211 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acquired resistance to the PRMT5 inhibitor confers collateral sensitivity to MEK inhibition in MTAP-null non-small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13131504/
  3. May 2026
  4. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70264
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    Gasdermin C reprograms metabolism through the CAMKK2-AMPK axis to promote lung adenocarcinoma progression and radioresistance
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    sciencedirect.com/science/article/pii/S221112472600505X
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Extracellular matrix-driven patient stratification and network modeling reveal distinct molecular grades with potential clinical implications
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    pmc.ncbi.nlm.nih.gov/articles/PMC13168567/
  7. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70490
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GFAT2-mediated HSPD1 O-GlcNAcylation drives chemotherapy resistance in non-small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13141267/
  9. aacrjournals.org aacrjournals.org
    Constitutive EGFR activation induced by PTPRR downregulation confers resistance to KRAS inhibitors
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    aacrjournals.org/cancerrescommun/article/6/4/728/781786/Constitutive-EGFR-Activation-Induced-by-PTPRR
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    JIN-A02, a Mutant-Selective Fourth-Generation EGFR inhibitor, Overcomes C797S-Mediated Resistance and Demonstrates Intracranial Activity in NSCLC
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    pmc.ncbi.nlm.nih.gov/articles/PMC13133602/
  11. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R-Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202521238
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acquired resistance to the PRMT5 inhibitor confers collateral sensitivity to MEK inhibition in MTAP-null non-small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13131504/
  13. Apr 2026
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FOXM1-specific TCR-engineered T cells target non-small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13119620/
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    IGF2R as a master regulator of acquired EGFR inhibitor resistance and therapeutic target in non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S014181302602146X
  16. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A covalent molecular glue hijacks the E3 ligase MKRN2 to degrade the ribosomal protein RPS7 and induce synthetic lethality in p53-deficient NSCLC cells
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70434
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Base Editing of TIGIT Reprograms CD155 Signaling in Natural Killer Cells to Enhance Cancer Immunotherapy Efficacy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13080321/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nutrient Availability Dictates Cancer Metabolism–Based Therapeutic Responses to Nononcology Drugs
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    pmc.ncbi.nlm.nih.gov/articles/PMC13055633/
  19. link.springer.com link.springer.com
    HIF-1α siRNA Enhances the Efficacy of Erlotinib in Non-small Cell Lung Cancer: A Novel Strategy to Reverse Hypoxia-Induced Drug Resistance
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    link.springer.com/article/10.1007/s40268-025-00534-5
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mitofusin-2 suppresses tumor immune escape through EGFR/STAT3-mediated PD-L1 transcription
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    pmc.ncbi.nlm.nih.gov/articles/PMC13039860/
  21. Mar 2026
  22. link.springer.com link.springer.com
    CCNB2, NUSAP1, GTSE1, and TK1: potential dual biomarkers for pneumonia and lung adenocarcinoma
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    link.springer.com/article/10.1007/s10616-026-00940-w
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    UFMylation-dependent inhibition of AKT signaling by PHLDA3 in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124726002329
  24. pubs.acs.org pubs.acs.org
    EXAGO: An Argonaute-Based Primer-Free Exponential Amplification Strategy for Ultrasensitive Zero-Background Detection of Point Mutation
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    pubs.acs.org/doi/10.1021/acs.analchem.5c06961
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The STAT3–ZEB1 axis contributes to CCL2-mediated resistance to osimertinib in lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12962936/
  26. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    SATB2 Mediates H3K9 Delactylation by Recruiting HDAC3 to Repress LCN2 and Inhibit Lung Tumor Growth and Metastasis
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202522996
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sym024 interacts with a unique epitope on the CD73 homodimer, favoring effective bivalent binding to improve anti-PD1 therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12950896/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Aspartate availability drives differential engagement of the malate-aspartate shuttle
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  29. Feb 2026
  30. www.sciencedirect.com www.sciencedirect.com
    SQSTM1/p62-mediated PD-L1 biomolecular condensate formation promotes lung tumorigenesis
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    sciencedirect.com/science/article/pii/S2090123226001785
  31. spj.science.org spj.science.org
    Tumor Exosomal L1 Cell Adhesion Molecule Promotes Brain Metastasis of Lung Cancer
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    spj.science.org/doi/10.34133/research.1126
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    High-throughput identification of endogenous biomolecular condensates and phase-separating proteins
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    nature.com/articles/s41596-025-01327-5
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumor Exosomal L1 Cell Adhesion Molecule Promotes Brain Metastasis of Lung Cancer
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    PARP inhibitor combined with platinum activates the cGAS-STING pathway to enhance anti-PD-L1 immunotherapy in lung adenocarcinoma
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  35. Jan 2026
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SERPINB3 enhances NPM1 sumoylation via inhibiting SENP3’s activity and promotes lung tumorigenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12847774/
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    Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD+ to eradicate KRAS-driven AML
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    sciencedirect.com/science/article/pii/S155041312600001X
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A combined strategy of EGFR-MET bispecific antibody and HER3 ADC to overcome osimertinib resistance in NSCLC
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    pmc.ncbi.nlm.nih.gov/articles/PMC12847129/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Profiling of Extracellular Vesicles of Non‐Small Cell Lung Cancer Reveals Proteins Associated With Osimertinib Resistance
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    Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202511408
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    ANP32A-mediated Histone 3 K27 Acetylation is Essential for Sotorasib Activity in KRAS-mutant Non-Small Cell Lung Cancer
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    Mitigating tumor heterogeneity in lung Cancer: A dual-targeted NIR-II imaging strategy for accurate tumor localization and intraoperative navigation
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    sciencedirect.com/science/article/pii/S0304383526000042
  43. Dec 2025
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sappanchalcone Suppresses NSCLC by Oxidative Stress-Driven DNA Damage and ER Stress Activation through PIEZO1 Modulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12702247/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical pharmacokinetic, pharmacodynamic, and safety profile of OBI-992: a novel TROP2-targeted antibody–drug conjugate
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    pmc.ncbi.nlm.nih.gov/articles/PMC12670072/
  46. Nov 2025
  47. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    Lysine methylation-mediated SMYD2 degradation by casticin sensitizes non-small-cell lung cancer cells to osimertinib therapy
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    sciencedirect.com:5037/science/article/pii/S0006295225008275
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DUSP11 is an intracellular innate immune checkpoint in lung adenocarcinoma
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  49. 54.241.53.176 54.241.53.176
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    Anti-NSCLC efficacy of a novel ROR1/PI3Kα/BRD4 multi-target inhibitor
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    sciencedirect.com/science/article/pii/S0968089625004249
  52. Oct 2025
  53. www.sciencedirect.com www.sciencedirect.com
    Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer
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    sciencedirect.com/science/article/pii/S1550413125004358
  54. www.biorxiv.org www.biorxiv.org
    Co-targeting MERTK and EGFR with a Bispecific Antibody Overcomes Drug Resistance Across Mutations in Exons 19, 20, and 21
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    biorxiv.org/content/10.1101/2025.10.16.681972v1
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    tRF3a-MetCAT Promotes EGFR-Targeted Therapeutic Resistance through the TRIM21–STAT1–C5a Axis in Lung Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12501432/
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    Optimized arenaviruses with tumor-tropic mutations promote safe anti-tumor efficacy via sustainable immune modulatory properties
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    sciencedirect.com/science/article/pii/S2666379125004847
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    A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases
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    sciencedirect.com/science/article/pii/S2211124725011799
  58. Sep 2025
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    Safe immunosuppression-resistant pan-cancer immunotherapeutics by velcro-like density-dependent targeting of tumor-associated carbohydrate antigens
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    sciencedirect.com/science/article/pii/S0092867425010323
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    Extracellular Matrix-Guided Tumor Stratification and Network Models Reveal Clinical Molecular Grades
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    biorxiv.org/content/10.1101/2025.08.29.672994v1
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Notch3 mediated TGF-β1 activation enhances epithelial-mesenchymal transition and cancer stemness in non-small lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12370359/
  63. Aug 2025
  64. www.science.org www.science.org
    Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer
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    science.org/doi/10.1126/sciadv.adt1798
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    EGFR Targeted Liposomal PROTAC Assisted With Epigenetic Regulation as an Efficient Strategy for Osimertinib-Resistant Lung Cancer Therapy
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202510197
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    HACD3 promotes malignant progression of NSCLC by suppressing the MKK7/MAPK10 signaling axis
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    bmccancer.biomedcentral.com/articles/10.1186/s12885-025-14621-y
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical Evaluation of DB-1419, a Novel Bifunctional and Bispecific Anti–B7-H3 × PD-L1 Antibody–Drug Conjugate
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    Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR-TKI resistance and metastasis
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    sciencedirect.com/science/article/pii/S153458072500471X
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    NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers
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    Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures
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    FBXW5 Promotes Epithelial-Mesenchymal Transition in Lung Adenocarcinoma Through the KLF13/TROAP Signaling Pathway
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    onlinelibrary.wiley.com/doi/full/10.1002/mc.70018
  73. Jul 2025
  74. pubs.acs.org pubs.acs.org
    Novel Aptamer-Drug Conjugate for Targeted Therapy in Triple-Negative Breast Cancer
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    pubs.acs.org/doi/full/10.1021/acs.jmedchem.5c00492
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    Prediction of Lung Cancer Metastasis Risk Based on Single-Cell Metabolic Profiling of Circulating Tumor Cells
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202508878
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Utility of CK8/18 in identifying circulating tumor cells derived from lesions in patients with non-small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12261347/
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    STX-721, a Covalent EGFR/HER2 Exon 20 Inhibitor, Utilizes Exon 20–Mutant Dynamic Protein States and Achieves Unique Mutant Selectivity Across Human Cancer Models
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    KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer
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    Strictosamide and mitraphylline inhibit cancer cell motility by suppressing epithelial-mesenchymal transition via integrin α4-mediated signaling
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    link.springer.com/article/10.1038/s41598-025-04064-7
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Prognostic model of lung adenocarcinoma based on disulfidptosis-related genes and analysis of in vitro cell experiments for PPP1R14B in the model
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  82. Jun 2025
  83. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer
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    Membrane-bound IL-15 co-expression powers a potent and persistent CD70-targeted TRuC T-cell therapy
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  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutation of SMARCA4 Induces Cancer Cell–Intrinsic Defects in the Enhancer Landscape and Resistance to Immunotherapy
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    Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation
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    sciencedirect.com/science/article/pii/S2451945625001667
  91. May 2025
  92. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Avelumab induces greater Fc-Fc receptor-dependent natural killer cell activation and dendritic cell crosstalk compared to durvalumab
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  93. Apr 2025
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    Combined inhibition of hexokinase 2 and pyruvate dehydrogenase surmounts SHP2 inhibitor resistance in non-small cell lung cancer with hybrid metabolic state harboring KRAS Q61H mutation
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  96. Mar 2025
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    Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma
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