159 Matching Annotations
  1. Aug 2025
  2. www.science.org www.science.org
    Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer
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    science.org/doi/10.1126/sciadv.adt1798
  3. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.70238
  4. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    EGFR Targeted Liposomal PROTAC Assisted With Epigenetic Regulation as an Efficient Strategy for Osimertinib-Resistant Lung Cancer Therapy
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202510197
  5. bmccancer.biomedcentral.com bmccancer.biomedcentral.com
    HACD3 promotes malignant progression of NSCLC by suppressing the MKK7/MAPK10 signaling axis
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    bmccancer.biomedcentral.com/articles/10.1186/s12885-025-14621-y
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical Evaluation of DB-1419, a Novel Bifunctional and Bispecific Anti–B7-H3 × PD-L1 Antibody–Drug Conjugate
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    pmc.ncbi.nlm.nih.gov/articles/PMC12351279/
  7. www.sciencedirect.com www.sciencedirect.com
    Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR-TKI resistance and metastasis
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    sciencedirect.com/science/article/pii/S153458072500471X
  8. www.nature.com www.nature.com
    NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers
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    nature.com/articles/s41586-025-09299-y
  9. www.sciencedirect.com www.sciencedirect.com
    Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures
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    sciencedirect.com/science/article/pii/S1535610825003174
  10. onlinelibrary.wiley.com onlinelibrary.wiley.com
    FBXW5 Promotes Epithelial-Mesenchymal Transition in Lung Adenocarcinoma Through the KLF13/TROAP Signaling Pathway
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    onlinelibrary.wiley.com/doi/full/10.1002/mc.70018
  11. Jul 2025
  12. pubs.acs.org pubs.acs.org
    Novel Aptamer-Drug Conjugate for Targeted Therapy in Triple-Negative Breast Cancer
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    pubs.acs.org/doi/full/10.1021/acs.jmedchem.5c00492
  13. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.70097
  14. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Prediction of Lung Cancer Metastasis Risk Based on Single-Cell Metabolic Profiling of Circulating Tumor Cells
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202508878
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Utility of CK8/18 in identifying circulating tumor cells derived from lesions in patients with non-small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12261347/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    STX-721, a Covalent EGFR/HER2 Exon 20 Inhibitor, Utilizes Exon 20–Mutant Dynamic Protein States and Achieves Unique Mutant Selectivity Across Human Cancer Models
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    pmc.ncbi.nlm.nih.gov/articles/PMC12260510/
  17. www.sciencedirect.com www.sciencedirect.com
    KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S1535610825002612
  18. link.springer.com link.springer.com
    Strictosamide and mitraphylline inhibit cancer cell motility by suppressing epithelial-mesenchymal transition via integrin α4-mediated signaling
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    link.springer.com/article/10.1038/s41598-025-04064-7
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Prognostic model of lung adenocarcinoma based on disulfidptosis-related genes and analysis of in vitro cell experiments for PPP1R14B in the model
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    pmc.ncbi.nlm.nih.gov/articles/PMC12210501/
  20. Jun 2025
  21. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202503322
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PDF-html.html
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    pmc.ncbi.nlm.nih.gov/articles/PMC12270665/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Membrane-bound IL-15 co-expression powers a potent and persistent CD70-targeted TRuC T-cell therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12162932/
  24. 52.53.155.43 52.53.155.43
    PDF-html.html
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  25. 52.53.155.43 52.53.155.43
    1-s2.0-S155608642500766X-main-html.html
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  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mutation of SMARCA4 Induces Cancer Cell–Intrinsic Defects in the Enhancer Landscape and Resistance to Immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12127800/
  28. www.sciencedirect.com www.sciencedirect.com
    Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation
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    sciencedirect.com/science/article/pii/S2451945625001667
  29. May 2025
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Avelumab induces greater Fc-Fc receptor-dependent natural killer cell activation and dendritic cell crosstalk compared to durvalumab
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    pmc.ncbi.nlm.nih.gov/articles/PMC12051578/
  31. Apr 2025
  32. www.sciencedirect.com www.sciencedirect.com
    Combined inhibition of hexokinase 2 and pyruvate dehydrogenase surmounts SHP2 inhibitor resistance in non-small cell lung cancer with hybrid metabolic state harboring KRAS Q61H mutation
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    sciencedirect.com/science/article/pii/S0925443925002042
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PDF-html.html
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    pmc.ncbi.nlm.nih.gov/articles/PMC11990068/
  34. Mar 2025
  35. www.sciencedirect.com www.sciencedirect.com
    Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S1097276525001947
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chromosomal Instability Is Associated with cGAS–STING Activation in EGFR-TKI Refractory Non-Small-Cell Lung Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11941500/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical evaluation of a novel antibody–drug conjugate OBI-992 for Cancer therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11906863/
  38. Feb 2025
  39. www.sciencedirect.com www.sciencedirect.com
    JNJ-78306358, a first-in-class bispecific T cell engaging antibody targeting CD3 and HLA-G
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    sciencedirect.com/science/article/pii/S2589004225001361
  40. www.sciencedirect.com www.sciencedirect.com
    TGF-β1-mediated intercellular signaling fuels cooperative cellular invasion
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    sciencedirect.com/science/article/pii/S2211124725000865
  41. cellandbioscience.biomedcentral.com cellandbioscience.biomedcentral.com
    Epsin3 promotes non-small cell lung cancer progression via modulating EGFR stability
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    cellandbioscience.biomedcentral.com/articles/10.1186/s13578-025-01358-1
  42. Jan 2025
  43. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225001245-main-html.html
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  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intratumor heterogeneity of EGFR expression mediates targeted therapy resistance and formation of drug tolerant microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695629/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Improving PD-1 blockade plus chemotherapy for complete remission of lung cancer by nanoPDLIM2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11668523/
  46. Dec 2024
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Imaging NRF2 activation in non-small cell lung cancer with positron emission tomography
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    pmc.ncbi.nlm.nih.gov/articles/PMC11652680/
  48. www.sciencedirect.com www.sciencedirect.com
    A Novel Sensitizer Reduces EGFR-TKI Resistance by Regulating the PI3K/Akt/mTOR Pathway and Autophagy
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    sciencedirect.com/science/article/pii/S2405844024171356
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pericytes Modulate Third‐Generation Tyrosine Kinase Inhibitor Sensitivity in EGFR‐Mutated Lung Cancer Cells Through IL32‐β5‐Integrin Paracrine Signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11633494/
  50. www.sciencedirect.com www.sciencedirect.com
    p53 induces circFRMD4A to suppress cancer development through glycolytic reprogramming and cuproptosis
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    sciencedirect.com/science/article/pii/S1097276524009183
  51. www.sciencedirect.com www.sciencedirect.com
    Therapeutic induction of ferroptosis in tumors using PD-L1 targeting antibody nanogel conjugates
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    sciencedirect.com/science/article/pii/S2451945624004586
  52. Nov 2024
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dynamic roles of neutrophil extracellular traps in cancer cell adhesion and activation of Notch 1-mediated epithelial-to-mesenchymal transition in EGFR-driven lung cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11487346/
  54. Oct 2024
  55. www.sciencedirect.com www.sciencedirect.com
    Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer
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    sciencedirect.com/science/article/pii/S2451945624003969
  56. Sep 2024
  57. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13705
  58. www.sciencedirect.com www.sciencedirect.com
    Customised design of antisense oligonucleotides targeting EGFR driver mutants for personalised treatment of non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S235239642400392X
  59. www.nature.com www.nature.com
    Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer
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    nature.com/articles/s41467-024-51831-7
  60. www.sciencedirect.com www.sciencedirect.com
    A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib
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    sciencedirect.com/science/article/pii/S2666379124004245
  61. Aug 2024
  62. www.pnas.org www.pnas.org
    Activation of polyamine catabolism promotes glutamine metabolism and creates a targetable vulnerability in lung cancer
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    pnas.org/doi/10.1073/pnas.2319429121
  63. aacrjournals.org aacrjournals.org
    MTX-13, a novel PTK7-directed antibody-drug conjugate with widened therapeutic index shows sustained tumor regressions for a broader spectrum of PTK7-positive tumors
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    aacrjournals.org/mct/article/22/10/1128/729312/MTX-13-a-Novel-PTK7-Directed-Antibody-Drug
  64. 52.53.155.43 52.53.155.43
    Molecular Oncology - 2023 - Horie-html.html
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    52.53.155.43/b5e8e877c627d157950951119edc64db79086ad6/Molecular Oncology - 2023 - Horie-html.html
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic alterations predict poor efficacy, outcomes and resistance to second-line osimertinib treatment in non-small cell lung cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10839301/
  66. Jul 2024
  67. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Novel ectopic expression of zona pellucida 3 glycoprotein in lung cancer promotes tumor growth
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    onlinelibrary.wiley.com/doi/full/10.1002/ijc.35098
  68. www.sciencedirect.com www.sciencedirect.com
    NAMPT-targeting PROTAC and nicotinic acid co-administration elicit safe and robust anti-tumor efficacy in NAPRT-deficient pan-cancers
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    sciencedirect.com/science/article/pii/S2451945624002083
  69. www.sciencedirect.com www.sciencedirect.com
    Harnessing the CD44-targeted delivery of self-assembled hyaluronan nanogel to reverse the antagonism between Cisplatin and Gefitinib in NSCLC cancer therapy
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    sciencedirect.com/science/article/pii/S0144861724007471
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11215406/
  71. May 2024
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11030525/
  73. Apr 2024
  74. aacrjournals.org aacrjournals.org
    EGFR-driven lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth
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    aacrjournals.org/cancerdiscovery/article/14/3/524/734906/EGFR-Driven-Lung-Adenocarcinomas-Co-opt-Alveolar
  75. www.sciencedirect.com www.sciencedirect.com
    S1PR3 agonism and S1P lyase inhibition rescue mice in the severe state of experimental sepsis
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    sciencedirect.com/science/article/pii/S0753332224004591
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IL-17 induces NSCLC cell migration and invasion by elevating MMP19 gene transcription and expression through the interaction of p300-dependent STAT3-K631 acetylation and its Y705-phosphorylation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10972722/
  77. Mar 2024
  78. www.sciencedirect.com www.sciencedirect.com
    Silibinin is a suppressor of the metastasis-promoting transcription factor ID3
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    sciencedirect.com/science/article/pii/S0944711324001570
  79. Feb 2024
  80. aacrjournals.org aacrjournals.org
    First-in-Human Study with preclinical data of BCL-2/BCL-xL Inhibitor Pelcitoclax in Locally Advanced or Metastatic Solid Tumors
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    aacrjournals.org/clincancerres/article/30/3/506/733551/First-in-Human-Study-with-Preclinical-Data-of-BCL
  81. www.biorxiv.org www.biorxiv.org
    A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer
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    biorxiv.org/content/10.1101/2024.02.05.578972v1
  82. Jan 2024
  83. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13564
  84. www.sciencedirect.com www.sciencedirect.com
    Alisertib inhibits migration and invasion of EGFR-TKI resistant cells by partially reversing the epithelial-mesenchymal transition
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    sciencedirect.com/science/article/pii/S0167488921000707
  85. Dec 2023
  86. www.sciencedirect.com www.sciencedirect.com
    Phosphoprotein dynamics of interacting T cells and tumor cells by HySic
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    sciencedirect.com/science/article/pii/S2211124723016108
  87. www.nature.com www.nature.com
    Proximity extracellular protein-protein interaction analysis of EGFR using AirID-conjugated fragment of antigen binding
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    nature.com/articles/s41467-023-43931-7
  88. Nov 2023
  89. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Fast proliferating and slowly migrating non-small cell lung cancer cells are vulnerable to decitabine and retinoic acid combinatorial treatment
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34783
  90. 52.53.155.43 52.53.155.43
    British J Pharmacology - 2023 - Chen - Identification of arnicolide C as a novel chemosensitizer to suppress mTOR E2F1-html.html
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    52.53.155.43/fa9809949a94f3d698a02ed4d13d532c010d3e91/British J Pharmacology - 2023 - Chen - Identification of arnicolide C as a novel chemosensitizer to suppress mTOR E2F1-html.html
  91. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13505
  92. Oct 2023
  93. www.cell.com www.cell.com
    PUF60 promotes cell cycle and lung cancer progression by regulating alternative splicing of CDC25C
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    cell.com/cell-reports/fulltext/S2211-1247(23)01052-5
  94. Sep 2023
  95. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16165
  96. Aug 2023
  97. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Canagliflozin mediates tumor suppression alone and in combination with radiotherapy in non-small cell lung cancer (NSCLC) through inhibition of HIF-1α
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.13508
  98. 52.53.155.43 52.53.155.43
    Molecular Oncology - 2023 - Pan-html.html
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    52.53.155.43/0c03bb3198bd7f61266aaeb6cf8a257d677212b0/Molecular Oncology - 2023 - Pan-html.html
  99. 52.53.155.43 52.53.155.43
    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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    52.53.155.43/bb31ad2b14838f5cede2aca897c595e2febf2f88/PIIS2666379123002951-html.html
  100. www.sciencedirect.com www.sciencedirect.com
    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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    sciencedirect.com/science/article/pii/S1535610823002453
  101. Jul 2023
  102. 52.53.155.43 52.53.155.43
    mct-23-0164-html.html
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  103. www.nature.com www.nature.com
    E3 ligase MG53 suppresses tumor growth by degrading cyclin D1
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    nature.com/articles/s41392-023-01458-9
  104. www.sciencedirect.com www.sciencedirect.com
    TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry
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    sciencedirect.com/science/article/pii/S0092867423006451
  105. www.nature.com www.nature.com
    MLK4 promotes glucose metabolism in lung adenocarcinoma through CREB-mediated activation of phosphoenolpyruvate carboxykinase and is regulated by KLF5
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    nature.com/articles/s41389-023-00478-y
  106. Jun 2023
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