962 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TCF3::HLF orchestrates an enhancer-promoter network with activation of MEF2C to promote immature HSC gene expression in leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC13148343/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Distinct cytokines regulate gene expression and anti-tumor activity in regenerated CD8+ T cells from induced pluripotent stem cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC13145887/
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    Leukemic stem cell subtypes determine venetoclax resistance and therapeutic vulnerabilities in AML
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    sciencedirect.com/science/article/pii/S1934590926001529
  5. May 2026
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MECOM Function Is Critical for AR-Driven Treatment-Resistant Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13136877/
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    mRNA lipid-nanoparticle-mediated mitochondrial apoptosis augments adoptive T cell immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13130659/
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    Human cerebral organoids with microglia and vasculature model glioma stem cell interactions and radiotherapy response
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    sciencedirect.com/science/article/pii/S2667237526001256
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    GLS1 Orchestrates Exosome-Mediated Tumor-Endothelial Communication to Facilitate Angiogenesis
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.75510
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    Preclinical Characterization and Clinical Activity of RNK08954, a Highly Selective and Orally Bioavailable KRAS G12D Inhibitor
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    pmc.ncbi.nlm.nih.gov/articles/PMC13133609/
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    Implantable vascularized endocrine constructs for clinically scalable insulin delivery
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    sciencedirect.com/science/article/pii/S0167779926001290
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    ADT-030, a novel PDE10 inhibitor, demonstrates potent antitumor activity in pancreatic ductal adenocarcinoma
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    biorxiv.org/content/10.64898/2026.02.11.705411v1
  13. Apr 2026
  14. aacrjournals.org aacrjournals.org
    QW-5-70 targets the colchicine site and demonstrates antitumor activity in P-gp–overexpressing cancer models
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    aacrjournals.org/mct/article/doi/10.1158/1535-7163.MCT-25-1013/784192/QW-5-70-Targets-the-Colchicine-Site-and
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    PALINCODE: Recording cell lineage with ternary palindromic CRISPR bits
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    biorxiv.org/content/10.64898/2026.04.16.718941v1
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    Bone Metastatic Progression of Prostate Cancer is Regulated by TRIM28-LDHA Mediated Metabolism
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    aacrjournals.org/mcr/article/24/2/93/772003/Bone-Metastatic-Progression-of-Prostate-Cancer-Is
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    The allogeneic FAP-CAR-IL15 iNKT therapy MiNK-215 remodels the tumor stroma to enhance antitumor immunity
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    aacrjournals.org/cancerimmunolres/article/14/2/243/771961/The-Allogeneic-FAP-CAR-IL15-iNKT-Therapy-MiNK-215
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    Endoglin-directed CAR-T cells Comprehensively Target Tumors in Advanced Sarcomas
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    aacrjournals.org/cancerimmunolres/article/13/10/1591/765477/Endoglin-Directed-CAR-T-Cells-Comprehensively
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    KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia
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    RHOV is a Detachment-Responsive Rho GTPase Necessary for Ovarian Cancer Peritoneal Metastasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13089303/
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    Advanced models of lobular breast cancer metastasis capture clinical organ tropism, endocrine response, and bone remodeling
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    biorxiv.org/content/10.64898/2026.03.13.711653v1
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    Recurrent Resistance Mutations to Lirafugratinib Inform Treatment Sequencing in FGFR2-Driven Tumors
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  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Synergistic Treatment of Prostate Cancer and Multiple Myeloma using CD46-Targeted Radioimmunotherapy Antibody–Drug Conjugates
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    pmc.ncbi.nlm.nih.gov/articles/PMC13080322/
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    Targeting tumor microenvironment-derived NRG1-HER2/3 signaling with zenocutuzumab restores sensitivity to AR inhibition in PTEN wild-type prostate cancer
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    aacrjournals.org/mct/article/25/4/662/776472/Targeting-Tumor-Microenvironment-Derived-NRG1-HER2
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    Rationally designed light-inducible RNA-releasing protein for translational regulation and optogenetic control of gene therapies
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    Defining the functional role and potential as an immunotherapeutic target of ALCAM in neuroblastoma
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  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-Cell Lineage Tracing Uncovers Resistance Signatures and Sensitizing Strategies to FLT3 Inhibitors in Acute Myeloid Leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC7618455/
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    Anti-tumor activity of trastuzumab deruxtecan in pediatric solid tumors with variable HER2 expression
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    αvβ3 CAR-T Cells Simultaneously Targeting Tumor and Metastases Produce Highly Effective Control in Preclinical Models of Melanoma and Triple-Negative Breast Cancer
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  34. Mar 2026
  35. www.sciencedirect.com www.sciencedirect.com
    NOT-gated chimeric antigen receptor circuits in T and NK cells
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    A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy
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    Targeting PI3Kδ suppresses pancreatic cancer by dual disruption of fibrosis and immune evasion
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    Hyperdiploidy impairs fetal hematopoietic progenitor fitness and differentiation enabling persistence of rare preleukemic aneuploid clones
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    A novel humanized immune stroma PDX cancer model for therapeutic studies
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  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD70-Targeting CAR NK Cells Overcome BCMA Downregulation and Improve Survival in High-risk Multiple Myeloma Models
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    pmc.ncbi.nlm.nih.gov/articles/PMC13012245/
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    Radiotherapy synergizes with an inducible AAV-based immunotherapy platform to program local and systemic antitumor immunity
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    Disruption of WNT/Notch signaling in pancreatic cancer reveals tumors depend on the intricate equilibrium of malignant cell states
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    Deep-learning-based de novo discovery and design of therapeutics that reverse disease-associated transcriptional phenotypes
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    Plasticity of squamous differentiation drives drug resistance in HNSCC
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    biorxiv.org/content/10.64898/2026.03.09.710514v1
  45. www.science.org www.science.org
    IL-7/IL-15/IL-21 cytokine-fusion scaffold generates highly functional CAR T cells enriched in long-lived T memory stem cells
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    science.org/doi/10.1126/sciadv.aec2632
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Recurrent Immunogenic Neoantigens and Their Cognate T-cell Receptors in Treatment-Resistant Metastatic Prostate Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12749549/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RRAS and RRAS2 mutations are recurrent oncogenic drivers in lung cancer and are sensitive to the pan-RAS inhibitor RMC-6236
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    pmc.ncbi.nlm.nih.gov/articles/PMC12978839/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IL-7/IL-15/IL-21 cytokine-fusion scaffold generates highly functional CAR T cells enriched in long-lived T memory stem cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12985740/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatiotemporal profiling reveals distinct dynamics and checkpoint regulations of CAR-T and CAR-NKT cells against solid tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12987976/
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    Membrane Curvature Activates Src kinase and Promotes Metastatic Cancer Cell Survival
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    biorxiv.org/content/10.64898/2026.03.03.709279v1
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    Genomic enrichment and functional impact of TP53 and CYLD alterations in recurrent and metastatic HPV-associated head and neck cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12959380/
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    Macrophage metabolic exhaustion and PANoptotic cell death drive chronic tissue inflammation in rheumatoid arthritis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13020464/
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    β-hydroxybutyrate enhances the metabolic fitness of CAR T cells in cancer
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    A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies
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    Vascular STING activation facilitates NK cell anti-tumor immunity in small cell lung cancer
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  56. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    GPX4 Inhibitor Resistance and Metastatic Features in Triple-Negative Breast Cancer
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202523198
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    PTPN1/2 inhibits alveolar macrophage-mediated control of lung metastasis
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    biorxiv.org/content/10.64898/2026.02.25.707995v1
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    XPO1R749Q Mutations Co-occur with POLE Mutations in Cancer and can be Targeted to Overcome Chemoresistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12354660/
  59. Feb 2026
  60. www.sciencedirect.com www.sciencedirect.com
    CRISPR-based functional genomics for dissecting therapeutic dependency in primary acute myeloid leukemia samples
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    HIV broadly neutralizing antibody escape dynamics drive the outcome of AAV-vectored immunotherapy in humanized mice
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    An Enhancement of Extrachromosomal Circular DNA Enrichment and Amplification to Address the Extremely Low Overlap Between Replicates
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  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Repurposing statins and phenothiazines to treat chemoresistant neuroblastoma
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    Syndecan-1-targeted therapeutic antibody impairs macropinocytosis and elicits antitumor immunity in pancreatic cancer
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    ADT-030, a novel PDE10 inhibitor, demonstrates potent antitumor activity in pancreatic ductal adenocarcinoma
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    biorxiv.org/content/10.64898/2026.02.11.705411v1
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    Tumor Exosomal L1 Cell Adhesion Molecule Promotes Brain Metastasis of Lung Cancer
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    spj.science.org/doi/10.34133/research.1126
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    HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer
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    Non-invasive ovulation tracking enables genetic engineering in wild rodents
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    Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12900515/
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    Hypoxia restores the acidosis-induced inhibition of cancer cell dissemination
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    sciencedirect.com/science/article/pii/S2211124726000483
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    Tumor Exosomal L1 Cell Adhesion Molecule Promotes Brain Metastasis of Lung Cancer
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    RAB3GAP2 is a regulator of skeletal muscle endothelial cell proliferation and associated with capillary-to-fiber ratio
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  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Epigenetic and Transcriptional Programs Define Osteosarcoma Subtypes and Establish Targetable Vulnerabilities
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    Compartmentalized branched-chain amino acid metabolism orchestrates colorectal cancer dissemination via an UMP-vimentin axis
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  75. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Colorectal cancer-derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.70212
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Microbial Bile Acid Metabolite 3-oxo-LCA Inhibits Colorectal Cancer Progression
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  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protocol for the generation and xenotransplantation of human induced pluripotent stem cell-derived neural progenitor cells into the mouse forebrain
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    The SWI/SNF-related protein SMARCA3 is a histone H3K23 ubiquitin ligase that regulates H3K9me3 in cancer
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    Male-biased Yap1-Cd276/B7-H3 axis for immune evasion in medulloblastoma
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  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting the tumor cell-intrinsic ITGB2 axis inhibits melanoma progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12744402/
  81. Jan 2026
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ATAD2 drives melanoma growth and progression and inhibits ferroptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12852765/
  83. www.biorxiv.org www.biorxiv.org
    NK Cells Engineered with a Chimeric Antigen Receptor Delay HIV Rebound and Reshape HIV Reservoir Composition
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    biorxiv.org/content/10.64898/2026.01.22.700964v1
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A CD8αβ co-receptor modified to contain an intracellular CD28 signaling tail enhances TCR-engineered T cell function independent of solid-tumor-associated co-stimulatory ligands
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    pmc.ncbi.nlm.nih.gov/articles/PMC12820041/
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Discovery of potent and brain-penetrable tubulin inhibitors that effectively suppress breast cancer brain metastasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12830028/
  86. www.nature.com www.nature.com
    CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p21/p27 induction
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    nature.com/articles/s41467-025-67865-4
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    Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers
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    SREBP-1 upregulates SOAT1 to promote tumor growth by preventing lipotoxicity
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    Pan-cancer N-glycoproteomic atlas of patient-derived xenografts uncovers FAT2 as an actionable surface target
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