184 Matching Annotations
  1. Last 7 days
  2. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Genome-Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle-Mediated siRNA Delivery
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202517617
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    Single-cell glycome and transcriptome profiling enabled by a library of anti-glycan antibodies
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    sciencedirect.com:5037/science/article/pii/S2451945625003769
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    Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R-Loop Accumulation and DNA Repair Deficiencies
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202512074
  5. Dec 2025
  6. 54.241.53.176 54.241.53.176
    v17p0074-html.html
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  7. Nov 2025
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12616247/
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    USP10-mediated deubiquitination and activation of KRAS mutants promotes colorectal cancer via a novel USP10/KRAS positive feedback circuit
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    sciencedirect.com/science/article/pii/S2211383525007452
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    CDC7 stabilized by KRAS signaling reactivation impairs chemosensitivity in KRAS-mutant colorectal cancer
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    sciencedirect.com/science/article/pii/S1043661825004529
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    Cytoplasmic HMGB1 promotes and interacts with BECN1 through ZNF460 to induce autophagy and accelerate radioresistance in colorectal cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12558843/
  12. Oct 2025
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    Hotspot mutant p53-R273H enhances mitochondrial biogenesis and cell migration in primary colorectal cancer in response to oxaliplatin
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    sciencedirect.com/science/article/pii/S0167488925001788
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    Purinergic Ecto-Enzyme CD73 is a Context-Dependent Tumor Suppressor in Colorectal Cancer
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    sciencedirect.com/science/article/pii/S0021925825027164
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    Development of the FGFR4-ADC bearing the ferroptosis inducer sulfasalazine for hepatocellular carcinoma
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    sciencedirect.com/science/article/pii/S2589004225019790
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    Phase separation of circCHD6-encoded 216aa protein promotes colorectal cancer metastasis
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    sciencedirect.com/science/article/pii/S0141813025089792
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    Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties
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    sciencedirect.com/science/article/pii/S2666379125004847
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    The Role of NOL3 in Colon Adenocarcinoma Metastasis and Its Association With DNA Methylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12488313/
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    CD169+ macrophages identify and eliminate tumor cells in colorectal cancer through CD169/CD43 interaction and FasL-driven apoptosis
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    sciencedirect.com/science/article/pii/S2211124725011222
  20. Sep 2025
  21. www.biorxiv.org www.biorxiv.org
    Dual EZH1/2 inhibition enhances DNMT inhibitor efficacy in colon cancer through targeting H3K27me1
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    biorxiv.org/content/10.1101/2025.09.16.676613v1
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    sciencedirect.com/science/article/pii/S2666379125004367
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    A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2
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    nature.com/articles/s41587-025-02793-8
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    Knockdown of translocon-associated protein subunit beta (TRAPβ) stimulates cell cycle arrest and apoptosis in human colorectal cancer cells
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  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Wnt10b signaling regulates replication stress–induced chromosomal instability in human cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12373720/
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    A covalent inhibitor targeting Cys16 on RhoA in colorectal cancer
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    sciencedirect.com/science/article/pii/S2451945625002557
  28. Aug 2025
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    YTHDF proteins and m6A-RNA clients undergo autophagic turnover during contact inhibition
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    Tissue-dependent mechanosensing by cells derived from human tumors
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  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transcript PHF19-207 May Be a Long Non-Coding RNA with Tumor-Promoting Role in Colon Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12292646/
  32. Jul 2025
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel MIR100HG transcript enhances tumorigenesis by inducing BCLAF1-mediated alternative splicing in colorectal cancer
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    Mediator Kinase Inhibitor Selectivity and Activity in Colorectal Cancer
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    pubs.acs.org/doi/full/10.1021/acschembio.5c00338
  35. www.biorxiv.org www.biorxiv.org
    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    biorxiv.org/content/10.1101/2025.06.18.660406v1
  36. Jun 2025
  37. www.cell.com www.cell.com
    BAG2 releases SAMD4B upon sensing of arginine deficiency to promote tumor cell survival
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    Hyperacute response proteins synthesized on γ-tubulin-FTO-MARK4 translation microdomains regulate cancer’s acute stress response
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    sciencedirect.com/science/article/pii/S2211124725006424
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    Modulating autophagy in KRAS mutant colorectal cancer using combination of oncolytic reovirus and carbamazepine
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    Ribosomal RNA transcription regulates splicing through ribosomal protein RPL22
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    sciencedirect.com/science/article/pii/S2451945625001734
  42. May 2025
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    Generation of T cell responses against broad KRAS hotspot neoantigens for cell therapy or TCR discovery
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    sciencedirect.com/science/article/pii/S2667237525000852
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    Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer
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  45. Apr 2025
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    A new EGFR and c-Met bispecific NIR-II fluorescent probe for visualising colorectal cancer and metastatic lymph nodes
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    Streptomycin targets tumor-initiating cells by disrupting oxidative phosphorylation
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  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    N6-methyladenosine in DNA promotes genome stability
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    An Aurora kinase A-BOD1L1-PP2A B56 axis promotes chromosome segregation fidelity
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    Augmenting CAR T Cell Functions with LIGHT
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    pmc.ncbi.nlm.nih.gov/articles/PMC11444887/
  52. Mar 2025
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ORMDL3 restrains type I interferon signaling and anti-tumor immunity by promoting RIG-I degradation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11932694/
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    Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells
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  55. Feb 2025
  56. 52.53.155.43 52.53.155.43
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    The integrative genomic and functional immunological analyses of colorectal cancer initiating cells to modulate stemness properties and the susceptibility to immune responses
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    link.springer.com/article/10.1186/s12967-025-06176-0
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    Identification of Lipid Species Signatures in FOLFOXIRI-Resistant Colorectal Cancer Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11818583/
  59. aacrjournals.org aacrjournals.org
    Serotonin receptor HTR2B facilitates colorectal cancer metastasis via CREB1-ZEB1 axis mediated epithelial-mesenchymal transition
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    aacrjournals.org/mcr/article/22/6/538/745428/Serotonin-Receptor-HTR2B-Facilitates-Colorectal
  60. Jan 2025
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Missense Mutant p53 Transactivates Wnt/β-Catenin Signaling in Neighboring p53-Destabilized Cells through the COX-2/PGE2 Pathway
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    Unraveling the mechanism of microRNA-134 in colon cancer progression: targeting KRAS and PIK3CA for cell cycle control and histone deacetylase regulation.
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    sciencedirect.com/science/article/pii/S0014482724004762
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    IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth
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    sciencedirect.com/science/article/pii/S2211124724014670
  64. Dec 2024
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11601497/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer
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    Anti-Colon Cancer Effects of Lysate from Potential Probiotic Yeast Strains Derived from Human Breast Milk
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    link.springer.com/article/10.1007/s12602-024-10410-4
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    p53 induces circFRMD4A to suppress cancer development through glycolytic reprogramming and cuproptosis
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    sciencedirect.com/science/article/pii/S1097276524009183
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    B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies
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  70. Oct 2024
  71. aacrjournals.org aacrjournals.org
    NK Receptor Signaling Lowers TCR Activation Threshold, Enhancing Selective Recognition of Cancer Cells by TAA-Specific CTLs
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    aacrjournals.org/cancerimmunolres/article/12/10/1421/748722/NK-Receptor-Signaling-Lowers-TCR-Activation
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    2-Hydroxylation of Fatty Acids Represses Colorectal Tumorigenesis and Metastasis via the YAP Transcriptional Axis
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    aacrjournals.org/cancerres/article/81/2/289/649623/2-Hydroxylation-of-Fatty-Acids-Represses
  73. Sep 2024
  74. www.biorxiv.org www.biorxiv.org
    Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer
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    biorxiv.org/content/10.1101/2024.09.05.611458v1
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    Comprehensive Proteogenomic Profiling Reveals the Molecular Characteristics of Colorectal Cancer at Distinct Stages of Progression
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  76. Aug 2024
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    HTS384 NCI60: The Next Phase of the NCI60 Screen
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    The SW480 cell line as a model of resident and migrating colon cancer stem cells
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    Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer
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    aacrjournals.org/mct/article/22/8/962/727921/Vincristine-Enhances-the-Efficacy-of-MEK
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    Small-molecule NSC59984 induces mutant p53 degradation through a ROS-ERK2-MDM2 axis in cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8983457/
  82. Jul 2024
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    NAMPT-targeting PROTAC and nicotinic acid co-administration elicit safe and robust anti-tumor efficacy in NAPRT-deficient pan-cancers
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    Cell-cell contact-dependent secretion of large-extracellular vesicles from EFNBhigh cancer cells accelerates peritoneal dissemination
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    Identification and characterization of TM4SF1+ tumor self-seeded cells
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  86. Jun 2024
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    Potentially functional genetic variants in interferon regulatory factor family genes are associated with colorectal cancer survival
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  88. May 2024
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  90. Apr 2024
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 screening identifies INTS3 as an anti-apoptotic RNA-binding protein and therapeutic target for colorectal cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11043890/
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    Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.14861
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    Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome
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    sciencedirect.com/science/article/pii/S221112472400439X
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13645
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    Novel diarylated tacrine derivatives: Synthesis, characterization, anticancer, antiepileptic, antibacterial, and antifungal activities
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    onlinelibrary.wiley.com/doi/10.1002/jbt.23706
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    Downregulation of ABCC3 activates MAPK signaling through accumulation of deoxycholic acid in colorectal cancer cells
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    onlinelibrary.wiley.com/doi/10.1111/cas.16132
  99. Mar 2024
  100. www.sciencedirect.com www.sciencedirect.com
    Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling
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  101. 52.53.155.43 52.53.155.43
    Eosinophils exhibit a unique transcriptional signature and increased sensitivity to IL-3-induced activation in response to colorectal cancer cells
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  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reduced chemokine C‐C motif ligand 1 expression may negatively regulate colorectal cancer progression at liver metastatic sites
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    ncbi.nlm.nih.gov/pmc/articles/PMC10952021/
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    FEBS Press
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  104. Feb 2024
  105. aacrjournals.org aacrjournals.org
    First-in-Human Study with preclinical data of BCL-2/BCL-xL Inhibitor Pelcitoclax in Locally Advanced or Metastatic Solid Tumors
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  220. Aug 2020
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    Zinc-finger antiviral protein acts as a tumor suppressor in colorectal cancer
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    nature.com/articles/s41388-020-01416-7
  222. www.sciencedirect.com www.sciencedirect.com
    Organoid modelling identifies that DACH1 functions as a tumour promoter in colorectal cancer by modulating BMP signalling
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    sciencedirect.com/science/article/pii/S2352396420301754
  223. cancerres.aacrjournals.org cancerres.aacrjournals.org
    CoA Synthase (COASY) mediates radiation resistance via PI3K signaling in rectal cancer
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    cancerres.aacrjournals.org/content/80/2/334
  224. Jan 2020
  225. www.sciencedirect.com www.sciencedirect.com
    PTPS Facilitates Compartmentalized LTBP1 S-Nitrosylation and Promotes Tumor Growth under Hypoxia
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    sciencedirect.com/science/article/pii/S1097276519307233
  226. www.sciencedirect.com www.sciencedirect.com
    Ethanol promotes alcohol-related colorectal cancer metastasis via the TGF-β/RUNX3/Snail axis by inducing TGF-β1 upregulation and RUNX3 cytoplasmic mislocalization
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    sciencedirect.com/science/article/pii/S2352396419307522
  227. www.sciencedirect.com www.sciencedirect.com
    Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer
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    sciencedirect.com/science/article/pii/S1535610819302557
  228. Apr 2019
  229. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TP53 drives invasion through expression of its Δ133p53β variant
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    ncbi.nlm.nih.gov/pmc/articles/PMC5067115/
  230. Nov 2018
  231. www.sciencedirect.com www.sciencedirect.com
    A Short Tandem Repeat-Enriched RNA Assembles a Nuclear Compartment to Control Alternative Splicing and Promote Cell Survival
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    sciencedirect.com/science/article/pii/S1097276518307019
  232. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy
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    ncbi.nlm.nih.gov/pmc/articles/PMC6173768/
  233. www.sciencedirect.com www.sciencedirect.com
    The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer
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    sciencedirect.com/science/article/pii/S235239641830241X
  234. www.sciencedirect.com www.sciencedirect.com
    PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis
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    sciencedirect.com/science/article/pii/S1534580718301059
  235. www.sciencedirect.com www.sciencedirect.com
    A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth
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    sciencedirect.com/science/article/pii/S1097276517306664
  236. Nov 2017
  237. elifesciences.org elifesciences.org
    Affimer proteins are versatile and renewable affinity reagents
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    elifesciences.org/articles/24903
  238. www.sciencedirect.com www.sciencedirect.com
    CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes
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    sciencedirect.com/science/article/pii/S1535610817301605
  239. www.sciencedirect.com www.sciencedirect.com
    Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature
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    sciencedirect.com/science/article/pii/S1535610817301010
  240. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases
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    ncbi.nlm.nih.gov/pmc/articles/PMC5224920/
  241. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC5127641/