611 Matching Annotations
  1. Oct 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oncogenic cells of renal embryonic lineage sensitive to the small molecule inhibitor QC6352 display depletion of KDM4 levels and disruption of ribosome biogenesis
    1
    1. scibot 04 Oct 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/1535-7163.MCT-23-0312

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    ncbi.nlm.nih.gov/pmc/articles/PMC10987284/
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Redirecting B7-H3.CAR T cells to Chemokines Expressed in Osteosarcoma Enhances Homing and Antitumor Activity in Preclinical Models
    1
    1. scibot 04 Oct 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/1078-0432.CCR-23-3298

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    ncbi.nlm.nih.gov/pmc/articles/PMC11443211/
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Development of a [89Zr]Zr-labeled human antibody using a novel phage-displayed human scFv library
    1
    1. scibot 03 Oct 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/1078-0432.CCR-23-3647

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    ncbi.nlm.nih.gov/pmc/articles/PMC10984770/
  5. aacrjournals.org aacrjournals.org
    H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
    1
    1. scibot 02 Oct 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2159-8290.CD-20-0461

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    aacrjournals.org/cancerdiscovery/article/10/12/1968/2414/H3-3-G34W-Promotes-Growth-and-Impedes
  6. www.sciencedirect.com www.sciencedirect.com
    A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration
    1
    1. scibot 02 Oct 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.stem.2024.09.001

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    sciencedirect.com/science/article/pii/S1934590924003151
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multivalent MVA-vectored vaccine elicits EBV neutralizing antibodies in rhesus macaques that reduce EBV infection in humanized mice
    1
    1. scibot 02 Oct 2024
      RRID:IMSR_JAX:005557

      DOI: 10.3389/fimmu.2024.1445209

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    ncbi.nlm.nih.gov/pmc/articles/PMC11427267/
  8. Sep 2024
  9. www.biorxiv.org www.biorxiv.org
    Engineered Receptors for Soluble Cell-to-Cell Communication
    1
    1. scibot 28 Sep 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1101/2024.09.17.613377

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    biorxiv.org/content/10.1101/2024.09.17.613377v1
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of immortal-like and functional CAR T cells by defined factors
    1
    1. scibot 27 Sep 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1084/jem.20232368

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    ncbi.nlm.nih.gov/pmc/articles/PMC10965394/
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING
    1
    1. scibot 26 Sep 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1101/2024.09.03.610968

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    ncbi.nlm.nih.gov/pmc/articles/PMC11398426/
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A benzarone derivative inhibits EYA to suppress tumor growth in SHH medulloblastoma
    1
    1. scibot 25 Sep 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/0008-5472.CAN-22-3784

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    ncbi.nlm.nih.gov/pmc/articles/PMC10948029/
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Novel immunotherapeutics against LGR5 to target multiple cancer types
    1
    1. scibot 25 Sep 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1038/s44321-024-00121-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC11393416/
  14. www.sciencedirect.com www.sciencedirect.com
    Integrative identification of non-coding regulatory regions driving metastatic prostate cancer
    1
    1. scibot 17 Sep 2024
      Strain#005557

      DOI: 10.1016/j.celrep.2024.114764

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      Curator: @vtello

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    sciencedirect.com/science/article/pii/S221112472401115X
  15. www.sciencedirect.com www.sciencedirect.com
    Rewired glutamate metabolism diminishes cytostatic action of L-asparaginase
    1
    1. scibot 17 Sep 2024
      JAX:005557

      DOI: 10.1016/j.canlet.2024.217242

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    sciencedirect.com/science/article/pii/S0304383524006372
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRMT5 supports multiple oncogenic pathways in mantle cell lymphoma
    1
    1. scibot 12 Sep 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1182/blood.2022019419

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    ncbi.nlm.nih.gov/pmc/articles/PMC10517215/
  17. aacrjournals.org aacrjournals.org
    Aberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma
    1
    1. scibot 12 Sep 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/0008-5472.CAN-22-0677

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    aacrjournals.org/cancerres/article/83/2/195/715074/Aberrant-L-Fucose-Accumulation-and-Increased-Core
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bifunctional inhibitor reveals NEK2 as a therapeutic target and regulator of oncogenic pathways in lymphoma
    1
    1. scibot 05 Sep 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/1535-7163.MCT-23-0299

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    ncbi.nlm.nih.gov/pmc/articles/PMC10932871/
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting AKR1B10 by drug repurposing with epalrestat overcomes chemoresistance in non-small cell lung cancer patient-derived tumor organoids
    1
    1. scibot 05 Sep 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/1078-0432.CCR-23-3980

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    ncbi.nlm.nih.gov/pmc/articles/PMC11369614/
  20. www.sciencedirect.com www.sciencedirect.com
    A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib
    1
    1. scibot 04 Sep 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.xcrm.2024.101703

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    sciencedirect.com/science/article/pii/S2666379124004245
  21. www.sciencedirect.com www.sciencedirect.com
    Smarcd1 subunit of SWI/SNF chromatin-remodeling complexes collaborates with E2a to promote murine lymphoid specification
    1
    1. scibot 04 Sep 2024
      JAX:005557

      DOI: 10.1016/j.devcel.2024.08.007

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    sciencedirect.com/science/article/pii/S1534580724004908
  22. Aug 2024
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Role of Forkhead Box P3 in Interferon γ-mediated PD-L1 Expression and Bladder Cancer Epithelial-to-Mesenchymal Transition
    1
    1. scibot 28 Aug 2024
      JAX_005557

      DOI: 10.1158/2767-9764.CRC-23-0493

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      Curator: @vtello

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      RRIDCUR:Unresolved RRID:IMSR_JAX:005557
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    ncbi.nlm.nih.gov/pmc/articles/PMC11345674/
  24. www.cell.com www.cell.com
    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
    1
    1. scibot 22 Aug 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.cell.2020.02.019

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    cell.com/cell/fulltext/S0092-8674(20)30163-X
  25. www.sciencedirect.com www.sciencedirect.com
    Interleukin-21 engineering enhances NK cell activity against glioblastoma via CEBPD
    1
    1. scibot 21 Aug 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2024.07.007

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    sciencedirect.com/science/article/pii/S1535610824002721
  26. www.sciencedirect.com www.sciencedirect.com
    Nuclear PKM2 binds pre-mRNA at folded G-quadruplexes and reveals their gene regulatory role
    1
    1. scibot 20 Aug 2024
      005557

      DOI: 10.1016/j.molcel.2024.07.025

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    sciencedirect.com/science/article/pii/S1097276524006233
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-EGFR Antibody–Drug Conjugate Carrying an Inhibitor Targeting CDK Restricts Triple-Negative Breast Cancer Growth
    1
    1. scibot 18 Aug 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/1078-0432.CCR-23-3110

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    ncbi.nlm.nih.gov/pmc/articles/PMC11292198/
  28. www.sciencedirect.com www.sciencedirect.com
    Time- and cell-specific activation of BMP signaling restrains chondrocyte hypertrophy
    1
    1. scibot 13 Aug 2024
      005557

      DOI: 10.1016/j.isci.2024.110537

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    sciencedirect.com/science/article/pii/S2589004224017620
  29. www.biorxiv.org www.biorxiv.org
    Senescent fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity
    1
    1. scibot 13 Aug 2024
      Jackson Laboratory, catalog #005557

      DOI: 10.1101/2024.07.29.605645

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      Curator: @dhovakimyan1

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      RRID:IMSR_JAX:005557 DOI:10.1101/2024.07.29.605645
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    biorxiv.org/content/10.1101/2024.07.29.605645v1
  30. www.nature.com www.nature.com
    A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses
    1
    1. scibot 13 Aug 2024
      RRID: IMSR_JAX: 005557

      DOI: 10.1038/s41590-024-01880-3

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      Curator: @AniH

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    nature.com/articles/s41590-024-01880-3
  31. cancerci.biomedcentral.com cancerci.biomedcentral.com
    Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer
    1
    1. scibot 02 Aug 2024
      RRID: IMSR_JAX:005557

      DOI: 10.1186/s12935-024-03231-6

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      Curator: @anisehay

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    cancerci.biomedcentral.com/articles/10.1186/s12935-024-03231-6
  32. www.biorxiv.org www.biorxiv.org
    Salmonella enterica serovar Typhi uses two type 3 secretion systems to replicate in human macrophages and to colonize humanized mice
    1
    1. scibot 02 Aug 2024
      Humanized-NOD-scid IL2rγ-null mice

      DOI: 10.1101/2023.06.06.543980

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      Curator: @evieth

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    biorxiv.org/content/10.1101/2023.06.06.543980v1
  33. Jul 2024
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N-Myristoyltransferase Inhibition causes Mitochondrial Iron Overload and Parthanatos in TIM17A-dependent Aggressive Lung Carcinoma
    1
    1. scibot 27 Jul 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2767-9764.CRC-23-0428

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    ncbi.nlm.nih.gov/pmc/articles/PMC11270646/
  35. www.sciencedirect.com www.sciencedirect.com
    Protocol for assessing GD2 on formalin-fixed paraffin-embedded tissue sections using immunofluorescence staining
    1
    1. scibot 26 Jul 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.xpro.2024.103199

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    sciencedirect.com/science/article/pii/S2666166724003642
  36. www.sciencedirect.com www.sciencedirect.com
    Integrated transcriptomics of human blood vessels defines a spatially controlled niche for early mesenchymal progenitor cells
    1
    1. scibot 26 Jul 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.devcel.2024.06.015

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    sciencedirect.com/science/article/pii/S1534580724003939
  37. www.sciencedirect.com www.sciencedirect.com
    PAI-1 uncouples integrin-β1 from restrain by membrane-bound β-catenin to promote collagen fibril remodeling in obesity-related neoplasms
    1
    1. scibot 25 Jul 2024
      005557

      DOI: 10.1016/j.celrep.2024.114527

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    sciencedirect.com/science/article/pii/S2211124724008568
  38. www.sciencedirect.com www.sciencedirect.com
    Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies
    1
    1. scibot 25 Jul 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2024.06.006

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    sciencedirect.com/science/article/pii/S1535610824002319
  39. www.sciencedirect.com www.sciencedirect.com
    Preclinical proof of principle for orally delivered Th17 antagonist miniproteins
    1
    1. scibot 23 Jul 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.cell.2024.05.052

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    sciencedirect.com/science/article/pii/S0092867424006317
  40. www.sciencedirect.com www.sciencedirect.com
    Protocol to construct humanized mice with adult CD34+ hematopoietic stem and progenitor cells
    1
    1. scibot 20 Jul 2024
      JAX:005557

      DOI: 10.1016/j.xpro.2024.103155

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    sciencedirect.com/science/article/pii/S2666166724003204
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling
    1
    1. scibot 17 Jul 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.xcrm.2024.101645

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    ncbi.nlm.nih.gov/pmc/articles/PMC11293342/
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression
    1
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      RRID:IMSR_JAX:005557

      DOI: 10.1038/s41598-024-66811-6

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  43. www.biorxiv.org www.biorxiv.org
    Organoid Models Derived from Primary Tumors and Patient-Derive Xenograft Tumors Reflect Platinum Sensitivity of Ovarian Cancer Patients
    1
    1. scibot 16 Jul 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1101/2024.06.28.601283

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    biorxiv.org/content/10.1101/2024.06.28.601283v1
  44. www.cell.com www.cell.com
    Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis
    1
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      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2024.114431

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    cell.com/cell-reports/fulltext/S2211-1247(24)00760-5
  45. www.mdpi.com www.mdpi.com
    HER4 Affects Sensitivity to Tamoxifen and Abemaciclib in Luminal Breast Cancer Cells and Restricts Tumor Growth in MCF-7-Based Humanized Tumor Mice
    1
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      RRID:IMSR_JAX:005557

      DOI: 10.3390/ijms25137475

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    mdpi.com/1422-0067/25/13/7475
  46. www.cell.com www.cell.com
    Genetic ablation of adhesion ligands mitigates rejection of allogeneic cellular immunotherapies
    1
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      JAX:005557

      DOI: 10.1016/j.stem.2024.06.011

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    cell.com/cell-stem-cell/abstract/S1934-5909(24)00219-4
  47. Jun 2024
  48. www.nature.com www.nature.com
    A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses
    1
    1. scibot 28 Jun 2024
      JAX:005557

      DOI: 10.1038/s41590-024-01880-3

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    nature.com/articles/s41590-024-01880-3
  49. www.sciencedirect.com www.sciencedirect.com
    TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons
    1
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      JAX:005557

      DOI: 10.1016/j.cell.2024.05.030

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    sciencedirect.com/science/article/pii/S0092867424005750
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation
    1
    1. scibot 15 Jun 2024
      JAX:005557

      DOI: 10.1038/s43018-023-00704-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC11175596/
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The exonuclease TREX1 constitutes an innate immune checkpoint limiting cGAS/STING-mediated antitumor immunity
    1
    1. scibot 08 Jun 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2326-6066.CIR-23-1078

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  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nextflow pipeline for Visium and H&E data from patient-derived xenograft samples
    1
    1. scibot 08 Jun 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.crmeth.2024.100759

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  53. www.sciencedirect.com www.sciencedirect.com
    De novo and salvage purine synthesis pathways across tissues and tumors
    1
    1. scibot 04 Jun 2024
      005557

      DOI: 10.1016/j.cell.2024.05.011

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    sciencedirect.com/science/article/pii/S0092867424005208
  54. www.cell.com www.cell.com
    DARPin-fused T cell engager for adenovirus-mediated cancer therapy
    1
    1. scibot 04 Jun 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.omton.2024.200821

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    cell.com/molecular-therapy-family/oncology/abstract/S2950-3299(24)00063-8
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enhancing PKA-dependent mesothelial barrier integrity reduces ovarian cancer spheroid transmesothelial migration via inhibition of contractility
    1
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      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.isci.2024.109950

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    ncbi.nlm.nih.gov/pmc/articles/PMC11134878/
  56. May 2024
  57. www.sciencedirect.com www.sciencedirect.com
    Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite
    2
    1. scibot 31 May 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2024.05.006

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      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2024.05.006

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    sciencedirect.com/science/article/pii/S1535610824001697
  58. www.biorxiv.org www.biorxiv.org
    SMAD4 and KRAS status shape malignant-stromal crosstalk in pancreatic cancer
    1
    1. scibot 23 May 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1101/2024.04.28.591518

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    biorxiv.org/content/10.1101/2024.04.28.591518v1
  59. aacrjournals.org aacrjournals.org
    Development of chromosome 1q+ specific treatment for highest risk pediatric posterior fossa ependymoma
    1
    1. scibot 23 May 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/1078-0432.CCR-23-3156

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    aacrjournals.org/clincancerres/article/30/8/1544/742119/Development-of-Chromosome-1q-Specific-Treatment
  60. 52.53.155.43 52.53.155.43
    cir-23-1078-html.html
    1
    1. scibot 23 May 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2326-6066.cir-23-1078

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    52.53.155.43/ee0bd7762d373e957152429ed1d9032329c895e5/cir-23-1078-html.html
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma
    2
    1. scibot 23 May 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1101/2024.04.23.590638

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      RRID:IMSR_JAX:005557

      DOI: 10.1101/2024.04.23.590638

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    ncbi.nlm.nih.gov/pmc/articles/PMC11071395/
  62. www.sciencedirect.com www.sciencedirect.com
    linc-ADAIN, a human adipose lincRNA, regulates adipogenesis by modulating KLF5 and IL-8 mRNA stability
    1
    1. scibot 16 May 2024
      005557

      DOI: 10.1016/j.celrep.2024.114240

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  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neoadjuvant radiotherapy in ER+, HER2+, and triple-negative -specific breast cancer based humanized tumor mice enhances anti-PD-L1 treatment efficacy
    1
    1. scibot 15 May 2024
      JAX:005557

      DOI: 10.3389/fimmu.2024.1355130

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    ncbi.nlm.nih.gov/pmc/articles/PMC11089195/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human CD4+ Memory Phenotype T cells use mitochondrial metabolism to generate sensitive IFN-γ responses
    1
    1. scibot 11 May 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.isci.2024.109775

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  65. www.sciencedirect.com www.sciencedirect.com
    Inhibition of protein translational machinery in triple-negative breast cancer as a promising therapeutic strategy
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    1. scibot 10 May 2024
      005557

      DOI: 10.1016/j.xcrm.2024.101552

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  66. www.sciencedirect.com www.sciencedirect.com
    Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma
    1
    1. scibot 09 May 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2024.114211

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  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Urolithin-A Promotes CD8+ T Cell–mediated Cancer Immunosurveillance via FOXO1 Activation
    1
    1. scibot 08 May 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2767-9764.CRC-24-0022

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    ncbi.nlm.nih.gov/pmc/articles/PMC11067828/
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive Transcriptomic Analysis of EWSR1::WT1 Targets Identifies CDK4/6 Inhibitors as an Effective Therapy for Desmoplastic Small Round Cell Tumors
    1
    1. scibot 04 May 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/0008-5472.CAN-23-3334

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    ncbi.nlm.nih.gov/pmc/articles/PMC11063761/
  69. www.biorxiv.org www.biorxiv.org
    Imipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma
    1
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      RRID:IMSR_JAX:005557

      DOI: 10.1101/2024.01.12.575058

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    biorxiv.org/content/10.1101/2024.01.12.575058v1
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preclinical Multi-Omic Assessment of Pioglitazone in Skeletal Muscles of Mice Implanted with Human HER2/neu Overexpressing Breast Cancer Xenografts
    1
    1. scibot 03 May 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1101/2024.04.15.589557

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  71. www.sciencedirect.com www.sciencedirect.com
    Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas
    1
    1. scibot 03 May 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2024.04.007

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  72. Apr 2024
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vitro platform to model the function of ionocytes in the human airway epithelium
    1
    1. scibot 30 Apr 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1186/s12931-024-02800-7

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  74. www.sciencedirect.com www.sciencedirect.com
    Selective refueling of CAR T cells using ADA1 and CD26 boosts antitumor immunity
    1
    1. scibot 30 Apr 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.xcrm.2024.101530

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  75. www.sciencedirect.com www.sciencedirect.com
    Development of a chimeric cytokine receptor that captures IL-6 and enhances the antitumor response of CAR-T cells
    1
    1. scibot 26 Apr 2024
      Jackson LaboratoryStrain #:005557

      DOI: 10.1016/j.xcrm.2024.101526

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    sciencedirect.com/science/article/pii/S2666379124001952
  76. www.sciencedirect.com www.sciencedirect.com
    Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer
    1
    1. scibot 25 Apr 2024
      Jackson LaboratoryStrain# 005557

      DOI: 10.1016/j.stem.2024.03.018

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    sciencedirect.com/science/article/pii/S1934590924001243
  77. www.pnas.org www.pnas.org
    NOVA1 acts as an oncogenic RNA-binding protein to regulate cholesterol homeostasis in human glioblastoma cells
    1
    1. scibot 25 Apr 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1073/pnas.2314695121

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    pnas.org/doi/abs/10.1073/pnas.2314695121
  78. link.springer.com link.springer.com
    Single-cell analysis reveals context-dependent, cell-level selection of mtDNA
    1
    1. scibot 25 Apr 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1038/s41586-024-07332-0

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    link.springer.com/article/10.1038/s41586-024-07332-0
  79. www.liebertpub.com www.liebertpub.com
    Biodistribution and Safety of Human Multi-Chimeric Cells (HMCC) After Systemic Intraosseous and Intravenous Administration in the Experimental Mouse Model
    2
    1. scibot 25 Apr 2024
      RRID:ISMR_JAK:005557

      DOI: 10.1089/scd.2024.0007

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      RRID:ISMR_JAK:005557

      DOI: 10.1089/scd.2024.0007

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    liebertpub.com/doi/10.1089/scd.2024.0007
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression
    1
    1. scibot 24 Apr 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1093/narcan/zcae018

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    ncbi.nlm.nih.gov/pmc/articles/PMC11034028/
  81. www.sciencedirect.com www.sciencedirect.com
    Differential RNA Expression Between Metastatic and Primary Neuroblastoma Cells
    1
    1. scibot 19 Apr 2024
      RRID:IMSR_JAX:005

      DOI: 10.1016/j.jss.2024.03.032

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    sciencedirect.com/science/article/pii/S0022480424001434
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Memory-like differentiation, tumor targeting monoclonal antibodies, and chimeric antigen receptors enhance natural killer cell responses to head and neck cancer
    1
    1. scibot 18 Apr 2024
      JAX:005557

      DOI: 10.1158/1078-0432.CCR-23-0156

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    ncbi.nlm.nih.gov/pmc/articles/PMC10796148/
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    iPSC-based modeling of preeclampsia identifies epigenetic defects in extravillous trophoblast differentiation
    1
    1. scibot 18 Apr 2024
      JAX:005557

      DOI: 10.1016/j.isci.2024.109569

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    ncbi.nlm.nih.gov/pmc/articles/PMC11016801/
  84. www.sciencedirect.com www.sciencedirect.com
    Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons
    1
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      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.stem.2024.03.013

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    sciencedirect.com/science/article/pii/S1934590924000948
  85. www.sciencedirect.com www.sciencedirect.com
    Pharmacological induction of chromatin remodeling drives chemosensitization in triple-negative breast cancer
    1
    1. scibot 09 Apr 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.xcrm.2024.101504

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    sciencedirect.com/science/article/pii/S2666379124001733
  86. www.sciencedirect.com www.sciencedirect.com
    Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer
    1
    1. scibot 04 Apr 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2024.114041

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    sciencedirect.com/science/article/pii/S2211124724003693
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma
    1
    1. scibot 03 Apr 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.xcrm.2024.101472

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    ncbi.nlm.nih.gov/pmc/articles/PMC10983107/
  88. www.nature.com www.nature.com
    Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade
    1
    1. scibot 03 Apr 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1038/s41467-024-47069-y

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    nature.com/articles/s41467-024-47069-y
  89. www.sciencedirect.com www.sciencedirect.com
    Targeting DNMT3A-mediated oxidative phosphorylation to overcome ibrutinib resistance in mantle cell lymphoma
    1
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      Jackson Laboratory5557

      DOI: 10.1016/j.xcrm.2024.101484

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    sciencedirect.com/science/article/pii/S2666379124001307
  90. Mar 2024
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MARCH2, a novel oncogene-regulated SNAIL E3 ligase, suppresses triple negative breast cancer metastases
    1
    1. scibot 31 Mar 2024
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      DOI: 10.1158/2767-9764.CRC-23-0090

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  92. www.sciencedirect.com www.sciencedirect.com
    Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma
    1
    1. scibot 29 Mar 2024
      005557

      DOI: 10.1016/j.xcrm.2024.101468

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    sciencedirect.com/science/article/pii/S2666379124001149
  93. www.sciencedirect.com www.sciencedirect.com
    Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1
    1
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      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.chembiol.2024.02.014

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    sciencedirect.com/science/article/pii/S2451945624000886
  94. www.nature.com www.nature.com
    Regulatory T cells expressing CD19-targeted chimeric antigen receptor restore homeostasis in Systemic Lupus Erythematosus
    1
    1. scibot 28 Mar 2024
      RRID:IMSR_JAX

      DOI: 10.1038/s41467-024-46448-9

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  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers
    1
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      RRID:IMSR_JAX:005557

      DOI: 10.1038/s41467-024-46284-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC10951324/
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The bone ecosystem facilitates multiple myeloma relapse and the evolution of heterogeneous drug resistant disease
    1
    1. scibot 22 Mar 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1038/s41467-024-46594-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC10951361/
  97. www.sciencedirect.com www.sciencedirect.com
    FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis
    1
    1. scibot 22 Mar 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.molcel.2024.02.037

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    sciencedirect.com/science/article/pii/S1097276524001801
  98. www.pnas.org www.pnas.org
    CD73 contributes to the pathogenesis of fusion-negative rhabdomyosarcoma through the purinergic signaling pathway
    1
    1. scibot 21 Mar 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1073/pnas.2315925121

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    pnas.org/doi/abs/10.1073/pnas.2315925121
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor
    1
    1. scibot 17 Mar 2024
      RRID:IMSR_JAX:005557

      DOI: 10.7554/eLife.90993

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    ncbi.nlm.nih.gov/pmc/articles/PMC10942784/
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Precision Enhancement of CAR-NK Cells through Non-Viral Engineering and Highly Multiplexed Base Editing
    1
    1. scibot 15 Mar 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1101/2024.03.05.582637

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  101. www.sciencedirect.com www.sciencedirect.com
    ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis
    1
    1. scibot 08 Mar 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2024.02.010

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  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ALK upregulates POSTN and WNT signaling to drive neuroblastoma
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      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2024.113927

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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neutralizing antibodies impair the oncolytic efficacy of reovirus but permit effective combination with T cell-based immunotherapies
    1
    1. scibot 06 Mar 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2326-6066.CIR-23-0480

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    ncbi.nlm.nih.gov/pmc/articles/PMC10911706/
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Engraftment of adult hematopoietic stem and progenitor cells in a novel model of humanized mice
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      JAX:005557

      DOI: 10.1016/j.isci.2024.109238

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    ncbi.nlm.nih.gov/pmc/articles/PMC10904995/
  105. www.sciencedirect.com www.sciencedirect.com
    Identification and characterization of a potent and selective HUNK inhibitor for treatment of HER2+ breast cancer
    2
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      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.chembiol.2024.01.001

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  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression
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      DOI: 10.1038/s44321-023-00006-w

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  107. 52.53.155.43 52.53.155.43
    FEBS Press
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      RRID:IMSR_JAX:005557

      DOI: 10.1002/1878-0261.13561

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    52.53.155.43/47007dbc2cda4f961c79d2e8158521ca8af7c5b7/Molecular Oncology - 2023 - Bots - Preclinical evaluation of the gorilla-derived HAdV-B AdV-lumc007 oncolytic adenovirus -html.html
  108. Feb 2024
  109. aacrjournals.org aacrjournals.org
    Single-cell transcriptomics reveals the heterogeneity of the immune landscape of IDH-wildtype high-grade gliomas
    2
    1. scibot 27 Feb 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2326-6066.CIR-23-0211

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      DOI: 10.1158/2326-6066.CIR-23-0211

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    aacrjournals.org/cancerimmunolres/article/12/2/232/733764/Single-Cell-Transcriptomics-Reveals-the
  110. www.sciencedirect.com www.sciencedirect.com
    A versatile CRISPR-Cas13d platform for multiplexed transcriptomic regulation and metabolic engineering in primary human T cells
    1
    1. scibot 22 Feb 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.cell.2024.01.035

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  111. www.sciencedirect.com www.sciencedirect.com
    SLC25A51 decouples the mitochondrial NAD+/NADH ratio to control proliferation of AML cells
    1
    1. scibot 16 Feb 2024
      Jackson Laboratories# 005557

      DOI: 10.1016/j.cmet.2024.01.013

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    sciencedirect.com/science/article/pii/S1550413124000135
  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stromal-derived MAOB promotes prostate cancer growth and progression
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    1. scibot 14 Feb 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1126/sciadv.adi4935

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  113. www.sciencedirect.com www.sciencedirect.com
    Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks
    2
    1. scibot 14 Feb 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.immuni.2024.01.011

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      DOI: 10.1016/j.immuni.2024.01.011

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  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
    1
    1. scibot 11 Feb 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2767-9764.CRC-23-0321

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  115. www.biorxiv.org www.biorxiv.org
    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
    3
    1. scibot 09 Feb 2024
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      DOI: 10.1101/2023.12.05.570182

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      DOI: 10.1101/2023.12.05.570182

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      DOI: 10.1101/2023.12.05.570182

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    biorxiv.org/content/10.1101/2023.12.05.570182v1
  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma
    1
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      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.isci.2024.108925

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    ncbi.nlm.nih.gov/pmc/articles/PMC10844834/
  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of choline metabolism in an angioimmunoblastic T-cell lymphoma preclinical model reveals a new metabolic vulnerability as possible target for treatment
    1
    1. scibot 08 Feb 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1186/s13046-024-02952-w

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    ncbi.nlm.nih.gov/pmc/articles/PMC10845598/
  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FPFT-2216, a novel anti-lymphoma compound, induces simultaneous degradation of IKZF1/3 and CK1α to activate p53 and inhibit NF-κB signaling
    1
    1. scibot 08 Feb 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2767-9764.CRC-23-0264

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    ncbi.nlm.nih.gov/pmc/articles/PMC10846380/
  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas
    1
    1. scibot 06 Feb 2024
      RRID:IMSR_JAX

      DOI: 10.1158/2159-8290.CD-22-1401

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    ncbi.nlm.nih.gov/pmc/articles/PMC10524254/
  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ORAOV1, CCND1, and MIR548K Are the Driver Oncogenes of the 11q13 Amplicon in Squamous Cell Carcinoma
    1
    1. scibot 03 Feb 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/1541-7786.MCR-23-0746

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    ncbi.nlm.nih.gov/pmc/articles/PMC10831340/
  121. www.sciencedirect.com www.sciencedirect.com
    SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion
    1
    1. scibot 02 Feb 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.cell.2024.01.008

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    sciencedirect.com/science/article/pii/S0092867424000102
  122. Jan 2024
  123. www.sciencedirect.com www.sciencedirect.com
    Inosine induces stemness features in CAR-T cells and enhances potency
    1
    1. scibot 26 Jan 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2024.01.002

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    sciencedirect.com/science/article/pii/S1535610824000084
  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor cell–intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling
    2
    1. scibot 25 Jan 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1126/sciadv.adi2012

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    2. scibot 23 Jan 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1126/sciadv.adi2012

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    ncbi.nlm.nih.gov/pmc/articles/PMC10798567/
  125. www.sciencedirect.com www.sciencedirect.com
    Cholinergic signaling via muscarinic M1 receptor confers resistance to docetaxel in prostate cancer
    1
    1. scibot 23 Jan 2024
      Jackson LaboratoryCat# 005557

      DOI: 10.1016/j.xcrm.2023.101388

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    sciencedirect.com/science/article/pii/S2666379123006171
  126. www.sciencedirect.com www.sciencedirect.com
    Selective induction of human renal interstitial progenitor-like cell lineages from iPSCs reveals development of mesangial and EPO-producing cells
    1
    1. scibot 19 Jan 2024
      Jackson Laboratory: Stock No: 005557

      DOI: 10.1016/j.celrep.2023.113602

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    sciencedirect.com/science/article/pii/S2211124723016145
  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fusion-negative rhabdomyosarcoma 3D organoids to predict effective drug combinations: A proof-of-concept on cell death inducers
    1
    1. scibot 12 Jan 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.xcrm.2023.101339

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    ncbi.nlm.nih.gov/pmc/articles/PMC10772578/
  128. www.sciencedirect.com www.sciencedirect.com
    Metabolic reprogramming by histone deacetylase inhibition preferentially targets NRF2-activated tumors
    1
    1. scibot 11 Jan 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2023.113629

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    sciencedirect.com/science/article/pii/S2211124723016406
  129. www.sciencedirect.com www.sciencedirect.com
    Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
    1
    1. scibot 11 Jan 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.molcel.2023.12.003

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    sciencedirect.com/science/article/pii/S1097276523010225
  130. www.sciencedirect.com www.sciencedirect.com
    Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo
    1
    1. scibot 11 Jan 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.stem.2023.12.003

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    sciencedirect.com/science/article/pii/S1934590923004332
  131. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    β-catenin-driven differentiation is a tissue-specific epigenetic vulnerability in adrenal cancer
    1
    1. scibot 10 Jan 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/0008-5472.CAN-22-2712

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    ncbi.nlm.nih.gov/pmc/articles/PMC10330305/
  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence
    1
    1. scibot 05 Jan 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/1535-7163.MCT-23-0026

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    ncbi.nlm.nih.gov/pmc/articles/PMC10762335/
  133. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Brentuximab Vedotin–Driven Microtubule Disruption Results in Endoplasmic Reticulum Stress Leading to Immunogenic Cell Death and Antitumor Immunity
    1
    1. scibot 05 Jan 2024
      RRID:IMSR_JAX:005557

      DOI: 10.1158/1535-7163.MCT-23-0118

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    ncbi.nlm.nih.gov/pmc/articles/PMC10762337/
  134. Dec 2023
  135. www.embopress.org www.embopress.org
    Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression
    1
    1. scibot 29 Dec 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1038/s44321-023-00006-w

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    embopress.org/doi/10.1038/s44321-023-00006-w
  136. www.sciencedirect.com www.sciencedirect.com
    The sinoatrial node extracellular matrix promotes pacemaker phenotype and protects automaticity in engineered heart tissues from cyclic strain
    2
    1. scibot 20 Dec 2023
      The Jackson LaboratoryStrain # 005557

      DOI: 10.1016/j.celrep.2023.113505

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    2. scibot 20 Dec 2023
      JAX:005557

      DOI: 10.1016/j.celrep.2023.113505

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    sciencedirect.com/science/article/pii/S2211124723015176
  137. www.sciencedirect.com www.sciencedirect.com
    FLT3L-dependent dendritic cells control tumor immunity by modulating Treg and NK cell homeostasis
    1
    1. scibot 20 Dec 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.xcrm.2023.101256

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    sciencedirect.com/science/article/pii/S2666379123004330
  138. www.sciencedirect.com www.sciencedirect.com
    AA2P-mediated DNA demethylation synergizes with stem cell agonists to promote expansion of hematopoietic stem cells
    3
    1. scibot 17 Dec 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.crmeth.2023.100663

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    2. scibot 17 Dec 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.crmeth.2023.100663

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    3. scibot 17 Dec 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.crmeth.2023.100663

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    sciencedirect.com/science/article/pii/S2667237523003405
  139. link.springer.com link.springer.com
    Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining DNA repair
    1
    1. scibot 16 Dec 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1038/s41551-023-01157-4

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    link.springer.com/article/10.1038/s41551-023-01157-4
  140. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Interleukin-30 subverts prostate cancer-endothelium crosstalk by fostering angiogenesis and activating immunoregulatory and oncogenic signaling pathways
    1
    1. scibot 15 Dec 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1186/s13046-023-02902-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC10714661/
  141. link.springer.com link.springer.com
    Generation of antigen-specific mature T cells from RAG1−/−RAG2−/−B2M−/− stem cells by engineering their microenvironment
    1
    1. scibot 08 Dec 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1038/s41551-023-01146-7

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    link.springer.com/article/10.1038/s41551-023-01146-7
  142. www.sciencedirect.com www.sciencedirect.com
    Prospective isolation of neural stem and progenitor cells from the developing human brain
    1
    1. scibot 02 Dec 2023
      JAX:005557

      DOI: 10.1016/j.xpro.2023.102674

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    sciencedirect.com/science/article/pii/S266616672300641X
  143. www.sciencedirect.com www.sciencedirect.com
    ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells
    1
    1. scibot 02 Dec 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2023.11.004

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    sciencedirect.com/science/article/pii/S1535610823003951
  144. www.biorxiv.org www.biorxiv.org
    H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs
    1
    1. scibot 02 Dec 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1101/2023.11.28.567931

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    biorxiv.org/content/10.1101/2023.11.28.567931v1
  145. link.springer.com link.springer.com
    The DNA/RNA helicase DHX9 orchestrates the KDM2B-mediated transcriptional regulation of YAP1 in Ewing sarcoma
    1
    1. scibot 02 Dec 2023
      JAX:005557

      DOI: 10.1038/s41388-023-02894-1

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    link.springer.com/article/10.1038/s41388-023-02894-1
  146. Nov 2023
  147. www.sciencedirect.com www.sciencedirect.com
    SERPINB3-MYC axis induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer
    1
    1. scibot 28 Nov 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2023.113434

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    sciencedirect.com/science/article/pii/S2211124723014468
  148. www.sciencedirect.com www.sciencedirect.com
    Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation
    1
    1. scibot 28 Nov 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2023.10.009

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    sciencedirect.com/science/article/pii/S1535610823003653
  149. www.sciencedirect.com www.sciencedirect.com
    Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML
    1
    1. scibot 22 Nov 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.xcrm.2023.101290

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    sciencedirect.com/science/article/pii/S2666379123004846
  150. www.biorxiv.org www.biorxiv.org
    Induction of immortal-like and functional CAR-T cells by defined factors
    1
    1. scibot 17 Nov 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1101/2023.11.06.565785

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    biorxiv.org/content/10.1101/2023.11.06.565785v1
  151. www.biorxiv.org www.biorxiv.org
    One infusion of engineered long-lasting and multifunctional T cells cures asthma in mice
    1
    1. scibot 17 Nov 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1101/2023.11.06.565713

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    biorxiv.org/content/10.1101/2023.11.06.565713v1
  152. link.springer.com link.springer.com
    Human Wharton’s jelly-derived mesenchymal stromal cells promote bone formation in immunodeficient mice when administered into a bone microenvironment
    1
    1. scibot 12 Nov 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1186/s12967-023-04672-9

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    link.springer.com/article/10.1186/s12967-023-04672-9
  153. link.springer.com link.springer.com
    Multimeric immunotherapeutic complexes activating natural killer cells towards HIV-1 cure
    1
    1. scibot 10 Nov 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1186/s12967-023-04669-4

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    link.springer.com/article/10.1186/s12967-023-04669-4
  154. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target
    2
    1. scibot 03 Nov 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2643-3230.BCD-22-0086

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      RRID:IMSR_JAX:005557
    2. scibot 03 Nov 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2643-3230.BCD-22-0086

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    ncbi.nlm.nih.gov/pmc/articles/PMC10150294/
  155. www.sciencedirect.com www.sciencedirect.com
    Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers
    1
    1. scibot 02 Nov 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.immuni.2023.09.013

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    sciencedirect.com/science/article/pii/S1074761323004181
  156. Oct 2023
  157. www.sciencedirect.com www.sciencedirect.com
    Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer
    1
    1. scibot 28 Oct 2023
      JAX:005557

      DOI: 10.1016/j.cmet.2023.10.002

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    sciencedirect.com/science/article/pii/S1550413123003716
  158. www.sciencedirect.com www.sciencedirect.com
    Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages
    1
    1. scibot 28 Oct 2023
      JAX:5557

      DOI: 10.1016/j.celrep.2023.113256

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    sciencedirect.com/science/article/pii/S2211124723012688
  159. 52.53.155.43 52.53.155.43
    The T766M-EGFR lung cancer mutation promotes tumor growth by exploiting newfound assembly mechanisms in ligand-free EGFR oligomers
    1
    1. scibot 14 Oct 2023
      RRID:IMSR_JAX:00

      DOI: 10.1101/2023.06.16.545259

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    52.53.155.43/e45e39aa6be90d4518c1365e2458466145a6420b/2023.06.16.545259v2.full-html.html
  160. www.sciencedirect.com www.sciencedirect.com
    Genetic and pharmaceutical targeting of HIF1α allows combo-immunotherapy to boost graft vs. leukemia without exacerbation graft vs. host disease
    1
    1. scibot 13 Oct 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.xcrm.2023.101236

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    sciencedirect.com/science/article/pii/S2666379123004135
  161. www.biorxiv.org www.biorxiv.org
    Long-term engraftment of adult hematopoietic progenitors in a novel model of humanized mice
    1
    1. scibot 13 Oct 2023
      JAX:005557

      DOI: 10.1101/2023.10.02.560534

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    biorxiv.org/content/10.1101/2023.10.02.560534v1
  162. www.sciencedirect.com www.sciencedirect.com
    Cooperative CAR targeting to selectively eliminate AML and minimize escape
    1
    1. scibot 13 Oct 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2023.09.010

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    sciencedirect.com/science/article/pii/S1535610823003264
  163. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nuclear speckles regulate HIF-2α programs and correlate with patient survival in kidney cancer
    1
    1. scibot 05 Oct 2023
      Jackson Laboratories, Strain #:005557

      DOI: 10.1101/2023.09.14.557228

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    ncbi.nlm.nih.gov/pmc/articles/PMC10515914/
  164. Sep 2023
  165. www.sciencedirect.com www.sciencedirect.com
    Signaling-induced systematic repression of miRNAs uncovers cancer vulnerabilities and targeted therapy sensitivity
    1
    1. scibot 30 Sep 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.xcrm.2023.101200

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    sciencedirect.com/science/article/pii/S2666379123003671
  166. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Myeloid leukemia vulnerabilities embedded in long noncoding RNA locus MYNRL15
    2
    1. scibot 29 Sep 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.isci.2023.107844

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    2. scibot 29 Sep 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.isci.2023.107844

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    ncbi.nlm.nih.gov/pmc/articles/PMC10520325/
  167. www.sciencedirect.com www.sciencedirect.com
    Modular pooled discovery of synthetic knockin sequences to program durable cell therapies
    1
    1. scibot 16 Sep 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.cell.2023.08.013

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    sciencedirect.com/science/article/pii/S0092867423009029
  168. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mouse intraductal modeling of primary ductal carcinoma in situ
    1
    1. scibot 08 Sep 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.xpro.2023.102526

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    ncbi.nlm.nih.gov/pmc/articles/PMC10480770/
  169. link.springer.com link.springer.com
    59 th EASD Annual Meeting of the European Association for the Study of Diabetes
    1
    1. scibot 07 Sep 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1007/s00125-023-05969-6

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    link.springer.com/article/10.1007/s00125-023-05969-6
  170. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Salmonella enterica serovar Typhi uses two type 3 secretion systems to replicate in human macrophages and colonize humanized mice
    1
    1. scibot 07 Sep 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1128/mbio.01137-23

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    ncbi.nlm.nih.gov/pmc/articles/PMC10470537/
  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Low-dose carboplatin modifies the tumor microenvironment to augment CAR T cell efficacy in human prostate cancer models
    1
    1. scibot 06 Sep 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1038/s41467-023-40852-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC10475084/
  172. Aug 2023
  173. www.sciencedirect.com www.sciencedirect.com
    Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus
    1
    1. scibot 31 Aug 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.devcel.2023.08.017

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    sciencedirect.com/science/article/pii/S1534580723004136
  174. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The circadian clock circuitry modulates leukemia initiating cell activity in T-cell acute lymphoblastic leukemia
    1
    1. scibot 31 Aug 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1186/s13046-023-02799-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC10464343/
  175. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Skin-Grafting and Dendritic Cell “Boosted” Humanized Mouse Models Allow the Pre-Clinical Evaluation of Therapeutic Cancer Vaccines
    1
    1. scibot 29 Aug 2023
      RRID:IMSR_JAX:005557

      DOI: 10.3390/cells12162094

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    ncbi.nlm.nih.gov/pmc/articles/PMC10453599/
  176. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activating Inducible T cell Co-stimulator (ICOS) yields anti-tumor activity alone and in combination with anti-PD-1 checkpoint blockade
    3
    1. scibot 26 Aug 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2767-9764.CRC-22-0293

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    2. scibot 26 Aug 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2767-9764.CRC-22-0293

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    3. scibot 26 Aug 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2767-9764.CRC-22-0293

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    ncbi.nlm.nih.gov/pmc/articles/PMC10430783/
  177. 52.53.155.43 52.53.155.43
    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
    2
    1. scibot 18 Aug 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.xcrm.2023.101142

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    2. scibot 10 Aug 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.xcrm.2023.101142

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    52.53.155.43/bb31ad2b14838f5cede2aca897c595e2febf2f88/PIIS2666379123002951-html.html
  178. 52.53.155.43 52.53.155.43
    SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine
    2
    1. scibot 17 Aug 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2023.112940

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      RRID:IMSR_JAX:005557
    2. scibot 16 Aug 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2023.112940

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    52.53.155.43/746dceaaaecd8ad8008d9df523b985f7a77f181a/PIIS2211124723009518-html.html
  179. 52.53.155.43 52.53.155.43
    crc-22-0293-html.html
    2
    1. scibot 11 Aug 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2767-9764.crc-22-0293

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      RRID:IMSR_JAX:005557
    2. scibot 11 Aug 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2767-9764.crc-22-0293

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    52.53.155.43/4f107a6ec2874295e908f0e6a1a5e9653abe6492/crc-22-0293-html.html
  180. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effectors Enabling Adaptation to Mitochondrial Complex I Loss in Hürthle Cell Carcinoma
    1
    1. scibot 10 Aug 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2159-8290.CD-22-0976

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    ncbi.nlm.nih.gov/pmc/articles/PMC10401073/
  181. www.sciencedirect.com www.sciencedirect.com
    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
    1
    1. scibot 04 Aug 2023
      JAX:005557

      DOI: 10.1016/j.ccell.2023.07.005

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    sciencedirect.com/science/article/pii/S1535610823002453
  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway
    1
    1. scibot 03 Aug 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1158/0008-5472.CAN-22-3173

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    ncbi.nlm.nih.gov/pmc/articles/PMC10391328/
  183. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BET Inhibitors Target the SCLC-N subtype of Small Cell Lung Cancer by Blocking NEUROD1 Transactivation
    1
    1. scibot 02 Aug 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1158/1541-7786.MCR-22-0594

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    ncbi.nlm.nih.gov/pmc/articles/PMC9898120/
  184. Jul 2023
  185. www.science.org www.science.org
    Targeting the chromatin effector Pygo2 promotes cytotoxic T cell responses and overcomes immunotherapy resistance in prostate cancer
    1
    1. scibot 14 Jul 2023
      JAX:005557

      DOI: 10.1126/sciimmunol.ade4656

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    science.org/doi/10.1126/sciimmunol.ade4656
  186. www.sciencedirect.com www.sciencedirect.com
    Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer
    1
    1. scibot 14 Jul 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.xcrm.2023.101120

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    sciencedirect.com/science/article/pii/S2666379123002483
  187. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses
    1
    1. scibot 08 Jul 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2643-3230.BCD-22-0029

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    ncbi.nlm.nih.gov/pmc/articles/PMC9816815/
  188. 52.53.155.43 52.53.155.43
    can-22-3173-html.html
    1
    1. scibot 08 Jul 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1158/0008-5472.can-22-3173

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    52.53.155.43/7a07162d3285902b20a1a359628fdd8826284ee8/can-22-3173-html.html
  189. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGF1R inhibition enhances the therapeutic effects of Gq/11 inhibition in metastatic uveal melanoma progression
    1
    1. scibot 06 Jul 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1158/1535-7163.MCT-22-0147

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    ncbi.nlm.nih.gov/pmc/articles/PMC9812929/
  190. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    T-BET and EOMES sustain mature human NK cell identity and anti-tumor function
    1
    1. scibot 06 Jul 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1172/JCI162530

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  191. Jun 2023
  192. 52.53.155.43 52.53.155.43
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    1. scibot 30 Jun 2023
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      DOI: 10.1158/0008-5472.CAN-22-3173

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  193. 52.53.155.43 52.53.155.43
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  194. www.sciencedirect.com www.sciencedirect.com
    QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism
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      DOI: 10.1016/j.cell.2023.05.047

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  195. currentprotocols.onlinelibrary.wiley.com currentprotocols.onlinelibrary.wiley.com
    Production of Humanized Mice through Stem Cell Transfer
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      DOI: 10.1002/cpz1.800

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  196. 52.53.155.43 52.53.155.43
    ZIC1 dictates osteogenesis versus adipogenesis in human mesenchymal progenitor cells via a Hedgehog dependent mechanism
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    Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways
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      DOI: 10.1016/j.cmet.2023.05.007

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  198. www.nature.com www.nature.com
    CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling
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      DOI: 10.1038/s41467-023-39281-z

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