239 Matching Annotations
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  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Slap restricts oncogenic Src-family kinase signaling to maintain colonic epithelial homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13553065/
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    Structure-dependent interactions of bile acids with ACE2 and FXR-associated modulation of ACE2 expression: an in vitro comparative study related to SARS-CoV-2 entry
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    sciencedirect.com/science/article/pii/S2212429226017682
  4. Aug 2026
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    Pentachlorophenol enhances bladder cancer cell invasion through altered protein stability
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    sciencedirect.com/science/article/pii/S2589004226027355
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    Viral mimicry redirects immunosuppressed colorectal tumour landscapes towards a proinflammatory and CMS1-like regenerative state
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    pmc.ncbi.nlm.nih.gov/articles/PMC13486658/
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    CDK8/19 inhibition prevents adaptive resistance to CDK4/6 inhibitors in vitro and in vivo
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    sciencedirect.com/science/article/pii/S2666379126004210
  8. Jul 2026
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pharmacologic Activation of TRPA1 Induces Multi-Target Anticancer Responses via Apoptotic and Mitochondrial Pathways
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    pmc.ncbi.nlm.nih.gov/articles/PMC13414800/
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    DHODH is a synthetic lethal target in PIK3CA-mutant colorectal cancer
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    sciencedirect.com/science/article/pii/S2211124726007977
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    SOCS5 suppresses antitumor immunity in colorectal cancer by promoting IFNAR1 ubiquitylation and type I interferon response
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    sciencedirect.com/science/article/pii/S0925443926002309
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 Overexpression Abrogates ST6GAL1 Mediated Rectal Cancer Chemoradiation Resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC13321710/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A whole genomic CRISPR-Cas9 screen identifies the amino acid transporter SLC43A1 (LAT3) as a major determinant of oxaliplatin sensitivity in colorectal cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC13317012/
  14. Jun 2026
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DDR1 Promotes Immune Evasion in Colorectal Cancer by Orchestrating IL33-Mediated M2-like Polarization of Tumor-Associated Macrophages
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    pmc.ncbi.nlm.nih.gov/articles/PMC13227095/
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    Repurposing Artesunate to Combat Progression and Metastasis via Targeting Circulating Tumor Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC13223190/
  17. May 2026
  18. www.sciencedirect.com www.sciencedirect.com
    Targeting EP2/EP4-driven expansion of suppressive VSIG4high macrophages overcomes immunotherapy resistance in colorectal cancer
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    sciencedirect.com/science/article/pii/S2211124726005280
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Non-Temperature-Induced Antitumor Effects of Amplitude-Modulated Radiofrequency: Molecular and Functional Synergies with Radiotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13204345/
  20. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Molecular Mechanism of NSUN6-Mediated Epigenetic Modifications in the Malignant Progression of Colorectal Cancer Cells
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    faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202600351R
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    Synergistic Anticancer Effects of Akkermansia muciniphila Combined With 5-Fluorouracil Through BAX/BCL2 Dependent Apoptosis in Colorectal Cancer Cells
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    Metabolic stress conditions dictate MAPKAPK2-dependent efficiency of MEK1/2 inhibition in colorectal carcinoma
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  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Comparison of sterilisation methods for deer velvet antler extracts and their impact on anticancer activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC13136180/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Subcellular Redistribution of Endomembrane GPR15 Promotes NAD+-Mediated Metabolic Reprogramming and Boosts 5-FU Chemosensitivity in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13136880/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IFITM1-targeted NIR-II fluorescence imaging enables visualisation of colorectal cancer and metastatic lymph nodes
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    pmc.ncbi.nlm.nih.gov/articles/PMC13134288/
  26. Apr 2026
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Folate promotes colorectal cancer progression by impairing CD8+ T cell function and recruitment via SLC19A1/p-AKT/NOTCH1 axis and CCL5 downregulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13101128/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protocol to identify covalent inhibitors targeting RhoA Cys16
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    pmc.ncbi.nlm.nih.gov/articles/PMC13092739/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Role of Ca2+‐Dependent Epithelial‐Mesenchymal Transition in Malignant Progression of Colorectal Cancer: Special Focus on REG Iα/EDNRB
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    pmc.ncbi.nlm.nih.gov/articles/PMC13072048/
  30. aacrjournals.org aacrjournals.org
    TUB-040, a Homogeneous and Hydrophilic NaPi2b-Targeting ADC with Stably Linked Exatecan, Exhibits Long-lasting Antitumor Activity and a Well-Tolerated Safety Profile
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    aacrjournals.org/mct/article/24/11/1685/766863/TUB-040-a-Homogeneous-and-Hydrophilic-NaPi2b
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13042376/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    AURKA-mediated destabilization of SAPS3 drives ferroptosis evasion via 7-dehydrocholesterol biosynthesis in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13039981/
  33. Mar 2026
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    A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy
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  35. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202516557
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    Early-stage multi-cancer detection through a plasma extracellular vesicle protein signature
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    Engineered pistol ribozymes selectively target KRAS G12V with enhanced efficacy by capping modification
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  38. www.science.org www.science.org
    Amino acid supplementation enhances in vivo efficacy of lipid nanoparticle–mediated mRNA delivery in preclinical models
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    science.org/doi/10.1126/scitranslmed.adx4097
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    Nigakinone enhances FXR expression to synergize with irinotecan in suppressing colorectal cancer cells and xenografts
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    sciencedirect.com/science/article/pii/S0006295226002376
  40. Feb 2026
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KRASG12V/HLA-A*02:01–targeted chimeric antigen receptor T cells exhibit potent preclinical activity against solid tumors
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  42. www.science.org www.science.org
    KRASG12V/HLA-A*02:01–targeted chimeric antigen receptor T cells exhibit potent preclinical activity against solid tumors
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    science.org/doi/10.1126/sciadv.aea2511
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    Discovery of novel coumarin-containing triazolo[1,5-a]pyrimidine derivatives as potent ABCB1 inhibitor for modulation of multidrug resistance
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  44. www.tandfonline.com www.tandfonline.com
    Discovery of novel coumarin-containing triazolo[1,5-a]pyrimidine derivatives as potent ABCB1 inhibitor for modulation of multidrug resistance
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    tandfonline.com/doi/abs/10.1080/14756366.2026.2629074
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    A comprehensive review of anti-colorectal cancer alkaloids from traditional Chinese medicine: Sources, chemical structures, mechanisms and therapeutic applications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70343
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    Colorectal cancer-derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver
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  47. Jan 2026
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Thimerosal Inhibits Tumor Malignant Progression through Direct Action and Enhancing the Efficacy of PD-1-Based Immunotherapy
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  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    USP10-mediated deubiquitination and activation of KRAS mutants promotes colorectal cancer via a novel USP10/KRAS positive feedback circuit
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    pmc.ncbi.nlm.nih.gov/articles/PMC12827889/
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    Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers
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    sciencedirect.com/science/article/pii/S2666379125006500
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A single-cell derived spheroid approach to dissect intratumoural heterogeneity in colorectal cancer: cell lines show changes in proteomes and therapeutic response to 5-FU
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    pmc.ncbi.nlm.nih.gov/articles/PMC12831780/
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    Expanding the payload scope in antibody-drug conjugates by delivery of hydroxy-containing drugs through self-immolative phosphoramidates
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    Basroparib inhibits YAP-driven cancers by stabilizing angiomotin
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70209
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    Immune gene diversity and STING1 variants in shaping cancer immunity across different genetic ancestry populations
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    pmc.ncbi.nlm.nih.gov/articles/PMC13019158/
  55. www.biorxiv.org www.biorxiv.org
    A Novel miR-4745-KLC2 Axis Regulates Cancer Stem Cell Traits in Colorectal Cancer
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    biorxiv.org/content/10.64898/2026.01.07.697660v2
  56. www.jstage.jst.go.jp www.jstage.jst.go.jp
    IFI6 Downregulation Reverses Oxaliplatin Resistance of Colorectal Cancer Cells by Activating the ROS-Induced p38MAPK Signaling Pathway
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    Itaconate‐Related Gene Signatures as Prognostic Markers in Colon Cancer: Insights From Transcriptomic and Spatial Analysis
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  59. Dec 2025
  60. www.sciencedirect.com www.sciencedirect.com
    A TRIM21–UCHL3–ITCH–SIPA1 axis promotes colorectal cancer growth and metastasis
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    sciencedirect.com/science/article/pii/S0304383525007931
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    KRT81 promotes metastasis of colorectal cancer by acting as a protein scaffold for ezrin
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  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RAS mutation–specific responses to paralog- and state-selective RAS inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12710464/
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    Machine learning-based development of a cytotoxicity prediction model for NK cell therapy in cancers
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    Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole-3-Acetic Acid
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    Nuclear translocation of Cx43 promotes to CRC progression and associates with β-catenin accumulation
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    Genome-Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle-Mediated siRNA Delivery
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202517617
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    Single-cell glycome and transcriptome profiling enabled by a library of anti-glycan antibodies
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    sciencedirect.com:5037/science/article/pii/S2451945625003769
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    Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R-Loop Accumulation and DNA Repair Deficiencies
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202512074
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    v17p0074-html.html
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  70. Nov 2025
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12616247/
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    USP10-mediated deubiquitination and activation of KRAS mutants promotes colorectal cancer via a novel USP10/KRAS positive feedback circuit
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    pmc.ncbi.nlm.nih.gov/articles/PMC12827889/
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    CDC7 stabilized by KRAS signaling reactivation impairs chemosensitivity in KRAS-mutant colorectal cancer
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    sciencedirect.com/science/article/pii/S1043661825004529
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cytoplasmic HMGB1 promotes and interacts with BECN1 through ZNF460 to induce autophagy and accelerate radioresistance in colorectal cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12558843/
  75. Oct 2025
  76. www.sciencedirect.com www.sciencedirect.com
    Hotspot mutant p53-R273H enhances mitochondrial biogenesis and cell migration in primary colorectal cancer in response to oxaliplatin
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    sciencedirect.com/science/article/pii/S0167488925001788
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    Purinergic Ecto-Enzyme CD73 is a Context-Dependent Tumor Suppressor in Colorectal Cancer
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    sciencedirect.com/science/article/pii/S0021925825027164
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    Development of the FGFR4-ADC bearing the ferroptosis inducer sulfasalazine for hepatocellular carcinoma
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    sciencedirect.com/science/article/pii/S2589004225019790
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    Phase separation of circCHD6-encoded 216aa protein promotes colorectal cancer metastasis
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    sciencedirect.com/science/article/pii/S0141813025089792
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    Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties
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    sciencedirect.com/science/article/pii/S2666379125004847
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Role of NOL3 in Colon Adenocarcinoma Metastasis and Its Association With DNA Methylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12488313/
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    CD169+ macrophages identify and eliminate tumor cells in colorectal cancer through CD169/CD43 interaction and FasL-driven apoptosis
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    sciencedirect.com/science/article/pii/S2211124725011222
  83. Sep 2025
  84. www.biorxiv.org www.biorxiv.org
    Dual EZH1/2 inhibition enhances DNMT inhibitor efficacy in colon cancer through targeting H3K27me1
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    biorxiv.org/content/10.1101/2025.09.16.676613v1
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    sciencedirect.com/science/article/pii/S2666379125004367
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    A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2
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    nature.com/articles/s41587-025-02793-8
  87. www.sciencedirect.com www.sciencedirect.com
    Knockdown of translocon-associated protein subunit beta (TRAPβ) stimulates cell cycle arrest and apoptosis in human colorectal cancer cells
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    sciencedirect.com/science/article/pii/S0167488925001624
  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875910/
  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Wnt10b signaling regulates replication stress–induced chromosomal instability in human cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12373720/
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    A covalent inhibitor targeting Cys16 on RhoA in colorectal cancer
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    sciencedirect.com/science/article/pii/S2451945625002557
  91. Aug 2025
  92. www.sciencedirect.com www.sciencedirect.com
    YTHDF proteins and m6A-RNA clients undergo autophagic turnover during contact inhibition
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    sciencedirect.com/science/article/pii/S2211124725009593
  93. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tissue-dependent mechanosensing by cells derived from human tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12328224/
  94. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transcript PHF19-207 May Be a Long Non-Coding RNA with Tumor-Promoting Role in Colon Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12292646/
  95. Jul 2025
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  210. Nov 2022
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  217. Sep 2022
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  224. Jun 2022
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  229. Apr 2022
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  236. Dec 2021
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  239. Oct 2021
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  242. Sep 2021
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  244. Aug 2021
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  249. Jul 2021
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  253. May 2021
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