41418-025-01634-0
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RAS mutation–specific responses to paralog- and state-selective RAS inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12710464/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Niclosamide nanoparticles enhance pancreatic cancer sensitivity to gemcitabine via HIF-1α inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12704315/
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    The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage
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    pmc.ncbi.nlm.nih.gov/articles/PMC12700215/
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    Study of the blood–brain barrier-penetrating KRAS G12C inhibitor JMKX1899 in KRAS G12C-mutated NSCLC with brain metastases
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    sciencedirect.com:5037/science/article/pii/S266700542500122X
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    DYRK1A regulates cancer cell and cancer-associated fibroblast secretomes to foster an immunosuppressive microenvironment in pancreatic cancer
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    biorxiv.org/content/10.1101/2025.11.26.690756v1
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    RASH3D19 mediates RAS activation through a positive feedback loop in KRAS-mutant cancer
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    nature.com/articles/s41556-025-01816-5
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Interactions between Siglec-10 and α3β1 Integrin Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12671567/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sustained reductions in valine and isoleucine mediate anti-cancer pharmacological effects of inhibiting amino acid transporter LAT1 in cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12673697/
  17. 54.241.53.176 54.241.53.176
    1-s2.0-S2589004225025647-main-html.html
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    Extracellular vesicles from obese visceral adipose promote pancreatic cancer development and resistance to immune checkpoint blockade therapy
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  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IFN-γ-driven UBE2D3 upregulation impairs antigen presentation pathways and anti-tumor immunity in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12663187/
  20. Nov 2025
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    Dynasore as a dual modulator of lipid rafts and cell death in pancreatic cancer
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    sciencedirect.com/science/article/pii/S1476558625001344
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    KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2
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    nature.com/articles/s41467-025-66007-0
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A pentacyclic triterpene tormentic acid inhibits the proliferation and migration of pancreatic ductal adenocarcinoma cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12605405/
  24. 54.241.53.176 54.241.53.176
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  26. Oct 2025
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    Plakophilin 3 drives acinar cell transformation and promotes cancer initiation and progression in pancreas
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    sciencedirect.com/science/article/pii/S2211124725012586
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    MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202513552
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    Integrated spatial morpho-transcriptomics predicts functional traits in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12533583/
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    Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity
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    Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma
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  33. www.science.org www.science.org
    Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer
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    science.org/doi/10.1126/scisignal.adu7145
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12484808/
  35. Sep 2025
  36. link.springer.com link.springer.com
    STYK1 as a targetable vulnerability enhances the efficacy of anti-PD-L1 therapy in pancreatic cancer
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    link.springer.com/article/10.1007/s00535-025-02291-3
  37. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma
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  38. www.biorxiv.org www.biorxiv.org
    BOGO: A Proteome-Wide Gene Overexpression Platform for Discovering Rational Cancer Combination Therapies
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    biorxiv.org/content/10.1101/2025.09.02.673780v1
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    c-MYC mRNA destabilization inhibited lethal pancreatic cancer in vivo with significant survival outcomes
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    Loss of Sorting Nexin 10 accelerates KRAS-induced pancreatic tumorigenesis
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    Targeting the IRS1 macromolecular signaling node by Trienomycin a triggers cytoprotective autophagy in pancreatic adenocarcinoma
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    sciencedirect.com/science/article/pii/S0141813025081048
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    Multi-parametric magnetic resonance imaging evaluation of a novel ex ovo chick chorioallantoic membrane model for cancer research
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    pmc.ncbi.nlm.nih.gov/articles/PMC12397616/
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    Stress and obesity signaling converge on CREB phosphorylation to promote pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875952/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HuR-regulated extracellular vesicles promote endothelial cell remodeling in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12405104/
  45. Aug 2025
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer
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  47. 52.53.155.43 52.53.155.43
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    SP1-Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202510071
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    Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance
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  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11584292/
  53. www.nature.com www.nature.com
    NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers
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    nature.com/articles/s41586-025-09299-y
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrated real-time imaging of executioner caspase dynamics, apoptosis-induced proliferation, and immunogenic cell death using a stable fluorescent reporter platform
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    pmc.ncbi.nlm.nih.gov/articles/PMC12328661/
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    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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    sciencedirect.com/science/article/pii/S1535610825003101
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    Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells
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    The urokinase receptor/uPAR is a major effector of p53 gain-of-function mutations in gemcitabine-treated pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S0021925825024123
  58. www.degruyterbrill.com www.degruyterbrill.com
    KRAS-driven pancreatic ductal adenocarcinoma cell lines harbour putative cancer stem cells
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    degruyterbrill.com/document/doi/10.1515/oncologie-2025-0171/html
  59. Jul 2025
  60. www.sciencedirect.com www.sciencedirect.com
    Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers
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    Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
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    science.org/doi/10.1126/science.adq8331
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    The role of RAB GTPases in predicting prognosis and therapy response in pancreatic cancer
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    A STAT3/integrin axis accelerates pancreatic cancer initiation and progression
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    SenExo-cCCT2 Reprograms Senescence Response and Anti-Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma
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    CRO-67 has anti-cancer activity in pancreatic tumor cells and stromal cancer-associated fibroblasts
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    nature.com/articles/s41598-025-09411-2
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    TP53 missense–specific transcriptional plasticity drives resistance against cell cycle inhibitors in pancreatic cancer
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    science.org/doi/10.1126/sciadv.adu2339
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    Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma
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    Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12189944/
  70. Jun 2025
  71. www.science.org www.science.org
    Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy
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    science.org/doi/10.1126/sciadv.adu9948
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    EMT-associated bias in the Parsortix® system observed with pancreatic cancer cell lines
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.70066
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    Protocol for RNA extraction from glioblastoma cell-line-derived spheroids embedded in atelocollagen gel guided by real-time imaging
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    Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation
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    Efficacy of SOAT1 Inhibitors Against Pancreatic Cancer with TP53 Mutations
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    link.springer.com/article/10.1245/s10434-025-17482-8
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    Mechanism by which the molecular glue-like verteporfin induces IRE1α dimerization and activation to synergize with AKT inhibition in breast cancer
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    sciencedirect.com/science/article/pii/S2451945625001655
  78. May 2025
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    ILF3 mediates lipid metabolism to promote pancreatic cancer development by regulating CPT1A-activated PPARa signaling pathway
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    Pharmacologic ascorbate resistant pancreatic cancer demonstrates enhanced metastatic potential
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    sciencedirect.com/science/article/pii/S2213231725002071
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Induced mitochondrial deficit by NDUFS3 transient silencing reduces RAB7 expression and causes lysosomal dysfunction in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12079996/
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glecirasib, a Potent and Selective Covalent KRAS G12C Inhibitor Exhibiting Synergism with Cetuximab or SHP2 Inhibitor JAB-3312
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  85. Apr 2025
  86. www.sciencedirect.com www.sciencedirect.com
    Cytosolic cytochrome c represses ferroptosis
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    CD44 Identified as a Diagnostic Biomarker for Highly Malignant CA19-9 Negative Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S0304383525002794
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    PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124725003122
  89. www.nature.com www.nature.com
    Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways
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    nature.com/articles/s41598-025-95766-5
  90. Mar 2025
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    Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202410718
  92. Feb 2025
  93. aacrjournals.org aacrjournals.org
    MR1 gene and protein expression are enhanced by inhibition of the extracellular signal-regulated kinase ERK
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    aacrjournals.org/cancerimmunolres/article/12/10/1452/748716/MR1-Gene-and-Protein-Expression-Are-Enhanced-by
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    The Selective WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Activity with KRASG12C Inhibitors in Preclinical Models
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  178. Dec 2023
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  185. Nov 2023
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  189. Oct 2023
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    Combined Targeting of NAD Biosynthesis and the NAD-dependent Transcription Factor C-terminal Binding Protein as a Promising Novel Therapy for Pancreatic Cancer
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  194. Sep 2023
  195. www.biorxiv.org www.biorxiv.org
    ELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
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  196. www.sciencedirect.com www.sciencedirect.com
    Deubiquitinating PABPC1 by USP10 upregulates CLK2 translation to promote tumor progression in pancreatic ductal adenocarcinoma
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  197. link.springer.com link.springer.com
    Use of Native-PAGE for the Identification of Epichaperomes in Cell Lines
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  198. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Removal of gemcitabine-induced senescent cancer cells by targeting glutaminase1 improves the therapeutic effect in pancreatic ductal adenocarcinoma
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34725
  199. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Collagen XVII regulates tumor growth in pancreatic cancer through interaction with the tumor microenvironment
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  200. 52.53.155.43 52.53.155.43
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  201. Aug 2023
  202. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression
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  203. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  204. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Palbociclib suppresses the cancer stem cell properties and cell proliferation through increased levels of miR-506 or miR-150 in Panc-1 and MiaPaCa-2 cells
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  205. Jul 2023
  206. www.sciencedirect.com www.sciencedirect.com
    Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy
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  207. Jun 2023
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    Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells
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    Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
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  210. aacrjournals.org aacrjournals.org
    Enhanced glutaminolysis drives hypoxia-induced chemoresistance in pancreatic cancer
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  212. May 2023
  213. www.nature.com www.nature.com
    Roundabout homolog 1 inhibits proliferation via the YY1-ROBO1-CCNA2-CDK2 axis in human pancreatic cancer
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    KMT2D links TGF-β signaling to noncanonical activin pathway and regulates pancreatic cancer cell plasticity
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  215. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors
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  217. Apr 2023
  218. link.springer.com link.springer.com
    Activation of Vitamin D/VDR Signaling Reverses Gemcitabine Resistance of Pancreatic Cancer Cells Through Inhibition of MUC1 Expression
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  219. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950
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  220. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  221. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    A group of novel VEGF splice variants as alternative therapeutic targets in renal cell carcinoma
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  223. Mar 2023
  224. www.spandidos-publications.com www.spandidos-publications.com
    HNF1A regulates oxaliplatin resistance in pancreatic cancer by targeting 53BP1
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  225. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZL-1211 Exhibits Robust Antitumor Activity by Enhancing ADCC and Activating NK Cell–mediated Inflammation in CLDN18.2-High and -Low Expressing Gastric Cancer Models
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  226. www.nature.com www.nature.com
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  227. Feb 2023
  228. www.sciencedirect.com www.sciencedirect.com
    Global profiling of AMG510 modified proteins identified tumor suppressor KEAP1 as an off-target
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  229. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stress Granules determine the Development of Obesity-associated Pancreatic Cancer
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  230. Jan 2023
  231. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PhAc-ALGP-Dox, a Novel Anticancer Prodrug with Targeted Activation and Improved Therapeutic Index
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  232. www.nature.com www.nature.com
    NF-κB/RelA controlled A20 limits TRAIL-induced apoptosis in pancreatic cancer
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  233. www.mdpi.com www.mdpi.com
    Identification of Genes Associated with Liver Metastasis in Pancreatic Cancer Reveals PCSK6 as a Crucial Mediator
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