194 Matching Annotations
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    A Novel miR-4745-KLC2 Axis Regulates Cancer Stem Cell Traits in Colorectal Cancer
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    biorxiv.org/content/10.64898/2026.01.07.697660v2
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    IFI6 Downregulation Reverses Oxaliplatin Resistance of Colorectal Cancer Cells by Activating the ROS-Induced p38MAPK Signaling Pathway
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    jstage.jst.go.jp/article/bpb/46/1/46_b22-00439/_html/-char/en
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    Itaconate‐Related Gene Signatures as Prognostic Markers in Colon Cancer: Insights From Transcriptomic and Spatial Analysis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12790287/
  5. Jan 2026
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    Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer
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    sciencedirect.com/science/article/pii/S266637912500607X
  7. Dec 2025
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    A TRIM21–UCHL3–ITCH–SIPA1 axis promotes colorectal cancer growth and metastasis
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    sciencedirect.com/science/article/pii/S0304383525007931
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    KRT81 promotes metastasis of colorectal cancer by acting as a protein scaffold for ezrin
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    nature.com/articles/s41388-025-03665-w
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    RAS mutation–specific responses to paralog- and state-selective RAS inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12710464/
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    Machine learning-based development of a cytotoxicity prediction model for NK cell therapy in cancers
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    Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole-3-Acetic Acid
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    Nuclear translocation of Cx43 promotes to CRC progression and associates with β-catenin accumulation
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    Genome-Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle-Mediated siRNA Delivery
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202517617
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    Single-cell glycome and transcriptome profiling enabled by a library of anti-glycan antibodies
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    Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R-Loop Accumulation and DNA Repair Deficiencies
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  18. Nov 2025
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression
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    USP10-mediated deubiquitination and activation of KRAS mutants promotes colorectal cancer via a novel USP10/KRAS positive feedback circuit
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    sciencedirect.com/science/article/pii/S2211383525007452
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    CDC7 stabilized by KRAS signaling reactivation impairs chemosensitivity in KRAS-mutant colorectal cancer
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    Cytoplasmic HMGB1 promotes and interacts with BECN1 through ZNF460 to induce autophagy and accelerate radioresistance in colorectal cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12558843/
  23. Oct 2025
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    Hotspot mutant p53-R273H enhances mitochondrial biogenesis and cell migration in primary colorectal cancer in response to oxaliplatin
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    Purinergic Ecto-Enzyme CD73 is a Context-Dependent Tumor Suppressor in Colorectal Cancer
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    Development of the FGFR4-ADC bearing the ferroptosis inducer sulfasalazine for hepatocellular carcinoma
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    Phase separation of circCHD6-encoded 216aa protein promotes colorectal cancer metastasis
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    Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties
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    CD169+ macrophages identify and eliminate tumor cells in colorectal cancer through CD169/CD43 interaction and FasL-driven apoptosis
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  31. Sep 2025
  32. www.biorxiv.org www.biorxiv.org
    Dual EZH1/2 inhibition enhances DNMT inhibitor efficacy in colon cancer through targeting H3K27me1
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    Knockdown of translocon-associated protein subunit beta (TRAPβ) stimulates cell cycle arrest and apoptosis in human colorectal cancer cells
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    Wnt10b signaling regulates replication stress–induced chromosomal instability in human cancer
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    A covalent inhibitor targeting Cys16 on RhoA in colorectal cancer
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  39. Aug 2025
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    YTHDF proteins and m6A-RNA clients undergo autophagic turnover during contact inhibition
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    Transcript PHF19-207 May Be a Long Non-Coding RNA with Tumor-Promoting Role in Colon Cancer
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  43. Jul 2025
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    A novel MIR100HG transcript enhances tumorigenesis by inducing BCLAF1-mediated alternative splicing in colorectal cancer
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    Cetuximab increases LGR5 expression and augments LGR5-targeting antibody-drug conjugate efficacy in patient-derived colorectal cancer models
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    biorxiv.org/content/10.1101/2025.06.18.660406v1
  47. Jun 2025
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    BAG2 releases SAMD4B upon sensing of arginine deficiency to promote tumor cell survival
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    Hyperacute response proteins synthesized on γ-tubulin-FTO-MARK4 translation microdomains regulate cancer’s acute stress response
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    Modulating autophagy in KRAS mutant colorectal cancer using combination of oncolytic reovirus and carbamazepine
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    Ribosomal RNA transcription regulates splicing through ribosomal protein RPL22
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  53. May 2025
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    Generation of T cell responses against broad KRAS hotspot neoantigens for cell therapy or TCR discovery
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  56. Apr 2025
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    A new EGFR and c-Met bispecific NIR-II fluorescent probe for visualising colorectal cancer and metastatic lymph nodes
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    Streptomycin targets tumor-initiating cells by disrupting oxidative phosphorylation
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    An Aurora kinase A-BOD1L1-PP2A B56 axis promotes chromosome segregation fidelity
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  63. Mar 2025
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    ORMDL3 restrains type I interferon signaling and anti-tumor immunity by promoting RIG-I degradation
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  66. Feb 2025
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    The integrative genomic and functional immunological analyses of colorectal cancer initiating cells to modulate stemness properties and the susceptibility to immune responses
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    Identification of Lipid Species Signatures in FOLFOXIRI-Resistant Colorectal Cancer Cells
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  71. Jan 2025
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    Unraveling the mechanism of microRNA-134 in colon cancer progression: targeting KRAS and PIK3CA for cell cycle control and histone deacetylase regulation.
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    IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth
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  75. Dec 2024
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    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer
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    Anti-Colon Cancer Effects of Lysate from Potential Probiotic Yeast Strains Derived from Human Breast Milk
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    p53 induces circFRMD4A to suppress cancer development through glycolytic reprogramming and cuproptosis
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    B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies
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  81. Oct 2024
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    NK Receptor Signaling Lowers TCR Activation Threshold, Enhancing Selective Recognition of Cancer Cells by TAA-Specific CTLs
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  84. Sep 2024
  85. www.biorxiv.org www.biorxiv.org
    Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer
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    biorxiv.org/content/10.1101/2024.09.05.611458v1
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    Comprehensive Proteogenomic Profiling Reveals the Molecular Characteristics of Colorectal Cancer at Distinct Stages of Progression
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  87. Aug 2024
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    Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer
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    Small-molecule NSC59984 induces mutant p53 degradation through a ROS-ERK2-MDM2 axis in cancer cells
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  93. Jul 2024
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    NAMPT-targeting PROTAC and nicotinic acid co-administration elicit safe and robust anti-tumor efficacy in NAPRT-deficient pan-cancers
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    Cell-cell contact-dependent secretion of large-extracellular vesicles from EFNBhigh cancer cells accelerates peritoneal dissemination
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    Identification and characterization of TM4SF1+ tumor self-seeded cells
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  97. Jun 2024
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    Potentially functional genetic variants in interferon regulatory factor family genes are associated with colorectal cancer survival
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  99. May 2024
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  101. Apr 2024
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 screening identifies INTS3 as an anti-apoptotic RNA-binding protein and therapeutic target for colorectal cancer
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    Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases
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    The long noncoding RNA LUCAT1 promotes colorectal cancer cell proliferation by antagonizing Nucleolin to regulate MYC expression
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  221. Sep 2020
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    Therapeutic targeting of soluble CD146/MCAM with the M2J‐1 monoclonal antibody prevents metastasis development and procoagulant activity in CD146‐positive invasive tumors
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    onlinelibrary.wiley.com/doi/10.1002/ijc.32909
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    Cotargeting BET proteins overcomes resistance arising from PI3K/mTOR blockade‐induced protumorigenic senescence in colorectal cancer
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  231. Aug 2020
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    Zinc-finger antiviral protein acts as a tumor suppressor in colorectal cancer
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    Organoid modelling identifies that DACH1 functions as a tumour promoter in colorectal cancer by modulating BMP signalling
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  235. Jan 2020
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    PTPS Facilitates Compartmentalized LTBP1 S-Nitrosylation and Promotes Tumor Growth under Hypoxia
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    Ethanol promotes alcohol-related colorectal cancer metastasis via the TGF-β/RUNX3/Snail axis by inducing TGF-β1 upregulation and RUNX3 cytoplasmic mislocalization
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    Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer
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  239. Apr 2019
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    TP53 drives invasion through expression of its Δ133p53β variant
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  241. Nov 2018
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    A Short Tandem Repeat-Enriched RNA Assembles a Nuclear Compartment to Control Alternative Splicing and Promote Cell Survival
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    The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer
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    A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth
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  247. Nov 2017
  248. elifesciences.org elifesciences.org
    Affimer proteins are versatile and renewable affinity reagents
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    CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes
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