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pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma

1
1. scibot 19 Apr 2025
  
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  JAX:005557
  
  DOI: 10.1038/s41419-025-07623-y
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12003641/
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Fate and state transitions during human blood vessel organoid development

1
1. scibot 19 Apr 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.cell.2025.03.037
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S0092867425003873
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Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation

1
1. scibot 19 Apr 2025
  
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  JAX:5557
  
  DOI: 10.1016/j.ccell.2025.03.027
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S153561082500128X
52.53.155.43 52.53.155.43

1-s2.0-S2589004225006972-main-html.html

1
1. scibot 17 Apr 2025
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.isci.2025.112436
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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52.53.155.43/be11899c572d4eef940b4fb0c7f6692cd5cc7cb8/1-s2.0-S2589004225006972-main-html.html
Apr 2025
www.biorxiv.org www.biorxiv.org

Inhibition of EMT driver PTK6 enhances anti-tumor immune responses against triple-negative breast cancer

1
1. scibot 15 Apr 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1101/2025.01.11.632044
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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biorxiv.org/content/10.1101/2025.01.11.632044v1
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Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity

1
1. scibot 15 Apr 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.cell.2025.03.017
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S0092867425002909
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Library-based single-cell analysis of CAR signaling reveals drivers of in vivo persistence

1
1. scibot 11 Apr 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.cels.2025.101260
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S2405471225000936
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Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance

1
1. scibot 11 Apr 2025
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.ccell.2025.03.031
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S1535610825001321
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A cloaked human stem-cell-derived neural graft capable of functional integration and immune evasion in rodent models

1
1. scibot 10 Apr 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.stem.2025.03.008
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S1934590925000980
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Protocol for optimizing culture conditions for ex vivo activation during CRISPR-Cas9 gene editing in human hematopoietic stem and progenitor cells

1
1. scibot 05 Apr 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.xpro.2025.103722
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S2666166725001285
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CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer

1
1. scibot 05 Apr 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.xcrm.2025.102053
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S2666379125001260
www.biorxiv.org www.biorxiv.org

The SRG RAT® supports human cell xenotransplantation through enhanced tumor microenvironment interactions

1
1. scibot 04 Apr 2025
  
  in Public
  
  strain: 005557
  
  DOI: 10.1101/2025.03.27.645250
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @sjvitug
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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biorxiv.org/content/10.1101/2025.03.27.645250v1
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Engineering sonogenetic EchoBack-CAR T cells

1
1. scibot 03 Apr 2025
  
  in Public
  
  Jackson Laboratory Cat_005557
  
  DOI: 10.1016/j.cell.2025.02.035
  
  Resource: None
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRIDCUR:Unresolved RRID:IMSR_JAX:005557
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sciencedirect.com/science/article/pii/S0092867425002715
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A Checkpoint Reversal Receptor Mediates Bipartite Activation and Enhances CAR T-cell Function

1
1. scibot 02 Apr 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/2767-9764.CRC-24-0125
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11955954/
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Signaling and transcriptional dynamics underlying early adaptation to oncogenic BRAF inhibition

1
1. scibot 01 Apr 2025
  
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  Jackson Laboratory Cat_005557
  
  DOI: 10.1016/j.cels.2025.101239
  
  Resource: None
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRIDCUR:Unresolved RRID:IMSR_JAX:005557
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sciencedirect.com/science/article/pii/S2405471225000729
Mar 2025
www.sciencedirect.com www.sciencedirect.com

A patient-derived T cell lymphoma biorepository uncovers pathogenetic mechanisms and host-related therapeutic vulnerabilities

1
1. scibot 29 Mar 2025
  
  in Public
  
  The Jackson Laboratory5557
  
  DOI: 10.1016/j.xcrm.2025.102029
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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sciencedirect.com/science/article/pii/S2666379125001028
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Antagonistic roles for MITF and TFE3 in melanoma plasticity

1
1. scibot 29 Mar 2025
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.celrep.2025.115474
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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sciencedirect.com/science/article/pii/S2211124725002451
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Translation dysregulation in cancer as a source for targetable antigens

1
1. scibot 28 Mar 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.ccell.2025.03.003
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
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  RRID:IMSR_JAX:005557
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sciencedirect.com/science/article/pii/S1535610825000820
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Targeting WEE1 kinase as a therapeutic strategy in ATIP3-deficient breast cancers

1
1. scibot 25 Mar 2025
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.canlet.2025.217665
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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sciencedirect.com/science/article/pii/S0304383525002319
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 24 Mar 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/1535-7163.mct-24-0856
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
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52.53.155.43/b715c1a68ef0cb7b0448e003b2c7b73d6290765e/PDF-html.html
www.biorxiv.org www.biorxiv.org

The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasis

1
1. scibot 24 Mar 2025
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1101/2025.03.18.644053
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
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  RRID:IMSR_JAX:005557
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biorxiv.org/content/10.1101/2025.03.18.644053v1
www.cell.com www.cell.com

Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites

1
1. scibot 23 Mar 2025
  
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  JAX:005557
  
  DOI: 10.1016/j.stem.2025.02.013
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
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  RRID:IMSR_JAX:005557
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cell.com/cell-stem-cell/abstract/S1934-5909(25)00081-5
www.cell.com www.cell.com

Small-molecule RNA therapeutics to target prostate cancer

1
1. scibot 23 Mar 2025
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.ccell.2025.02.027
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
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  RRID:IMSR_JAX:005557
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cell.com/cancer-cell/fulltext/S1535-6108(25)00079-0
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Bioengineering the metabolic network of CAR T cells with GLP-1 and Urolithin A increases persistence and long-term anti-tumor activity

1
1. scibot 20 Mar 2025
  
  in Public
  
  The Jackson Laboratory005557
  
  DOI: 10.1016/j.xcrm.2025.102021
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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pmc.ncbi.nlm.nih.gov/articles/PMC11970383/
www.sciencedirect.com www.sciencedirect.com

Effective targeting of PDGFRA-altered high-grade glioma with avapritinib

1
1. scibot 14 Mar 2025
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.ccell.2025.02.018
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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sciencedirect.com/science/article/pii/S1535610825000704
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Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits

1
1. scibot 13 Mar 2025
  
  in Public
  
  NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ, Stock No: 005557
  
  DOI: 10.1016/j.cell.2025.02.012
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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sciencedirect.com/science/article/pii/S0092867425001977
www.sciencedirect.com www.sciencedirect.com

CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety

1
1. scibot 11 Mar 2025
  
  in Public
  
  Jackson Laboratories5557
  
  DOI: 10.1016/j.ccell.2025.02.006
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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sciencedirect.com/science/article/pii/S1535610825000583
www.sciencedirect.com www.sciencedirect.com

Restoration of LAT activity improves CAR T cell sensitivity and persistence in response to antigen-low acute lymphoblastic leukemia

1
1. scibot 11 Mar 2025
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.ccell.2025.02.008
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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sciencedirect.com/science/article/pii/S1535610825000601
www.cell.com www.cell.com

Inhibition of PRC2 enables self-renewal of blastoid-competent naive pluripotent stem cells from chimpanzee

1
1. scibot 07 Mar 2025
  
  in Public
  
  005557
  
  DOI: 10.1016/j.stem.2025.02.002
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @sjvitug
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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cell.com/cell-stem-cell/fulltext/S1934-5909(25)00041-4
www.cell.com www.cell.com

Metabolic engineering to facilitate anti-tumor immunity

1
1. scibot 07 Mar 2025
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.ccell.2025.02.004
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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cell.com/cancer-cell/fulltext/S1535-6108(25)00056-X
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

DHX9 helicase impacts on splicing decisions by modulating U2 snRNP recruitment in Ewing sarcoma cells

1
1. scibot 07 Mar 2025
  
  in Public
  
  JAX:005
  
  DOI: 10.1093/nar/gkaf068
  
  Resource: None
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557 RRIDCUR:Unresolved
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pmc.ncbi.nlm.nih.gov/articles/PMC11826090/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

TMEM41B is an endoplasmic reticulum Ca2+ release channel maintaining naive T cell quiescence and responsiveness

1
1. scibot 06 Mar 2025
  
  in Public
  
  JAX:005557
  
  DOI: 10.1038/s41421-024-00766-w
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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pmc.ncbi.nlm.nih.gov/articles/PMC11880246/
www.sciencedirect.com www.sciencedirect.com

Adhesion strength of tumor cells predicts metastatic disease in vivo

1
1. scibot 06 Mar 2025
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.celrep.2025.115359
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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sciencedirect.com/science/article/pii/S2211124725001305
52.53.155.43 52.53.155.43

1-s2.0-S2589004225003827-main-html.html

1
1. scibot 04 Mar 2025
  
  in Public
  
  JAX:005557
  
  DOI: 10.1016/j.isci.2025.112122
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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52.53.155.43/9971826d61a2d36f2abda36396d24ddec628d233/1-s2.0-S2589004225003827-main-html.html
www.cell.com www.cell.com

Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response

1
1. scibot 04 Mar 2025
  
  in Public
  
  Jackson Laboratory Cat_005557
  
  DOI: 10.1016/j.cell.2025.01.043
  
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  Curator: @areedewitt04
  
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cell.com/cell/abstract/S0092-8674(25)00145-X
Feb 2025
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FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma

1
1. scibot 28 Feb 2025
  
  in Public
  
  Jackson Laboratorystock 5557
  
  DOI: 10.1016/j.ccell.2025.02.001
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S1535610825000534
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 28 Feb 2025
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1101/2025.02.17.638725
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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52.53.155.43/14aa111ce8a1e5484e892552f2e3d7e5be8c5aa9/PDF-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Engineered receptors for soluble cellular communication and disease sensing

1
1. scibot 26 Feb 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1038/s41586-024-08366-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11839477/
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Potentiating anti-tumor immunity by re-engaging immune synapse molecules

1
1. scibot 25 Feb 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.xcrm.2025.101975
  
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EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models

1
1. scibot 25 Feb 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.ccell.2025.01.013
  
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cell.com/cancer-cell/abstract/S1535-6108(25)00031-5
ashpublications.org ashpublications.org

CD70-specific CAR-NK cells expressing IL-15 for the treatment of CD19-negative B cell malignancy

1
1. scibot 20 Feb 2025
  
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  IMSR_JAX:005557
  
  DOI: 10.1182/bloodadvances.2023012202
  
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ashpublications.org/bloodadvances/article/8/11/2635/515576/CD70-specific-CAR-NK-cells-expressing-IL-15-for
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Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation

1
1. scibot 20 Feb 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.stem.2025.01.011
  
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PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1

1
1. scibot 20 Feb 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.stem.2025.01.010
  
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sciencedirect.com/science/article/pii/S1934590925000104
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TGF-β1-mediated intercellular signaling fuels cooperative cellular invasion

1
1. scibot 20 Feb 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.celrep.2025.115315
  
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aacrjournals.org aacrjournals.org

A targetable secreted neural protein drives pancreatic cancer metastatic colonization and HIF1a nuclear retention

1
1. scibot 14 Feb 2025
  
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  JAX:005557
  
  DOI: 10.1158/2159-8290.CD-23-1323
  
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aacrjournals.org/cancerdiscovery/article/14/12/2489/750146/A-Targetable-Secreted-Neural-Protein-Drives
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Synonymous mutations promote tumorigenesis by disrupting m6A-dependent mRNA metabolism

1
1. scibot 14 Feb 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.cell.2025.01.026
  
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sciencedirect.com/science/article/pii/S0092867425000959
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VPAC2 Receptor Signaling Promotes Growth and Immunosuppression in Pancreatic Cancer

1
1. scibot 13 Feb 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/0008-5472.CAN-23-3628
  
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aacrjournals.org/cancerres/article/84/18/2954/747784/VPAC2-Receptor-Signaling-Promotes-Growth-and
www.biorxiv.org www.biorxiv.org

Exploring ID4 as a Driver of Aggression and a Therapeutic Target in Triple-Negative Breast Cancer

1
1. scibot 13 Feb 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1101/2025.02.07.637072
  
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biorxiv.org/content/10.1101/2025.02.07.637072v1
52.53.155.43 52.53.155.43

1-s2.0-S2950329925000189-main-html.html

1
1. scibot 13 Feb 2025
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.omton.2025.200949
  
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52.53.155.43/c3e833800adc8f621ec9d7dbe012c414845f900d/1-s2.0-S2950329925000189-main-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma

1
1. scibot 11 Feb 2025
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/2159-8290.CD-24-0187
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11803400/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

SMAD4 and KRAS Status Shape Cancer Cell-Stromal Crosstalk and Therapeutic Response in Pancreatic Cancer

1
1. scibot 11 Feb 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/0008-5472.CAN-24-2330
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617379/
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Bioengineering of a human iPSC-derived vascularized endocrine pancreas for type 1 diabetes

1
1. scibot 11 Feb 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.xcrm.2025.101938
  
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Repurposing statins and phenothiazines to treat chemoresistant neuroblastoma

1
1. scibot 07 Feb 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1101/2025.01.28.635193
  
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biorxiv.org/content/10.1101/2025.01.28.635193v1
52.53.155.43 52.53.155.43

Advanced human cerebral organoids as a model for investigating glioma stem cell interactions with microglia and vascular cells and response to radiotherapy

1
1. scibot 07 Feb 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1101/2024.11.28.625826
  
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52.53.155.43/80cf3e536b33c80506079b55aea33c35bffc1d62/2024.11.28.625826.full-html.html
www.sciencedirect.com www.sciencedirect.com

GUK1 activation is a metabolic liability in lung cancer

1
1. scibot 07 Feb 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.cell.2025.01.024
  
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link.springer.com link.springer.com

Selective JAK2 pathway inhibition enhances anti-leukemic functionality in CD19 CAR-T cells

1
1. scibot 07 Feb 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1007/s00262-024-03927-8
  
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link.springer.com/article/10.1007/s00262-024-03927-8
Jan 2025
www.biorxiv.org www.biorxiv.org

Avoidance of pyroptosis accounts for the relatively high metastatic potential observed in early hybrid EMT states

1
1. scibot 31 Jan 2025
  
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  #005557
  
  DOI: 10.1101/2025.01.26.634904
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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biorxiv.org/content/10.1101/2025.01.26.634904v1
52.53.155.43 52.53.155.43

noaf027-html.html

1
1. scibot 31 Jan 2025
  
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  JAX:005557
  
  DOI: 10.1093/neuonc/noaf027
  
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52.53.155.43/a42e4ad0320594867d94aa87881c83143f6c1704/noaf027-html.html
www.sciencedirect.com www.sciencedirect.com

Targeting HLA-E-overexpressing cancers with a NKG2A/C switch receptor

1
1. scibot 30 Jan 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.medj.2024.09.010
  
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sciencedirect.com/science/article/pii/S2666634024003775
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Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy

1
1. scibot 30 Jan 2025
  
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  Jackson Laboratories005557
  
  DOI: 10.1016/j.cmet.2024.12.007
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

An Autophagy-Targeting Chimera Induces Degradation of Androgen Receptor Mutants and AR-v7 in Castration-Resistant Prostate Cancer

1
1. scibot 25 Jan 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/0008-5472.CAN-24-0591
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11733533/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Single-cell analysis of neoplastic plasma cells identifies myeloma pathobiology mediators and potential targets

1
1. scibot 24 Jan 2025
  
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  Jackson Laboratory005557
  
  DOI: 10.1016/j.xcrm.2024.101925
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11866523/
52.53.155.43 52.53.155.43

1-s2.0-S2589004225001026-main-html.html

1
1. scibot 23 Jan 2025
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.isci.2025.111842
  
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52.53.155.43/9cdc52fc0b70ce3d9f24b335db5892b38840adb3/1-s2.0-S2589004225001026-main-html.html
onlinelibrary.wiley.com onlinelibrary.wiley.com

Fibroblast growth factor receptor four inhibitor FGF401 improves the efficacy of trastuzumab in FGFR4-overexpressing breast cancer cells

1
1. scibot 17 Jan 2025
  
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  JAX, 005557
  
  DOI: 10.1002/ijc.35271
  
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onlinelibrary.wiley.com/doi/10.1002/ijc.35271
www.nature.com www.nature.com

Nuclear speckles regulate functional programs in cancer

1
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  005557
  
  DOI: 10.1038/s41556-024-01570-0
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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nature.com/articles/s41556-024-01570-0
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Bone marrow mesenchymal stromal cells support translation in refractory acute myeloid leukemia

1
1. scibot 03 Jan 2025
  
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  JAX:005557
  
  DOI: 10.1016/j.celrep.2024.115151
  
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sciencedirect.com/science/article/pii/S221112472401502X
Dec 2024
www.cell.com www.cell.com

Mechanism of enhancing chemotherapy efficacy in pancreatic ductal adenocarcinoma with paricalcitol and hydroxychloroquine

2
1. scibot 29 Dec 2024
  
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  005557
  
  DOI: 10.14309/01.ajg.0000966496.32906.2f
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @sjvitug
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
  What is this?
  
  RRID:IMSR_JAX:005557
2. scibot 29 Dec 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.xcrm.2024.101881
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00652-9
www.cell.com www.cell.com

Targeting P4HA1 promotes CD8+ T cell progenitor expansion toward immune memory and systemic anti-tumor immunity

1
1. scibot 29 Dec 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.ccell.2024.12.001
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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cell.com/cancer-cell/fulltext/S1535-6108(24)00476-8
www.cell.com www.cell.com

MIRO2 promotes cancer invasion and metastasis via MYO9B suppression of RhoA activity

1
1. scibot 28 Dec 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.celrep.2024.115120
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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cell.com/cell-reports/abstract/S2211-1247(24)01471-2
www.cell.com www.cell.com

Cell therapy with human IL-10-producing ILC2s limits xenogeneic graft-versus-host disease by inhibiting pathogenic T cell responses

1
1. scibot 28 Dec 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.celrep.2024.115102
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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cell.com/cell-reports/fulltext/S2211-1247(24)01453-0
www.sciencedirect.com www.sciencedirect.com

RNA sensing induced by chromosome missegregation augments anti-tumor immunity

1
1. scibot 24 Dec 2024
  
  in Public
  
  The Jackson LaboratoryStrain #: 005557
  
  DOI: 10.1016/j.molcel.2024.11.025
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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sciencedirect.com/science/article/pii/S109727652400950X
www.sciencedirect.com www.sciencedirect.com

A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor

1
1. scibot 24 Dec 2024
  
  in Public
  
  Jackson laboratoriesStrain 005557
  
  DOI: 10.1016/j.cell.2024.11.009
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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sciencedirect.com/science/article/pii/S0092867424013266
52.53.155.43 52.53.155.43

ccr-24-1522-html.html

1
1. scibot 24 Dec 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/1078-0432.ccr-24-1522
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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52.53.155.43/e29ff64f8436a731bd410b919921fd37358d7b82/ccr-24-1522-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation

1
1. scibot 21 Dec 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1172/JCI176851
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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pmc.ncbi.nlm.nih.gov/articles/PMC11563687/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer

1
1. scibot 21 Dec 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1101/2024.02.20.581056
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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pmc.ncbi.nlm.nih.gov/articles/PMC11601497/
52.53.155.43 52.53.155.43

mcr-24-0689-html.html

1
1. scibot 19 Dec 2024
  
  in Public
  
  JAX:005557
  
  DOI: 10.1158/1541-7786.mcr-24-0689
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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52.53.155.43/13f82acf0696e8bf1f1a9feca475cc80ec2fe945/mcr-24-0689-html.html
www.sciencedirect.com www.sciencedirect.com

YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies

1
1. scibot 18 Dec 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.cell.2024.11.007
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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sciencedirect.com/science/article/pii/S0092867424013242
www.sciencedirect.com www.sciencedirect.com

Combinatorial genetic engineering strategy for immune protection of stem cell-derived beta cells by chimeric antigen receptor regulatory T cells

1
1. scibot 14 Dec 2024
  
  in Public
  
  JAX:005557
  
  DOI: 10.1016/j.celrep.2024.114994
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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sciencedirect.com/science/article/pii/S2211124724013457
www.tandfonline.com www.tandfonline.com

A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer

1
1. scibot 13 Dec 2024
  
  in Public
  
  Stock Number 005557; The Jackson Laboratory
  
  DOI: 10.1080/19420862.2024.2438173
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @AlecAsdourian
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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tandfonline.com/doi/full/10.1080/19420862.2024.2438173
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Reciprocal inhibition of NOTCH and SOX2 shapes tumor cell plasticity and therapeutic escape in triple-negative breast cancer

1
1. scibot 13 Dec 2024
  
  in Public
  
  Jackson Laboratory Cat_005557
  
  DOI: 10.1038/s44321-024-00161-8
  
  Resource: None
  
  Curator: @evieth
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRIDCUR:Unresolved RRID:IMSR_JAX:005557
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pmc.ncbi.nlm.nih.gov/articles/PMC11628624/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

TCR-Engineered T Cells Directed against Ropporin-1 Constitute a Safe and Effective Treatment for Triple-Negative Breast Cancer

1
1. scibot 12 Dec 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/2159-8290.CD-24-0168
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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pmc.ncbi.nlm.nih.gov/articles/PMC11609630/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

mLumiOpto Is a Mitochondrial-Targeted Gene Therapy for Treating Cancer

1
1. scibot 12 Dec 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/0008-5472.CAN-24-0984
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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pmc.ncbi.nlm.nih.gov/articles/PMC11609628/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Preclinical Characterization of ARX517, a Site-Specific Stable PSMA-Targeted Antibody–Drug Conjugate for the Treatment of Metastatic Castration-Resistant Prostate Cancer

1
1. scibot 11 Dec 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/1535-7163.MCT-23-0927
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
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  RRID:IMSR_JAX:005557
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pmc.ncbi.nlm.nih.gov/articles/PMC11612621/
www.sciencedirect.com www.sciencedirect.com

BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate

1
1. scibot 10 Dec 2024
  
  in Public
  
  JAX:005557
  
  DOI: 10.1016/j.stem.2024.10.014
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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sciencedirect.com/science/article/pii/S193459092400376X
52.53.155.43 52.53.155.43

Bivalent SMAC mimetic APG-1387 reduces HIV reservoirs and limits viral rebound in humanized mice

1
1. scibot 06 Dec 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.isci.2024.111470
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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52.53.155.43/f9ca87b1abaf28874b4c47b89498458fbdf5e637/1-s2.0-S258900422402697X-main-html.html
www.sciencedirect.com www.sciencedirect.com

EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell function

1
1. scibot 06 Dec 2024
  
  in Public
  
  Jackson Laboratory Stock_005557
  
  DOI: 10.1016/j.ccell.2024.11.006
  
  Resource: None
  
  Curator: @areedewitt04
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRIDCUR:Unresolved RRID:IMSR_JAX:005557
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sciencedirect.com/science/article/pii/S1535610824004410
www.nature.com www.nature.com

The dysadherin/MMP9 axis modifies the extracellular matrix to accelerate colorectal cancer progression

1
1. scibot 03 Dec 2024
  
  in Public
  
  Cat#005557; Jackson Laboratory
  
  DOI: 10.1038/s41467-024-54920-9
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @AlecAsdourian
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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nature.com/articles/s41467-024-54920-9
www.sciencedirect.com www.sciencedirect.com

Macrophages are activated toward phagocytic lymphoma cell clearance by pentose phosphate pathway inhibition

1
1. scibot 02 Dec 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.xcrm.2024.101830
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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sciencedirect.com/science/article/pii/S2666379124006013
Nov 2024
www.nature.com www.nature.com

A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia

1
1. scibot 28 Nov 2024
  
  in Public
  
  RRID:IMSR_JSX:005557
  
  DOI: 10.1038/s43018-024-00863-5
  
  Resource: None
  
  Curator: @AlecAsdourian
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557 RRIDCUR:Unresolved
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nature.com/articles/s43018-024-00863-5
www.sciencedirect.com www.sciencedirect.com

Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint

1
1. scibot 24 Nov 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.immuni.2024.10.013
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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sciencedirect.com/science/article/pii/S107476132400493X
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A single‐chain variable fragment‐based bispecific T‐cell activating antibody against CD117 enables T‐cell mediated lysis of acute myeloid leukemia and hematopoietic stem and progenitor cells

1
1. scibot 21 Nov 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1002/hem3.70055
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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pmc.ncbi.nlm.nih.gov/articles/PMC11574467/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Preclinical Multi-Omic Assessment of Pioglitazone in Skeletal Muscles of Mice Implanted with Human HER2/neu Overexpressing Breast Cancer Xenografts

1
1. scibot 14 Nov 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.3390/cancers16213640
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
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  RRID:IMSR_JAX:005557
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pmc.ncbi.nlm.nih.gov/articles/PMC11544806/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Enhancing anti-EGFRvIII CAR T cell therapy against glioblastoma with a paracrine SIRPγ-derived CD47 blocker

1
1. scibot 14 Nov 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1038/s41467-024-54129-w
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
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  RRID:IMSR_JAX:005557
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pmc.ncbi.nlm.nih.gov/articles/PMC11550474/
www.sciencedirect.com www.sciencedirect.com

A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR-Cas9 gene editing in hematopoietic stem and progenitor cells

1
1. scibot 14 Nov 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.xcrm.2024.101823
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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sciencedirect.com/science/article/pii/S2666379124005949
www.sciencedirect.com www.sciencedirect.com

Itaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistance

1
1. scibot 11 Nov 2024
  
  in Public
  
  JAX:005557
  
  DOI: 10.1016/j.ccell.2024.10.010
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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sciencedirect.com/science/article/pii/S1535610824003982
Oct 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Oncogenic cells of renal embryonic lineage sensitive to the small molecule inhibitor QC6352 display depletion of KDM4 levels and disruption of ribosome biogenesis

1
1. scibot 04 Oct 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/1535-7163.MCT-23-0312
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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ncbi.nlm.nih.gov/pmc/articles/PMC10987284/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Redirecting B7-H3.CAR T cells to Chemokines Expressed in Osteosarcoma Enhances Homing and Antitumor Activity in Preclinical Models

1
1. scibot 04 Oct 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/1078-0432.CCR-23-3298
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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ncbi.nlm.nih.gov/pmc/articles/PMC11443211/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Development of a [89Zr]Zr-labeled human antibody using a novel phage-displayed human scFv library

1
1. scibot 03 Oct 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/1078-0432.CCR-23-3647
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRID:IMSR_JAX:005557
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ncbi.nlm.nih.gov/pmc/articles/PMC10984770/
aacrjournals.org aacrjournals.org

H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone

1
1. scibot 02 Oct 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/2159-8290.CD-20-0461
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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aacrjournals.org/cancerdiscovery/article/10/12/1968/2414/H3-3-G34W-Promotes-Growth-and-Impedes
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A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration

1
1. scibot 02 Oct 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.stem.2024.09.001
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S1934590924003151
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Multivalent MVA-vectored vaccine elicits EBV neutralizing antibodies in rhesus macaques that reduce EBV infection in humanized mice

1
1. scibot 02 Oct 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.3389/fimmu.2024.1445209
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11427267/
Sep 2024
www.biorxiv.org www.biorxiv.org

Engineered Receptors for Soluble Cell-to-Cell Communication

1
1. scibot 28 Sep 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1101/2024.09.17.613377
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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biorxiv.org/content/10.1101/2024.09.17.613377v1
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Induction of immortal-like and functional CAR T cells by defined factors

1
1. scibot 27 Sep 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1084/jem.20232368
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10965394/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING

1
1. scibot 26 Sep 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1101/2024.09.03.610968
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11398426/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A benzarone derivative inhibits EYA to suppress tumor growth in SHH medulloblastoma

1
1. scibot 25 Sep 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/0008-5472.CAN-22-3784
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10948029/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Novel immunotherapeutics against LGR5 to target multiple cancer types

1
1. scibot 25 Sep 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1038/s44321-024-00121-2
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11393416/
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Integrative identification of non-coding regulatory regions driving metastatic prostate cancer

1
1. scibot 17 Sep 2024
  
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  Strain#005557
  
  DOI: 10.1016/j.celrep.2024.114764
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @vtello
  
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sciencedirect.com/science/article/pii/S221112472401115X
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Rewired glutamate metabolism diminishes cytostatic action of L-asparaginase

1
1. scibot 17 Sep 2024
  
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  JAX:005557
  
  DOI: 10.1016/j.canlet.2024.217242
  
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sciencedirect.com/science/article/pii/S0304383524006372
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PRMT5 supports multiple oncogenic pathways in mantle cell lymphoma

1
1. scibot 12 Sep 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1182/blood.2022019419
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10517215/
aacrjournals.org aacrjournals.org

Aberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma

1
1. scibot 12 Sep 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/0008-5472.CAN-22-0677
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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aacrjournals.org/cancerres/article/83/2/195/715074/Aberrant-L-Fucose-Accumulation-and-Increased-Core
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Bifunctional inhibitor reveals NEK2 as a therapeutic target and regulator of oncogenic pathways in lymphoma

1
1. scibot 05 Sep 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/1535-7163.MCT-23-0299
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10932871/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Targeting AKR1B10 by drug repurposing with epalrestat overcomes chemoresistance in non-small cell lung cancer patient-derived tumor organoids

1
1. scibot 05 Sep 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/1078-0432.CCR-23-3980
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11369614/
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A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib

1
1. scibot 04 Sep 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.xcrm.2024.101703
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S2666379124004245
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Smarcd1 subunit of SWI/SNF chromatin-remodeling complexes collaborates with E2a to promote murine lymphoid specification

1
1. scibot 04 Sep 2024
  
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  JAX:005557
  
  DOI: 10.1016/j.devcel.2024.08.007
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S1534580724004908
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Role of Forkhead Box P3 in Interferon γ-mediated PD-L1 Expression and Bladder Cancer Epithelial-to-Mesenchymal Transition

1
1. scibot 28 Aug 2024
  
  in Public
  
  JAX_005557
  
  DOI: 10.1158/2767-9764.CRC-23-0493
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @vtello
  
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  RRIDCUR:Unresolved RRID:IMSR_JAX:005557
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ncbi.nlm.nih.gov/pmc/articles/PMC11345674/
www.cell.com www.cell.com

Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies

1
1. scibot 22 Aug 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.cell.2020.02.019
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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cell.com/cell/fulltext/S0092-8674(20)30163-X
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Interleukin-21 engineering enhances NK cell activity against glioblastoma via CEBPD

1
1. scibot 21 Aug 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.ccell.2024.07.007
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S1535610824002721
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Nuclear PKM2 binds pre-mRNA at folded G-quadruplexes and reveals their gene regulatory role

1
1. scibot 20 Aug 2024
  
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  005557
  
  DOI: 10.1016/j.molcel.2024.07.025
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @vtello
  
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sciencedirect.com/science/article/pii/S1097276524006233
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Anti-EGFR Antibody–Drug Conjugate Carrying an Inhibitor Targeting CDK Restricts Triple-Negative Breast Cancer Growth

1
1. scibot 18 Aug 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/1078-0432.CCR-23-3110
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11292198/
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Time- and cell-specific activation of BMP signaling restrains chondrocyte hypertrophy

1
1. scibot 13 Aug 2024
  
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  005557
  
  DOI: 10.1016/j.isci.2024.110537
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S2589004224017620
www.biorxiv.org www.biorxiv.org

Senescent fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity

1
1. scibot 13 Aug 2024
  
  in Public
  
  Jackson Laboratory, catalog #005557
  
  DOI: 10.1101/2024.07.29.605645
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @dhovakimyan1
  
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  RRID:IMSR_JAX:005557 DOI:10.1101/2024.07.29.605645
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biorxiv.org/content/10.1101/2024.07.29.605645v1
www.nature.com www.nature.com

A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses

1
1. scibot 13 Aug 2024
  
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  RRID: IMSR_JAX: 005557
  
  DOI: 10.1038/s41590-024-01880-3
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @AniH
  
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nature.com/articles/s41590-024-01880-3
cancerci.biomedcentral.com cancerci.biomedcentral.com

Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer

1
1. scibot 02 Aug 2024
  
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  RRID: IMSR_JAX:005557
  
  DOI: 10.1186/s12935-024-03231-6
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @anisehay
  
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cancerci.biomedcentral.com/articles/10.1186/s12935-024-03231-6
www.biorxiv.org www.biorxiv.org

Salmonella enterica serovar Typhi uses two type 3 secretion systems to replicate in human macrophages and to colonize humanized mice

1
1. scibot 02 Aug 2024
  
  in Public
  
  Humanized-NOD-scid IL2rγ-null mice
  
  DOI: 10.1101/2023.06.06.543980
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @evieth
  
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biorxiv.org/content/10.1101/2023.06.06.543980v1
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

N-Myristoyltransferase Inhibition causes Mitochondrial Iron Overload and Parthanatos in TIM17A-dependent Aggressive Lung Carcinoma

1
1. scibot 27 Jul 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/2767-9764.CRC-23-0428
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11270646/
www.sciencedirect.com www.sciencedirect.com

Protocol for assessing GD2 on formalin-fixed paraffin-embedded tissue sections using immunofluorescence staining

1
1. scibot 26 Jul 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.xpro.2024.103199
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S2666166724003642
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Integrated transcriptomics of human blood vessels defines a spatially controlled niche for early mesenchymal progenitor cells

1
1. scibot 26 Jul 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.devcel.2024.06.015
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1534580724003939
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PAI-1 uncouples integrin-β1 from restrain by membrane-bound β-catenin to promote collagen fibril remodeling in obesity-related neoplasms

1
1. scibot 25 Jul 2024
  
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  005557
  
  DOI: 10.1016/j.celrep.2024.114527
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @vtello
  
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sciencedirect.com/science/article/pii/S2211124724008568
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Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies

1
1. scibot 25 Jul 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.ccell.2024.06.006
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S1535610824002319
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Preclinical proof of principle for orally delivered Th17 antagonist miniproteins

1
1. scibot 23 Jul 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.cell.2024.05.052
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S0092867424006317
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Protocol to construct humanized mice with adult CD34+ hematopoietic stem and progenitor cells

1
1. scibot 20 Jul 2024
  
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  JAX:005557
  
  DOI: 10.1016/j.xpro.2024.103155
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S2666166724003204
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling

1
1. scibot 17 Jul 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.xcrm.2024.101645
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11293342/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression

1
1. scibot 17 Jul 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1038/s41598-024-66811-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11239875/
www.biorxiv.org www.biorxiv.org

Organoid Models Derived from Primary Tumors and Patient-Derive Xenograft Tumors Reflect Platinum Sensitivity of Ovarian Cancer Patients

1
1. scibot 16 Jul 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1101/2024.06.28.601283
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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biorxiv.org/content/10.1101/2024.06.28.601283v1
www.cell.com www.cell.com

Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis

1
1. scibot 12 Jul 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.celrep.2024.114431
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00760-5
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HER4 Affects Sensitivity to Tamoxifen and Abemaciclib in Luminal Breast Cancer Cells and Restricts Tumor Growth in MCF-7-Based Humanized Tumor Mice

1
1. scibot 12 Jul 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.3390/ijms25137475
  
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mdpi.com/1422-0067/25/13/7475
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Genetic ablation of adhesion ligands mitigates rejection of allogeneic cellular immunotherapies

1
1. scibot 11 Jul 2024
  
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  JAX:005557
  
  DOI: 10.1016/j.stem.2024.06.011
  
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cell.com/cell-stem-cell/abstract/S1934-5909(24)00219-4
Jun 2024
www.nature.com www.nature.com

A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses

1
1. scibot 28 Jun 2024
  
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  JAX:005557
  
  DOI: 10.1038/s41590-024-01880-3
  
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nature.com/articles/s41590-024-01880-3
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TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons

1
1. scibot 21 Jun 2024
  
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  JAX:005557
  
  DOI: 10.1016/j.cell.2024.05.030
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S0092867424005750
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation

1
1. scibot 15 Jun 2024
  
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  JAX:005557
  
  DOI: 10.1038/s43018-023-00704-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11175596/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The exonuclease TREX1 constitutes an innate immune checkpoint limiting cGAS/STING-mediated antitumor immunity

1
1. scibot 08 Jun 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/2326-6066.CIR-23-1078
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11148535/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Nextflow pipeline for Visium and H&E data from patient-derived xenograft samples

1
1. scibot 08 Jun 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.crmeth.2024.100759
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11133696/
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De novo and salvage purine synthesis pathways across tissues and tumors

1
1. scibot 04 Jun 2024
  
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  005557
  
  DOI: 10.1016/j.cell.2024.05.011
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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  RRID:IMSR_JAX:005557 DOI:10.1016/j.cell.2024.05.011
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sciencedirect.com/science/article/pii/S0092867424005208
www.cell.com www.cell.com

DARPin-fused T cell engager for adenovirus-mediated cancer therapy

1
1. scibot 04 Jun 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.omton.2024.200821
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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cell.com/molecular-therapy-family/oncology/abstract/S2950-3299(24)00063-8
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Enhancing PKA-dependent mesothelial barrier integrity reduces ovarian cancer spheroid transmesothelial migration via inhibition of contractility

1
1. scibot 02 Jun 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.isci.2024.109950
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11134878/
May 2024
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Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite

2
1. scibot 31 May 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.ccell.2024.05.006
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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2. scibot 31 May 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.ccell.2024.05.006
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S1535610824001697
www.biorxiv.org www.biorxiv.org

SMAD4 and KRAS status shape malignant-stromal crosstalk in pancreatic cancer

1
1. scibot 23 May 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1101/2024.04.28.591518
  
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biorxiv.org/content/10.1101/2024.04.28.591518v1
aacrjournals.org aacrjournals.org

Development of chromosome 1q+ specific treatment for highest risk pediatric posterior fossa ependymoma

1
1. scibot 23 May 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/1078-0432.CCR-23-3156
  
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aacrjournals.org/clincancerres/article/30/8/1544/742119/Development-of-Chromosome-1q-Specific-Treatment
52.53.155.43 52.53.155.43

cir-23-1078-html.html

1
1. scibot 23 May 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/2326-6066.cir-23-1078
  
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52.53.155.43/ee0bd7762d373e957152429ed1d9032329c895e5/cir-23-1078-html.html
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma

2
1. scibot 23 May 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1101/2024.04.23.590638
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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2. scibot 23 May 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1101/2024.04.23.590638
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11071395/
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linc-ADAIN, a human adipose lincRNA, regulates adipogenesis by modulating KLF5 and IL-8 mRNA stability

1
1. scibot 16 May 2024
  
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  005557
  
  DOI: 10.1016/j.celrep.2024.114240
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S2211124724005680
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Neoadjuvant radiotherapy in ER+, HER2+, and triple-negative -specific breast cancer based humanized tumor mice enhances anti-PD-L1 treatment efficacy

1
1. scibot 15 May 2024
  
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  JAX:005557
  
  DOI: 10.3389/fimmu.2024.1355130
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11089195/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Human CD4+ Memory Phenotype T cells use mitochondrial metabolism to generate sensitive IFN-γ responses

1
1. scibot 11 May 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.isci.2024.109775
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11079467/
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Inhibition of protein translational machinery in triple-negative breast cancer as a promising therapeutic strategy

1
1. scibot 10 May 2024
  
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  005557
  
  DOI: 10.1016/j.xcrm.2024.101552
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S2666379124002441
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Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma

1
1. scibot 09 May 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.celrep.2024.114211
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S2211124724005394
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Urolithin-A Promotes CD8+ T Cell–mediated Cancer Immunosurveillance via FOXO1 Activation

1
1. scibot 08 May 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/2767-9764.CRC-24-0022
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11067828/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Comprehensive Transcriptomic Analysis of EWSR1::WT1 Targets Identifies CDK4/6 Inhibitors as an Effective Therapy for Desmoplastic Small Round Cell Tumors

1
1. scibot 04 May 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/0008-5472.CAN-23-3334
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11063761/
www.biorxiv.org www.biorxiv.org

Imipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma

1
1. scibot 03 May 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1101/2024.01.12.575058
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @abever99
  
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biorxiv.org/content/10.1101/2024.01.12.575058v1
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Preclinical Multi-Omic Assessment of Pioglitazone in Skeletal Muscles of Mice Implanted with Human HER2/neu Overexpressing Breast Cancer Xenografts

1
1. scibot 03 May 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1101/2024.04.15.589557
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11042380/
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Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas

1
1. scibot 03 May 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.ccell.2024.04.007
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S1535610824001314
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

In vitro platform to model the function of ionocytes in the human airway epithelium

1
1. scibot 30 Apr 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1186/s12931-024-02800-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11045446/
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Selective refueling of CAR T cells using ADA1 and CD26 boosts antitumor immunity

1
1. scibot 30 Apr 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.xcrm.2024.101530
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S266637912400199X
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Development of a chimeric cytokine receptor that captures IL-6 and enhances the antitumor response of CAR-T cells

1
1. scibot 26 Apr 2024
  
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  Jackson LaboratoryStrain #:005557
  
  DOI: 10.1016/j.xcrm.2024.101526
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S2666379124001952
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Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer

1
1. scibot 25 Apr 2024
  
  in Public
  
  Jackson LaboratoryStrain# 005557
  
  DOI: 10.1016/j.stem.2024.03.018
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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NOVA1 acts as an oncogenic RNA-binding protein to regulate cholesterol homeostasis in human glioblastoma cells

1
1. scibot 25 Apr 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1073/pnas.2314695121
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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pnas.org/doi/abs/10.1073/pnas.2314695121
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Single-cell analysis reveals context-dependent, cell-level selection of mtDNA

1
1. scibot 25 Apr 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1038/s41586-024-07332-0
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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link.springer.com/article/10.1038/s41586-024-07332-0
www.liebertpub.com www.liebertpub.com

Biodistribution and Safety of Human Multi-Chimeric Cells (HMCC) After Systemic Intraosseous and Intravenous Administration in the Experimental Mouse Model

2
1. scibot 25 Apr 2024
  
  in Public
  
  RRID:ISMR_JAK:005557
  
  DOI: 10.1089/scd.2024.0007
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @abever99
  
  SciCrunch record: RRID:IMSR_JAX:005557
  
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  RRIDCUR:Unresolved RRID:IMSR_JAX:005557
2. scibot 25 Apr 2024
  
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  RRID:ISMR_JAK:005557
  
  DOI: 10.1089/scd.2024.0007
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @abever99
  
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liebertpub.com/doi/10.1089/scd.2024.0007
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HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression

1
1. scibot 24 Apr 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1093/narcan/zcae018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11034028/
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Differential RNA Expression Between Metastatic and Primary Neuroblastoma Cells

1
1. scibot 19 Apr 2024
  
  in Public
  
  RRID:IMSR_JAX:005
  
  DOI: 10.1016/j.jss.2024.03.032
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S0022480424001434
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Memory-like differentiation, tumor targeting monoclonal antibodies, and chimeric antigen receptors enhance natural killer cell responses to head and neck cancer

1
1. scibot 18 Apr 2024
  
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  JAX:005557
  
  DOI: 10.1158/1078-0432.CCR-23-0156
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10796148/
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iPSC-based modeling of preeclampsia identifies epigenetic defects in extravillous trophoblast differentiation

1
1. scibot 18 Apr 2024
  
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  JAX:005557
  
  DOI: 10.1016/j.isci.2024.109569
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11016801/
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Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons

1
1. scibot 16 Apr 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.stem.2024.03.013
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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Pharmacological induction of chromatin remodeling drives chemosensitization in triple-negative breast cancer

1
1. scibot 09 Apr 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.xcrm.2024.101504
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S2666379124001733
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Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer

1
1. scibot 04 Apr 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.celrep.2024.114041
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma

1
1. scibot 03 Apr 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.xcrm.2024.101472
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10983107/
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Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade

1
1. scibot 03 Apr 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1038/s41467-024-47069-y
  
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nature.com/articles/s41467-024-47069-y
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Targeting DNMT3A-mediated oxidative phosphorylation to overcome ibrutinib resistance in mantle cell lymphoma

1
1. scibot 02 Apr 2024
  
  in Public
  
  Jackson Laboratory5557
  
  DOI: 10.1016/j.xcrm.2024.101484
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S2666379124001307
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

MARCH2, a novel oncogene-regulated SNAIL E3 ligase, suppresses triple negative breast cancer metastases

1
1. scibot 31 Mar 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/2767-9764.CRC-23-0090
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10977041/
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Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma

1
1. scibot 29 Mar 2024
  
  in Public
  
  005557
  
  DOI: 10.1016/j.xcrm.2024.101468
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S2666379124001149
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Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1

1
1. scibot 28 Mar 2024
  
  in Public
  
  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.chembiol.2024.02.014
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S2451945624000886
www.nature.com www.nature.com

Regulatory T cells expressing CD19-targeted chimeric antigen receptor restore homeostasis in Systemic Lupus Erythematosus

1
1. scibot 28 Mar 2024
  
  in Public
  
  RRID:IMSR_JAX
  
  DOI: 10.1038/s41467-024-46448-9
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
  Curator: @anisehay
  
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  RRIDCUR:Unresolved RRID:IMSR_JAX:005557
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nature.com/articles/s41467-024-46448-9
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers

1
1. scibot 22 Mar 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1038/s41467-024-46284-x
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10951324/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The bone ecosystem facilitates multiple myeloma relapse and the evolution of heterogeneous drug resistant disease

1
1. scibot 22 Mar 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1038/s41467-024-46594-0
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10951361/
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FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis

1
1. scibot 22 Mar 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.molcel.2024.02.037
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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sciencedirect.com/science/article/pii/S1097276524001801
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CD73 contributes to the pathogenesis of fusion-negative rhabdomyosarcoma through the purinergic signaling pathway

1
1. scibot 21 Mar 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1073/pnas.2315925121
  
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pnas.org/doi/abs/10.1073/pnas.2315925121
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Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor

1
1. scibot 17 Mar 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.7554/eLife.90993
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10942784/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Precision Enhancement of CAR-NK Cells through Non-Viral Engineering and Highly Multiplexed Base Editing

1
1. scibot 15 Mar 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1101/2024.03.05.582637
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10942345/
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ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis

1
1. scibot 08 Mar 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.ccell.2024.02.010
  
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ALK upregulates POSTN and WNT signaling to drive neuroblastoma

1
1. scibot 06 Mar 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.celrep.2024.113927
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11101011/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Neutralizing antibodies impair the oncolytic efficacy of reovirus but permit effective combination with T cell-based immunotherapies

1
1. scibot 06 Mar 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/2326-6066.CIR-23-0480
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10911706/
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Engraftment of adult hematopoietic stem and progenitor cells in a novel model of humanized mice

1
1. scibot 06 Mar 2024
  
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  JAX:005557
  
  DOI: 10.1016/j.isci.2024.109238
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10904995/
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Identification and characterization of a potent and selective HUNK inhibitor for treatment of HER2+ breast cancer

2
1. scibot 06 Mar 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.chembiol.2024.01.001
  
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2. scibot 06 Mar 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1016/j.chembiol.2024.01.001
  
  Resource: (IMSR Cat# JAX_005557,RRID:IMSR_JAX:005557)
  
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Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression

1
1. scibot 03 Mar 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1038/s44321-023-00006-w
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10897411/
52.53.155.43 52.53.155.43

FEBS Press

1
1. scibot 01 Mar 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1002/1878-0261.13561
  
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52.53.155.43/47007dbc2cda4f961c79d2e8158521ca8af7c5b7/Molecular Oncology - 2023 - Bots - Preclinical evaluation of the gorilla-derived HAdV-B AdV-lumc007 oncolytic adenovirus -html.html
Feb 2024
aacrjournals.org aacrjournals.org

Single-cell transcriptomics reveals the heterogeneity of the immune landscape of IDH-wildtype high-grade gliomas

1
1. scibot 27 Feb 2024
  
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  RRID:IMSR_JAX:005557
  
  DOI: 10.1158/2326-6066.CIR-23-0211
  
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aacrjournals.org/cancerimmunolres/article/12/2/232/733764/Single-Cell-Transcriptomics-Reveals-the

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